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The map label for this gene is vanR [H]

Identifier: 169823820

GI number: 169823820

Start: 142055

End: 142756

Strand: Direct

Name: vanR [H]

Synonym: FMG_0123

Alternate gene names: 169823820

Gene position: 142055-142756 (Clockwise)

Preceding gene: 169823819

Following gene: 169823821

Centisome position: 7.9

GC content: 32.19

Gene sequence:

>702_bases
ATGAAAATTATGGTAGTTGAAGATGATATTGATTTATCAGAATTAATTAGGATGTATTTGATTCCAGAAGGATGGGAGAT
AGAAACTTTTCATACTGGTAAAAAAGCAGTTGAAAGTTTTAATCGAAATCATTATGATTTAATACTTTTGGACTTATTGC
TTCCAGATATAAATGGGTTTGAGATATGCAAACAAATACGAGAAAAATCCACAATTCCAATAATTATGCTCACTGCTCTG
GAAGATTCTATTCATAAAGTACAAGGATTAAATATGGGTGCAGATGACTATATCATAAAACCTTTTGAGCCAACAGAATT
AGTCGCCAGGATTAAGTCAAATCTCAGGAGAAGCTATGAATTTTCTTCTGTAAAACCTTTAGACAATGAAGAACACGAAC
GTGACGAACTCGTTGTAGGAAGTTTGCGATTGAACAGAAAAACTCATAAAAGTTTTTATAATGAAATAGAAATAATTTTA
ACGCCGAAAGAATTTGATATTTTATGGCTGTTGATGGAAAAACCAGACGATGTTCACAATATGGATGAAATACATTACAA
AATTTGGAAAGATGAAGTGCTGTCAACAGAGGTAAATCCCGTTATGGTTCACATAAGAAGAATACGAGCTAAATTCGAAC
AATGCGGAATAAGTTCAATAATAAAGACAATATGGGGAGTGGGGTATAAGATTAATGCGTAA

Upstream 100 bases:

>100_bases
ACCAAGCACAAAGAATATCAGATAGGATTTTGTTTATTGAAGATAAAAAACTGGTTGAACAAGATGAAATATAATAAAAG
ATTTGAGGACGAGAAAAAAC

Downstream 100 bases:

>100_bases
AGAAAATTCATATATTAAAAGAATCATTCTGTATCAATGTTTATGGATAGCTGTTGGAATTTTTATTACATTTGCTTTTC
ATCAATTGATAGACACCTTG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKIMVVEDDIDLSELIRMYLIPEGWEIETFHTGKKAVESFNRNHYDLILLDLLLPDINGFEICKQIREKSTIPIIMLTAL
EDSIHKVQGLNMGADDYIIKPFEPTELVARIKSNLRRSYEFSSVKPLDNEEHERDELVVGSLRLNRKTHKSFYNEIEIIL
TPKEFDILWLLMEKPDDVHNMDEIHYKIWKDEVLSTEVNPVMVHIRRIRAKFEQCGISSIIKTIWGVGYKINA

Sequences:

>Translated_233_residues
MKIMVVEDDIDLSELIRMYLIPEGWEIETFHTGKKAVESFNRNHYDLILLDLLLPDINGFEICKQIREKSTIPIIMLTAL
EDSIHKVQGLNMGADDYIIKPFEPTELVARIKSNLRRSYEFSSVKPLDNEEHERDELVVGSLRLNRKTHKSFYNEIEIIL
TPKEFDILWLLMEKPDDVHNMDEIHYKIWKDEVLSTEVNPVMVHIRRIRAKFEQCGISSIIKTIWGVGYKINA
>Mature_233_residues
MKIMVVEDDIDLSELIRMYLIPEGWEIETFHTGKKAVESFNRNHYDLILLDLLLPDINGFEICKQIREKSTIPIIMLTAL
EDSIHKVQGLNMGADDYIIKPFEPTELVARIKSNLRRSYEFSSVKPLDNEEHERDELVVGSLRLNRKTHKSFYNEIEIIL
TPKEFDILWLLMEKPDDVHNMDEIHYKIWKDEVLSTEVNPVMVHIRRIRAKFEQCGISSIIKTIWGVGYKINA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=233, Percent_Identity=32.618025751073, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1786599, Length=235, Percent_Identity=34.0425531914894, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=33.0434782608696, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790552, Length=238, Percent_Identity=37.3949579831933, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=32.618025751073, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=30.4721030042918, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=31.0344827586207, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789402, Length=235, Percent_Identity=32.3404255319149, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=31.0344827586207, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=31.7596566523605, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1786911, Length=232, Percent_Identity=30.1724137931034, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=27.7056277056277, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=30.1310043668122, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=26.9565217391304, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1788550, Length=127, Percent_Identity=29.9212598425197, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790437, Length=125, Percent_Identity=28, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=30.6306306306306, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=119, Percent_Identity=36.1344537815126, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27325; Mature: 27325

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIMVVEDDIDLSELIRMYLIPEGWEIETFHTGKKAVESFNRNHYDLILLDLLLPDINGF
CEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCHHEEEEEHHCCCCCHH
EICKQIREKSTIPIIMLTALEDSIHKVQGLNMGADDYIIKPFEPTELVARIKSNLRRSYE
HHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCC
FSSVKPLDNEEHERDELVVGSLRLNRKTHKSFYNEIEIILTPKEFDILWLLMEKPDDVHN
CCCCCCCCCCCCCCHHEEEEHHHHCHHHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCC
MDEIHYKIWKDEVLSTEVNPVMVHIRRIRAKFEQCGISSIIKTIWGVGYKINA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MKIMVVEDDIDLSELIRMYLIPEGWEIETFHTGKKAVESFNRNHYDLILLDLLLPDINGF
CEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCHHEEEEEHHCCCCCHH
EICKQIREKSTIPIIMLTALEDSIHKVQGLNMGADDYIIKPFEPTELVARIKSNLRRSYE
HHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCC
FSSVKPLDNEEHERDELVVGSLRLNRKTHKSFYNEIEIILTPKEFDILWLLMEKPDDVHN
CCCCCCCCCCCCCCHHEEEEHHHHCHHHHHHHHCCEEEEECCCCCEEEEEEECCCCCCCC
MDEIHYKIWKDEVLSTEVNPVMVHIRRIRAKFEQCGISSIIKTIWGVGYKINA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]