BacMap

Definition	Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence.
Accession	NC_010397
Length	5,067,172

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The map label for this gene is fabG [C]

Identifier: 169630507

GI number: 169630507

Start: 3472067

End: 3472876

Strand: Reverse

Name: fabG [C]

Synonym: MAB_3426c

Alternate gene names: 169630507

Gene position: 3472876-3472067 (Counterclockwise)

Preceding gene: 169630509

Following gene: 169630506

Centisome position: 68.54

GC content: 62.35

Gene sequence:

>810_bases
ATGGTCGACATCCCACACACCATCGATCCGGTTCAGCCCTATCGGCCGCAGGAACAGCCGCTGCGAGGGAAGGTCGCCGT
GATCACCGGCGCATCGGCCAATATGGGTGCGGCGCTTGCGCGGACACTGGCCCAGGACGGCGCCCAAGTTGTCGTGCACT
ATCGCAGCGATAGCAAGGCCCAGCAGGCGGAGCGGGTTGTTCGGCAGATTCAGGAGTCCGGTAGCGACGCGGTGAGCTTC
CAGGCGGATCTGTCCGTCCCCGAGAACTGCACCAAGCTTGCCGATGCCGCCTTCGAAGCGTTCGGCCGATGGGACATCCT
GATCAACACCGCCGGCATGATCGTGCGGAAACCTTTGGCGGATATCACCGAAGACGAATATGACGGGGTCTTCAACGCCA
ACGCCAAGACGGTGTTCTTCATGATGCGTGAGGCGGCGCGCCGGATGGCCGACAACGGCCGGATCCTGAGCTTTGTCACC
ACGATGGTCGGGGCACTGGCACCCACCTACAGTGCGTACGCCGGGTCCAAGGCTCCCGTCGAGCATTTCACCAAGGCATT
GGCCAAAGAGGTTGGTGGGCGCGGGATCACCGCGAACTGCATCGCGCCGGGCCCCTTGCAGACCAGCTTTTTCTATCCGG
CCGAATCCGACGAGAACATCGCCTGGCTGGAGTCGATGAGTATCAACGGACAGATCGGGCGCGGTGATGACATCCTGCCG
GTGGCCAGGCTGTTGGTCCTTCCGGAATCGGGGTGGACGACGGCGCAGACTATTTTCGTCAACGGCGGCATCATCTCGAC
CATCAACTAG

Upstream 100 bases:

>100_bases
ACTTGTTAGCTGTCAACAATCTTTTGTTGGCTCGGGCTAGGTAGATCTCATAGCGTTGGGGCTTGCCCGCGTGGGCGACT
GATTGCTACCAGGAGTGGAT

Downstream 100 bases:

>100_bases
TTGACGGCTTTACCTAGACTGGGCCGTGTGCGGAGAAGTGTCGAGAACATAGCTTGATCCCGGTCACCATCGTCTCCGGG
TTCTTGGGTGCCGGTAAGAC

Product: putative short chain dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MVDIPHTIDPVQPYRPQEQPLRGKVAVITGASANMGAALARTLAQDGAQVVVHYRSDSKAQQAERVVRQIQESGSDAVSF
QADLSVPENCTKLADAAFEAFGRWDILINTAGMIVRKPLADITEDEYDGVFNANAKTVFFMMREAARRMADNGRILSFVT
TMVGALAPTYSAYAGSKAPVEHFTKALAKEVGGRGITANCIAPGPLQTSFFYPAESDENIAWLESMSINGQIGRGDDILP
VARLLVLPESGWTTAQTIFVNGGIISTIN

Sequences:

>Translated_269_residues
MVDIPHTIDPVQPYRPQEQPLRGKVAVITGASANMGAALARTLAQDGAQVVVHYRSDSKAQQAERVVRQIQESGSDAVSF
QADLSVPENCTKLADAAFEAFGRWDILINTAGMIVRKPLADITEDEYDGVFNANAKTVFFMMREAARRMADNGRILSFVT
TMVGALAPTYSAYAGSKAPVEHFTKALAKEVGGRGITANCIAPGPLQTSFFYPAESDENIAWLESMSINGQIGRGDDILP
VARLLVLPESGWTTAQTIFVNGGIISTIN
>Mature_269_residues
MVDIPHTIDPVQPYRPQEQPLRGKVAVITGASANMGAALARTLAQDGAQVVVHYRSDSKAQQAERVVRQIQESGSDAVSF
QADLSVPENCTKLADAAFEAFGRWDILINTAGMIVRKPLADITEDEYDGVFNANAKTVFFMMREAARRMADNGRILSFVT
TMVGALAPTYSAYAGSKAPVEHFTKALAKEVGGRGITANCIAPGPLQTSFFYPAESDENIAWLESMSINGQIGRGDDILP
VARLLVLPESGWTTAQTIFVNGGIISTIN

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=29.5719844357977, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=27.2, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=28.7937743190661, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=29.5918367346939, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=24.124513618677, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI10190704, Length=203, Percent_Identity=29.064039408867, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4504505, Length=196, Percent_Identity=30.1020408163265, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723191, Length=191, Percent_Identity=29.3193717277487, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7706318, Length=207, Percent_Identity=28.9855072463768, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI109715829, Length=207, Percent_Identity=28.5024154589372, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=26, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=23.9043824701195, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=30.7692307692308, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=30.8300395256917, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1789378, Length=245, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=31.4741035856574, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=28.4046692607004, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=28.4552845528455, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082160, Length=266, Percent_Identity=27.0676691729323, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=29.1338582677165, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367175, Length=197, Percent_Identity=30.9644670050761, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=27.734375, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787526, Length=216, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=29.4354838709677, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=261, Percent_Identity=28.3524904214559, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=29.8387096774194, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193204405, Length=256, Percent_Identity=26.171875, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562906, Length=259, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=27.5303643724696, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=28.9473684210526, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=225, Percent_Identity=29.7777777777778, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=260, Percent_Identity=28.0769230769231, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=258, Percent_Identity=26.3565891472868, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=256, Percent_Identity=26.5625, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=214, Percent_Identity=26.6355140186916, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=191, Percent_Identity=30.8900523560209, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=29.1497975708502, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=193, Percent_Identity=25.3886010362694, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=26.7441860465116, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=260, Percent_Identity=26.1538461538462, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=27.906976744186, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=24.21875, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=196, Percent_Identity=29.5918367346939, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=27.5193798449612, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17561272, Length=253, Percent_Identity=30.0395256916996, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=28.3464566929134, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=198, Percent_Identity=25.7575757575758, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=27, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=25.0950570342205, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=24.609375, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=196, Percent_Identity=27.0408163265306, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=194, Percent_Identity=28.8659793814433, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=29.9610894941634, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=29.7619047619048, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=27.2, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=28.3464566929134, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24644339, Length=247, Percent_Identity=25.9109311740891, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=25.2, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24643142, Length=187, Percent_Identity=32.0855614973262, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=28.7081339712919, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859837, Length=142, Percent_Identity=34.5070422535211, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28936; Mature: 28936

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDIPHTIDPVQPYRPQEQPLRGKVAVITGASANMGAALARTLAQDGAQVVVHYRSDSKA
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHH
QQAERVVRQIQESGSDAVSFQADLSVPENCTKLADAAFEAFGRWDILINTAGMIVRKPLA
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHH
DITEDEYDGVFNANAKTVFFMMREAARRMADNGRILSFVTTMVGALAPTYSAYAGSKAPV
HCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCH
EHFTKALAKEVGGRGITANCIAPGPLQTSFFYPAESDENIAWLESMSINGQIGRGDDILP
HHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCHHH
VARLLVLPESGWTTAQTIFVNGGIISTIN
HHHHHEECCCCCCEEEEEEEECCEEEECC
>Mature Secondary Structure
MVDIPHTIDPVQPYRPQEQPLRGKVAVITGASANMGAALARTLAQDGAQVVVHYRSDSKA
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHH
QQAERVVRQIQESGSDAVSFQADLSVPENCTKLADAAFEAFGRWDILINTAGMIVRKPLA
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHH
DITEDEYDGVFNANAKTVFFMMREAARRMADNGRILSFVTTMVGALAPTYSAYAGSKAPV
HCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCH
EHFTKALAKEVGGRGITANCIAPGPLQTSFFYPAESDENIAWLESMSINGQIGRGDDILP
HHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCHHH
VARLLVLPESGWTTAQTIFVNGGIISTIN
HHHHHEECCCCCCEEEEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]