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The map label for this gene is serS

Identifier: 169823798

GI number: 169823798

Start: 121046

End: 122311

Strand: Direct

Name: serS

Synonym: FMG_0101

Alternate gene names: 169823798

Gene position: 121046-122311 (Clockwise)

Preceding gene: 169823797

Following gene: 169823799

Centisome position: 6.73

GC content: 34.6

Gene sequence:

>1266_bases
ATGTTAGATATTAAAAGAATTAGAAACAATCCAGAAGAAATCGTTGAAGCGCTTAAAAAAAGAAGAGGAGAATATCCTAT
TCAAAAACTTTTGGCTACTGATGAAAAAAGACGTGAAGTTATTCAAAAAGTAGAATCAATGAAGGCAGAACAAAATAAAT
TATCTAAACAAGTTCCACAAATGAAGAAAAACGGAGAAGATACTACAGAACTTTTCAAAAATTTGAAGAAGTTGTCTGAT
GATATCAAAAATTTGGATGATGATTTGAAAGATATCGACGATGAAATCAGAGAATATTTGATGGAAATTCCAAACACTCC
TAACAAGGATGTTCCAGTTGGTTTGGATGATACTGAAAATTTGGAAATGAGAAAATGGGGAGAACCTCGTAAATTTGATT
TCGATATAAAAGCTCACTGGGATTTGGGTGTTGACTTGGATATTTTGGATTTCGAAAGAGCAACTAAGATTTCCAAATCA
AGATTTTCTGTATTCAAAGGAAAAGGCGCTAGACTTGAAAGAGCTTTGATGAATTTCATGGTGGATCTTCACACTGATAA
ACAAGGATACACTGAAATGAATACTCCAGTATTGATGAGCCCAAGTGCGATGATGGGTACTGGTCAAATTCCAAAATTCA
AAGAAGATATGTTTTATTGCGAAAAAGACGATATGTATCTTGCTCCTACTGCAGAAGTTCCAGTAACTAATTTATTAGGA
GGAGAAATTTTGGAACAAGGAAGCTTGCCAATTTATTACACAGCATTTACTCAATGTTTCAGAAGAGAAGCAGGAAGTGC
TGGACGTGACACGAGAGGTTTGATTAGAAATCACCAATTTGAAAAAGTTGAAATGGTAAAATTCGTTGAACCTTCTACAA
GTTATGACGAATTAGAAAAACTTACTAATAACGCGGAAGAAATCTTGCAATTGTTGGAAATTCCATACAGAGTTGTTAGA
CTTTGTTCTGGGGATTTGGGATTCTCATCTGCAATGACTTACGACATCGAAGTGTGGATGCCAAGTTACAACAGATACGT
TGAAATCTCAAGCTGTTCTAACTTTGAAGATTTCCAAGCAAGACGTGCAAATATTAGATATCGTGACGAAAATAATAAGC
CACAATACGTTCACACATTAAACGGGTCTGGACTTGCTATTGGACGTTGTTTTGCAGCTGTAATAGAAAACTATCAACAA
GCTGATGGATCTATAAAAATTCCTGAAGTGCTACAAAAATACACAGGATTTGATATAATAGACTAG

Upstream 100 bases:

>100_bases
TATTAGTTGAGAGAGCTTATGCTAATTAGGGTGGCAGTCGCGGAAACGTAATTTTCGTCCCTTGGTATGAGTTTTTTTAT
TGTTTTATAAGGAGAAGGTT

Downstream 100 bases:

>100_bases
TAAACTAAAATTAAGATAGGAAAAGAAATGAAGGCTTATATAATCGCTAGAGGTTATCCGACGGATAAATACAAAATGAA
CGGAATATTTGAACTGGATC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MLDIKRIRNNPEEIVEALKKRRGEYPIQKLLATDEKRREVIQKVESMKAEQNKLSKQVPQMKKNGEDTTELFKNLKKLSD
DIKNLDDDLKDIDDEIREYLMEIPNTPNKDVPVGLDDTENLEMRKWGEPRKFDFDIKAHWDLGVDLDILDFERATKISKS
RFSVFKGKGARLERALMNFMVDLHTDKQGYTEMNTPVLMSPSAMMGTGQIPKFKEDMFYCEKDDMYLAPTAEVPVTNLLG
GEILEQGSLPIYYTAFTQCFRREAGSAGRDTRGLIRNHQFEKVEMVKFVEPSTSYDELEKLTNNAEEILQLLEIPYRVVR
LCSGDLGFSSAMTYDIEVWMPSYNRYVEISSCSNFEDFQARRANIRYRDENNKPQYVHTLNGSGLAIGRCFAAVIENYQQ
ADGSIKIPEVLQKYTGFDIID

Sequences:

>Translated_421_residues
MLDIKRIRNNPEEIVEALKKRRGEYPIQKLLATDEKRREVIQKVESMKAEQNKLSKQVPQMKKNGEDTTELFKNLKKLSD
DIKNLDDDLKDIDDEIREYLMEIPNTPNKDVPVGLDDTENLEMRKWGEPRKFDFDIKAHWDLGVDLDILDFERATKISKS
RFSVFKGKGARLERALMNFMVDLHTDKQGYTEMNTPVLMSPSAMMGTGQIPKFKEDMFYCEKDDMYLAPTAEVPVTNLLG
GEILEQGSLPIYYTAFTQCFRREAGSAGRDTRGLIRNHQFEKVEMVKFVEPSTSYDELEKLTNNAEEILQLLEIPYRVVR
LCSGDLGFSSAMTYDIEVWMPSYNRYVEISSCSNFEDFQARRANIRYRDENNKPQYVHTLNGSGLAIGRCFAAVIENYQQ
ADGSIKIPEVLQKYTGFDIID
>Mature_421_residues
MLDIKRIRNNPEEIVEALKKRRGEYPIQKLLATDEKRREVIQKVESMKAEQNKLSKQVPQMKKNGEDTTELFKNLKKLSD
DIKNLDDDLKDIDDEIREYLMEIPNTPNKDVPVGLDDTENLEMRKWGEPRKFDFDIKAHWDLGVDLDILDFERATKISKS
RFSVFKGKGARLERALMNFMVDLHTDKQGYTEMNTPVLMSPSAMMGTGQIPKFKEDMFYCEKDDMYLAPTAEVPVTNLLG
GEILEQGSLPIYYTAFTQCFRREAGSAGRDTRGLIRNHQFEKVEMVKFVEPSTSYDELEKLTNNAEEILQLLEIPYRVVR
LCSGDLGFSSAMTYDIEVWMPSYNRYVEISSCSNFEDFQARRANIRYRDENNKPQYVHTLNGSGLAIGRCFAAVIENYQQ
ADGSIKIPEVLQKYTGFDIID

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=437, Percent_Identity=30.6636155606407, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI225579074, Length=441, Percent_Identity=29.2517006802721, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI16306548, Length=364, Percent_Identity=34.6153846153846, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1787120, Length=422, Percent_Identity=49.0521327014218, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17539260, Length=337, Percent_Identity=32.9376854599407, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=328, Percent_Identity=31.7073170731707, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=441, Percent_Identity=32.6530612244898, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6321799, Length=364, Percent_Identity=33.2417582417582, Blast_Score=196, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24581334, Length=463, Percent_Identity=31.317494600432, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17737985, Length=346, Percent_Identity=28.3236994219653, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_FINM2 (B0RZY8)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691409.1
- ProteinModelPortal:   B0RZY8
- SMR:   B0RZY8
- GeneID:   6019965
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0101
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- BioCyc:   FMAG334413:FMG_0101-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48642; Mature: 48642

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKRIRNNPEEIVEALKKRRGEYPIQKLLATDEKRREVIQKVESMKAEQNKLSKQVPQ
CCCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MKKNGEDTTELFKNLKKLSDDIKNLDDDLKDIDDEIREYLMEIPNTPNKDVPVGLDDTEN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
LEMRKWGEPRKFDFDIKAHWDLGVDLDILDFERATKISKSRFSVFKGKGARLERALMNFM
CCHHHCCCCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VDLHTDKQGYTEMNTPVLMSPSAMMGTGQIPKFKEDMFYCEKDDMYLAPTAEVPVTNLLG
HHHCCCCCCCCCCCCCEEECCCHHCCCCCCCCHHHHHEEECCCCEEECCCCCCCHHHHHH
GEILEQGSLPIYYTAFTQCFRREAGSAGRDTRGLIRNHQFEKVEMVKFVEPSTSYDELEK
HHHHHCCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHH
LTNNAEEILQLLEIPYRVVRLCSGDLGFSSAMTYDIEVWMPSYNRYVEISSCSNFEDFQA
HHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEECCCCCCHHHHH
RRANIRYRDENNKPQYVHTLNGSGLAIGRCFAAVIENYQQADGSIKIPEVLQKYTGFDII
HHCCCEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCC
D
C
>Mature Secondary Structure
MLDIKRIRNNPEEIVEALKKRRGEYPIQKLLATDEKRREVIQKVESMKAEQNKLSKQVPQ
CCCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MKKNGEDTTELFKNLKKLSDDIKNLDDDLKDIDDEIREYLMEIPNTPNKDVPVGLDDTEN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
LEMRKWGEPRKFDFDIKAHWDLGVDLDILDFERATKISKSRFSVFKGKGARLERALMNFM
CCHHHCCCCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VDLHTDKQGYTEMNTPVLMSPSAMMGTGQIPKFKEDMFYCEKDDMYLAPTAEVPVTNLLG
HHHCCCCCCCCCCCCCEEECCCHHCCCCCCCCHHHHHEEECCCCEEECCCCCCCHHHHHH
GEILEQGSLPIYYTAFTQCFRREAGSAGRDTRGLIRNHQFEKVEMVKFVEPSTSYDELEK
HHHHHCCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHH
LTNNAEEILQLLEIPYRVVRLCSGDLGFSSAMTYDIEVWMPSYNRYVEISSCSNFEDFQA
HHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEECCCCCCHHHHH
RRANIRYRDENNKPQYVHTLNGSGLAIGRCFAAVIENYQQADGSIKIPEVLQKYTGFDII
HHCCCEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA