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The map label for this gene is dxr [H]

Identifier: 169630253

GI number: 169630253

Start: 3218604

End: 3219773

Strand: Reverse

Name: dxr [H]

Synonym: MAB_3171c

Alternate gene names: 169630253

Gene position: 3219773-3218604 (Counterclockwise)

Preceding gene: 169630254

Following gene: 169630252

Centisome position: 63.54

GC content: 66.84

Gene sequence:

>1170_bases
GTGAGTTCAGAGGTCTGCCGCGTCCTTCTTCTCGGCAGTACCGGGTCCATCGGTACCCAGGCGCTTGAGGTCATCGCCGC
CAACCCGGAGCGCTTTGAAGTGGTCGGTTTGGCTGCCGGCGGCGGGAACGTAGAGCTGCTGCGCCAGCAGATCTCCGAAA
CCGGGGTCACCAATGTCGCGGTGGCAGACGAGCGCGCTGCCGTGCGGCTCGACATCCCCGTGCTGAGCGGACCGGATGCC
GTCACCGAGTTGGTGGAGAACACCGAGGCCGATGTGGTCCTCAACGCGCTGGTCGGCGCCCTCGGCCTGCGGCCGACCCT
GGCCGCGCTGAAGTCGGGAGCCCGGTTGGCCTTGGCCAATAAGGAATCCCTGGTGGCCGGTGGGCCGCTTGTCACCAAGG
CCGCCGCGCCCGGGCAAATCGTGCCTGTCGATTCCGAACACTCCGCGCTGGCGCAATGTCTGCGGGGAGGGACCCGTGGC
GAGGTCGCGCAGCTGATCTTGACCGCGTCGGGCGGGCCGTTTCGGGGTTGGACCGCGCAGCAGCTCACCGCCGTGACCCC
CGAGCAGGCGGGCGCCCACCCCACCTGGTCCATGGGCCCGATGAACACGCTCAACTCGGCATCGCTGGTCAATAAGGGGC
TCGAACTCATCGAGACGCATCTGCTCTTCGGCGTTCCCTACCGGCAGATCGGTGTGGTGGTGCACCCGCAGTCGATCGTG
CACTCGATGGTGACGTTCACCGATGGGTCGACGCTGGCGCAGGCCAGCCCGCCCGACATGAAACTGCCCATCGCGCTCGC
CCTGGGCTGGCCGGACCGAGTACCGGCAGCAGCGTCGGCCTGCGACTTCAGCACCGCCTCCACCTGGGAGTTCGAGCCGC
TGGATGCCCAGGTGTTTCCCGCCGTCGACCTGGCCCGCAGTGCCGGAGAAGCGGGGGGATGCATGACCGCTGTCTACAAC
GCCGCCAATGAAACCGCGGCCGCCGCCTTCCTGGACGGGCGTATCGGATTCAGGTCCATCGTGCGAACAATTGCCGATGT
GCTCGATGTGGCAAGCCAATGGGAGGGAACTTCCGCAGAACCCGCTACCGTTGACGATGTACTCGACGCGCAGCGCTGGG
CTGGCCAGCAGGCTGCGCAATTCATCTTCGCGGAGGAAAATCGGACCTGA

Upstream 100 bases:

>100_bases
TGAACATCCGCACGGCCAAGGGGGATGTCGACCTGCACCGCCCGGTGGCGCTTGCGGGGTAGGGACAGCCGCATGGCCGG
GGCAGAATGAGCGGGTGACA

Downstream 100 bases:

>100_bases
TGGCTGCGTACGCGATCGGAATTGCGTTGTTCGCGCTGGCGATCTTGGTATCGGTGGCGTTGCACGAGTGCGGGCACATG
TGGGTGGCGCAGGCCACCGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSSEVCRVLLLGSTGSIGTQALEVIAANPERFEVVGLAAGGGNVELLRQQISETGVTNVAVADERAAVRLDIPVLSGPDA
VTELVENTEADVVLNALVGALGLRPTLAALKSGARLALANKESLVAGGPLVTKAAAPGQIVPVDSEHSALAQCLRGGTRG
EVAQLILTASGGPFRGWTAQQLTAVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETHLLFGVPYRQIGVVVHPQSIV
HSMVTFTDGSTLAQASPPDMKLPIALALGWPDRVPAAASACDFSTASTWEFEPLDAQVFPAVDLARSAGEAGGCMTAVYN
AANETAAAAFLDGRIGFRSIVRTIADVLDVASQWEGTSAEPATVDDVLDAQRWAGQQAAQFIFAEENRT

Sequences:

>Translated_389_residues
MSSEVCRVLLLGSTGSIGTQALEVIAANPERFEVVGLAAGGGNVELLRQQISETGVTNVAVADERAAVRLDIPVLSGPDA
VTELVENTEADVVLNALVGALGLRPTLAALKSGARLALANKESLVAGGPLVTKAAAPGQIVPVDSEHSALAQCLRGGTRG
EVAQLILTASGGPFRGWTAQQLTAVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETHLLFGVPYRQIGVVVHPQSIV
HSMVTFTDGSTLAQASPPDMKLPIALALGWPDRVPAAASACDFSTASTWEFEPLDAQVFPAVDLARSAGEAGGCMTAVYN
AANETAAAAFLDGRIGFRSIVRTIADVLDVASQWEGTSAEPATVDDVLDAQRWAGQQAAQFIFAEENRT
>Mature_388_residues
SSEVCRVLLLGSTGSIGTQALEVIAANPERFEVVGLAAGGGNVELLRQQISETGVTNVAVADERAAVRLDIPVLSGPDAV
TELVENTEADVVLNALVGALGLRPTLAALKSGARLALANKESLVAGGPLVTKAAAPGQIVPVDSEHSALAQCLRGGTRGE
VAQLILTASGGPFRGWTAQQLTAVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETHLLFGVPYRQIGVVVHPQSIVH
SMVTFTDGSTLAQASPPDMKLPIALALGWPDRVPAAASACDFSTASTWEFEPLDAQVFPAVDLARSAGEAGGCMTAVYNA
ANETAAAAFLDGRIGFRSIVRTIADVLDVASQWEGTSAEPATVDDVLDAQRWAGQQAAQFIFAEENRT

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=384, Percent_Identity=41.1458333333333, Blast_Score=246, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40306; Mature: 40175

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEVCRVLLLGSTGSIGTQALEVIAANPERFEVVGLAAGGGNVELLRQQISETGVTNVA
CCCHHEEEEEECCCCCCHHHHHHHEECCCCEEEEEEEECCCCCHHHHHHHHHHCCCCEEE
VADERAAVRLDIPVLSGPDAVTELVENTEADVVLNALVGALGLRPTLAALKSGARLALAN
EECCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEC
KESLVAGGPLVTKAAAPGQIVPVDSEHSALAQCLRGGTRGEVAQLILTASGGPFRGWTAQ
CCCEEECCCEEECCCCCCCEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHH
QLTAVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETHLLFGVPYRQIGVVVHPQSIV
HHEEECCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCHHHH
HSMVTFTDGSTLAQASPPDMKLPIALALGWPDRVPAAASACDFSTASTWEFEPLDAQVFP
HHHHHCCCCCEECCCCCCCCEEEEEEEECCCCCCCCHHHHCCCCCCCCCEECCCCCCCCC
AVDLARSAGEAGGCMTAVYNAANETAAAAFLDGRIGFRSIVRTIADVLDVASQWEGTSAE
HHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PATVDDVLDAQRWAGQQAAQFIFAEENRT
CCHHHHHHHHHHHCCHHHHHEEEECCCCC
>Mature Secondary Structure 
SSEVCRVLLLGSTGSIGTQALEVIAANPERFEVVGLAAGGGNVELLRQQISETGVTNVA
CCHHEEEEEECCCCCCHHHHHHHEECCCCEEEEEEEECCCCCHHHHHHHHHHCCCCEEE
VADERAAVRLDIPVLSGPDAVTELVENTEADVVLNALVGALGLRPTLAALKSGARLALAN
EECCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEC
KESLVAGGPLVTKAAAPGQIVPVDSEHSALAQCLRGGTRGEVAQLILTASGGPFRGWTAQ
CCCEEECCCEEECCCCCCCEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHH
QLTAVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETHLLFGVPYRQIGVVVHPQSIV
HHEEECCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCHHHH
HSMVTFTDGSTLAQASPPDMKLPIALALGWPDRVPAAASACDFSTASTWEFEPLDAQVFP
HHHHHCCCCCEECCCCCCCCEEEEEEEECCCCCCCCHHHHCCCCCCCCCEECCCCCCCCC
AVDLARSAGEAGGCMTAVYNAANETAAAAFLDGRIGFRSIVRTIADVLDVASQWEGTSAE
HHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PATVDDVLDAQRWAGQQAAQFIFAEENRT
CCHHHHHHHHHHHCCHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA