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The map label for this gene is ubiB [C]

Identifier: 169630588

GI number: 169630588

Start: 3549479

End: 3550828

Strand: Direct

Name: ubiB [C]

Synonym: MAB_3507

Alternate gene names: 169630588

Gene position: 3549479-3550828 (Clockwise)

Preceding gene: 169630585

Following gene: 169630593

Centisome position: 70.05

GC content: 63.04

Gene sequence:

>1350_bases
ATGGCAGATATTCGCCGCGGCGGACTCAGCCGAATGACCAAACTGGCAAGCCTGCCCGCCGGCATGGCAGGACGGGCCGT
CCTTGGTGTTGGCAAACGGCTGACCGGGACGTCGGCCGACGAGGTCAACGCCGAACTCTTGGAGAAGGCGGCCGACGAGC
TGTTCAAGGTGCTCGGCGAACTCAAGGGCGGCGCCATGAAAGTGGGGCAGGCATTGTCGGTGATGGAGGCCGCGATACCG
CCCCAATTCGCCGACCCGTTCCGCGAGGCGTTGGTGAAACTGCAGAGCGAGGCACCGCCGCTGCCGACACCCAAGGTGCA
TCGCGTGCTCGACGCACAGCTCGGCACCAAATGGCGCGAACGCTTCCAATCCTTCGACGACACTCCCGTCGCTTCGGCCA
GCATCGGCCAGGTGCACAAGGGAGTATGGAAGGACGGCCGCGAGGTGGCCGTCAAGATCCAGTACCCGGGCGCCGACGAT
GCCTTACGCGCGGATCTCAAACTCATTCAGCGGATGACACCGTTGGCCAAACAGATTGCGCCCAAGGCAGATATCGACAG
GCTGGTGGCCGAGATCAGCGACCGCATCGAAGCCGAGCTGGACTATCGCCTGGAGGCGTCCAATCAGCGCGCGTTCGCAA
AGGTCTTCGCCAGCGATCCGAAGTTCTTTGTACCGGCGGTTGTCGCCAGCGCTCCCAAGGTGATCATCGCCGAGTGGATG
GAAGGACGCCGGATCTCAAAGATCATCGCCGAGGGCACCCGCGAGGAGCGTGACTCCGCGGGCGCCTTGATGCTCGAATT
CACAGTGAAGTCACCGGAAAGCGTGGGGCTGGTGCATGCCGATCCGCACCCCGGAAACTTCATGCTGTTGCCCGACGGAC
GTTTCGGCATCATCGATTTCGGTGCGGTCTCGGAGCACCCTGGCGGCATTCCGCCGGAGTTCGGCGAGGTGCTGTGCTGG
GCGCGCGATGAGCAGTGGGACCAGGTGATCCGTCTGATCAAGCAGCTCGGCTTCATGCCGCCGGACGTTCAGCTGTCCGG
GGATCAGGTGATGGATTACATCAGACCGCTTTGGCCCTATGTCGATCCGCTGCGCGCGGGTGAGTTCCATTTCACCCGCG
AGTGGTTCCAGCAGGCCGCAGTCGCGTCGACCGACCTGTTGGACGAGGGATTCGCGGACCGATTCAAATTGGCGCGTCAG
ATGACGGTGCCGCCGGGTTACGTCATGCTGCTGCGCACTCTCGGCGGCATGATCGGGGTTCTGGTGCAACTCGATGCGCA
TGTGAACTACGCGGCGATCGCCGAACAATGGATGCCGGGATTCTTCCCGCCTAACTCCACATCGGCCTAA

Upstream 100 bases:

>100_bases
GGTCCTGACCGGGAGCGTATTCACGCCACAGCATCGGCACGGCTACTCTTCCGAGAGGACGTCACGGCAACGATGCCGGA
CCGAGAGGGTACGAGGTGAC

Downstream 100 bases:

>100_bases
ACGCATTGCTCCCCATCGCCGAATGACGATGGGGAGCAATGGTTATCAGGCCCTACAACCTTCTTGGCCGGCGGCGTCAT
GCCGCGGCGGTGTCGGCGTC

Product: ABC transporter ATP-binding protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MADIRRGGLSRMTKLASLPAGMAGRAVLGVGKRLTGTSADEVNAELLEKAADELFKVLGELKGGAMKVGQALSVMEAAIP
PQFADPFREALVKLQSEAPPLPTPKVHRVLDAQLGTKWRERFQSFDDTPVASASIGQVHKGVWKDGREVAVKIQYPGADD
ALRADLKLIQRMTPLAKQIAPKADIDRLVAEISDRIEAELDYRLEASNQRAFAKVFASDPKFFVPAVVASAPKVIIAEWM
EGRRISKIIAEGTREERDSAGALMLEFTVKSPESVGLVHADPHPGNFMLLPDGRFGIIDFGAVSEHPGGIPPEFGEVLCW
ARDEQWDQVIRLIKQLGFMPPDVQLSGDQVMDYIRPLWPYVDPLRAGEFHFTREWFQQAAVASTDLLDEGFADRFKLARQ
MTVPPGYVMLLRTLGGMIGVLVQLDAHVNYAAIAEQWMPGFFPPNSTSA

Sequences:

>Translated_449_residues
MADIRRGGLSRMTKLASLPAGMAGRAVLGVGKRLTGTSADEVNAELLEKAADELFKVLGELKGGAMKVGQALSVMEAAIP
PQFADPFREALVKLQSEAPPLPTPKVHRVLDAQLGTKWRERFQSFDDTPVASASIGQVHKGVWKDGREVAVKIQYPGADD
ALRADLKLIQRMTPLAKQIAPKADIDRLVAEISDRIEAELDYRLEASNQRAFAKVFASDPKFFVPAVVASAPKVIIAEWM
EGRRISKIIAEGTREERDSAGALMLEFTVKSPESVGLVHADPHPGNFMLLPDGRFGIIDFGAVSEHPGGIPPEFGEVLCW
ARDEQWDQVIRLIKQLGFMPPDVQLSGDQVMDYIRPLWPYVDPLRAGEFHFTREWFQQAAVASTDLLDEGFADRFKLARQ
MTVPPGYVMLLRTLGGMIGVLVQLDAHVNYAAIAEQWMPGFFPPNSTSA
>Mature_448_residues
ADIRRGGLSRMTKLASLPAGMAGRAVLGVGKRLTGTSADEVNAELLEKAADELFKVLGELKGGAMKVGQALSVMEAAIPP
QFADPFREALVKLQSEAPPLPTPKVHRVLDAQLGTKWRERFQSFDDTPVASASIGQVHKGVWKDGREVAVKIQYPGADDA
LRADLKLIQRMTPLAKQIAPKADIDRLVAEISDRIEAELDYRLEASNQRAFAKVFASDPKFFVPAVVASAPKVIIAEWME
GRRISKIIAEGTREERDSAGALMLEFTVKSPESVGLVHADPHPGNFMLLPDGRFGIIDFGAVSEHPGGIPPEFGEVLCWA
RDEQWDQVIRLIKQLGFMPPDVQLSGDQVMDYIRPLWPYVDPLRAGEFHFTREWFQQAAVASTDLLDEGFADRFKLARQM
TVPPGYVMLLRTLGGMIGVLVQLDAHVNYAAIAEQWMPGFFPPNSTSA

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=404, Percent_Identity=25.990099009901, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI27363457, Length=323, Percent_Identity=28.4829721362229, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI40254938, Length=263, Percent_Identity=27.7566539923954, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI217416386, Length=275, Percent_Identity=28, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=28.2051282051282, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI217035081, Length=199, Percent_Identity=30.1507537688442, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI2367309, Length=305, Percent_Identity=27.2131147540984, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI32565180, Length=346, Percent_Identity=28.6127167630058, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17559152, Length=323, Percent_Identity=28.1733746130031, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=443, Percent_Identity=25.5079006772009, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323282, Length=236, Percent_Identity=27.5423728813559, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18859849, Length=293, Percent_Identity=29.3515358361775, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI22024280, Length=260, Percent_Identity=29.6153846153846, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24662575, Length=279, Percent_Identity=27.5985663082437, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49320; Mature: 49189

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIRRGGLSRMTKLASLPAGMAGRAVLGVGKRLTGTSADEVNAELLEKAADELFKVLGE
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKGGAMKVGQALSVMEAAIPPQFADPFREALVKLQSEAPPLPTPKVHRVLDAQLGTKWRE
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHH
RFQSFDDTPVASASIGQVHKGVWKDGREVAVKIQYPGADDALRADLKLIQRMTPLAKQIA
HHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
PKADIDRLVAEISDRIEAELDYRLEASNQRAFAKVFASDPKFFVPAVVASAPKVIIAEWM
CHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
EGRRISKIIAEGTREERDSAGALMLEFTVKSPESVGLVHADPHPGNFMLLPDGRFGIIDF
CCHHHHHHHHHCCHHHHHCCCEEEEEEEECCCCCCCEEECCCCCCCEEEECCCCCCEEEC
GAVSEHPGGIPPEFGEVLCWARDEQWDQVIRLIKQLGFMPPDVQLSGDQVMDYIRPLWPY
CCCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHH
VDPLRAGEFHFTREWFQQAAVASTDLLDEGFADRFKLARQMTVPPGYVMLLRTLGGMIGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LVQLDAHVNYAAIAEQWMPGFFPPNSTSA
HHHHCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ADIRRGGLSRMTKLASLPAGMAGRAVLGVGKRLTGTSADEVNAELLEKAADELFKVLGE
CCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LKGGAMKVGQALSVMEAAIPPQFADPFREALVKLQSEAPPLPTPKVHRVLDAQLGTKWRE
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHH
RFQSFDDTPVASASIGQVHKGVWKDGREVAVKIQYPGADDALRADLKLIQRMTPLAKQIA
HHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
PKADIDRLVAEISDRIEAELDYRLEASNQRAFAKVFASDPKFFVPAVVASAPKVIIAEWM
CHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
EGRRISKIIAEGTREERDSAGALMLEFTVKSPESVGLVHADPHPGNFMLLPDGRFGIIDF
CCHHHHHHHHHCCHHHHHCCCEEEEEEEECCCCCCCEEECCCCCCCEEEECCCCCCEEEC
GAVSEHPGGIPPEFGEVLCWARDEQWDQVIRLIKQLGFMPPDVQLSGDQVMDYIRPLWPY
CCCCCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHH
VDPLRAGEFHFTREWFQQAAVASTDLLDEGFADRFKLARQMTVPPGYVMLLRTLGGMIGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LVQLDAHVNYAAIAEQWMPGFFPPNSTSA
HHHHCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]