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The map label for this gene is cysG [H]

Identifier: 169630225

GI number: 169630225

Start: 3182145

End: 3183341

Strand: Reverse

Name: cysG [H]

Synonym: MAB_3143c

Alternate gene names: 169630225

Gene position: 3183341-3182145 (Counterclockwise)

Preceding gene: 169630228

Following gene: 169630224

Centisome position: 62.82

GC content: 65.58

Gene sequence:

>1197_bases
GTGACTCATGACGCCTACCTCGTCGGCCTCCGCCTTGCCGGACGCAAGGTTGTAGTCGTCGGCGCCGGATCTGTCGCGCA
GCGGCGTCTCGGCCTGTTGATCGCCAGCGGAGCCGATGTCCACGTGATCGCGCCGCACGCGACCCCGGCCGTCGAAGGCA
TGGCCTCGATCAATCTCCAGCTGCGGCCCTATCAGGACGGTGACCTGGACGGAGCCTGGTACGCGATCGCCTGCACCGAC
GACCCAGCCGTCAATGCCGCCGTCGTGGACGAAGCGGAACGGCGGCACATCTTCTGTGTGCGGGCCGACTCGGCGCGAGA
CGGTACTGCTGTCACTCCCGCGTCCTTCAACCACGATGGCATTGCCGTGGGCGTTTTGACCGGTGGCCAGCACAAACGGT
CGGCAGCGCTACGTTCAGCGATCCATGAAGCGCTGCAACGCGGCTTGATTACCGAGACCGCGGACGTCAAACCCGAAGGC
GTCGCGCTTGTCGGCGGGGGACCGGGTGATCCTGATCTCATTACCGTCCGCGGACGCAGACTCCTTGCACAGGCCGACGT
GGTCGTCGCCGATCGGCTCGCCCCCGCCGAACTACTCGCCGATCTGGGACCTCATGTCGAGGTCATCGACGCGGCGAAGA
TCCCGTACGGGCGCGCGATGGCGCAGCAGGAGATCAACCGAGTGCTTATCGAACGCGCCCAAGAAGGCAAGTTCGTCGTG
CGCCTGAAGGGCGGAGACCCGTTCGTCTTCGCTCGCGGCTACGAAGAAGTGCTGGCGTGCGCCGAGGCCGGTGTGCAGGT
GACCGTCGTGCCCGGCGTGACCAGCGCGATCTCCGTTCCTGCGGCGGCCGGTGTGCCCGTCACTCATCGCGCCGTGAACC
ACGAGTTCGTTGTCGTCAGCGGACACGTAGCCCCCGGCCACCCGGAATCGTTAGTCAATTGGGATGCGCTTGCTGCCTTG
AACGGCACCATCGTGTTGCTGATGGCTGTCGAGCGCATCGAGCAGTTCGCGAGGGTGCTCATTGAAGGGGGCCGACCTGC
GCATACCCCGGTATTGGTGGTTCAACACGGCACCACCGACGAGCAACGTGTGTTGCGTGCCGACCTCGCGACCGCGCCAG
AACGCATTCGCTCGCAGGGCATCAGACCGCCGGCAATCATCGTCATCGGGCCTGTCGCTGCTTACGGCGCCTTCTGA

Upstream 100 bases:

>100_bases
CTGGGCCAACTCCGCTGGTTGCATGCGATGGGATTGCACTGGGACCGATTAGAGCATGGCTAACCCAGCCCCGCGATCTG
CGTCCACGTAAACTCGCGCG

Downstream 100 bases:

>100_bases
TCTCTAAAGCGACGTTAAGAGGACGGTAAGGTGTCCTCCATGTCTGGCCTCAGCGTCGAGCAGCTCACTCAAAAGGCGCG
CGAATTTCTGCCATCCCGGC

Product: multifunctional siroheme synthase CysG/uroporphyrin-III C-methyltransferase-like protein

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTHDAYLVGLRLAGRKVVVVGAGSVAQRRLGLLIASGADVHVIAPHATPAVEGMASINLQLRPYQDGDLDGAWYAIACTD
DPAVNAAVVDEAERRHIFCVRADSARDGTAVTPASFNHDGIAVGVLTGGQHKRSAALRSAIHEALQRGLITETADVKPEG
VALVGGGPGDPDLITVRGRRLLAQADVVVADRLAPAELLADLGPHVEVIDAAKIPYGRAMAQQEINRVLIERAQEGKFVV
RLKGGDPFVFARGYEEVLACAEAGVQVTVVPGVTSAISVPAAAGVPVTHRAVNHEFVVVSGHVAPGHPESLVNWDALAAL
NGTIVLLMAVERIEQFARVLIEGGRPAHTPVLVVQHGTTDEQRVLRADLATAPERIRSQGIRPPAIIVIGPVAAYGAF

Sequences:

>Translated_398_residues
MTHDAYLVGLRLAGRKVVVVGAGSVAQRRLGLLIASGADVHVIAPHATPAVEGMASINLQLRPYQDGDLDGAWYAIACTD
DPAVNAAVVDEAERRHIFCVRADSARDGTAVTPASFNHDGIAVGVLTGGQHKRSAALRSAIHEALQRGLITETADVKPEG
VALVGGGPGDPDLITVRGRRLLAQADVVVADRLAPAELLADLGPHVEVIDAAKIPYGRAMAQQEINRVLIERAQEGKFVV
RLKGGDPFVFARGYEEVLACAEAGVQVTVVPGVTSAISVPAAAGVPVTHRAVNHEFVVVSGHVAPGHPESLVNWDALAAL
NGTIVLLMAVERIEQFARVLIEGGRPAHTPVLVVQHGTTDEQRVLRADLATAPERIRSQGIRPPAIIVIGPVAAYGAF
>Mature_397_residues
THDAYLVGLRLAGRKVVVVGAGSVAQRRLGLLIASGADVHVIAPHATPAVEGMASINLQLRPYQDGDLDGAWYAIACTDD
PAVNAAVVDEAERRHIFCVRADSARDGTAVTPASFNHDGIAVGVLTGGQHKRSAALRSAIHEALQRGLITETADVKPEGV
ALVGGGPGDPDLITVRGRRLLAQADVVVADRLAPAELLADLGPHVEVIDAAKIPYGRAMAQQEINRVLIERAQEGKFVVR
LKGGDPFVFARGYEEVLACAEAGVQVTVVPGVTSAISVPAAAGVPVTHRAVNHEFVVVSGHVAPGHPESLVNWDALAALN
GTIVLLMAVERIEQFARVLIEGGRPAHTPVLVVQHGTTDEQRVLRADLATAPERIRSQGIRPPAIIVIGPVAAYGAF

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=442, Percent_Identity=31.9004524886878, Blast_Score=201, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6322922, Length=234, Percent_Identity=32.0512820512821, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 41699; Mature: 41568

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDAYLVGLRLAGRKVVVVGAGSVAQRRLGLLIASGADVHVIAPHATPAVEGMASINLQ
CCCCEEEEEEEECCCEEEEEECCHHHHHEEEEEEECCCCEEEECCCCCCHHCCCEEEEEE
LRPYQDGDLDGAWYAIACTDDPAVNAAVVDEAERRHIFCVRADSARDGTAVTPASFNHDG
EEECCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCEEEEEECCCCCCCCEECCCCCCCCC
IAVGVLTGGQHKRSAALRSAIHEALQRGLITETADVKPEGVALVGGGPGDPDLITVRGRR
EEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCE
LLAQADVVVADRLAPAELLADLGPHVEVIDAAKIPYGRAMAQQEINRVLIERAQEGKFVV
EEECCCEEEECCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
RLKGGDPFVFARGYEEVLACAEAGVQVTVVPGVTSAISVPAAAGVPVTHRAVNHEFVVVS
EEECCCCEEEECCHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCCEEEEECCCEEEEEE
GHVAPGHPESLVNWDALAALNGTIVLLMAVERIEQFARVLIEGGRPAHTPVLVVQHGTTD
CCCCCCCCHHHCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCH
EQRVLRADLATAPERIRSQGIRPPAIIVIGPVAAYGAF
HHHHHHHHHHCCHHHHHHCCCCCCEEEEECCHHHCCCC
>Mature Secondary Structure 
THDAYLVGLRLAGRKVVVVGAGSVAQRRLGLLIASGADVHVIAPHATPAVEGMASINLQ
CCCEEEEEEEECCCEEEEEECCHHHHHEEEEEEECCCCEEEECCCCCCHHCCCEEEEEE
LRPYQDGDLDGAWYAIACTDDPAVNAAVVDEAERRHIFCVRADSARDGTAVTPASFNHDG
EEECCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCEEEEEECCCCCCCCEECCCCCCCCC
IAVGVLTGGQHKRSAALRSAIHEALQRGLITETADVKPEGVALVGGGPGDPDLITVRGRR
EEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCE
LLAQADVVVADRLAPAELLADLGPHVEVIDAAKIPYGRAMAQQEINRVLIERAQEGKFVV
EEECCCEEEECCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
RLKGGDPFVFARGYEEVLACAEAGVQVTVVPGVTSAISVPAAAGVPVTHRAVNHEFVVVS
EEECCCCEEEECCHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCCEEEEECCCEEEEEE
GHVAPGHPESLVNWDALAALNGTIVLLMAVERIEQFARVLIEGGRPAHTPVLVVQHGTTD
CCCCCCCCHHHCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCH
EQRVLRADLATAPERIRSQGIRPPAIIVIGPVAAYGAF
HHHHHHHHHHCCHHHHHHCCCCCCEEEEECCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA