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The map label for this gene is rmlC [H]

Identifier: 169630860

GI number: 169630860

Start: 3835872

End: 3836489

Strand: Direct

Name: rmlC [H]

Synonym: MAB_3780

Alternate gene names: 169630860

Gene position: 3835872-3836489 (Clockwise)

Preceding gene: 169630859

Following gene: 169630861

Centisome position: 75.7

GC content: 64.4

Gene sequence:

>618_bases
GTGAAGATCCGCGAACTTTCGGTGCCCGGTTCCTTCGAGATCACCCCGGTGCAGCATCACGACAGCCGCGGAGTTTTCCT
CGAATTGTTCAAGGGCCCAGCGCTTGCCGAGGCCATCGGGCATCCGTTCGAGCTGCAGCAGGCCAACTGTTCGGTGTCGG
CAGCCGGATCGCTGCGCGGCATCCATTTCGCCGACGTACCACCCGGCCAGGCCAAATACGTGACCTGTCTGACCGGTTCC
GTGTACGACGTCGTGGTCGATATCCGTGTCGGCTCACCGACGTTCGGCGCTTGGGACGCCGTGCTTCTCGACCCTCGCGA
CCGGCGGGCCGTCTACGTTCCCGAGGGGGTGGGGCACGGTTTCCTCGCACTCGAGGATGACTCCACGGTGGTCTATCTCT
GCTCCGCCGGATATGCCCCCGGCCGCGAGCACGGCATCGATCCGCTGGACCCAACAGTTGGGATCCAGTGGCCGACCCGT
AGGCCCGACGGCACCGAGCTGTCACTACTCGTTTCCGAAAAGGACGGTGCTGCACCGTCATTGCTGGATGCCAGGGATTC
GGGTCTACTGCCCGATGCCGCCGAAGTGCAGGCTTTCCTTGACGGCCTGTCCGGCTGA

Upstream 100 bases:

>100_bases
AGTGATGAGCGTTTACGCGAAGACAGAGGGCAGTGATGAGCGTTTACACGAAGACAGAGGGCAGTGATGAGCGTTTACGC
GAAGAACAGAGGGCACTGAC

Downstream 100 bases:

>100_bases
TCGATCACGCCACCAACGCCACATCGTGTTTGCTAAAGTCCCTACATGACGCAACCGCCTGCAGGGCCTCCGCCACCGGA
TCCCGGGCAACCGGAGTTTC

Product: dTDP-4-dehydrorhamnose 3,5-epimerase RmlC

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MKIRELSVPGSFEITPVQHHDSRGVFLELFKGPALAEAIGHPFELQQANCSVSAAGSLRGIHFADVPPGQAKYVTCLTGS
VYDVVVDIRVGSPTFGAWDAVLLDPRDRRAVYVPEGVGHGFLALEDDSTVVYLCSAGYAPGREHGIDPLDPTVGIQWPTR
RPDGTELSLLVSEKDGAAPSLLDARDSGLLPDAAEVQAFLDGLSG

Sequences:

>Translated_205_residues
MKIRELSVPGSFEITPVQHHDSRGVFLELFKGPALAEAIGHPFELQQANCSVSAAGSLRGIHFADVPPGQAKYVTCLTGS
VYDVVVDIRVGSPTFGAWDAVLLDPRDRRAVYVPEGVGHGFLALEDDSTVVYLCSAGYAPGREHGIDPLDPTVGIQWPTR
RPDGTELSLLVSEKDGAAPSLLDARDSGLLPDAAEVQAFLDGLSG
>Mature_205_residues
MKIRELSVPGSFEITPVQHHDSRGVFLELFKGPALAEAIGHPFELQQANCSVSAAGSLRGIHFADVPPGQAKYVTCLTGS
VYDVVVDIRVGSPTFGAWDAVLLDPRDRRAVYVPEGVGHGFLALEDDSTVVYLCSAGYAPGREHGIDPLDPTVGIQWPTR
RPDGTELSLLVSEKDGAAPSLLDARDSGLLPDAAEVQAFLDGLSG

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N- acetylglucosamine-L-r

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=158, Percent_Identity=35.4430379746835, Blast_Score=107, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17550412, Length=176, Percent_Identity=38.6363636363636, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21748; Mature: 21748

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRELSVPGSFEITPVQHHDSRGVFLELFKGPALAEAIGHPFELQQANCSVSAAGSLRG
CCEEEECCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHCCCEEEECCCCCEEECCCCCC
IHFADVPPGQAKYVTCLTGSVYDVVVDIRVGSPTFGAWDAVLLDPRDRRAVYVPEGVGHG
EEECCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCC
FLALEDDSTVVYLCSAGYAPGREHGIDPLDPTVGIQWPTRRPDGTELSLLVSEKDGAAPS
EEEEECCCEEEEEEECCCCCCHHCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCC
LLDARDSGLLPDAAEVQAFLDGLSG
EECCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKIRELSVPGSFEITPVQHHDSRGVFLELFKGPALAEAIGHPFELQQANCSVSAAGSLRG
CCEEEECCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHCCCEEEECCCCCEEECCCCCC
IHFADVPPGQAKYVTCLTGSVYDVVVDIRVGSPTFGAWDAVLLDPRDRRAVYVPEGVGHG
EEECCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCCCEEEEECCCCCEEEECCCCCCCC
FLALEDDSTVVYLCSAGYAPGREHGIDPLDPTVGIQWPTRRPDGTELSLLVSEKDGAAPS
EEEEECCCEEEEEEECCCCCCHHCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCC
LLDARDSGLLPDAAEVQAFLDGLSG
EECCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA