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The map label for this gene is groL1 [H]

Identifier: 169630810

GI number: 169630810

Start: 3785567

End: 3787186

Strand: Reverse

Name: groL1 [H]

Synonym: MAB_3731c

Alternate gene names: 169630810

Gene position: 3787186-3785567 (Counterclockwise)

Preceding gene: 169630811

Following gene: 169630809

Centisome position: 74.74

GC content: 67.1

Gene sequence:

>1620_bases
ATGAGCAAGCTGATCGAATTCAACGAGACCGCGCGCCGCGCCCTGGAAGCCGGGGTCAACAAGCTGGCCGACGCGGTCAA
GGTCACGCTCGGTCCCCGCGGACGGCACGTGGTGCTGGCCAAGGCATTCGGCGGTCCCGCCGTGACCAACGACGGTGTCA
CCATCGCTCGTGACATCGACCTGGAAGACCCGTTCGAGAACCTGGGCGCCCAGCTGGTCAAGTCGGTGGCGACCAAGACC
AACGACGTTGCCGGTGACGGCACCACCACCGCCACCGTGCTGGCTCAGGCACTGGTCAGAGCCGGCCTGCGCAACGTGGC
CGCGGGTGCCAACCCGATCGCCCTCGGTGCCGGTATCTCCCGGGCCGCCGACGCGGTGTCCGAGCGGCTGCTGACGGTCG
CCGCGCCGGTTGCCGGCGAGCACGCCATTGCGCAGGTGGCCACCGTATCTTCGCGCGATCCCGAGATCGGCGAGCTGGTC
GGCGAGGCCATGACCAAGGTGGGTGGCGACGGTGTCGTTAGCGTCGAGGAGTCCTCGACCATCAACACCGAGCTGGTCAT
CACCGACGGTGTGCAGTTCGACAAGGGCTATCTGTCGCAGTACTTCGTGACCGACTTCGACGACCAGAAGGCGGTTCTGG
AGGACGCACTGGTGCTGCTGCATCGCGACAAGATCAGCTCGCTGCCCGACCTGCTTCCGCTGCTGGAACTGGTGGCCAAG
GAAGGCAAGCCGCTACTGATCGTGGCCGAAGACGTGGAGGGTGAGCCACTGTCGACCCTGGTGGTCAACGCGATTCGCAA
GACCCTCAAGGCCGTCGCCGTCAAGGCGCCGTTCTTCGGTGACCGCCGCAAGGCATTCCTGGAGGACCTGGCCATCGTCA
CCAACGCCCAGGTGGTCAACCCGGATGTGGGGCTGTCGCTGCGTGAGGTGGGTATCGAGGTGCTGGGCACCGCCCGCCGC
GTCGTGGTGAGCAAGGACGAGACGGTCATCGTCGACGGTGGCGGTTCCGAGGACGCCATCAAGGCACGTGTCGCCCAGTT
GAAGGCGGAGATCGAAACCACCGACTCGGACTGGGACCGCGAGAAGCTGCAGGAGCGTCTGGCCAAGCTGGCCGGCGGCG
TTGCCGTGATCAAGGTGGGCGCCCCCACCGACACCGCCCTCAAGGAGCGCAAGCATCGCGTCGAGGACGCCGTCTCGGCG
GCCAAGGCCGCCGTGGAAGAGGGCATTGTGGCCGGTGGCGGTAGCGCCCTGGTGCAGGCCCGTTCGGCGCTGGACGGTCT
GCGTGCCGAACTGAAGGGTGACGAGGCCAAGGGTGTCGACGTGTTCGAGGCCGCGTTGTCCGCTCCGCTGTTCTGGATTG
CCACCAACGCCGGCCTGGATGGTGCCGTGGTGGTGAGCAAGGTGGCCGAGCTGGACGCCGGGCACGGCTTCAACGCGGCG
ACGCTGGAGTACGGCGACCTGATTGCCGATGGCGTCATCGATCCGGTGAAGGTGACTCGCTCGGCCGTCATCAACGCGGC
ATCGGCGGCTCGCATGATCCTGACGACCGAGACCAGCATCGTGGACAAGCCTGCCGAAGAGGCCGACCACGGGCACGGCC
ACCACGGTCACGCCCACTAG

Upstream 100 bases:

>100_bases
TGACCGCCCCGGAAAGAACCTGCGTTGCAGGCGATTTCCGGGGCGGCGCGCGTTTTACCCATTCCTGTCCGGTGCTGATA
AAGCCGACTAGAGAGAACAC

Downstream 100 bases:

>100_bases
TTTGTGCGCAACGAAAGCACCCCTGGTCCTGTAGAGGCCGGGGGTGTTCTCGTCTTGGAAGTGGGTTCAACTCCTACCGG
GAGGATTGCTGGCTAACGCA

Product: 60 kDa chaperonin 1 (GroEL protein 1)

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MSKLIEFNETARRALEAGVNKLADAVKVTLGPRGRHVVLAKAFGGPAVTNDGVTIARDIDLEDPFENLGAQLVKSVATKT
NDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGISRAADAVSERLLTVAAPVAGEHAIAQVATVSSRDPEIGELV
GEAMTKVGGDGVVSVEESSTINTELVITDGVQFDKGYLSQYFVTDFDDQKAVLEDALVLLHRDKISSLPDLLPLLELVAK
EGKPLLIVAEDVEGEPLSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTNAQVVNPDVGLSLREVGIEVLGTARR
VVVSKDETVIVDGGGSEDAIKARVAQLKAEIETTDSDWDREKLQERLAKLAGGVAVIKVGAPTDTALKERKHRVEDAVSA
AKAAVEEGIVAGGGSALVQARSALDGLRAELKGDEAKGVDVFEAALSAPLFWIATNAGLDGAVVVSKVAELDAGHGFNAA
TLEYGDLIADGVIDPVKVTRSAVINAASAARMILTTETSIVDKPAEEADHGHGHHGHAH

Sequences:

>Translated_539_residues
MSKLIEFNETARRALEAGVNKLADAVKVTLGPRGRHVVLAKAFGGPAVTNDGVTIARDIDLEDPFENLGAQLVKSVATKT
NDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGISRAADAVSERLLTVAAPVAGEHAIAQVATVSSRDPEIGELV
GEAMTKVGGDGVVSVEESSTINTELVITDGVQFDKGYLSQYFVTDFDDQKAVLEDALVLLHRDKISSLPDLLPLLELVAK
EGKPLLIVAEDVEGEPLSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTNAQVVNPDVGLSLREVGIEVLGTARR
VVVSKDETVIVDGGGSEDAIKARVAQLKAEIETTDSDWDREKLQERLAKLAGGVAVIKVGAPTDTALKERKHRVEDAVSA
AKAAVEEGIVAGGGSALVQARSALDGLRAELKGDEAKGVDVFEAALSAPLFWIATNAGLDGAVVVSKVAELDAGHGFNAA
TLEYGDLIADGVIDPVKVTRSAVINAASAARMILTTETSIVDKPAEEADHGHGHHGHAH
>Mature_538_residues
SKLIEFNETARRALEAGVNKLADAVKVTLGPRGRHVVLAKAFGGPAVTNDGVTIARDIDLEDPFENLGAQLVKSVATKTN
DVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGISRAADAVSERLLTVAAPVAGEHAIAQVATVSSRDPEIGELVG
EAMTKVGGDGVVSVEESSTINTELVITDGVQFDKGYLSQYFVTDFDDQKAVLEDALVLLHRDKISSLPDLLPLLELVAKE
GKPLLIVAEDVEGEPLSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTNAQVVNPDVGLSLREVGIEVLGTARRV
VVSKDETVIVDGGGSEDAIKARVAQLKAEIETTDSDWDREKLQERLAKLAGGVAVIKVGAPTDTALKERKHRVEDAVSAA
KAAVEEGIVAGGGSALVQARSALDGLRAELKGDEAKGVDVFEAALSAPLFWIATNAGLDGAVVVSKVAELDAGHGFNAAT
LEYGDLIADGVIDPVKVTRSAVINAASAARMILTTETSIVDKPAEEADHGHGHHGHAH

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=43.7735849056604, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=43.7735849056604, Blast_Score=437, Evalue=1e-122,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=53.4090909090909, Blast_Score=535, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=42.1845574387947, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI193210679, Length=217, Percent_Identity=38.7096774193548, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=44.3809523809524, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322524, Length=122, Percent_Identity=35.2459016393443, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=45.0757575757576, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=45.0757575757576, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=43.1818181818182, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=43.1818181818182, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=43.1818181818182, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI17864606, Length=524, Percent_Identity=40.4580152671756, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24584129, Length=525, Percent_Identity=33.3333333333333, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI19921262, Length=525, Percent_Identity=33.3333333333333, Blast_Score=262, Evalue=4e-70,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56061; Mature: 55930

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLIEFNETARRALEAGVNKLADAVKVTLGPRGRHVVLAKAFGGPAVTNDGVTIARDID
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCCCCCCCCEEEEEECC
LEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGIS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHH
RAADAVSERLLTVAAPVAGEHAIAQVATVSSRDPEIGELVGEAMTKVGGDGVVSVEESST
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
INTELVITDGVQFDKGYLSQYFVTDFDDQKAVLEDALVLLHRDKISSLPDLLPLLELVAK
CCEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
EGKPLLIVAEDVEGEPLSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTNAQVVN
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEC
PDVGLSLREVGIEVLGTARRVVVSKDETVIVDGGGSEDAIKARVAQLKAEIETTDSDWDR
CCCCCHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCH
EKLQERLAKLAGGVAVIKVGAPTDTALKERKHRVEDAVSAAKAAVEEGIVAGGGSALVQA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RSALDGLRAELKGDEAKGVDVFEAALSAPLFWIATNAGLDGAVVVSKVAELDAGHGFNAA
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEE
TLEYGDLIADGVIDPVKVTRSAVINAASAARMILTTETSIVDKPAEEADHGHGHHGHAH
EEEHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEECHHHHCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SKLIEFNETARRALEAGVNKLADAVKVTLGPRGRHVVLAKAFGGPAVTNDGVTIARDID
CCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEECCCCCCCCCCEEEEEECC
LEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGIS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHH
RAADAVSERLLTVAAPVAGEHAIAQVATVSSRDPEIGELVGEAMTKVGGDGVVSVEESST
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
INTELVITDGVQFDKGYLSQYFVTDFDDQKAVLEDALVLLHRDKISSLPDLLPLLELVAK
CCEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
EGKPLLIVAEDVEGEPLSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLEDLAIVTNAQVVN
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEC
PDVGLSLREVGIEVLGTARRVVVSKDETVIVDGGGSEDAIKARVAQLKAEIETTDSDWDR
CCCCCHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCH
EKLQERLAKLAGGVAVIKVGAPTDTALKERKHRVEDAVSAAKAAVEEGIVAGGGSALVQA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RSALDGLRAELKGDEAKGVDVFEAALSAPLFWIATNAGLDGAVVVSKVAELDAGHGFNAA
HHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEE
TLEYGDLIADGVIDPVKVTRSAVINAASAARMILTTETSIVDKPAEEADHGHGHHGHAH
EEEHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEECHHHHCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1354834; 11234002 [H]