Click here to switch to the map view.

The map label for this gene is mutM

Identifier: 169630336

GI number: 169630336

Start: 3294595

End: 3295455

Strand: Reverse

Name: mutM

Synonym: MAB_3255c

Alternate gene names: 169630336

Gene position: 3295455-3294595 (Counterclockwise)

Preceding gene: 169630337

Following gene: 169630335

Centisome position: 65.04

GC content: 64.23

Gene sequence:

>861_bases
GTGCCTGAGCTTCCCGAGGTGGAGGTGGTTCGCCGCGGACTGCACCACCACCTTGTCGGCAAGACCATCGCATCGACGCT
GGTGTACCACGAGCGTGCTGTGCGCAGACAGTCCGGCGGGGCCGTCGAACTGGCCGGACTGCTTGCCGGACAACAGATCA
GCGGTACAGGCCGACGGGGAAAGTACCTGTGGCTGACCTTGGAAGGTTCGAGCGGCGCACAGGCCCTGGTGGTGCACCTG
GGAATGAGCGGACAGATGCTCATCGGGCCGATCTCCAGGCCTCAGCATTTGCGTATCGCCGCGACCCTCGATGACGGATC
GGTATTGAGCTTCGTCGACCAACGCACATTCGGCGGCTGGATGGTGACCGACCTGGTCACCGTGGACGGCAGCGAGCTTC
CCGAGCCGGTCGCGCATATCGCGCGTGACCCACTGGACGAACTGTTCGAGATAGGCGCCGTTGTCACCCGATTGCGGGGG
AAGCACACCGAGATCAAGCGCGCACTGCTCGATCAAACGGTGGTCTCCGGCGTCGGAAATATCTACGCCGATGAAGCTCT
CTGGCAGGCGCGGGTGCATGGGCGACGCCTCACCGACGGCATGAGCCGGGCCAAGCTCACCGAAGTGCTCGACAGCGCTG
CCGCGGTCATGCGCCTGGCGCTGGCTCAGGGCGGCACGTCATTCGACGATCTGTACGTCAACGTCAATGGTGAATCCGGT
TATTTCGACCGCTCGTTGGAGGCCTACGGGCGCGAGGGCGAACCGTGCCGCAGGTGTGGACGCGCCATGCGCCGGGAGGC
CTTCATGAACCGGTCGTCCTACTTCTGCCCGAGCTGTCAACGGCTGGTTGAACCGCGTTAA

Upstream 100 bases:

>100_bases
GCCGCAGAGGCATGGAACAGCATCAGCGGCGATGAGCCTCTTGGGGGAAGAGCAGAAGGCGGCGATGAGCCTCTTGAGGG
AAGAGCAGAAGGCACGGTGA

Downstream 100 bases:

>100_bases
TAGCGCGTCAATGGCGCCACATGGGCGCGTCAAGGGGTCGTAAAGAACGCAGGTAGGGCCCTTGGCCGGGGCCATGATCT
TGGCCGTGACTGATTTTTGG

Product: formamidopyrimidine-DNA glycosylase (MutM)

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPELPEVEVVRRGLHHHLVGKTIASTLVYHERAVRRQSGGAVELAGLLAGQQISGTGRRGKYLWLTLEGSSGAQALVVHL
GMSGQMLIGPISRPQHLRIAATLDDGSVLSFVDQRTFGGWMVTDLVTVDGSELPEPVAHIARDPLDELFEIGAVVTRLRG
KHTEIKRALLDQTVVSGVGNIYADEALWQARVHGRRLTDGMSRAKLTEVLDSAAAVMRLALAQGGTSFDDLYVNVNGESG
YFDRSLEAYGREGEPCRRCGRAMRREAFMNRSSYFCPSCQRLVEPR

Sequences:

>Translated_286_residues
MPELPEVEVVRRGLHHHLVGKTIASTLVYHERAVRRQSGGAVELAGLLAGQQISGTGRRGKYLWLTLEGSSGAQALVVHL
GMSGQMLIGPISRPQHLRIAATLDDGSVLSFVDQRTFGGWMVTDLVTVDGSELPEPVAHIARDPLDELFEIGAVVTRLRG
KHTEIKRALLDQTVVSGVGNIYADEALWQARVHGRRLTDGMSRAKLTEVLDSAAAVMRLALAQGGTSFDDLYVNVNGESG
YFDRSLEAYGREGEPCRRCGRAMRREAFMNRSSYFCPSCQRLVEPR
>Mature_285_residues
PELPEVEVVRRGLHHHLVGKTIASTLVYHERAVRRQSGGAVELAGLLAGQQISGTGRRGKYLWLTLEGSSGAQALVVHLG
MSGQMLIGPISRPQHLRIAATLDDGSVLSFVDQRTFGGWMVTDLVTVDGSELPEPVAHIARDPLDELFEIGAVVTRLRGK
HTEIKRALLDQTVVSGVGNIYADEALWQARVHGRRLTDGMSRAKLTEVLDSAAAVMRLALAQGGTSFDDLYVNVNGESGY
FDRSLEAYGREGEPCRRCGRAMRREAFMNRSSYFCPSCQRLVEPR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=284, Percent_Identity=36.6197183098592, Blast_Score=168, Evalue=3e-43,
Organism=Escherichia coli, GI1786932, Length=287, Percent_Identity=24.7386759581882, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_MYCA9 (B1MDL2)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703985.1
- ProteinModelPortal:   B1MDL2
- SMR:   B1MDL2
- EnsemblBacteria:   EBMYCT00000008663
- GeneID:   5965756
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_3255c
- GeneTree:   EBGT00050000016359
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- BioCyc:   MABS561007:MAB_3255C-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31350; Mature: 31219

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 271-271 BINDING 96-96 BINDING 115-115 BINDING 161-161

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRRGLHHHLVGKTIASTLVYHERAVRRQSGGAVELAGLLAGQQISGTGRRG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCCCC
KYLWLTLEGSSGAQALVVHLGMSGQMLIGPISRPQHLRIAATLDDGSVLSFVDQRTFGGW
CEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHHCCCCE
MVTDLVTVDGSELPEPVAHIARDPLDELFEIGAVVTRLRGKHTEIKRALLDQTVVSGVGN
EEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IYADEALWQARVHGRRLTDGMSRAKLTEVLDSAAAVMRLALAQGGTSFDDLYVNVNGESG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
YFDRSLEAYGREGEPCRRCGRAMRREAFMNRSSYFCPSCQRLVEPR
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
PELPEVEVVRRGLHHHLVGKTIASTLVYHERAVRRQSGGAVELAGLLAGQQISGTGRRG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCCCC
KYLWLTLEGSSGAQALVVHLGMSGQMLIGPISRPQHLRIAATLDDGSVLSFVDQRTFGGW
CEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHHCCCCE
MVTDLVTVDGSELPEPVAHIARDPLDELFEIGAVVTRLRGKHTEIKRALLDQTVVSGVGN
EEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IYADEALWQARVHGRRLTDGMSRAKLTEVLDSAAAVMRLALAQGGTSFDDLYVNVNGESG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
YFDRSLEAYGREGEPCRRCGRAMRREAFMNRSSYFCPSCQRLVEPR
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA