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The map label for this gene is hyuA [H]

Identifier: 169629901

GI number: 169629901

Start: 2866786

End: 2868207

Strand: Reverse

Name: hyuA [H]

Synonym: MAB_2817c

Alternate gene names: 169629901

Gene position: 2868207-2866786 (Counterclockwise)

Preceding gene: 169629902

Following gene: 169629900

Centisome position: 56.6

GC content: 62.52

Gene sequence:

>1422_bases
ATGGCAACGACTTTGATCCGGGGCGGCACGGTGGTGTCGGCGACCGGACGCGGTGCCGCCGATGTCTTGGTGGACGGCGC
GACGATCGCGGCGGTCCTATTGCCCGGCAGCACCCTGCTCGGGATGGACCTCGCGAAAACCGTCGATACCGTGATCGAGG
CCCACGGCAAATACGTTATTCCCGGGGGCATCGACGCACACACTCACATGTCCATGCCCTTCGGCGGTACTACGGCATCC
GATGATTTCGAGACCGGCACGCGCGCCGCCGCGTGGGGCGGCACGACTACCATCATCGACTTCGCAGTGCAGAAATTCGG
TGAGCGGCTGCAGGATTCGCTGGATACCTGGCATGAGATGGCAGCCGGGCAATGTGCCATCGACTACTCGTTTCACCAGA
TTGTGGGAGATGTCAACGATGCTTCTTTGGCGGCGCTGCGCAGGCTGACCGACGAGGGCATCACCAGCTACAAGATGTTC
ATGGCCTATCCCGGGGTCTTCTACAGCGACGACGCACAGATAGTGCGGGCCATGCAGGTGGGCGCCGCGACGGGGCTGAT
GACGATGATGCATGCCGAGAATGGTCCCGCGATCGACGTTTTGGTGGCCCAGTTACTCGCCGAAGGCAAGACCGATCCTT
ATTACCACGGCATCGCCCGCGCGTGGCAGCTTGAGGAAGAGGCCACGCACCGCGCCATCATGCTGTCCAATCTGACCGGT
GCGCCGCTGTACGTGGTACACGTCTCGGCGAAACAGGCCGTCGCGCAATTGGCGGCCGCGCGTGACGCCGGCCAGAACGT
ATATGGCGAAACGTGCCCGCAATATCTGTATCTGTCCCTCGAGGACAACCTGGGCGCGCCCGGTTTCGACGGCGCCAAGT
GGGTCTGCTCGACGCCGCTGCGTGCCAAGCACGAGCATCATCAGGACGAAATGTGGCGCGCATTGCGCACCAACGACATT
CAGATGGTGTCCACGGACCACTGCCCGTTCTGCATGAAGGGGCAGAAGGACATGGGCATCGGGGATTTCTCCAAGATTCC
CAACGGTATCGGATCCATCGAACACCGGATGGACCTGCTCTACCAAGGTGTGGTGGACGGCCGGATCAGCGTGGAGCGGT
GGGTCGAGATCACCTCGACCACGCCGGCACGGATGTTCGGGCTGTACGGGCGCAAGGGCGTCATCGCCCCGGGGGCCGAT
GCGGACATCGTTGTCTACGACCCCAACGGGCACACCTCGATTGGACTGGGCAAGACCCATCACATGAATATGGACCACTC
GGCGTGGGAGGGGTACGAGATCGACGGGCACGTCGATACCGTGCTGTCCCGCGGAAAGGTGATCGTCGACGGCGACGAGT
ACCTCGGCAGTAAGGGGGACGGTGTGTTCCTGCGCCGCGACCTGTGTCAATACCTCATCTGA

Upstream 100 bases:

>100_bases
CGACCTGTCGCTGGTCCGTCAAGTTCGGGATGACTGGCAGTTTTACCGGGACCGCCGTCCGGATACCTACGGCCCGATCA
TCGCACCGTAGGAGGCTGCG

Downstream 100 bases:

>100_bases
GGCTGGTTGATAGAGAGGGCCCCGCGATGGATTTCGGAGTTGTCCTGCAATGCGACCCACCCGCGGTGCGTACCGTGCAG
CTGGCGAAACTTGCCGAGGC

Product: phenylhydantoinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MATTLIRGGTVVSATGRGAADVLVDGATIAAVLLPGSTLLGMDLAKTVDTVIEAHGKYVIPGGIDAHTHMSMPFGGTTAS
DDFETGTRAAAWGGTTTIIDFAVQKFGERLQDSLDTWHEMAAGQCAIDYSFHQIVGDVNDASLAALRRLTDEGITSYKMF
MAYPGVFYSDDAQIVRAMQVGAATGLMTMMHAENGPAIDVLVAQLLAEGKTDPYYHGIARAWQLEEEATHRAIMLSNLTG
APLYVVHVSAKQAVAQLAAARDAGQNVYGETCPQYLYLSLEDNLGAPGFDGAKWVCSTPLRAKHEHHQDEMWRALRTNDI
QMVSTDHCPFCMKGQKDMGIGDFSKIPNGIGSIEHRMDLLYQGVVDGRISVERWVEITSTTPARMFGLYGRKGVIAPGAD
ADIVVYDPNGHTSIGLGKTHHMNMDHSAWEGYEIDGHVDTVLSRGKVIVDGDEYLGSKGDGVFLRRDLCQYLI

Sequences:

>Translated_473_residues
MATTLIRGGTVVSATGRGAADVLVDGATIAAVLLPGSTLLGMDLAKTVDTVIEAHGKYVIPGGIDAHTHMSMPFGGTTAS
DDFETGTRAAAWGGTTTIIDFAVQKFGERLQDSLDTWHEMAAGQCAIDYSFHQIVGDVNDASLAALRRLTDEGITSYKMF
MAYPGVFYSDDAQIVRAMQVGAATGLMTMMHAENGPAIDVLVAQLLAEGKTDPYYHGIARAWQLEEEATHRAIMLSNLTG
APLYVVHVSAKQAVAQLAAARDAGQNVYGETCPQYLYLSLEDNLGAPGFDGAKWVCSTPLRAKHEHHQDEMWRALRTNDI
QMVSTDHCPFCMKGQKDMGIGDFSKIPNGIGSIEHRMDLLYQGVVDGRISVERWVEITSTTPARMFGLYGRKGVIAPGAD
ADIVVYDPNGHTSIGLGKTHHMNMDHSAWEGYEIDGHVDTVLSRGKVIVDGDEYLGSKGDGVFLRRDLCQYLI
>Mature_472_residues
ATTLIRGGTVVSATGRGAADVLVDGATIAAVLLPGSTLLGMDLAKTVDTVIEAHGKYVIPGGIDAHTHMSMPFGGTTASD
DFETGTRAAAWGGTTTIIDFAVQKFGERLQDSLDTWHEMAAGQCAIDYSFHQIVGDVNDASLAALRRLTDEGITSYKMFM
AYPGVFYSDDAQIVRAMQVGAATGLMTMMHAENGPAIDVLVAQLLAEGKTDPYYHGIARAWQLEEEATHRAIMLSNLTGA
PLYVVHVSAKQAVAQLAAARDAGQNVYGETCPQYLYLSLEDNLGAPGFDGAKWVCSTPLRAKHEHHQDEMWRALRTNDIQ
MVSTDHCPFCMKGQKDMGIGDFSKIPNGIGSIEHRMDLLYQGVVDGRISVERWVEITSTTPARMFGLYGRKGVIAPGADA
DIVVYDPNGHTSIGLGKTHHMNMDHSAWEGYEIDGHVDTVLSRGKVIVDGDEYLGSKGDGVFLRRDLCQYLI

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=475, Percent_Identity=38.1052631578947, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI4503051, Length=464, Percent_Identity=34.9137931034483, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI62422571, Length=464, Percent_Identity=34.9137931034483, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI4503377, Length=464, Percent_Identity=34.4827586206897, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI4503379, Length=462, Percent_Identity=33.1168831168831, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI190194363, Length=464, Percent_Identity=32.9741379310345, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI19923821, Length=462, Percent_Identity=34.4155844155844, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI87082175, Length=467, Percent_Identity=40.0428265524625, Blast_Score=328, Evalue=6e-91,
Organism=Escherichia coli, GI1786722, Length=476, Percent_Identity=29.8319327731092, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71989490, Length=466, Percent_Identity=36.0515021459227, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17539558, Length=465, Percent_Identity=34.8387096774194, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI86575075, Length=472, Percent_Identity=24.5762711864407, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322218, Length=400, Percent_Identity=29.75, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI221377917, Length=474, Percent_Identity=36.2869198312236, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI17137462, Length=461, Percent_Identity=35.1409978308026, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24644287, Length=310, Percent_Identity=36.4516129032258, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24644289, Length=233, Percent_Identity=36.0515021459227, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18859883, Length=427, Percent_Identity=26.6978922716628, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24642586, Length=397, Percent_Identity=23.6775818639798, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 51074; Mature: 50943

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTLIRGGTVVSATGRGAADVLVDGATIAAVLLPGSTLLGMDLAKTVDTVIEAHGKYVI
CCCEEEECCEEEEECCCCCHHEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
PGGIDAHTHMSMPFGGTTASDDFETGTRAAAWGGTTTIIDFAVQKFGERLQDSLDTWHEM
CCCCCCCCEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGQCAIDYSFHQIVGDVNDASLAALRRLTDEGITSYKMFMAYPGVFYSDDAQIVRAMQV
CCCCEEEECCHHHHHCCCCHHHHHHHHHHHHCCCHHEEHHHHCCCCEECCHHHHHHHHHH
GAATGLMTMMHAENGPAIDVLVAQLLAEGKTDPYYHGIARAWQLEEEATHRAIMLSNLTG
HHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCC
APLYVVHVSAKQAVAQLAAARDAGQNVYGETCPQYLYLSLEDNLGAPGFDGAKWVCSTPL
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCH
RAKHEHHQDEMWRALRTNDIQMVSTDHCPFCMKGQKDMGIGDFSKIPNGIGSIEHRMDLL
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCCCCCHHHCCCHHHHHHHHHHHH
YQGVVDGRISVERWVEITSTTPARMFGLYGRKGVIAPGADADIVVYDPNGHTSIGLGKTH
HHHHCCCCEEHHHEEEECCCCHHHHHHCCCCCCEECCCCCCCEEEECCCCCCEECCCCEE
HMNMDHSAWEGYEIDGHVDTVLSRGKVIVDGDEYLGSKGDGVFLRRDLCQYLI
ECCCCCCCCCCEECCCHHHHHHHCCEEEECCHHHCCCCCCCEEHHHHHHHHCC
>Mature Secondary Structure 
ATTLIRGGTVVSATGRGAADVLVDGATIAAVLLPGSTLLGMDLAKTVDTVIEAHGKYVI
CCEEEECCEEEEECCCCCHHEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
PGGIDAHTHMSMPFGGTTASDDFETGTRAAAWGGTTTIIDFAVQKFGERLQDSLDTWHEM
CCCCCCCCEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGQCAIDYSFHQIVGDVNDASLAALRRLTDEGITSYKMFMAYPGVFYSDDAQIVRAMQV
CCCCEEEECCHHHHHCCCCHHHHHHHHHHHHCCCHHEEHHHHCCCCEECCHHHHHHHHHH
GAATGLMTMMHAENGPAIDVLVAQLLAEGKTDPYYHGIARAWQLEEEATHRAIMLSNLTG
HHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCC
APLYVVHVSAKQAVAQLAAARDAGQNVYGETCPQYLYLSLEDNLGAPGFDGAKWVCSTPL
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCH
RAKHEHHQDEMWRALRTNDIQMVSTDHCPFCMKGQKDMGIGDFSKIPNGIGSIEHRMDLL
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCCCCCHHHCCCHHHHHHHHHHHH
YQGVVDGRISVERWVEITSTTPARMFGLYGRKGVIAPGADADIVVYDPNGHTSIGLGKTH
HHHHCCCCEEHHHEEEECCCCHHHHHHCCCCCCEECCCCCCCEEEECCCCCCEECCCCEE
HMNMDHSAWEGYEIDGHVDTVLSRGKVIVDGDEYLGSKGDGVFLRRDLCQYLI
ECCCCCCCCCCEECCCHHHHHHHCCEEEECCHHHCCCCCCCEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]