Click here to switch to the map view.

The map label for this gene is adk

Identifier: 169823873

GI number: 169823873

Start: 189897

End: 190544

Strand: Direct

Name: adk

Synonym: FMG_0176

Alternate gene names: 169823873

Gene position: 189897-190544 (Clockwise)

Preceding gene: 169823872

Following gene: 169823874

Centisome position: 10.56

GC content: 35.19

Gene sequence:

>648_bases
ATGAGATTAATATTATTAGGACCTCCGGGAGCAGGTAAAGGAACTCAAGCTAAAAGAGTTATTGAAGAATTTGATATTCC
TCACATTTCAACAGGAGATATTTTCAGAAAAAATATCAAAGAAAAGACAGAACTAGGTCAAAAAGTTGAAGGCTTACTTG
CACAAGGAAAACTTGTACCTGATGAGTTAACAATAGAAATAGTATGGGATAGACTAGATCAAGAAGATTGCAAGAACGGA
TTCTTACTTGATGGATTCCCAAGAACAATCCCTCAAGCCGAAGCCCTTGATGAAGGACTAGCTAAAAGAGGATTGAAACT
AGATCGTGTATTGAACATAGACGTTGACAAAGATTCTCTTGTAAAAAGACTTTCAGGAAGACGTGTATGTCCTAGCTGTG
GTGCAAGCTATCACATTGACAACAACCCTACAAAAGTTGATGGAATTTGTGATGCATGTCAAACTCCAGTAATCCAAAGA
GAAGACGACAAAGAAGAAACTGTACTAGATAGAATCAAAGTTTACGATTCACAAACTAAACCTTTAGTAGATTTCTACAA
CAAACAAGATTTAGTATTCACAGTTGATGGAACTCTTCCAATAGATGAAATCACTAATAAGTTAGTAACAGAATTAAAAA
AAGGTTAG

Upstream 100 bases:

>100_bases
ATCATCATCGTAGTAGGTGTTGTATTAGATACTGTAAAACAAATGGAAAGTATGCTAACTATGAAACACTATAAAGGATT
TTTGAAATAAGGAGTTTATA

Downstream 100 bases:

>100_bases
AATTAATGAGCCAATACAACAAACTTGAAACAGGACAAGTTGTTTTAAGTACTTGTGGTCGTGATATGGGCAAACTACAA
ATGGTTTTGGAAATTCTTGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRLILLGPPGAGKGTQAKRVIEEFDIPHISTGDIFRKNIKEKTELGQKVEGLLAQGKLVPDELTIEIVWDRLDQEDCKNG
FLLDGFPRTIPQAEALDEGLAKRGLKLDRVLNIDVDKDSLVKRLSGRRVCPSCGASYHIDNNPTKVDGICDACQTPVIQR
EDDKEETVLDRIKVYDSQTKPLVDFYNKQDLVFTVDGTLPIDEITNKLVTELKKG

Sequences:

>Translated_215_residues
MRLILLGPPGAGKGTQAKRVIEEFDIPHISTGDIFRKNIKEKTELGQKVEGLLAQGKLVPDELTIEIVWDRLDQEDCKNG
FLLDGFPRTIPQAEALDEGLAKRGLKLDRVLNIDVDKDSLVKRLSGRRVCPSCGASYHIDNNPTKVDGICDACQTPVIQR
EDDKEETVLDRIKVYDSQTKPLVDFYNKQDLVFTVDGTLPIDEITNKLVTELKKG
>Mature_215_residues
MRLILLGPPGAGKGTQAKRVIEEFDIPHISTGDIFRKNIKEKTELGQKVEGLLAQGKLVPDELTIEIVWDRLDQEDCKNG
FLLDGFPRTIPQAEALDEGLAKRGLKLDRVLNIDVDKDSLVKRLSGRRVCPSCGASYHIDNNPTKVDGICDACQTPVIQR
EDDKEETVLDRIKVYDSQTKPLVDFYNKQDLVFTVDGTLPIDEITNKLVTELKKG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=40.9302325581395, Blast_Score=183, Evalue=8e-47,
Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=40.9302325581395, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI19923437, Length=202, Percent_Identity=42.5742574257426, Blast_Score=172, Evalue=1e-43,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=36.8686868686869, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=36.8686868686869, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=36.8686868686869, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=36.8686868686869, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI4502011, Length=211, Percent_Identity=26.0663507109005, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=29.5698924731183, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI7706497, Length=212, Percent_Identity=28.7735849056604, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI28144897, Length=212, Percent_Identity=22.6415094339623, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI28144899, Length=212, Percent_Identity=22.6415094339623, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=47.4178403755869, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17552384, Length=204, Percent_Identity=40.1960784313725, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17537943, Length=201, Percent_Identity=31.3432835820896, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=26.9767441860465, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=201, Percent_Identity=28.3582089552239, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=27.8846153846154, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=41.3953488372093, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=37.9487179487179, Blast_Score=135, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=196, Percent_Identity=23.9795918367347, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI22026816, Length=195, Percent_Identity=45.6410256410256, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=39.0862944162437, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=39.0862944162437, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI221459597, Length=203, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21356893, Length=203, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=23.2227488151659, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=23.2227488151659, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_FINM2 (B0RZT0)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691484.1
- ProteinModelPortal:   B0RZT0
- SMR:   B0RZT0
- GeneID:   6018593
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0176
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- BioCyc:   FMAG334413:FMG_0176-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24028; Mature: 24028

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQAKRVIEEFDIPHISTGDIFRKNIKEKTELGQKVEGLLAQGKLVP
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DELTIEIVWDRLDQEDCKNGFLLDGFPRTIPQAEALDEGLAKRGLKLDRVLNIDVDKDSL
CCEEEEHHHHHCCHHHHCCCCEECCCCCCCCCHHHHHHHHHHCCCCCHHEEEECCCHHHH
VKRLSGRRVCPSCGASYHIDNNPTKVDGICDACQTPVIQREDDKEETVLDRIKVYDSQTK
HHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCC
PLVDFYNKQDLVFTVDGTLPIDEITNKLVTELKKG
CHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQAKRVIEEFDIPHISTGDIFRKNIKEKTELGQKVEGLLAQGKLVP
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DELTIEIVWDRLDQEDCKNGFLLDGFPRTIPQAEALDEGLAKRGLKLDRVLNIDVDKDSL
CCEEEEHHHHHCCHHHHCCCCEECCCCCCCCCHHHHHHHHHHCCCCCHHEEEECCCHHHH
VKRLSGRRVCPSCGASYHIDNNPTKVDGICDACQTPVIQREDDKEETVLDRIKVYDSQTK
HHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCC
PLVDFYNKQDLVFTVDGTLPIDEITNKLVTELKKG
CHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA