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The map label for this gene is gdh [H]

Identifier: 169630880

GI number: 169630880

Start: 3853487

End: 3854839

Strand: Reverse

Name: gdh [H]

Synonym: MAB_3800c

Alternate gene names: 169630880

Gene position: 3854839-3853487 (Counterclockwise)

Preceding gene: 169630881

Following gene: 169630879

Centisome position: 76.07

GC content: 63.78

Gene sequence:

>1353_bases
ATGCCAGAGGCCTTGCATCCCGTCTTCCAGTCACGCTTCGAGACCGTTCTCGCACGTAACCCCGGGGAGGCGGAGTTTCA
TCAGGCCGTCTTCGAGGTGATGGCCAGTTTGACGCCTCTGGTTGGCAAGACCCCGGACTACGACCGCTGGTCGATCCTGG
AACGCATCTGCGAACCTGAGCGGCAGATCATCTTCCGCGTCCCGTGGATCAGGGACGACGGCGCCGTCGAGATCAACCGC
GGTTACCGGGTGGAGTTCAACTCCGCGCTCGGCCCGTACAAGGGCGGCCTGCGCTTTCACCCGAGCGTGAGCCTGTCGAT
CATCAAGTTCCTCGGCTTCGAGCAGATGTTCAAGAACGCGCTCACCGGGCTCCCGATCGGCGGCGGCAAGGGCGGCTCCG
ATTTCGACCCCAAGGGCCGCTCAGATGCCGAGATCATGCGCTTCTGTCAGTCCTTCATGACCGAGTTGTACCGGCACATC
GGCGAATACACCGATGTGCCGGCCGGTGATATCGGTGTGGGACAGCGCGAGATCGGATACCTCTTCGGGCAGTACAAGCG
CGTTACCAATCGCTATGAGTCCGGCGTGCTCACCGGTAAGGGGTTGCCCTGGGGCGGATCTCAGGTGCGCACGGAAGCCA
CCGGATACGGCGTCGTGCTCTTCGCGCAGGAGATGCTGGCGACCCGTGCACAGTCACTGGACGGCAAGACGGTGGTGGTG
TCCGGTGCGGGCAACGTCGCGATCTATGCCGTCGAGAAGGCGCAGCAGCTGGGTGCCAGGGTCATCGCCTGCTCGGACAG
CGACGGTTACATCGTCGACGAACGCGGCCTGAACCTGGAACTGCTCAAGGAAATCAAGGAGGTTCGGCGGGGCCGGCTCT
CGGAGTACGTCGAAGAACACGGCGGGGGAGCTCGCCAGGTCACCGATGGCAACCTCTGGGAGGTGCCGTGCCAGGTCGCG
TTGCCGTGCGCAACCCAGAACGAGCTTGACGGCAAGGACGCCCGCAGGCTGATCGAGAACGGTGTGCAATTGGTCGCCGA
GGGCGCCAACATGCCGTGCACGCCGGAGGCGGTGAAGTACTTCCAGGACTCCGGTGTGCTGTATGCGCCGGGCAAGGCAT
CCAATGCCGGTGGCGTGGCCACGAGTGCGCTGGAGATGCAGCAGAACGCCAGCCGCGATTCGTGGTCCTTTGAACAGACC
GAAACGCGTCTGCGGTCGATCATGCGGTCCATCCACACCACCTGTATCGAGACCGCTGATCACTATGGGGACCCGGGGAA
CTACGTCACCGGCGCCAACCTCGCCGGATATACCCGGGTAGCCGACGCGATGGTCGCCCTCGGCGTCATCTGA

Upstream 100 bases:

>100_bases
TCAAGGGCAACGCTTTGGCGCCCGCGCCGGCTCCCGCTGCCTAATCGCGGGTCTGATGCCGCGTCGTTAGCCAAATGTGC
TGTGGTGCACTCTATTAGGT

Downstream 100 bases:

>100_bases
GGGCGTTGTTCGCCTTTCGGCGCCGAGCGCGCCGAGGCTGTGTTATCTGTGACGTATGCGCAGGTGCGGCGCTGCGGCGC
TGGCAGCGATCGGGGCACTG

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MPEALHPVFQSRFETVLARNPGEAEFHQAVFEVMASLTPLVGKTPDYDRWSILERICEPERQIIFRVPWIRDDGAVEINR
GYRVEFNSALGPYKGGLRFHPSVSLSIIKFLGFEQMFKNALTGLPIGGGKGGSDFDPKGRSDAEIMRFCQSFMTELYRHI
GEYTDVPAGDIGVGQREIGYLFGQYKRVTNRYESGVLTGKGLPWGGSQVRTEATGYGVVLFAQEMLATRAQSLDGKTVVV
SGAGNVAIYAVEKAQQLGARVIACSDSDGYIVDERGLNLELLKEIKEVRRGRLSEYVEEHGGGARQVTDGNLWEVPCQVA
LPCATQNELDGKDARRLIENGVQLVAEGANMPCTPEAVKYFQDSGVLYAPGKASNAGGVATSALEMQQNASRDSWSFEQT
ETRLRSIMRSIHTTCIETADHYGDPGNYVTGANLAGYTRVADAMVALGVI

Sequences:

>Translated_450_residues
MPEALHPVFQSRFETVLARNPGEAEFHQAVFEVMASLTPLVGKTPDYDRWSILERICEPERQIIFRVPWIRDDGAVEINR
GYRVEFNSALGPYKGGLRFHPSVSLSIIKFLGFEQMFKNALTGLPIGGGKGGSDFDPKGRSDAEIMRFCQSFMTELYRHI
GEYTDVPAGDIGVGQREIGYLFGQYKRVTNRYESGVLTGKGLPWGGSQVRTEATGYGVVLFAQEMLATRAQSLDGKTVVV
SGAGNVAIYAVEKAQQLGARVIACSDSDGYIVDERGLNLELLKEIKEVRRGRLSEYVEEHGGGARQVTDGNLWEVPCQVA
LPCATQNELDGKDARRLIENGVQLVAEGANMPCTPEAVKYFQDSGVLYAPGKASNAGGVATSALEMQQNASRDSWSFEQT
ETRLRSIMRSIHTTCIETADHYGDPGNYVTGANLAGYTRVADAMVALGVI
>Mature_449_residues
PEALHPVFQSRFETVLARNPGEAEFHQAVFEVMASLTPLVGKTPDYDRWSILERICEPERQIIFRVPWIRDDGAVEINRG
YRVEFNSALGPYKGGLRFHPSVSLSIIKFLGFEQMFKNALTGLPIGGGKGGSDFDPKGRSDAEIMRFCQSFMTELYRHIG
EYTDVPAGDIGVGQREIGYLFGQYKRVTNRYESGVLTGKGLPWGGSQVRTEATGYGVVLFAQEMLATRAQSLDGKTVVVS
GAGNVAIYAVEKAQQLGARVIACSDSDGYIVDERGLNLELLKEIKEVRRGRLSEYVEEHGGGARQVTDGNLWEVPCQVAL
PCATQNELDGKDARRLIENGVQLVAEGANMPCTPEAVKYFQDSGVLYAPGKASNAGGVATSALEMQQNASRDSWSFEQTE
TRLRSIMRSIHTTCIETADHYGDPGNYVTGANLAGYTRVADAMVALGVI

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=355, Percent_Identity=31.5492957746479, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI4885281, Length=355, Percent_Identity=30.9859154929577, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1788059, Length=445, Percent_Identity=56.8539325842697, Blast_Score=507, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17544676, Length=381, Percent_Identity=27.5590551181102, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319256, Length=454, Percent_Identity=49.1189427312775, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324951, Length=456, Percent_Identity=49.1228070175439, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24649283, Length=373, Percent_Identity=31.6353887399464, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45549226, Length=363, Percent_Identity=30.5785123966942, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45553475, Length=363, Percent_Identity=30.5785123966942, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24649460, Length=298, Percent_Identity=29.8657718120805, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 49228; Mature: 49097

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEALHPVFQSRFETVLARNPGEAEFHQAVFEVMASLTPLVGKTPDYDRWSILERICEPE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
RQIIFRVPWIRDDGAVEINRGYRVEFNSALGPYKGGLRFHPSVSLSIIKFLGFEQMFKNA
CEEEEECCEECCCCCEEECCCEEEEECCCCCCCCCCEEECCCHHHHHHHHHCHHHHHHHH
LTGLPIGGGKGGSDFDPKGRSDAEIMRFCQSFMTELYRHIGEYTDVPAGDIGVGQREIGY
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LFGQYKRVTNRYESGVLTGKGLPWGGSQVRTEATGYGVVLFAQEMLATRAQSLDGKTVVV
HHHHHHHHHHHHHCCCEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCEEEE
SGAGNVAIYAVEKAQQLGARVIACSDSDGYIVDERGLNLELLKEIKEVRRGRLSEYVEEH
ECCCCEEEEEEHHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
GGGARQVTDGNLWEVPCQVALPCATQNELDGKDARRLIENGVQLVAEGANMPCTPEAVKY
CCCCCCCCCCCEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCHHHHHH
FQDSGVLYAPGKASNAGGVATSALEMQQNASRDSWSFEQTETRLRSIMRSIHTTCIETAD
HHCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HYGDPGNYVTGANLAGYTRVADAMVALGVI
HCCCCCCEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEALHPVFQSRFETVLARNPGEAEFHQAVFEVMASLTPLVGKTPDYDRWSILERICEPE
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
RQIIFRVPWIRDDGAVEINRGYRVEFNSALGPYKGGLRFHPSVSLSIIKFLGFEQMFKNA
CEEEEECCEECCCCCEEECCCEEEEECCCCCCCCCCEEECCCHHHHHHHHHCHHHHHHHH
LTGLPIGGGKGGSDFDPKGRSDAEIMRFCQSFMTELYRHIGEYTDVPAGDIGVGQREIGY
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LFGQYKRVTNRYESGVLTGKGLPWGGSQVRTEATGYGVVLFAQEMLATRAQSLDGKTVVV
HHHHHHHHHHHHHCCCEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCEEEE
SGAGNVAIYAVEKAQQLGARVIACSDSDGYIVDERGLNLELLKEIKEVRRGRLSEYVEEH
ECCCCEEEEEEHHHHHCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
GGGARQVTDGNLWEVPCQVALPCATQNELDGKDARRLIENGVQLVAEGANMPCTPEAVKY
CCCCCCCCCCCEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCHHHHHH
FQDSGVLYAPGKASNAGGVATSALEMQQNASRDSWSFEQTETRLRSIMRSIHTTCIETAD
HHCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HYGDPGNYVTGANLAGYTRVADAMVALGVI
HCCCCCCEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]