BacMap

Definition	Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence.
Accession	NC_010397
Length	5,067,172

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The map label for this gene is limC [H]

Identifier: 169630164

GI number: 169630164

Start: 3126710

End: 3127528

Strand: Direct

Name: limC [H]

Synonym: MAB_3081

Alternate gene names: 169630164

Gene position: 3126710-3127528 (Clockwise)

Preceding gene: 169630163

Following gene: 169630165

Centisome position: 61.71

GC content: 65.45

Gene sequence:

>819_bases
ATGGGAAAACTGGACGGCAAGGTCGCGTTCATCACCGGCGCCGCCCGCGGTCAGGGGCGCGCCCACGCGATCAAACTGGC
TTCCGAAGGAGCCAGCATCATCGCGGTCGACATCTGCGCACAGATCCCGTCGGTGGAATACCCGATGGCGACCACCGAGG
ATCTGGACCTCACCGTCAAAGAGGTCGACGCCCTGGGGCGCGCCATCTCGGCACACGAGACCGACGTGCGTGACCGGGAA
GCCTTGCAGGCGGCGTTCGATGCCGGGGTGCACGATCTCGGGCCCGTCGACATCGTGGTCGCGAACGCCGGAATCGCCAC
TCTGACTCCCGAATGCGGAGACGACGGCTGGCGGGACGTCCTCGACGTGAACCTCACCGGCGTGTACCACACCATCGAGG
TGGCGCGACCGTCCATGGTGCAACGCGGGGCCGGCGGTTCGATTGTGCTCACCAGCTCAGTGGCCGGACTGACCGGCATG
GTGATGGACAACCCCGGAGGACTCGCCTACACCGCCGCCAAGCACGGACTCGTGGGCTTGATGCGCAGCTACGCGAATAT
GCTGGCCCCGCATAACATCCGGGTCAACACCATTCACCCGTCGGGTGTGGCGACGCCGATGCTGATCAATCCGGTCACCG
AGAAGCTATTCGCAGATGGCTCGCCCGAAGGCATGTCCGACACCGGAAACGCCTTGCCCGTCGTCCTGATGGAGCCCGAG
GATATGGCCAACACCGTGGCGTGGCTGGTGTCGGAGGACGCTCGGTACATCACCGGCGTCGCGCTTCCCGTCGACGCCGG
ATTCACCAACAGGCGGTAA

Upstream 100 bases:

>100_bases
TTCGGCAAGGTGGGTCCGCTGCTGAGCCAGCCACCGGAAATTGTTGTCGCCGAGGCTCTCCCGGCTGGTGATCCCGCCAA
GGGCGACTTGGTGCACTGAG

Downstream 100 bases:

>100_bases
CGTGCCACAGTCGAATCCCGCCGCCCAGACCGCCTTTGGCCCGATGGCCATCACCGCCGTCGAACAGCATGAGCCTGCGG
CGGCCCGGATCGTCGACGAC

Product: Short-chain dehydrogenase/reductase

Products: NA

Alternate protein names: (4R,6S)-carveol dehydrogenase; CDH; Carveol dehydrogenase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MGKLDGKVAFITGAARGQGRAHAIKLASEGASIIAVDICAQIPSVEYPMATTEDLDLTVKEVDALGRAISAHETDVRDRE
ALQAAFDAGVHDLGPVDIVVANAGIATLTPECGDDGWRDVLDVNLTGVYHTIEVARPSMVQRGAGGSIVLTSSVAGLTGM
VMDNPGGLAYTAAKHGLVGLMRSYANMLAPHNIRVNTIHPSGVATPMLINPVTEKLFADGSPEGMSDTGNALPVVLMEPE
DMANTVAWLVSEDARYITGVALPVDAGFTNRR

Sequences:

>Translated_272_residues
MGKLDGKVAFITGAARGQGRAHAIKLASEGASIIAVDICAQIPSVEYPMATTEDLDLTVKEVDALGRAISAHETDVRDRE
ALQAAFDAGVHDLGPVDIVVANAGIATLTPECGDDGWRDVLDVNLTGVYHTIEVARPSMVQRGAGGSIVLTSSVAGLTGM
VMDNPGGLAYTAAKHGLVGLMRSYANMLAPHNIRVNTIHPSGVATPMLINPVTEKLFADGSPEGMSDTGNALPVVLMEPE
DMANTVAWLVSEDARYITGVALPVDAGFTNRR
>Mature_271_residues
GKLDGKVAFITGAARGQGRAHAIKLASEGASIIAVDICAQIPSVEYPMATTEDLDLTVKEVDALGRAISAHETDVRDREA
LQAAFDAGVHDLGPVDIVVANAGIATLTPECGDDGWRDVLDVNLTGVYHTIEVARPSMVQRGAGGSIVLTSSVAGLTGMV
MDNPGGLAYTAAKHGLVGLMRSYANMLAPHNIRVNTIHPSGVATPMLINPVTEKLFADGSPEGMSDTGNALPVVLMEPED
MANTVAWLVSEDARYITGVALPVDAGFTNRR

Specific function: Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)-stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. Displays a broad substrate specificity with a preference

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=281, Percent_Identity=33.0960854092527, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI32483357, Length=272, Percent_Identity=33.0882352941176, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI7705925, Length=268, Percent_Identity=29.4776119402985, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI126723750, Length=272, Percent_Identity=30.5147058823529, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4504505, Length=273, Percent_Identity=29.6703296703297, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI66933014, Length=280, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI31542939, Length=209, Percent_Identity=33.4928229665072, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI5031737, Length=273, Percent_Identity=29.6703296703297, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4758504, Length=218, Percent_Identity=33.9449541284404, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI223718074, Length=229, Percent_Identity=31.4410480349345, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI40254992, Length=264, Percent_Identity=30.6818181818182, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI224922801, Length=184, Percent_Identity=33.695652173913, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723191, Length=199, Percent_Identity=32.1608040201005, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI19923817, Length=272, Percent_Identity=25, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI10190704, Length=268, Percent_Identity=28.3582089552239, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=207, Percent_Identity=30.9178743961353, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI83715985, Length=200, Percent_Identity=32.5, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI87082100, Length=276, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1789208, Length=271, Percent_Identity=30.6273062730627, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787335, Length=272, Percent_Identity=32.3529411764706, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788459, Length=271, Percent_Identity=32.1033210332103, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87082160, Length=275, Percent_Identity=30.1818181818182, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787905, Length=267, Percent_Identity=30.7116104868914, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790717, Length=267, Percent_Identity=30.3370786516854, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI2367365, Length=274, Percent_Identity=29.9270072992701, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI2367175, Length=272, Percent_Identity=28.6764705882353, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789378, Length=262, Percent_Identity=24.8091603053435, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788891, Length=239, Percent_Identity=29.2887029288703, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=271, Percent_Identity=29.8892988929889, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=279, Percent_Identity=30.8243727598566, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=279, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=270, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17568967, Length=202, Percent_Identity=31.6831683168317, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=291, Percent_Identity=27.8350515463918, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=211, Percent_Identity=29.3838862559242, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=210, Percent_Identity=30.4761904761905, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=272, Percent_Identity=30.8823529411765, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=281, Percent_Identity=29.1814946619217, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=207, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=288, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=284, Percent_Identity=27.112676056338, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=210, Percent_Identity=28.0952380952381, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=282, Percent_Identity=28.0141843971631, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=234, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=281, Percent_Identity=27.0462633451957, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=286, Percent_Identity=27.6223776223776, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=205, Percent_Identity=27.3170731707317, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=33.5, Blast_Score=82, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324126, Length=273, Percent_Identity=25.6410256410256, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355319, Length=281, Percent_Identity=30.6049822064057, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859837, Length=230, Percent_Identity=33.4782608695652, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24644339, Length=273, Percent_Identity=31.8681318681319, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639444, Length=275, Percent_Identity=29.0909090909091, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=28.9719626168224, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21355631, Length=183, Percent_Identity=31.1475409836066, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357041, Length=276, Percent_Identity=25.7246376811594, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737361, Length=218, Percent_Identity=29.8165137614679, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571526, Length=273, Percent_Identity=26.7399267399267, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357673, Length=241, Percent_Identity=26.9709543568465, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24649181, Length=226, Percent_Identity=30.9734513274336, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI23397609, Length=277, Percent_Identity=29.2418772563177, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28370; Mature: 28238

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLDGKVAFITGAARGQGRAHAIKLASEGASIIAVDICAQIPSVEYPMATTEDLDLTVK
CCCCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEEEHHHCCCCCCCCCCCCCCCCHHH
EVDALGRAISAHETDVRDREALQAAFDAGVHDLGPVDIVVANAGIATLTPECGDDGWRDV
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEECCCCCCCCCHHE
LDVNLTGVYHTIEVARPSMVQRGAGGSIVLTSSVAGLTGMVMDNPGGLAYTAAKHGLVGL
EEEEECEEEEEEEECCCHHHHCCCCCCEEEEECCCCEEEEEEECCCCEEEHHHHHHHHHH
MRSYANMLAPHNIRVNTIHPSGVATPMLINPVTEKLFADGSPEGMSDTGNALPVVLMEPE
HHHHHHHHCCCCEEEEEECCCCCCCCEEECHHHHHHHCCCCCCCCCCCCCCCEEEEECCH
DMANTVAWLVSEDARYITGVALPVDAGFTNRR
HHHHHHHHHHCCCCCEEEEEEEEECCCCCCCC
>Mature Secondary Structure 
GKLDGKVAFITGAARGQGRAHAIKLASEGASIIAVDICAQIPSVEYPMATTEDLDLTVK
CCCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEEEHHHCCCCCCCCCCCCCCCCHHH
EVDALGRAISAHETDVRDREALQAAFDAGVHDLGPVDIVVANAGIATLTPECGDDGWRDV
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEECCCCCCCCCHHE
LDVNLTGVYHTIEVARPSMVQRGAGGSIVLTSSVAGLTGMVMDNPGGLAYTAAKHGLVGL
EEEEECEEEEEEEECCCHHHHCCCCCCEEEEECCCCEEEEEEECCCCEEEHHHHHHHHHH
MRSYANMLAPHNIRVNTIHPSGVATPMLINPVTEKLFADGSPEGMSDTGNALPVVLMEPE
HHHHHHHHCCCCEEEEEECCCCCCCCEEECHHHHHHHCCCCCCCCCCCCCCCEEEEECCH
DMANTVAWLVSEDARYITGVALPVDAGFTNRR
HHHHHHHHHHCCCCCEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10473585 [H]