Click here to switch to the map view.

The map label for this gene is hbdH1 [H]

Identifier: 169630185

GI number: 169630185

Start: 3146887

End: 3147696

Strand: Reverse

Name: hbdH1 [H]

Synonym: MAB_3103c

Alternate gene names: 169630185

Gene position: 3147696-3146887 (Counterclockwise)

Preceding gene: 169630186

Following gene: 169630184

Centisome position: 62.12

GC content: 64.2

Gene sequence:

>810_bases
ATGGATATCAACGGCAGCGTCGCCATCGTCACCGGAGCCGGTTCGGGAATCGGACAGGCCCTTGCCTGGGGGCTTGTGGA
TGCCGGAGCCACCGTGGTGGCGTCAGATATCGACGCCGATGCCGTGGGGCGCACCGCCGCGGCTCGAGACGGCATCGTCG
GTCAGCGAGCCGATGCCAGCGCGGTCTCCGATATCGAGGATCTTATTGCTTTGGCGGAGAAGGAATTTGGTCCCGTCGAT
CTCTACGCGGCCAACGCCGGTATCGCCGGCGGCCTCGGGCTCGGTATCGGCGAGGCGGCATGGGACCTCACCATCGATGT
GAACCTTCGGGCGCATATCCGCGCGGCCACGCTGCTGGTGCCCGGATGGGTAGAGCGCGGCCGTGGCTATTTCCTGTCGG
TGGCATCAGCGGCCGGACTGCTCACCCAGATCGGTTCACCCGCGTATTCGGTGACCAAACATGCCGCGGTCGGCTTTGCC
GAGTGGCTCTCGATCACCTACGGCGGTCAGGGGGTCGGAGTGAGTTGCCTGTGTCCGATGGGGGTCAAGACGGCACTCTT
GGACGGCCTCACCGAATCCGATGACCCGGACGTGCGTGTGGCGGGTACCTCTATAACAGCGGCGGGTGACGTGCTCGAAC
CGGCGGTGGTGGCTGCCATGGCACTCGATGCGATCCGGGATGAGAAGTTCTTGGTCTTGCCGCATCCCCAGGTGCTCGAC
ATGTATCGCCAGAAGGGCGCCGATTACGACAGATGGATCGCGGGAATGCGCCGTTACCAGGCCATACTCGAAGACCAGAT
CATCCGGTAG

Upstream 100 bases:

>100_bases
CACCCAGTCTCCGCGGCGCACGGCCCGCGTCCTTGCCGGTGTTTTCGCGGTCGCGGCCGCCGCCGTGGGGGTCTTCGCGG
CCATCCAATAAGGTCCGGGT

Downstream 100 bases:

>100_bases
TGCTGTGATGCAGATCACTATTGATAGGAAGCGTGACTGAACCGGCCCTTGTCGTAGTGGGCCCGCGGCCTGCTACCGTT
GACGTAAGTCAGTCTTTCGT

Product: putative short chain dehydrogenase/reductase

Products: NA

Alternate protein names: BDH; 3-hydroxybutyrate dehydrogenase; 3-HBDH [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDINGSVAIVTGAGSGIGQALAWGLVDAGATVVASDIDADAVGRTAAARDGIVGQRADASAVSDIEDLIALAEKEFGPVD
LYAANAGIAGGLGLGIGEAAWDLTIDVNLRAHIRAATLLVPGWVERGRGYFLSVASAAGLLTQIGSPAYSVTKHAAVGFA
EWLSITYGGQGVGVSCLCPMGVKTALLDGLTESDDPDVRVAGTSITAAGDVLEPAVVAAMALDAIRDEKFLVLPHPQVLD
MYRQKGADYDRWIAGMRRYQAILEDQIIR

Sequences:

>Translated_269_residues
MDINGSVAIVTGAGSGIGQALAWGLVDAGATVVASDIDADAVGRTAAARDGIVGQRADASAVSDIEDLIALAEKEFGPVD
LYAANAGIAGGLGLGIGEAAWDLTIDVNLRAHIRAATLLVPGWVERGRGYFLSVASAAGLLTQIGSPAYSVTKHAAVGFA
EWLSITYGGQGVGVSCLCPMGVKTALLDGLTESDDPDVRVAGTSITAAGDVLEPAVVAAMALDAIRDEKFLVLPHPQVLD
MYRQKGADYDRWIAGMRRYQAILEDQIIR
>Mature_269_residues
MDINGSVAIVTGAGSGIGQALAWGLVDAGATVVASDIDADAVGRTAAARDGIVGQRADASAVSDIEDLIALAEKEFGPVD
LYAANAGIAGGLGLGIGEAAWDLTIDVNLRAHIRAATLLVPGWVERGRGYFLSVASAAGLLTQIGSPAYSVTKHAAVGFA
EWLSITYGGQGVGVSCLCPMGVKTALLDGLTESDDPDVRVAGTSITAAGDVLEPAVVAAMALDAIRDEKFLVLPHPQVLD
MYRQKGADYDRWIAGMRRYQAILEDQIIR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40807363, Length=253, Percent_Identity=26.4822134387352, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI142976729, Length=247, Percent_Identity=28.7449392712551, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI32483357, Length=188, Percent_Identity=31.3829787234043, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI31542939, Length=207, Percent_Identity=28.9855072463768, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI210032110, Length=276, Percent_Identity=27.1739130434783, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI310128830, Length=250, Percent_Identity=26.8, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI310115468, Length=250, Percent_Identity=26.8, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=30.3867403314917, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI5031737, Length=184, Percent_Identity=32.0652173913043, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI33667109, Length=184, Percent_Identity=32.0652173913043, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI25282469, Length=302, Percent_Identity=25.8278145695364, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504505, Length=212, Percent_Identity=26.4150943396226, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI126723750, Length=193, Percent_Identity=29.5336787564767, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI224922801, Length=186, Percent_Identity=28.494623655914, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082160, Length=191, Percent_Identity=32.4607329842932, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082100, Length=204, Percent_Identity=26.9607843137255, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787335, Length=200, Percent_Identity=28, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787905, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789208, Length=183, Percent_Identity=25.1366120218579, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=245, Percent_Identity=29.3877551020408, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193203115, Length=241, Percent_Identity=28.6307053941909, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=242, Percent_Identity=28.099173553719, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=28.5, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=196, Percent_Identity=30.1020408163265, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=186, Percent_Identity=29.5698924731183, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24581726, Length=250, Percent_Identity=28, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24649181, Length=191, Percent_Identity=28.7958115183246, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21355631, Length=168, Percent_Identity=27.9761904761905, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18859837, Length=206, Percent_Identity=30.5825242718447, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355319, Length=202, Percent_Identity=27.7227722772277, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=183, Percent_Identity=30.0546448087432, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221510726, Length=242, Percent_Identity=28.099173553719, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=26.2376237623762, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24639444, Length=200, Percent_Identity=28, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011294
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.30 [H]

Molecular weight: Translated: 27748; Mature: 27748

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINGSVAIVTGAGSGIGQALAWGLVDAGATVVASDIDADAVGRTAAARDGIVGQRADAS
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCHHHCCHHHHHCCCCCCCCCHH
AVSDIEDLIALAEKEFGPVDLYAANAGIAGGLGLGIGEAAWDLTIDVNLRAHIRAATLLV
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEEEEEC
PGWVERGRGYFLSVASAAGLLTQIGSPAYSVTKHAAVGFAEWLSITYGGQGVGVSCLCPM
CCHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCEEEECCC
GVKTALLDGLTESDDPDVRVAGTSITAAGDVLEPAVVAAMALDAIRDEKFLVLPHPQVLD
CHHHHHHHCCCCCCCCCEEEECCEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHH
MYRQKGADYDRWIAGMRRYQAILEDQIIR
HHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDINGSVAIVTGAGSGIGQALAWGLVDAGATVVASDIDADAVGRTAAARDGIVGQRADAS
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCHHHCCHHHHHCCCCCCCCCHH
AVSDIEDLIALAEKEFGPVDLYAANAGIAGGLGLGIGEAAWDLTIDVNLRAHIRAATLLV
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEEEEEC
PGWVERGRGYFLSVASAAGLLTQIGSPAYSVTKHAAVGFAEWLSITYGGQGVGVSCLCPM
CCHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCEEEECCC
GVKTALLDGLTESDDPDVRVAGTSITAAGDVLEPAVVAAMALDAIRDEKFLVLPHPQVLD
CHHHHHHHCCCCCCCCCEEEECCEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHH
MYRQKGADYDRWIAGMRRYQAILEDQIIR
HHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA