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The map label for this gene is fumC [H]

Identifier: 169823709

GI number: 169823709

Start: 11916

End: 13274

Strand: Direct

Name: fumC [H]

Synonym: FMG_0012

Alternate gene names: 169823709

Gene position: 11916-13274 (Clockwise)

Preceding gene: 169823708

Following gene: 169823710

Centisome position: 0.66

GC content: 38.04

Gene sequence:

>1359_bases
ATGAGAATTGAAAGGGATTCTATCGGAGAAATCGAAGTAAATGACGATGTGTTGTGGGGAGCACAAACTCAAAGAAGTTT
CAACAATTTTAAAATTGGAACAGAAAAAATGCCACTTGAAGTTATCAAAGCACTTACAAGATTAAAAAAAGCGTGTGCGA
TTTCAAACAACAAATTGGAAAAATTATCAGACGAAAAGAAGGATTTGATTGTGGGTGCGTGTGATGAAATCTTGGATCAC
CAACACGACAATGAATTTCCACTTGCTGTGTGGCAAACTGGATCTGGAACGCAATCCAACATGAATGTGAACGAAGTCAT
CGCTCACATCGCAAACAAAAAGTATGGAGAAAACATCATTCATCCAAACGATGATGTGAACAAATCCCAAAGTTCCAACG
ATACATTTCCATCTGCAATCCACATTGCATTAAAACACATGATTGATTCTGAATTAATCGCAGAACTTGAAAACACTGAA
AAAGTCTTGGAAAAATTGATGGAAGAAAACAAAGACATCATAAAAATCGGACGTACACATTTGCAAGATGCAGTGCCACT
AAGATTGTCACAAGAAATATCCGGATGGCTTTTCATGATTAAAAAAGGAAAACAACACATCATTGAAGCAAGCAAAGCAT
TGAATGAACTTGCAATTGGAGCAACAGCTGTGGGAACTGGACTCAACGCAGTTAAAGGATTCGACCAAATGGTAGTAGAT
GAAATCAACAAACAAACAAACGGAAAATTCGTCACTGCAGAAAACAAATTCCATGCACTAACATCAAAAGATGCAATAAG
CTTTACTCATGGAGCAATCACAGCCCTTGCCAATAATTTGATGAAAATTGCAAATGATGTGAGATTTTTGGCGAGTGGGC
CTAGATGTGGAATAGGAGAATTGTCAATTCCTGCAAATGAACCAGGATCATCAATCATGCCTGGCAAAGTAAATCCAACA
CAAGCAGAAGCATTGACAATGGTTTGTGTGCAAATAATGGGCAACAACACGACAATTCAAGTCGCAGCAAGCCAAGGAAA
CTACGAACTCAACGTCTACATGCCTGTGATTATTTACAACGCATTGCAATCTGTAAGATTAATCAAAGACGCTACGAAAT
CTTTTACGGACAATTGTCTTCGAGGACTCAAAGCAAACAGAGAAGTCATCGATTATTATTTGAACAATTCGTTGATGCTA
GTCACAGCTCTTAACACGAAAATTGGATACGACAAAGCAAGTACCATCGCAAAATACGCGCACAAAAACAACACAACATT
AAAACAAGCAGCGCTCGATTTGGAAATTCTGACAGAAGAAGAATTTGACGAATACGTCGACCCTACTAAAATGTGTTAG

Upstream 100 bases:

>100_bases
GAGCGTTAACATTGCAAGTTTCTTGTCGCTTTATCTAGGATACAAAAGTTTGATTAACAATAGAGAACAAATAAATTTTG
AATTGTAATTGGAGGAAAAA

Downstream 100 bases:

>100_bases
AAAAAAATATTTTATATTGAAAAATATTAGTACAAAATATATAATAGGTGTGAGGGTAATGGGGGGAGAATATGAAAAAG
AAATTAACGATATATGTGCT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRIERDSIGEIEVNDDVLWGAQTQRSFNNFKIGTEKMPLEVIKALTRLKKACAISNNKLEKLSDEKKDLIVGACDEILDH
QHDNEFPLAVWQTGSGTQSNMNVNEVIAHIANKKYGENIIHPNDDVNKSQSSNDTFPSAIHIALKHMIDSELIAELENTE
KVLEKLMEENKDIIKIGRTHLQDAVPLRLSQEISGWLFMIKKGKQHIIEASKALNELAIGATAVGTGLNAVKGFDQMVVD
EINKQTNGKFVTAENKFHALTSKDAISFTHGAITALANNLMKIANDVRFLASGPRCGIGELSIPANEPGSSIMPGKVNPT
QAEALTMVCVQIMGNNTTIQVAASQGNYELNVYMPVIIYNALQSVRLIKDATKSFTDNCLRGLKANREVIDYYLNNSLML
VTALNTKIGYDKASTIAKYAHKNNTTLKQAALDLEILTEEEFDEYVDPTKMC

Sequences:

>Translated_452_residues
MRIERDSIGEIEVNDDVLWGAQTQRSFNNFKIGTEKMPLEVIKALTRLKKACAISNNKLEKLSDEKKDLIVGACDEILDH
QHDNEFPLAVWQTGSGTQSNMNVNEVIAHIANKKYGENIIHPNDDVNKSQSSNDTFPSAIHIALKHMIDSELIAELENTE
KVLEKLMEENKDIIKIGRTHLQDAVPLRLSQEISGWLFMIKKGKQHIIEASKALNELAIGATAVGTGLNAVKGFDQMVVD
EINKQTNGKFVTAENKFHALTSKDAISFTHGAITALANNLMKIANDVRFLASGPRCGIGELSIPANEPGSSIMPGKVNPT
QAEALTMVCVQIMGNNTTIQVAASQGNYELNVYMPVIIYNALQSVRLIKDATKSFTDNCLRGLKANREVIDYYLNNSLML
VTALNTKIGYDKASTIAKYAHKNNTTLKQAALDLEILTEEEFDEYVDPTKMC
>Mature_452_residues
MRIERDSIGEIEVNDDVLWGAQTQRSFNNFKIGTEKMPLEVIKALTRLKKACAISNNKLEKLSDEKKDLIVGACDEILDH
QHDNEFPLAVWQTGSGTQSNMNVNEVIAHIANKKYGENIIHPNDDVNKSQSSNDTFPSAIHIALKHMIDSELIAELENTE
KVLEKLMEENKDIIKIGRTHLQDAVPLRLSQEISGWLFMIKKGKQHIIEASKALNELAIGATAVGTGLNAVKGFDQMVVD
EINKQTNGKFVTAENKFHALTSKDAISFTHGAITALANNLMKIANDVRFLASGPRCGIGELSIPANEPGSSIMPGKVNPT
QAEALTMVCVQIMGNNTTIQVAASQGNYELNVYMPVIIYNALQSVRLIKDATKSFTDNCLRGLKANREVIDYYLNNSLML
VTALNTKIGYDKASTIAKYAHKNNTTLKQAALDLEILTEEEFDEYVDPTKMC

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=458, Percent_Identity=52.8384279475983, Blast_Score=456, Evalue=1e-128,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=57.0175438596491, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI87082375, Length=452, Percent_Identity=36.5044247787611, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=53.2751091703057, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI32565146, Length=323, Percent_Identity=54.4891640866873, Blast_Score=356, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6324993, Length=457, Percent_Identity=55.3610503282276, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=51.9565217391304, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24640179, Length=459, Percent_Identity=51.6339869281046, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=51.6339869281046, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24662684, Length=459, Percent_Identity=50.5446623093682, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24583245, Length=459, Percent_Identity=44.0087145969499, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49962; Mature: 49962

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIERDSIGEIEVNDDVLWGAQTQRSFNNFKIGTEKMPLEVIKALTRLKKACAISNNKLE
CCCCCCCCCCEEECCCEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
KLSDEKKDLIVGACDEILDHQHDNEFPLAVWQTGSGTQSNMNVNEVIAHIANKKYGENII
HHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
HPNDDVNKSQSSNDTFPSAIHIALKHMIDSELIAELENTEKVLEKLMEENKDIIKIGRTH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
LQDAVPLRLSQEISGWLFMIKKGKQHIIEASKALNELAIGATAVGTGLNAVKGFDQMVVD
HHHCCCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHH
EINKQTNGKFVTAENKFHALTSKDAISFTHGAITALANNLMKIANDVRFLASGPRCGIGE
HHCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LSIPANEPGSSIMPGKVNPTQAEALTMVCVQIMGNNTTIQVAASQGNYELNVYMPVIIYN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHHHHH
ALQSVRLIKDATKSFTDNCLRGLKANREVIDYYLNNSLMLVTALNTKIGYDKASTIAKYA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHH
HKNNTTLKQAALDLEILTEEEFDEYVDPTKMC
HCCCCHHHHHHHHHHEECHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIERDSIGEIEVNDDVLWGAQTQRSFNNFKIGTEKMPLEVIKALTRLKKACAISNNKLE
CCCCCCCCCCEEECCCEEECCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
KLSDEKKDLIVGACDEILDHQHDNEFPLAVWQTGSGTQSNMNVNEVIAHIANKKYGENII
HHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
HPNDDVNKSQSSNDTFPSAIHIALKHMIDSELIAELENTEKVLEKLMEENKDIIKIGRTH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
LQDAVPLRLSQEISGWLFMIKKGKQHIIEASKALNELAIGATAVGTGLNAVKGFDQMVVD
HHHCCCHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHH
EINKQTNGKFVTAENKFHALTSKDAISFTHGAITALANNLMKIANDVRFLASGPRCGIGE
HHCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LSIPANEPGSSIMPGKVNPTQAEALTMVCVQIMGNNTTIQVAASQGNYELNVYMPVIIYN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHHHHH
ALQSVRLIKDATKSFTDNCLRGLKANREVIDYYLNNSLMLVTALNTKIGYDKASTIAKYA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHH
HKNNTTLKQAALDLEILTEEEFDEYVDPTKMC
HCCCCHHHHHHHHHHEECHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]