Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 169630304

GI number: 169630304

Start: 3259846

End: 3261090

Strand: Reverse

Name: lepB [H]

Synonym: MAB_3223c

Alternate gene names: 169630304

Gene position: 3261090-3259846 (Counterclockwise)

Preceding gene: 169630305

Following gene: 169630303

Centisome position: 64.36

GC content: 60.24

Gene sequence:

>1245_bases
GTGTCCTATGACGTCTACTTCGTGCGTCAGCATCCTCCCCAGGACTTCGAACACGTTCCGGAGAACGAACATCCGCTGAA
GGAATCGTCGGATCTGCGTTCCCGGCTCGTCGCCGACATGAACGCGCCCGAGGTTTTCGAGGGCTCGGACGGCACCTGGG
AACTCTCCGACTCCGTTACCACTGCGCAGGTGAACTATGCGCCGGACGGTGTGGGTATGGGAGTTTCGTACGGTTCGGCG
ACGTCCGATGAATTCGACTCGCGCATCGAGCATTTGATGCGACTGGCGAAGATCATCGAAGACGAGACTGGACTTACCGC
ATGGGATCCGCAGGCGGAGAAGGTTTTCGGCGATGTGACGTTGGATGACTCCCGTCAGTCTCTTGGACAGTTCGAGACCG
TCGGCGACAATGTCGAGCACGACGCCGCCGAGAAGGTGTCTGCGGTGGACTCCACCGACGAAGACCCGGCGCAGGATTCC
AAAGACGCATCCGACTCCGATGAGGGCGGATCCGGAATGCTGCGTGAGGTGGGCGTTCTGCTGCTGATTGCTCTGGTGCT
TTACTGCATCACACAGAACTTCATCGCCCGGCCGTATCTCATCCCGTCGGAATCGATGGAGCCGACGTTGCATGGATGCC
GTGGATGCACCGGCGACCGGATCATGGTCGACAAGGTGGTCTTCCGATTTTCCGAGCCGCAGCCCGGCGAAGTGGTTGTC
TTCAAGGGTCCGCCGGAATGGAACGGTAACTATCGGTCGATCCGTTCGTCCAACACCGCGGTCCGTTACGTGCAGAACGC
TCTTTCCTTTATCGGTGTGGTTCCGCCCGATGAGAATGACCTGGTGAAACGAGTTATCGCCACCGGTGGGCAGACCGTGG
AATGTCGTCCCAACACGGGCCTGACCGTCAACGGTAAGAAACTGGACGAGCCCTATCTTGACCCGGAAACCATCGGTCCG
AATATCGATGGCTGCTGGGGTTTCCCGTTCGGCCCGGTCAAGGTGCCCGAGGGCAAGCTCTGGATGATGGGGGACAACCG
TACCCATAGCGGAGACTCCCGTGCGCACTGCCAGAGCCGGGATCGCGACGCCGGACTCGACGTCGATATCGACCACAAGA
TCTATTGCACCGGCGACCCGAACATCGGCACGGTGCCCGTGGCCAACGTCATCGGCAAGGCGCGATTCATCGCATGGCCG
CCCGGTCGTTGGGGTGCGGTCAAGACGGTTAATCCCCAGACCTAG

Upstream 100 bases:

>100_bases
CTGTACTACCTGCGCGAGTTGCGCGGTAAGAAGGCCAAGATCAAGGAGAAGCGCTGACCGAGCCGGGACACTGGCCCCGC
CCCGGTAGAGGACGTCCATA

Downstream 100 bases:

>100_bases
CTTTCGCGGGATGAGTACCAGCTGGCCGCCACGCACGGTGATTCGCAAGGCATCCGGATTGCGAACGCTCGAATTGACGC
TCGACAGAGTGGGTTTAGGC

Product: signal peptidase I LepB

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSYDVYFVRQHPPQDFEHVPENEHPLKESSDLRSRLVADMNAPEVFEGSDGTWELSDSVTTAQVNYAPDGVGMGVSYGSA
TSDEFDSRIEHLMRLAKIIEDETGLTAWDPQAEKVFGDVTLDDSRQSLGQFETVGDNVEHDAAEKVSAVDSTDEDPAQDS
KDASDSDEGGSGMLREVGVLLLIALVLYCITQNFIARPYLIPSESMEPTLHGCRGCTGDRIMVDKVVFRFSEPQPGEVVV
FKGPPEWNGNYRSIRSSNTAVRYVQNALSFIGVVPPDENDLVKRVIATGGQTVECRPNTGLTVNGKKLDEPYLDPETIGP
NIDGCWGFPFGPVKVPEGKLWMMGDNRTHSGDSRAHCQSRDRDAGLDVDIDHKIYCTGDPNIGTVPVANVIGKARFIAWP
PGRWGAVKTVNPQT

Sequences:

>Translated_414_residues
MSYDVYFVRQHPPQDFEHVPENEHPLKESSDLRSRLVADMNAPEVFEGSDGTWELSDSVTTAQVNYAPDGVGMGVSYGSA
TSDEFDSRIEHLMRLAKIIEDETGLTAWDPQAEKVFGDVTLDDSRQSLGQFETVGDNVEHDAAEKVSAVDSTDEDPAQDS
KDASDSDEGGSGMLREVGVLLLIALVLYCITQNFIARPYLIPSESMEPTLHGCRGCTGDRIMVDKVVFRFSEPQPGEVVV
FKGPPEWNGNYRSIRSSNTAVRYVQNALSFIGVVPPDENDLVKRVIATGGQTVECRPNTGLTVNGKKLDEPYLDPETIGP
NIDGCWGFPFGPVKVPEGKLWMMGDNRTHSGDSRAHCQSRDRDAGLDVDIDHKIYCTGDPNIGTVPVANVIGKARFIAWP
PGRWGAVKTVNPQT
>Mature_413_residues
SYDVYFVRQHPPQDFEHVPENEHPLKESSDLRSRLVADMNAPEVFEGSDGTWELSDSVTTAQVNYAPDGVGMGVSYGSAT
SDEFDSRIEHLMRLAKIIEDETGLTAWDPQAEKVFGDVTLDDSRQSLGQFETVGDNVEHDAAEKVSAVDSTDEDPAQDSK
DASDSDEGGSGMLREVGVLLLIALVLYCITQNFIARPYLIPSESMEPTLHGCRGCTGDRIMVDKVVFRFSEPQPGEVVVF
KGPPEWNGNYRSIRSSNTAVRYVQNALSFIGVVPPDENDLVKRVIATGGQTVECRPNTGLTVNGKKLDEPYLDPETIGPN
IDGCWGFPFGPVKVPEGKLWMMGDNRTHSGDSRAHCQSRDRDAGLDVDIDHKIYCTGDPNIGTVPVANVIGKARFIAWPP
GRWGAVKTVNPQT

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 45363; Mature: 45232

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00501 SPASE_I_1 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDVYFVRQHPPQDFEHVPENEHPLKESSDLRSRLVADMNAPEVFEGSDGTWELSDSVT
CCCEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCEEECCCEE
TAQVNYAPDGVGMGVSYGSATSDEFDSRIEHLMRLAKIIEDETGLTAWDPQAEKVFGDVT
EEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCE
LDDSRQSLGQFETVGDNVEHDAAEKVSAVDSTDEDPAQDSKDASDSDEGGSGMLREVGVL
ECCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LLIALVLYCITQNFIARPYLIPSESMEPTLHGCRGCTGDRIMVDKVVFRFSEPQPGEVVV
HHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHCCCCCCEEEHHHHHHHCCCCCCCEEEE
FKGPPEWNGNYRSIRSSNTAVRYVQNALSFIGVVPPDENDLVKRVIATGGQTVECRPNTG
ECCCCCCCCCCCEECCCCHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCEEEECCCCC
LTVNGKKLDEPYLDPETIGPNIDGCWGFPFGPVKVPEGKLWMMGDNRTHSGDSRAHCQSR
EEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCCCCHHHHCCC
DRDAGLDVDIDHKIYCTGDPNIGTVPVANVIGKARFIAWPPGRWGAVKTVNPQT
CCCCCCCEECCCEEEECCCCCCCCCHHHHHHCCCEEEEECCCCCCCEEECCCCC
>Mature Secondary Structure 
SYDVYFVRQHPPQDFEHVPENEHPLKESSDLRSRLVADMNAPEVFEGSDGTWELSDSVT
CCEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCEEECCCEE
TAQVNYAPDGVGMGVSYGSATSDEFDSRIEHLMRLAKIIEDETGLTAWDPQAEKVFGDVT
EEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCE
LDDSRQSLGQFETVGDNVEHDAAEKVSAVDSTDEDPAQDSKDASDSDEGGSGMLREVGVL
ECCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
LLIALVLYCITQNFIARPYLIPSESMEPTLHGCRGCTGDRIMVDKVVFRFSEPQPGEVVV
HHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHCCCCCCEEEHHHHHHHCCCCCCCEEEE
FKGPPEWNGNYRSIRSSNTAVRYVQNALSFIGVVPPDENDLVKRVIATGGQTVECRPNTG
ECCCCCCCCCCCEECCCCHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCEEEECCCCC
LTVNGKKLDEPYLDPETIGPNIDGCWGFPFGPVKVPEGKLWMMGDNRTHSGDSRAHCQSR
EEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCCCCHHHHCCC
DRDAGLDVDIDHKIYCTGDPNIGTVPVANVIGKARFIAWPPGRWGAVKTVNPQT
CCCCCCCEECCCEEEECCCCCCCCCHHHHHHCCCEEEEECCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]