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The map label for this gene is cobB [H]

Identifier: 169630522

GI number: 169630522

Start: 3485155

End: 3485901

Strand: Reverse

Name: cobB [H]

Synonym: MAB_3441c

Alternate gene names: 169630522

Gene position: 3485901-3485155 (Counterclockwise)

Preceding gene: 169630525

Following gene: 169630521

Centisome position: 68.79

GC content: 64.66

Gene sequence:

>747_bases
ATGACCGAGGTTCCCGACGAGCTGATCGCCGCCGCGTCGAAGGCACGTTCCGTCACCGTGCTTACTGGCGCCGGCATGTC
CGCCGAGAGCGGGTTGCCCACGTTCCGCGATGCGCAGACGGGGCTGTGGTCGAAGTATGACCCGATGACCCTTGCCACCC
CGGAATCATGGCAAGAGGACCCGGGGCTGGTGTGGGCGTGGTATCAGAATCGGCGCATCCAGCTGCTGGCGGTACAACCC
AACGACGGGCATCGGGCGTTGGCGCAGTGGGGATCTCATCGCGACATTCGGATCGTCACCCAGAACGTCGATGATCTTCA
CGAACGTGCCGGCAGTTCGAATGTCACGCACGTTCACGGCAGCCTGCTCAAATCGCACTGCGACACCTGCCGCAGTGATT
TCGAGGCAACGGTTTCCGCCCCCGAAGCGGAGCGCGTGGCCCCGCCGGAGTGCGGTTGCGGGGGAAAGGTCCGCCCGAGC
ATCGTGTGGTTCGGGGAGATGCTTCCCGAGGTCGAGTTCGGTCATGCGGTAGCGCATTCGCAGAATTGCGATCTGATGTT
GCTCATCGGCACCTCCGGGATCGTGTATCCGGCGGCAGGGCTCCCGCAATTGGCTCTGAGTCGTGGCGCGACCGTGGTCG
AGATCAACCCGCAGGAGACCGACCTGTCCGATCGCGCGGACCTGGTTTGGAGATCCACTGCGGCCACGGCACTGCCTGCG
CTCCTCCAGGCGCTGGCACCGTTCTGA

Upstream 100 bases:

>100_bases
CTCCTCGCCCGGAGTTTTGACGTCTCATTCCATCGTAGGGAGGGGTGAGCGAGCCTTGAGGTCGGTCGAACGCGGGTCGA
ATCCGTAGTAAGAAAGACTC

Downstream 100 bases:

>100_bases
GCCTGCGCGCACAGGTCCATGGCTGATGGGGCTTGTCGCTCATAGCCGGGCACCAGGTGCCTCCCTGCACCGGCTCGTGA
CCATCCTTGCGCCTGATCCG

Product: NAD-dependent deacetylase (regulatory protein Sir2 homolog)

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTEVPDELIAAASKARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMTLATPESWQEDPGLVWAWYQNRRIQLLAVQP
NDGHRALAQWGSHRDIRIVTQNVDDLHERAGSSNVTHVHGSLLKSHCDTCRSDFEATVSAPEAERVAPPECGCGGKVRPS
IVWFGEMLPEVEFGHAVAHSQNCDLMLLIGTSGIVYPAAGLPQLALSRGATVVEINPQETDLSDRADLVWRSTAATALPA
LLQALAPF

Sequences:

>Translated_248_residues
MTEVPDELIAAASKARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMTLATPESWQEDPGLVWAWYQNRRIQLLAVQP
NDGHRALAQWGSHRDIRIVTQNVDDLHERAGSSNVTHVHGSLLKSHCDTCRSDFEATVSAPEAERVAPPECGCGGKVRPS
IVWFGEMLPEVEFGHAVAHSQNCDLMLLIGTSGIVYPAAGLPQLALSRGATVVEINPQETDLSDRADLVWRSTAATALPA
LLQALAPF
>Mature_247_residues
TEVPDELIAAASKARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMTLATPESWQEDPGLVWAWYQNRRIQLLAVQPN
DGHRALAQWGSHRDIRIVTQNVDDLHERAGSSNVTHVHGSLLKSHCDTCRSDFEATVSAPEAERVAPPECGCGGKVRPSI
VWFGEMLPEVEFGHAVAHSQNCDLMLLIGTSGIVYPAAGLPQLALSRGATVVEINPQETDLSDRADLVWRSTAATALPAL
LQALAPF

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=241, Percent_Identity=40.6639004149378, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI6912664, Length=259, Percent_Identity=37.8378378378378, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI13787215, Length=242, Percent_Identity=38.8429752066116, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI6912660, Length=247, Percent_Identity=32.7935222672065, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI6912662, Length=272, Percent_Identity=27.9411764705882, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI63054862, Length=233, Percent_Identity=31.7596566523605, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI300797577, Length=253, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI7657575, Length=214, Percent_Identity=29.4392523364486, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI308199517, Length=235, Percent_Identity=40, Blast_Score=148, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17541892, Length=199, Percent_Identity=29.1457286432161, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71990482, Length=220, Percent_Identity=29.0909090909091, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71990487, Length=222, Percent_Identity=28.8288288288288, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17567771, Length=254, Percent_Identity=27.1653543307087, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325242, Length=238, Percent_Identity=28.9915966386555, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571445, Length=199, Percent_Identity=32.1608040201005, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24648389, Length=198, Percent_Identity=30.8080808080808, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137536, Length=247, Percent_Identity=29.1497975708502, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24645650, Length=260, Percent_Identity=26.1538461538462, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571443, Length=125, Percent_Identity=35.2, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571441, Length=125, Percent_Identity=35.2, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26760; Mature: 26629

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVPDELIAAASKARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMTLATPESWQED
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
PGLVWAWYQNRRIQLLAVQPNDGHRALAQWGSHRDIRIVTQNVDDLHERAGSSNVTHVHG
CCEEEEEECCCEEEEEEECCCCCHHHHHHCCCCCCEEEEECCHHHHHHHCCCCCCCHHHH
SLLKSHCDTCRSDFEATVSAPEAERVAPPECGCGGKVRPSIVWFGEMLPEVEFGHAVAHS
HHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCHHCHHHHCC
QNCDLMLLIGTSGIVYPAAGLPQLALSRGATVVEINPQETDLSDRADLVWRSTAATALPA
CCCCEEEEECCCCEEECCCCCHHHHHHCCCEEEEECCCCCCCCCHHHHEEHHHHHHHHHH
LLQALAPF
HHHHHCCC
>Mature Secondary Structure 
TEVPDELIAAASKARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMTLATPESWQED
CCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
PGLVWAWYQNRRIQLLAVQPNDGHRALAQWGSHRDIRIVTQNVDDLHERAGSSNVTHVHG
CCEEEEEECCCEEEEEEECCCCCHHHHHHCCCCCCEEEEECCHHHHHHHCCCCCCCHHHH
SLLKSHCDTCRSDFEATVSAPEAERVAPPECGCGGKVRPSIVWFGEMLPEVEFGHAVAHS
HHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCHHCHHHHCC
QNCDLMLLIGTSGIVYPAAGLPQLALSRGATVVEINPQETDLSDRADLVWRSTAATALPA
CCCCEEEEECCCCEEECCCCCHHHHHHCCCEEEEECCCCCCCCCHHHHEEHHHHHHHHHH
LLQALAPF
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]