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The map label for this gene is cvrA [H]

Identifier: 169823727

GI number: 169823727

Start: 25971

End: 27560

Strand: Direct

Name: cvrA [H]

Synonym: FMG_0030

Alternate gene names: 169823727

Gene position: 25971-27560 (Clockwise)

Preceding gene: 169823723

Following gene: 169823728

Centisome position: 1.44

GC content: 37.92

Gene sequence:

>1590_bases
ATGTATATTTTAATTGTTGCCATTGTGCTGTTATTGGCGCTTTTGGCTGTAAAATTTTCAGATAAATTCGGTATTCCATC
GTTTTTATTGTTTATCCTACTAGGAATATCGTTTAATTTTTTCGGTAAAGATTTCAATAATTTCAAATTTGTTGACGAAT
TTTCGAGCGTTGCTCTGTTGTTTATCATGTTTTACGGTGGTTTCGGTACAAATTTGAAAATGGCAAAACCAGTGACAACA
CAAGGAGTCATCATGGCAAGTGCAGGTGTCGTGTTGACATCTGTTCTTACGGGAGTTTTTTGTTATTTCGTGCTTAAAAT
CAGTTTCGTGGAGTCTATGCTTTTGGGATCAGTTGTTGGTTCTACGGATTTTGCTTCGGTGAGTTCGATTTTACGAAGCA
AGAATTTGAACCTCAAATATTCCACAGCATCCATGCTTGAAATCGAAAGTGGTTCCAACGACCCGACAGCTTACACAATG
ACTATGATTTTCTTGTCGATTTTGGTAGGCTCCAAGACTTCTGTGTTCAAACTAATTCTTCTTCAAGTTGGTATCGGGCT
ATTGATTGGATTTGTGATGGCAAAATTGACCGAAAAATTGATTTTCAAGATCGATTTTTCAGAAGATGGACTGTTCACAG
TTCTCATCATTTCCTGCGCACTTTTAACCTTTGCGATTAGCAAGAATTTGGGTGGAAATGCGTTCTTGTCAGTGTATGTT
CTGGGGATTATGATTGGGAATTTGGAATATTACAGGAAAAAAGAGGTCGTGTTCTTCTTCGATGGTTTTTCGGGAATAAT
GCAGATTGGCTTGTTCTTTTTATTGGGACTGTTGGCAAATCCACAAAGTATCGTGAAGGCAATTCCTGTGGCTTTCTTGG
TGATGGTTTTCATCACAATTATTGCGAGACCATTGGCAAGTATTTTGCTTTTGAAACCATTTGGCTACAAGAAAAATCAG
CTCATCGTAATTTCTGCTGCGGGCTTCAGAGGAGCGGCTGCGATTGCGTTTGCTATTATGGTAATCAACAGTAACGCCAA
ATTATCCGTCGATTTGTTCCACATAATTTTCGTGATTTGTTTGTTGTCTTGTTTGATACAAGGTTCACTTTTCCCGATTA
TTTGCAGGAAAACTGATATGATTGATCCTGATGATACGGTGCTTAAAACTTTCAACTACTACAGCTCGAAAAGTGATGTC
GGATTTATTGAAACACAAATTAACGAGCATAGTGAGCTTGTTGGTAAGAAAGTTAAAGAGATTGGGCTTAATTTCGATAT
TATCGTGGCGAAAATTATTCGTAACAACAAACTTGTAATTCCACGTGGAGATACTGTGATTTGTGCGAATGACACTGTTG
TTATTGGAGGAAAATCGTATTTCGATCCGACAGGCTACGGTTTGATTGAAATCACAATCAGCGACAAGAACAACTGGAAT
GGTAAAAAATTGAAGGATATCGACATGATTGATTCCGAACTTGTGGTGATGATTCAGGGAAAAAACGGCGAAATCATCGT
TCCTACGGGAAGTGTCACGTTAAACGCAGGAGACAAGTTGATTATTCTGAAGGAAACTGTAAAATTTTAA

Upstream 100 bases:

>100_bases
GATATATATTTATTTTTCAAAAAAAACCGATAATTTATTATGATATACTATAATTAATTTAATATTTTTTATTAATTTAT
CAATCTTCCAAGGAGGGTTT

Downstream 100 bases:

>100_bases
TAAATTTTGAAAATTATTGCCAAACTTTGATATAATAATATGATAATTATATTTTAAGGAAGGAATTTATGATAGATTAT
TTGATTCAAAAATTTGTGAG

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MYILIVAIVLLLALLAVKFSDKFGIPSFLLFILLGISFNFFGKDFNNFKFVDEFSSVALLFIMFYGGFGTNLKMAKPVTT
QGVIMASAGVVLTSVLTGVFCYFVLKISFVESMLLGSVVGSTDFASVSSILRSKNLNLKYSTASMLEIESGSNDPTAYTM
TMIFLSILVGSKTSVFKLILLQVGIGLLIGFVMAKLTEKLIFKIDFSEDGLFTVLIISCALLTFAISKNLGGNAFLSVYV
LGIMIGNLEYYRKKEVVFFFDGFSGIMQIGLFFLLGLLANPQSIVKAIPVAFLVMVFITIIARPLASILLLKPFGYKKNQ
LIVISAAGFRGAAAIAFAIMVINSNAKLSVDLFHIIFVICLLSCLIQGSLFPIICRKTDMIDPDDTVLKTFNYYSSKSDV
GFIETQINEHSELVGKKVKEIGLNFDIIVAKIIRNNKLVIPRGDTVICANDTVVIGGKSYFDPTGYGLIEITISDKNNWN
GKKLKDIDMIDSELVVMIQGKNGEIIVPTGSVTLNAGDKLIILKETVKF

Sequences:

>Translated_529_residues
MYILIVAIVLLLALLAVKFSDKFGIPSFLLFILLGISFNFFGKDFNNFKFVDEFSSVALLFIMFYGGFGTNLKMAKPVTT
QGVIMASAGVVLTSVLTGVFCYFVLKISFVESMLLGSVVGSTDFASVSSILRSKNLNLKYSTASMLEIESGSNDPTAYTM
TMIFLSILVGSKTSVFKLILLQVGIGLLIGFVMAKLTEKLIFKIDFSEDGLFTVLIISCALLTFAISKNLGGNAFLSVYV
LGIMIGNLEYYRKKEVVFFFDGFSGIMQIGLFFLLGLLANPQSIVKAIPVAFLVMVFITIIARPLASILLLKPFGYKKNQ
LIVISAAGFRGAAAIAFAIMVINSNAKLSVDLFHIIFVICLLSCLIQGSLFPIICRKTDMIDPDDTVLKTFNYYSSKSDV
GFIETQINEHSELVGKKVKEIGLNFDIIVAKIIRNNKLVIPRGDTVICANDTVVIGGKSYFDPTGYGLIEITISDKNNWN
GKKLKDIDMIDSELVVMIQGKNGEIIVPTGSVTLNAGDKLIILKETVKF
>Mature_529_residues
MYILIVAIVLLLALLAVKFSDKFGIPSFLLFILLGISFNFFGKDFNNFKFVDEFSSVALLFIMFYGGFGTNLKMAKPVTT
QGVIMASAGVVLTSVLTGVFCYFVLKISFVESMLLGSVVGSTDFASVSSILRSKNLNLKYSTASMLEIESGSNDPTAYTM
TMIFLSILVGSKTSVFKLILLQVGIGLLIGFVMAKLTEKLIFKIDFSEDGLFTVLIISCALLTFAISKNLGGNAFLSVYV
LGIMIGNLEYYRKKEVVFFFDGFSGIMQIGLFFLLGLLANPQSIVKAIPVAFLVMVFITIIARPLASILLLKPFGYKKNQ
LIVISAAGFRGAAAIAFAIMVINSNAKLSVDLFHIIFVICLLSCLIQGSLFPIICRKTDMIDPDDTVLKTFNYYSSKSDV
GFIETQINEHSELVGKKVKEIGLNFDIIVAKIIRNNKLVIPRGDTVICANDTVVIGGKSYFDPTGYGLIEITISDKNNWN
GKKLKDIDMIDSELVVMIQGKNGEIIVPTGSVTLNAGDKLIILKETVKF

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=456, Percent_Identity=29.6052631578947, Blast_Score=171, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 57861; Mature: 57861

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYILIVAIVLLLALLAVKFSDKFGIPSFLLFILLGISFNFFGKDFNNFKFVDEFSSVALL
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCHHHHHHHHHHH
FIMFYGGFGTNLKMAKPVTTQGVIMASAGVVLTSVLTGVFCYFVLKISFVESMLLGSVVG
HHHHHCCCCCCCEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
STDFASVSSILRSKNLNLKYSTASMLEIESGSNDPTAYTMTMIFLSILVGSKTSVFKLIL
CCHHHHHHHHHHHCCCCEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
LQVGIGLLIGFVMAKLTEKLIFKIDFSEDGLFTVLIISCALLTFAISKNLGGNAFLSVYV
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LGIMIGNLEYYRKKEVVFFFDGFSGIMQIGLFFLLGLLANPQSIVKAIPVAFLVMVFITI
HHHHHCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IARPLASILLLKPFGYKKNQLIVISAAGFRGAAAIAFAIMVINSNAKLSVDLFHIIFVIC
HHHHHHHHHEECCCCCCCCEEEEEEECCCCHHHHHEEEEEEECCCCEEEHHHHHHHHHHH
LLSCLIQGSLFPIICRKTDMIDPDDTVLKTFNYYSSKSDVGFIETQINEHSELVGKKVKE
HHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHH
IGLNFDIIVAKIIRNNKLVIPRGDTVICANDTVVIGGKSYFDPTGYGLIEITISDKNNWN
HCCCHHHHHHHHHCCCEEEEECCCEEEEECCEEEECCCCCCCCCCCEEEEEEEECCCCCC
GKKLKDIDMIDSELVVMIQGKNGEIIVPTGSVTLNAGDKLIILKETVKF
CCCCCCHHCCCCEEEEEEECCCCCEEEECCEEEECCCCEEEEEECCCCC
>Mature Secondary Structure
MYILIVAIVLLLALLAVKFSDKFGIPSFLLFILLGISFNFFGKDFNNFKFVDEFSSVALL
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCHHHHHHHHHHH
FIMFYGGFGTNLKMAKPVTTQGVIMASAGVVLTSVLTGVFCYFVLKISFVESMLLGSVVG
HHHHHCCCCCCCEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
STDFASVSSILRSKNLNLKYSTASMLEIESGSNDPTAYTMTMIFLSILVGSKTSVFKLIL
CCHHHHHHHHHHHCCCCEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
LQVGIGLLIGFVMAKLTEKLIFKIDFSEDGLFTVLIISCALLTFAISKNLGGNAFLSVYV
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LGIMIGNLEYYRKKEVVFFFDGFSGIMQIGLFFLLGLLANPQSIVKAIPVAFLVMVFITI
HHHHHCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IARPLASILLLKPFGYKKNQLIVISAAGFRGAAAIAFAIMVINSNAKLSVDLFHIIFVIC
HHHHHHHHHEECCCCCCCCEEEEEEECCCCHHHHHEEEEEEECCCCEEEHHHHHHHHHHH
LLSCLIQGSLFPIICRKTDMIDPDDTVLKTFNYYSSKSDVGFIETQINEHSELVGKKVKE
HHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHH
IGLNFDIIVAKIIRNNKLVIPRGDTVICANDTVVIGGKSYFDPTGYGLIEITISDKNNWN
HCCCHHHHHHHHHCCCEEEEECCCEEEEECCEEEECCCCCCCCCCCEEEEEEEECCCCCC
GKKLKDIDMIDSELVVMIQGKNGEIIVPTGSVTLNAGDKLIILKETVKF
CCCCCCHHCCCCEEEEEEECCCCCEEEECCEEEECCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]