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The map label for this gene is lrp [H]

Identifier: 169630449

GI number: 169630449

Start: 3421701

End: 3422141

Strand: Reverse

Name: lrp [H]

Synonym: MAB_3368c

Alternate gene names: 169630449

Gene position: 3422141-3421701 (Counterclockwise)

Preceding gene: 169630452

Following gene: 169630444

Centisome position: 67.54

GC content: 61.45

Gene sequence:

>441_bases
ATGGACAAGCTAGATCGCGCAATAATCGATCAGCTTCAGGATCATGGGCGGCTGACGAACCAGGAATTGGCGGACCGGGT
TGGCCTTACTCCGGCCCCGTGCCTGCGGCGGGTGCGCCGGTTGGAAGCCGAGGGTGTCATTACGGGCTATACCGCACTGG
TGAATCCGGCGGCGCTGGGCCGCGACTTCGAGGTGATCATCTACGCAGATCTGGTGGCCAAAGACCTTGCCACGGTTGCG
TCTTTCGAGGAGCGCCTGGTGGCGATGGACGAAGTCGCCGAGCTGAGGCGAATGTTCGGCATTCCGGACTATTTCATCCG
GGTGCAGACAGCCGACCTTGCCGCCTATGAGCAGTGGTTGAGTGTCAAGCTGATGGGTGACCCGGCCATAGCCCGTGTCG
ACTCGCGGCTCACGATGAAGCTGCTCAAGTCACGCCGCTGA

Upstream 100 bases:

>100_bases
CGACAACACCTCCTGGCTCATGCAGCAATCATAGAGTGGATAACACGCACGATGGTTGTCGATATTGCTTCCAATCCGGT
CTGTGAGGCAATATAGATGC

Downstream 100 bases:

>100_bases
GGAAGCGCTTGGTGCGCATGCGCTCACAGCAGCCTGTGTGCTCGTAGATCGGCGATGTATTTGGCGATCAGCGCACGATC
GATTTGCGGAATATCGGCGC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MDKLDRAIIDQLQDHGRLTNQELADRVGLTPAPCLRRVRRLEAEGVITGYTALVNPAALGRDFEVIIYADLVAKDLATVA
SFEERLVAMDEVAELRRMFGIPDYFIRVQTADLAAYEQWLSVKLMGDPAIARVDSRLTMKLLKSRR

Sequences:

>Translated_146_residues
MDKLDRAIIDQLQDHGRLTNQELADRVGLTPAPCLRRVRRLEAEGVITGYTALVNPAALGRDFEVIIYADLVAKDLATVA
SFEERLVAMDEVAELRRMFGIPDYFIRVQTADLAAYEQWLSVKLMGDPAIARVDSRLTMKLLKSRR
>Mature_146_residues
MDKLDRAIIDQLQDHGRLTNQELADRVGLTPAPCLRRVRRLEAEGVITGYTALVNPAALGRDFEVIIYADLVAKDLATVA
SFEERLVAMDEVAELRRMFGIPDYFIRVQTADLAAYEQWLSVKLMGDPAIARVDSRLTMKLLKSRR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=144, Percent_Identity=35.4166666666667, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=31.4685314685315, Blast_Score=80, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 16474; Mature: 16474

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLDRAIIDQLQDHGRLTNQELADRVGLTPAPCLRRVRRLEAEGVITGYTALVNPAALG
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCEEEHHHHHHCHHHCC
RDFEVIIYADLVAKDLATVASFEERLVAMDEVAELRRMFGIPDYFIRVQTADLAAYEQWL
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEHHHHHHHHHHH
SVKLMGDPAIARVDSRLTMKLLKSRR
HEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKLDRAIIDQLQDHGRLTNQELADRVGLTPAPCLRRVRRLEAEGVITGYTALVNPAALG
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCEEEHHHHHHCHHHCC
RDFEVIIYADLVAKDLATVASFEERLVAMDEVAELRRMFGIPDYFIRVQTADLAAYEQWL
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEHHHHHHHHHHH
SVKLMGDPAIARVDSRLTMKLLKSRR
HEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]