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The map label for this gene is tetA [H]

Identifier: 169630530

GI number: 169630530

Start: 3491966

End: 3493240

Strand: Reverse

Name: tetA [H]

Synonym: MAB_3449c

Alternate gene names: 169630530

Gene position: 3493240-3491966 (Counterclockwise)

Preceding gene: 169630531

Following gene: 169630528

Centisome position: 68.94

GC content: 66.04

Gene sequence:

>1275_bases
TTGAGTAGCTGTCGCGAAGGAAACGCAGACAACGCGACGGTAAAGCCACGCCTGCCGTGGGAGATCTGGGTTCTGGTCGT
CGCAAGCCTGGTGATCGCGCTCGGGTTCGGCGTGGTGGCGCCCGCGCTGCCCCAATACGCCCGCAGCTTCGGGGTGAGCG
TGACCGCGGCGACTGCGGTGGTGAGTTCGTTCGCGGCCTTCCGGCTGGTGTTCGCACCCGTGGCCGGCGCACTGGTGCAG
CGGCTGGGGGAGCGCTGGGTCTACATGAGCGGACTGCTGATCGTCGCCGCATCTACCGGTATCTGCGCCTTCGTGCATAG
CTATTGGCAGCTGCTGGTGTTTCGCTCGGTCGGCGGGGTCGGTTCGACCATGTTCACCGTGTCCGCGGCGGCGCTGCTGG
TGCGCATTGCGCCGGAGGAGATTCGGGGACGAGCCCAGGGGTTGTACGGTTCGAGTTTCTTGCTGGGGATGGTAGCCGGG
CCTGCACTGGGCAGTGCTGTTGTGGGGCTGAGCCTTTCGGCGCCCTTTATCATCTACGCGGCTGCGCTGGTGATCGTTGT
CATGCTGGTCTATTTCGGACTGCGGCGCTCCACGCTGCTGGATGTCGCCGACGAGCACCACGGCACTCCGGTGAGGTTGA
CCTCGGCGCTGCGTCACCGGACGTTTCTGGCGGCACTGATGTCGAATTTCAGTGCCGGATGGGCGATTTTCGGGATTCGT
GGCGCACTGCTCCCGCTGTTGGTGGTCGAGGCGCTGCATCAGCGTCCTGGCGCGGCCGGGCTGGTATTCGCCGCATTCGC
CGCCGGCGACGTATCTACGGCCTTTTTGGCCGGGTCGTGGTCCGATGACATCGGTCGCAAGCCACTGGTGGTCGCCGGGC
TGGTGGTGTGTGGGTCCACCGTGGTGGCGATGGGGTTCGTGTCATCGCTGCCGGTGCTTGTCGTGCTCTCACTGATAGGC
GGGATCGGAGCAGGTTTGTACGCGTCCCCGCAGCAGGCCGCGGTGGCCGATGTGGTGGGCAGCAGGGGCAGGGCAGGCAC
GGCGCTGGCCACTTTCCAGATGACGTCCGATATCGGGCTGGTGGTTGGACCCGTCGTCGCCGGGGCGATCGCCGAGCACA
CGTCCTACGGGTGGGCGTTCGTGGTGGGTGGGGCGATGCCGCTGATAGCGGCCGTGGCATGGGTGTTCGCACCCGAGACG
CTGGGGAGACTTGCGTCACCGCAGGTAAGGAGTATGCAGGAAGTAGCAGAGGATGTCGGCGGCCCTGAGCGCTGA

Upstream 100 bases:

>100_bases
CCGAGGATGTATACAAGATCTATGCAGAATCATTTCTGGGCGCCGAGCACTTGAACCAGGTACAAGATGCCGCGAGGGAG
GTTGTCTCGGCGGTCATCGG

Downstream 100 bases:

>100_bases
GATTTTGAGAGCCCGTCGCCGTGGTGTAACTTCTTCCGAGCACGCAACTAAACAATGGGGCTATGGCGCAGCTGGTAGCG
CACCACACTGGCAGTGTGGG

Product: putative transporter

Products: NA

Alternate protein names: TetA(G) [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSSCREGNADNATVKPRLPWEIWVLVVASLVIALGFGVVAPALPQYARSFGVSVTAATAVVSSFAAFRLVFAPVAGALVQ
RLGERWVYMSGLLIVAASTGICAFVHSYWQLLVFRSVGGVGSTMFTVSAAALLVRIAPEEIRGRAQGLYGSSFLLGMVAG
PALGSAVVGLSLSAPFIIYAAALVIVVMLVYFGLRRSTLLDVADEHHGTPVRLTSALRHRTFLAALMSNFSAGWAIFGIR
GALLPLLVVEALHQRPGAAGLVFAAFAAGDVSTAFLAGSWSDDIGRKPLVVAGLVVCGSTVVAMGFVSSLPVLVVLSLIG
GIGAGLYASPQQAAVADVVGSRGRAGTALATFQMTSDIGLVVGPVVAGAIAEHTSYGWAFVVGGAMPLIAAVAWVFAPET
LGRLASPQVRSMQEVAEDVGGPER

Sequences:

>Translated_424_residues
MSSCREGNADNATVKPRLPWEIWVLVVASLVIALGFGVVAPALPQYARSFGVSVTAATAVVSSFAAFRLVFAPVAGALVQ
RLGERWVYMSGLLIVAASTGICAFVHSYWQLLVFRSVGGVGSTMFTVSAAALLVRIAPEEIRGRAQGLYGSSFLLGMVAG
PALGSAVVGLSLSAPFIIYAAALVIVVMLVYFGLRRSTLLDVADEHHGTPVRLTSALRHRTFLAALMSNFSAGWAIFGIR
GALLPLLVVEALHQRPGAAGLVFAAFAAGDVSTAFLAGSWSDDIGRKPLVVAGLVVCGSTVVAMGFVSSLPVLVVLSLIG
GIGAGLYASPQQAAVADVVGSRGRAGTALATFQMTSDIGLVVGPVVAGAIAEHTSYGWAFVVGGAMPLIAAVAWVFAPET
LGRLASPQVRSMQEVAEDVGGPER
>Mature_423_residues
SSCREGNADNATVKPRLPWEIWVLVVASLVIALGFGVVAPALPQYARSFGVSVTAATAVVSSFAAFRLVFAPVAGALVQR
LGERWVYMSGLLIVAASTGICAFVHSYWQLLVFRSVGGVGSTMFTVSAAALLVRIAPEEIRGRAQGLYGSSFLLGMVAGP
ALGSAVVGLSLSAPFIIYAAALVIVVMLVYFGLRRSTLLDVADEHHGTPVRLTSALRHRTFLAALMSNFSAGWAIFGIRG
ALLPLLVVEALHQRPGAAGLVFAAFAAGDVSTAFLAGSWSDDIGRKPLVVAGLVVCGSTVVAMGFVSSLPVLVVLSLIGG
IGAGLYASPQQAAVADVVGSRGRAGTALATFQMTSDIGLVVGPVVAGAIAEHTSYGWAFVVGGAMPLIAAVAWVFAPETL
GRLASPQVRSMQEVAEDVGGPER

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI42476325, Length=367, Percent_Identity=24.5231607629428, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62471715, Length=363, Percent_Identity=25.8953168044077, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62471713, Length=348, Percent_Identity=25.8620689655172, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI62471717, Length=348, Percent_Identity=25.8620689655172, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43666; Mature: 43534

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSCREGNADNATVKPRLPWEIWVLVVASLVIALGFGVVAPALPQYARSFGVSVTAATAV
CCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VSSFAAFRLVFAPVAGALVQRLGERWVYMSGLLIVAASTGICAFVHSYWQLLVFRSVGGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCHHHHHHHHHHHHHHHHHCCCC
GSTMFTVSAAALLVRIAPEEIRGRAQGLYGSSFLLGMVAGPALGSAVVGLSLSAPFIIYA
CHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHCCCCHHHHHH
AALVIVVMLVYFGLRRSTLLDVADEHHGTPVRLTSALRHRTFLAALMSNFSAGWAIFGIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GALLPLLVVEALHQRPGAAGLVFAAFAAGDVSTAFLAGSWSDDIGRKPLVVAGLVVCGST
HHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHEECCCCCCCCCCCHHHHHHHHHHHH
VVAMGFVSSLPVLVVLSLIGGIGAGLYASPQQAAVADVVGSRGRAGTALATFQMTSDIGL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCHH
VVGPVVAGAIAEHTSYGWAFVVGGAMPLIAAVAWVFAPETLGRLASPQVRSMQEVAEDVG
HHHHHHHHHHHHHCCCCHHEECCCHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHCC
GPER
CCCC
>Mature Secondary Structure 
SSCREGNADNATVKPRLPWEIWVLVVASLVIALGFGVVAPALPQYARSFGVSVTAATAV
CCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1479961 [H]