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The map label for this gene is qacA [H]

Identifier: 169630041

GI number: 169630041

Start: 3012204

End: 3013709

Strand: Direct

Name: qacA [H]

Synonym: MAB_2958

Alternate gene names: 169630041

Gene position: 3012204-3013709 (Clockwise)

Preceding gene: 169630039

Following gene: 169630042

Centisome position: 59.45

GC content: 66.2

Gene sequence:

>1506_bases
ATGACCAGCTGTAAGTCCACTGCGCCAGAAAACGCGACCGCCCCCGAGGGTGCCCGCGTCGGACGCCGCACGTGGTTCGG
ACTGGCCTCGCTGCTACTGCCCGTCTTCCTGGTGTCCATGGACGTCTCGGTGCTGTTCTTGGCCATGCCGCGACTGTCCG
AATCTCTCAATCCCTCGGCAGCCGAGCAGCTCTGGATACTAGACGTGTACGGATTCCTGCTCGCCGGTCTGCTCATCACC
ATGGGCAATCTGGGCGACCGCTGGGGACGTCGTCGCCTTATGCTCTGGGGTGCAACACTTTTCGCCGCAGCCTCGGTGCT
GGCAGCATTCGCGCCCACTCCGCTGGCGCTGATCGGCGCCCGGGCGCTGATGGGCGTCGGCGGGGCCACACTGCTCCCGG
CGAGCCTGGCGCTCATCGGAGTCATGTTCCCCAACCCGCGCCAGAAGGCGCTGGCCATCGGCATCTGGTCTGCGGCGTTC
TCGTTCGGTGCCGCCGTCGGGCCCGTAATCGGCGGAGTGCTGCTGCATCATTTCTGGTGGGGTTCGGTGTTCCTCATCAA
CGTGCCGGTGCTGATCGTGCTGTTACTCACCGCGGACGCGCTTATCCCCGAATACCGCAATCCCATACGAGCCCCCTTTG
ACCTCGTCGGCGTCGCGTTGTCCATGGTCGGCATCATGACGCTGGTCTATTCGGTGAAAGCCATGGCGACACACGGATTC
TCAGCAGCCGTAGCGATCACCGGCGCGGTCGGGGTACTCACCCTTGCGTTATTCGTCCGCCAACAGGTTCGCAACCCACA
TCCGCTACTGGCGCTGGATCTGTTCCGCAACCGCACCTTCACGGTGGCAATCGTCGGAACTGTCGGAGCCATGGCGACGT
TCGGCGCCACCACCTACCTCACCGGGCTCTATGTGCAGTCCGTTCTCGGTTTCGACGTGCTCGCCGCGGCATTCCTGGGC
CTGCCGATGGCGGTGGTCGTGGCCTATTTCTCCATGGACGCACCGCGCATCGAACGCGTGCTCGGCGAACGGTGGACATT
CGTCACATCGCTCTTGGCAATGGCCCTCGGAAACGCGGTGCTCCTGGCGCTGGGCCCACACGGGCCGGTAGCGGTCTATA
TCGCGGCGACCGTGATCGTCGGTGCCGGCGCGGGCGTCATGTTCACCTTCGTATCGGCCGTGGCCCTCGGTGCCGCCCCG
ACCGAACGCGCCGGGCAGGCCACCGGTATCTCCGAAATGAGCTTCGAACTGGGGACGGCTTTCGGGCTGGCGCTATTCGG
CGCGCTCGCCTCGGCGGTCTTCGCAGCGCGTACCCATGTGCACGAGACGCTCGGACAGGCTATGGCCAATGCCAAGGAAC
TCGGGGGCGACGCAGGGGCCGCCGCGGCCGAGCTGGCGCGCACCGGGTGGGCGGACGGCATCCACGCCGTAGCCAGCGTC
TCGACGCTGCTCCTGGTGGCCATCGCGGTCGCCGCCGCAGTCGTGATGCGCCGCACCCAGGACTGA

Upstream 100 bases:

>100_bases
CCTCCATACTCGATTGACCAGCTAGGCCAATTTGCGTACAGTGTACCCAGCCTGTTGCGTACGCCGTACGCGCCCAAATA
TACCGCCGGAGCGATGCCCC

Downstream 100 bases:

>100_bases
CCGGCCGCCCACCCGGGAACCTTCGGTGCTCCAGACTCGTAGAAAACATATGACCCGCGAGATCCGAGACATCGACTCCG
CATCCGAAGCCCTCGCACAC

Product: putative transmembrane-transport protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTSCKSTAPENATAPEGARVGRRTWFGLASLLLPVFLVSMDVSVLFLAMPRLSESLNPSAAEQLWILDVYGFLLAGLLIT
MGNLGDRWGRRRLMLWGATLFAAASVLAAFAPTPLALIGARALMGVGGATLLPASLALIGVMFPNPRQKALAIGIWSAAF
SFGAAVGPVIGGVLLHHFWWGSVFLINVPVLIVLLLTADALIPEYRNPIRAPFDLVGVALSMVGIMTLVYSVKAMATHGF
SAAVAITGAVGVLTLALFVRQQVRNPHPLLALDLFRNRTFTVAIVGTVGAMATFGATTYLTGLYVQSVLGFDVLAAAFLG
LPMAVVVAYFSMDAPRIERVLGERWTFVTSLLAMALGNAVLLALGPHGPVAVYIAATVIVGAGAGVMFTFVSAVALGAAP
TERAGQATGISEMSFELGTAFGLALFGALASAVFAARTHVHETLGQAMANAKELGGDAGAAAAELARTGWADGIHAVASV
STLLLVAIAVAAAVVMRRTQD

Sequences:

>Translated_501_residues
MTSCKSTAPENATAPEGARVGRRTWFGLASLLLPVFLVSMDVSVLFLAMPRLSESLNPSAAEQLWILDVYGFLLAGLLIT
MGNLGDRWGRRRLMLWGATLFAAASVLAAFAPTPLALIGARALMGVGGATLLPASLALIGVMFPNPRQKALAIGIWSAAF
SFGAAVGPVIGGVLLHHFWWGSVFLINVPVLIVLLLTADALIPEYRNPIRAPFDLVGVALSMVGIMTLVYSVKAMATHGF
SAAVAITGAVGVLTLALFVRQQVRNPHPLLALDLFRNRTFTVAIVGTVGAMATFGATTYLTGLYVQSVLGFDVLAAAFLG
LPMAVVVAYFSMDAPRIERVLGERWTFVTSLLAMALGNAVLLALGPHGPVAVYIAATVIVGAGAGVMFTFVSAVALGAAP
TERAGQATGISEMSFELGTAFGLALFGALASAVFAARTHVHETLGQAMANAKELGGDAGAAAAELARTGWADGIHAVASV
STLLLVAIAVAAAVVMRRTQD
>Mature_500_residues
TSCKSTAPENATAPEGARVGRRTWFGLASLLLPVFLVSMDVSVLFLAMPRLSESLNPSAAEQLWILDVYGFLLAGLLITM
GNLGDRWGRRRLMLWGATLFAAASVLAAFAPTPLALIGARALMGVGGATLLPASLALIGVMFPNPRQKALAIGIWSAAFS
FGAAVGPVIGGVLLHHFWWGSVFLINVPVLIVLLLTADALIPEYRNPIRAPFDLVGVALSMVGIMTLVYSVKAMATHGFS
AAVAITGAVGVLTLALFVRQQVRNPHPLLALDLFRNRTFTVAIVGTVGAMATFGATTYLTGLYVQSVLGFDVLAAAFLGL
PMAVVVAYFSMDAPRIERVLGERWTFVTSLLAMALGNAVLLALGPHGPVAVYIAATVIVGAGAGVMFTFVSAVALGAAPT
ERAGQATGISEMSFELGTAFGLALFGALASAVFAARTHVHETLGQAMANAKELGGDAGAAAAELARTGWADGIHAVASVS
TLLLVAIAVAAAVVMRRTQD

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=468, Percent_Identity=25.4273504273504, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87081983, Length=414, Percent_Identity=28.2608695652174, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1789042, Length=445, Percent_Identity=24.0449438202247, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788710, Length=311, Percent_Identity=27.0096463022508, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788392, Length=402, Percent_Identity=27.1144278606965, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322958, Length=219, Percent_Identity=29.2237442922374, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51910; Mature: 51779

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSCKSTAPENATAPEGARVGRRTWFGLASLLLPVFLVSMDVSVLFLAMPRLSESLNPSA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH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HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]