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The map label for this gene is norM [H]

Identifier: 169823849

GI number: 169823849

Start: 176774

End: 178114

Strand: Direct

Name: norM [H]

Synonym: FMG_0152

Alternate gene names: 169823849

Gene position: 176774-178114 (Clockwise)

Preceding gene: 169823848

Following gene: 169823851

Centisome position: 9.83

GC content: 38.63

Gene sequence:

>1341_bases
ATGAAGAATAAGAATTTTTACAAAAGAGCGATACAGGTGGCGTGGCCGTCGGTGTTGGAGAGCTTTTTCATTGCACTTGC
AGGAATTATCGACACATACATGGTGTCTTCGATTGGAAGCTCTGCAGTAGCAGCCGTAGGTCTTACAACCCAACCTAAAT
TTATAGCATTGTCGATATTTTTCGCCATAAACATCGCAACATCAGCACTTGTAGCTAGACGTCTCGGTGAAGAAGACAAA
GAAGGAGCAAACAGAATACTTGTCACAGCGATTATCATGGGACTTGTTCTAACAGTTGTGATAAGCACTTTGATGGTGTA
TTTTTCAGATAGCATATTGAGACTTGCAGGAAGTAACTCAGACACGCATACTGATGCATTGAATTATTTCAGAATAATAA
TGGGTGGAATGCTTTTTTCCGTAGTCAGTATGGCGATAAATGCAGCACAAAGAGGATCAGGAAACACGAGAATTGCCTTC
ACGACCAACTTAGTGTCTAGTATTGTCAATATATTTTTCAACTACTGTTTGATAGGTGGTAATTTTGGTTTTCCGAAGAT
GGAAGTTTCAGGAGCAGCGCTTGCAACAGTACTTGGAACAGTCGTAAGTAGTATTATGTGCATCAGATCTCTTTTCAGAA
AAGATGGTTTCGTACAAATCAAATACATTTTCAAGAAGAAAATCAAACCAACAGTTGAAGTATTCACAAGTATCGTCAAA
CTTGGAACCAATTTGTTCGTAGAAAATATAGCCATGAGAATCGGATTCTTGACAACAGCATTGATGGCAGCAGGACTAGG
AACTGACACATTTGCAGCACACAACGTAGGAATGAATCTTCTTAGCATTTGTTTTGCGTTCGCAGACGGGATGCAAGTTG
CAGCAGTCGTTCTAACAGGATCAAGCCTTGGCGCTGGCAAGAAAGAAAACGCCAAGATTTACGGCAAAGTCTGCCAACGA
ATAGGACTTATGATATCTCTTGTACTATCTTTGATATTGTTGTTATTTGGAAAAGGAATATTCCATTTGTTCTTCGACAA
ACTCTCCATCATAGAAACAGGAGAAATCATCGCAAGATTCATCACAGTAATAGTCCTTCTACAAATCTCACAAATCATCT
ACGGAGGATGTTTGAGATCAGCAGGTGATGTAAAATACACATTAATCTCTTCAATCATAAGTGTAACAATCATAAGGACA
GTAGTAACATACATCCTTGTATCTGTGTTTGAAATGGGAATCGTGGGAATATGGCTAGGAATCTTCTCCGACCAATTCTC
TAGATACATGTTCAATTCAATCAGATTTAGACAAGGTAAATGGGTTAACATTAAAATATAA

Upstream 100 bases:

>100_bases
ACACGCTAACTTGTATTAATTTTTTATTAAGAGTATGATGTAATATATAATTTTATTTTTAGATATTTGAATTAGATTGA
ATTTTAGAATGGATGATTAG

Downstream 100 bases:

>100_bases
AAAATCGTCTCGTTTTGATATGTACCATCCTTACTGGATGACCCGGTAAAGATGGCACACATCATTTTGAGACGATTTTT
TTAATACTCATGTTTGAAAG

Product: Na+driven multidrug efflux pump

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKNKNFYKRAIQVAWPSVLESFFIALAGIIDTYMVSSIGSSAVAAVGLTTQPKFIALSIFFAINIATSALVARRLGEEDK
EGANRILVTAIIMGLVLTVVISTLMVYFSDSILRLAGSNSDTHTDALNYFRIIMGGMLFSVVSMAINAAQRGSGNTRIAF
TTNLVSSIVNIFFNYCLIGGNFGFPKMEVSGAALATVLGTVVSSIMCIRSLFRKDGFVQIKYIFKKKIKPTVEVFTSIVK
LGTNLFVENIAMRIGFLTTALMAAGLGTDTFAAHNVGMNLLSICFAFADGMQVAAVVLTGSSLGAGKKENAKIYGKVCQR
IGLMISLVLSLILLLFGKGIFHLFFDKLSIIETGEIIARFITVIVLLQISQIIYGGCLRSAGDVKYTLISSIISVTIIRT
VVTYILVSVFEMGIVGIWLGIFSDQFSRYMFNSIRFRQGKWVNIKI

Sequences:

>Translated_446_residues
MKNKNFYKRAIQVAWPSVLESFFIALAGIIDTYMVSSIGSSAVAAVGLTTQPKFIALSIFFAINIATSALVARRLGEEDK
EGANRILVTAIIMGLVLTVVISTLMVYFSDSILRLAGSNSDTHTDALNYFRIIMGGMLFSVVSMAINAAQRGSGNTRIAF
TTNLVSSIVNIFFNYCLIGGNFGFPKMEVSGAALATVLGTVVSSIMCIRSLFRKDGFVQIKYIFKKKIKPTVEVFTSIVK
LGTNLFVENIAMRIGFLTTALMAAGLGTDTFAAHNVGMNLLSICFAFADGMQVAAVVLTGSSLGAGKKENAKIYGKVCQR
IGLMISLVLSLILLLFGKGIFHLFFDKLSIIETGEIIARFITVIVLLQISQIIYGGCLRSAGDVKYTLISSIISVTIIRT
VVTYILVSVFEMGIVGIWLGIFSDQFSRYMFNSIRFRQGKWVNIKI
>Mature_446_residues
MKNKNFYKRAIQVAWPSVLESFFIALAGIIDTYMVSSIGSSAVAAVGLTTQPKFIALSIFFAINIATSALVARRLGEEDK
EGANRILVTAIIMGLVLTVVISTLMVYFSDSILRLAGSNSDTHTDALNYFRIIMGGMLFSVVSMAINAAQRGSGNTRIAF
TTNLVSSIVNIFFNYCLIGGNFGFPKMEVSGAALATVLGTVVSSIMCIRSLFRKDGFVQIKYIFKKKIKPTVEVFTSIVK
LGTNLFVENIAMRIGFLTTALMAAGLGTDTFAAHNVGMNLLSICFAFADGMQVAAVVLTGSSLGAGKKENAKIYGKVCQR
IGLMISLVLSLILLLFGKGIFHLFFDKLSIIETGEIIARFITVIVLLQISQIIYGGCLRSAGDVKYTLISSIISVTIIRT
VVTYILVSVFEMGIVGIWLGIFSDQFSRYMFNSIRFRQGKWVNIKI

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=445, Percent_Identity=24.2696629213483, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI48994890, Length=424, Percent_Identity=22.4056603773585, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48516; Mature: 48516

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKNFYKRAIQVAWPSVLESFFIALAGIIDTYMVSSIGSSAVAAVGLTTQPKFIALSIF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHH
FAINIATSALVARRLGEEDKEGANRILVTAIIMGLVLTVVISTLMVYFSDSILRLAGSNS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DTHTDALNYFRIIMGGMLFSVVSMAINAAQRGSGNTRIAFTTNLVSSIVNIFFNYCLIGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCC
NFGFPKMEVSGAALATVLGTVVSSIMCIRSLFRKDGFVQIKYIFKKKIKPTVEVFTSIVK
CCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHH
LGTNLFVENIAMRIGFLTTALMAAGLGTDTFAAHNVGMNLLSICFAFADGMQVAAVVLTG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEHHEEEC
SSLGAGKKENAKIYGKVCQRIGLMISLVLSLILLLFGKGIFHLFFDKLSIIETGEIIARF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ITVIVLLQISQIIYGGCLRSAGDVKYTLISSIISVTIIRTVVTYILVSVFEMGIVGIWLG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFSDQFSRYMFNSIRFRQGKWVNIKI
HHHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MKNKNFYKRAIQVAWPSVLESFFIALAGIIDTYMVSSIGSSAVAAVGLTTQPKFIALSIF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHH
FAINIATSALVARRLGEEDKEGANRILVTAIIMGLVLTVVISTLMVYFSDSILRLAGSNS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DTHTDALNYFRIIMGGMLFSVVSMAINAAQRGSGNTRIAFTTNLVSSIVNIFFNYCLIGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCC
NFGFPKMEVSGAALATVLGTVVSSIMCIRSLFRKDGFVQIKYIFKKKIKPTVEVFTSIVK
CCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHH
LGTNLFVENIAMRIGFLTTALMAAGLGTDTFAAHNVGMNLLSICFAFADGMQVAAVVLTG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEHHEEEC
SSLGAGKKENAKIYGKVCQRIGLMISLVLSLILLLFGKGIFHLFFDKLSIIETGEIIARF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ITVIVLLQISQIIYGGCLRSAGDVKYTLISSIISVTIIRTVVTYILVSVFEMGIVGIWLG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFSDQFSRYMFNSIRFRQGKWVNIKI
HHHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]