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The map label for this gene is ffh [H]

Identifier: 169630318

GI number: 169630318

Start: 3271230

End: 3272801

Strand: Reverse

Name: ffh [H]

Synonym: MAB_3237c

Alternate gene names: 169630318

Gene position: 3272801-3271230 (Counterclockwise)

Preceding gene: 169630319

Following gene: 169630317

Centisome position: 64.59

GC content: 66.16

Gene sequence:

>1572_bases
GTGTTTGAATCGCTGTCTGACCGGTTGACCGACGCCCTTGCCGGCCTACGGGGCAAGGGACGTCTGTCCGACGCCGATAT
CGACGCGACCTGCCGGACCATCCGGCTGGCGCTGCTCGAAGCCGATGTGGCCCTGCCCGTCGTCCGTACCTTCATCACCC
GCATCAAGGAGCGCGCCAAGGGCGCCGAGGTGTCCGGTGCACTGAACCCGGCGCAGCAGGTCGTCAAGATCGTCAACGAG
GAGCTGATCGGCATCCTCGGTGGGGAGACCCGCCAGCTGGCCTTTGCCAAGACTCCGCCGACCGTTGTCATGCTCGCGGG
TCTGCAGGGTGCCGGTAAGACGACACTTGCCGGAAAGCTCGCGAAATGGCTTAAGGGACAAGGGCATACCCCACTTCTGG
TGGCCTGCGACCTGCAGCGTCCCGGTGCCGTCAACCAGCTGCAGGTGGTCGGTGAGCGCGCCGGCGTGTCGGTCTACGCC
CCTCACCCCGGTACCGCGGACGGAGGCCTGGAGGTCGGCTCGCTGGTCGGCGATCCGGTCGCGGTGGCTCGCGATGGCCT
GGCACATGCCAAGGCCCAGCACTTCGACGTGGTGCTCGTCGACACCGCCGGCCGTCTCGGCATCGACGCCGAACTAATGG
ACCAGGCGGCCCGCATTCGCGATGCTGTCGACCCCGACGAGGTGCTGTTCGTCCTCGACGCCATGATCGGCCAGGACGCG
GTGAGCACCGCCGAGGCCTTCCGTGAAGGCGTCGGGTTCACCGGCGTGGTGCTGACCAAGCTCGACGGCGACGCCCGTGG
TGGTGCCGCGCTCTCCGTACGCGAGATCACCGGGACGCCGATCCTGTTCGCGTCGACCGGGGAAAAGCTGGAGGACTTCG
ACGTCTTCCACCCCGATCGGATGGCCAGCCGCATTCTGGGCATGGGTGACCTGCTGTCCCTGATCGAGCAGGCCGAACAA
CACTTCGATGCCGAGCAATCCCTGGCAGCCGCCGAGAAGATCACCTCGGGGGAACTTACGCTCGAGGACTTCCTGGAGCA
GATGCTGGCGATCCGCAAGATGGGTCCTATCGGCAACCTGCTGGGCATGCTGCCCGGCGCCGGCCAGATGAAGGATGCGT
TGGCCGCCGTCGACGATAAGCAACTCGACCGGGTGCAGGCCATCATCCGCGGTATGACACCCGCCGAACGGGCCGATCCG
AAGATCATCAACGCCTCCCGCCGGCTGCGTATCGCCAACGGCTCCGGGGTCGCGGTATCCGAGGTCAACCAGCTGGTGGA
CCGCTTCTTCGAGGCGCGCAAGATGATGTCGTCCATGGCGGGCCGCATGGGCATGGGCGCCATCAATCGCAAGAGCAACC
GCAAGGGCGGCAAGAACAACAAGAAGGGCAAGAAGGGCTCACGGGGCCCCACTGCGCCGAAGCTGAAGGGTGGCTTCCCC
GGTATGGCTGGGCTTCCCGGCGGAATGCCGGCCGGATTCCCCGACCTGTCCGGCATGCCCGAAGGTCTGGGCGAACTGCC
CCCGGGTCTGGCCGATATCGACATCTCGAAGCTCAAGTTCCCCAAGAACTGA

Upstream 100 bases:

>100_bases
CTCCTAGCGTCGACACGCCGTTTGTTGACGCATCGGTCGAGTAGCTCGCGCAGAACACGGCGTGTCGGCAGGAAGAGGGT
GGCCAGCTAGGCTGGTCGAC

Downstream 100 bases:

>100_bases
GCCCGATGCGCGCGCACCTGCGTGGACGTACTCTCCCGTCCGAGGAGCCAATCGATCTGTGGGTGCACGACGGCGTCATC
AGCATCGAGCCGATTGCGGA

Product: Signal recognition particle protein Ffh

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MFESLSDRLTDALAGLRGKGRLSDADIDATCRTIRLALLEADVALPVVRTFITRIKERAKGAEVSGALNPAQQVVKIVNE
ELIGILGGETRQLAFAKTPPTVVMLAGLQGAGKTTLAGKLAKWLKGQGHTPLLVACDLQRPGAVNQLQVVGERAGVSVYA
PHPGTADGGLEVGSLVGDPVAVARDGLAHAKAQHFDVVLVDTAGRLGIDAELMDQAARIRDAVDPDEVLFVLDAMIGQDA
VSTAEAFREGVGFTGVVLTKLDGDARGGAALSVREITGTPILFASTGEKLEDFDVFHPDRMASRILGMGDLLSLIEQAEQ
HFDAEQSLAAAEKITSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMKDALAAVDDKQLDRVQAIIRGMTPAERADP
KIINASRRLRIANGSGVAVSEVNQLVDRFFEARKMMSSMAGRMGMGAINRKSNRKGGKNNKKGKKGSRGPTAPKLKGGFP
GMAGLPGGMPAGFPDLSGMPEGLGELPPGLADIDISKLKFPKN

Sequences:

>Translated_523_residues
MFESLSDRLTDALAGLRGKGRLSDADIDATCRTIRLALLEADVALPVVRTFITRIKERAKGAEVSGALNPAQQVVKIVNE
ELIGILGGETRQLAFAKTPPTVVMLAGLQGAGKTTLAGKLAKWLKGQGHTPLLVACDLQRPGAVNQLQVVGERAGVSVYA
PHPGTADGGLEVGSLVGDPVAVARDGLAHAKAQHFDVVLVDTAGRLGIDAELMDQAARIRDAVDPDEVLFVLDAMIGQDA
VSTAEAFREGVGFTGVVLTKLDGDARGGAALSVREITGTPILFASTGEKLEDFDVFHPDRMASRILGMGDLLSLIEQAEQ
HFDAEQSLAAAEKITSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMKDALAAVDDKQLDRVQAIIRGMTPAERADP
KIINASRRLRIANGSGVAVSEVNQLVDRFFEARKMMSSMAGRMGMGAINRKSNRKGGKNNKKGKKGSRGPTAPKLKGGFP
GMAGLPGGMPAGFPDLSGMPEGLGELPPGLADIDISKLKFPKN
>Mature_523_residues
MFESLSDRLTDALAGLRGKGRLSDADIDATCRTIRLALLEADVALPVVRTFITRIKERAKGAEVSGALNPAQQVVKIVNE
ELIGILGGETRQLAFAKTPPTVVMLAGLQGAGKTTLAGKLAKWLKGQGHTPLLVACDLQRPGAVNQLQVVGERAGVSVYA
PHPGTADGGLEVGSLVGDPVAVARDGLAHAKAQHFDVVLVDTAGRLGIDAELMDQAARIRDAVDPDEVLFVLDAMIGQDA
VSTAEAFREGVGFTGVVLTKLDGDARGGAALSVREITGTPILFASTGEKLEDFDVFHPDRMASRILGMGDLLSLIEQAEQ
HFDAEQSLAAAEKITSGELTLEDFLEQMLAIRKMGPIGNLLGMLPGAGQMKDALAAVDDKQLDRVQAIIRGMTPAERADP
KIINASRRLRIANGSGVAVSEVNQLVDRFFEARKMMSSMAGRMGMGAINRKSNRKGGKNNKKGKKGSRGPTAPKLKGGFP
GMAGLPGGMPAGFPDLSGMPEGLGELPPGLADIDISKLKFPKN

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=450, Percent_Identity=31.1111111111111, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI226371618, Length=392, Percent_Identity=31.8877551020408, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI23308697, Length=305, Percent_Identity=33.1147540983607, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI295424842, Length=305, Percent_Identity=33.1147540983607, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=37.5, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1788963, Length=432, Percent_Identity=49.3055555555556, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1789874, Length=276, Percent_Identity=36.5942028985507, Blast_Score=155, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=432, Percent_Identity=29.8611111111111, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI193206261, Length=304, Percent_Identity=31.25, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=490, Percent_Identity=32.0408163265306, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6320498, Length=213, Percent_Identity=31.4553990610329, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17647949, Length=449, Percent_Identity=30.7349665924276, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24641198, Length=321, Percent_Identity=28.0373831775701, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 54980; Mature: 54980

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSDRLTDALAGLRGKGRLSDADIDATCRTIRLALLEADVALPVVRTFITRIKERAK
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAEVSGALNPAQQVVKIVNEELIGILGGETRQLAFAKTPPTVVMLAGLQGAGKTTLAGKL
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
AKWLKGQGHTPLLVACDLQRPGAVNQLQVVGERAGVSVYAPHPGTADGGLEVGSLVGDPV
HHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHCCCCH
AVARDGLAHAKAQHFDVVLVDTAGRLGIDAELMDQAARIRDAVDPDEVLFVLDAMIGQDA
HHHHCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHH
VSTAEAFREGVGFTGVVLTKLDGDARGGAALSVREITGTPILFASTGEKLEDFDVFHPDR
HHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCHHHCCCCCHHH
MASRILGMGDLLSLIEQAEQHFDAEQSLAAAEKITSGELTLEDFLEQMLAIRKMGPIGNL
HHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHH
LGMLPGAGQMKDALAAVDDKQLDRVQAIIRGMTPAERADPKIINASRRLRIANGSGVAVS
HHCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCHHCCCCEECCCCEEEEECCCCCHHH
EVNQLVDRFFEARKMMSSMAGRMGMGAINRKSNRKGGKNNKKGKKGSRGPTAPKLKGGFP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GMAGLPGGMPAGFPDLSGMPEGLGELPPGLADIDISKLKFPKN
CCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHCCCCCC
>Mature Secondary Structure
MFESLSDRLTDALAGLRGKGRLSDADIDATCRTIRLALLEADVALPVVRTFITRIKERAK
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAEVSGALNPAQQVVKIVNEELIGILGGETRQLAFAKTPPTVVMLAGLQGAGKTTLAGKL
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
AKWLKGQGHTPLLVACDLQRPGAVNQLQVVGERAGVSVYAPHPGTADGGLEVGSLVGDPV
HHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCCCCHHHHCCCCH
AVARDGLAHAKAQHFDVVLVDTAGRLGIDAELMDQAARIRDAVDPDEVLFVLDAMIGQDA
HHHHCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHH
VSTAEAFREGVGFTGVVLTKLDGDARGGAALSVREITGTPILFASTGEKLEDFDVFHPDR
HHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCHHHCCCCCHHH
MASRILGMGDLLSLIEQAEQHFDAEQSLAAAEKITSGELTLEDFLEQMLAIRKMGPIGNL
HHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHH
LGMLPGAGQMKDALAAVDDKQLDRVQAIIRGMTPAERADPKIINASRRLRIANGSGVAVS
HHCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCHHCCCCEECCCCEEEEECCCCCHHH
EVNQLVDRFFEARKMMSSMAGRMGMGAINRKSNRKGGKNNKKGKKGSRGPTAPKLKGGFP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GMAGLPGGMPAGFPDLSGMPEGLGELPPGLADIDISKLKFPKN
CCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]