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The map label for this gene is dut [H]

Identifier: 169630086

GI number: 169630086

Start: 3063170

End: 3063622

Strand: Reverse

Name: dut [H]

Synonym: MAB_3003c

Alternate gene names: 169630086

Gene position: 3063622-3063170 (Counterclockwise)

Preceding gene: 169630088

Following gene: 169630085

Centisome position: 60.46

GC content: 63.36

Gene sequence:

>453_bases
TTGGCGATTGTTCGCCTCGATCGAGAGCTTCCCCTGCCTTCCCGTGCACATGCCGACGACGCGGGGGTTGATCTCTACAG
CGCCGAGGACGTGGTGATCGAGCCCGGCCGCCGGACACTGGTGGGCACCGGTATCGCCGTAGCCATCCCGTCGGGGATGG
TCGGCTTGGTGCACCCGCGCTCGGGTCTGGCTGCACGCGTGGGTCTTTCGATCGTCAACAGCCCCGGAACAATTGATGCC
GGATATCGTGGCGAGGTGAAGGTCAACCTGATTAACCTGGATTCGGAGGTCCCGATCGTCATTGCTCGTGGCGACCGGAT
CGCGCAGCTGCTGGTTCAGCAGGTTGAGTTGCCCGAACTGGTTGAGGTGGATTCATTTGACGAGGCCGGTCTGGCCGTGA
CCACGCGCGGTGCGGGTGGATACGGGTCCAGCGGCGGACATGCGAGTTTGTGA

Upstream 100 bases:

>100_bases
AACCCACAACCGCTCGAGATAGCGGATATCGGTCGTGTTGCTGGGAGATGCCATCACGCGGCCAAGGGTAGTCTGGGCGA
TCGTGCCCACACCTACGAGA

Downstream 100 bases:

>100_bases
TGGCTTTACACCGCAGTGGTGGTCTCAACGACCTGGATGACACGGCCGATGCTTCGGGCGAAACATTCGACGGCCCATAC
GAAATCGAGGATTTCGATAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MAIVRLDRELPLPSRAHADDAGVDLYSAEDVVIEPGRRTLVGTGIAVAIPSGMVGLVHPRSGLAARVGLSIVNSPGTIDA
GYRGEVKVNLINLDSEVPIVIARGDRIAQLLVQQVELPELVEVDSFDEAGLAVTTRGAGGYGSSGGHASL

Sequences:

>Translated_150_residues
MAIVRLDRELPLPSRAHADDAGVDLYSAEDVVIEPGRRTLVGTGIAVAIPSGMVGLVHPRSGLAARVGLSIVNSPGTIDA
GYRGEVKVNLINLDSEVPIVIARGDRIAQLLVQQVELPELVEVDSFDEAGLAVTTRGAGGYGSSGGHASL
>Mature_149_residues
AIVRLDRELPLPSRAHADDAGVDLYSAEDVVIEPGRRTLVGTGIAVAIPSGMVGLVHPRSGLAARVGLSIVNSPGTIDAG
YRGEVKVNLINLDSEVPIVIARGDRIAQLLVQQVELPELVEVDSFDEAGLAVTTRGAGGYGSSGGHASL

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=145, Percent_Identity=42.7586206896552, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4503423, Length=147, Percent_Identity=42.1768707482993, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI70906441, Length=145, Percent_Identity=42.7586206896552, Blast_Score=107, Evalue=6e-24,
Organism=Escherichia coli, GI1790071, Length=145, Percent_Identity=37.2413793103448, Blast_Score=79, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71988561, Length=150, Percent_Identity=43.3333333333333, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319729, Length=135, Percent_Identity=40, Blast_Score=91, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24583610, Length=133, Percent_Identity=40.6015037593985, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921126, Length=133, Percent_Identity=40.6015037593985, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15502; Mature: 15371

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVRLDRELPLPSRAHADDAGVDLYSAEDVVIEPGRRTLVGTGIAVAIPSGMVGLVHPR
CEEEEECCCCCCCCCCCCCCCCEEEECCCCEEECCCCEEEEECCEEEEECCCEEEEEECC
SGLAARVGLSIVNSPGTIDAGYRGEVKVNLINLDSEVPIVIARGDRIAQLLVQQVELPEL
CCCEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCHHHHHHHHHCCCCCE
VEVDSFDEAGLAVTTRGAGGYGSSGGHASL
EECCCCCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
AIVRLDRELPLPSRAHADDAGVDLYSAEDVVIEPGRRTLVGTGIAVAIPSGMVGLVHPR
EEEEECCCCCCCCCCCCCCCCEEEECCCCEEECCCCEEEEECCEEEEECCCEEEEEECC
SGLAARVGLSIVNSPGTIDAGYRGEVKVNLINLDSEVPIVIARGDRIAQLLVQQVELPEL
CCCEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCHHHHHHHHHCCCCCE
VEVDSFDEAGLAVTTRGAGGYGSSGGHASL
EECCCCCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA