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The map label for this gene is zwf [H]

Identifier: 169629845

GI number: 169629845

Start: 2809321

End: 2810871

Strand: Direct

Name: zwf [H]

Synonym: MAB_2761

Alternate gene names: 169629845

Gene position: 2809321-2810871 (Clockwise)

Preceding gene: 169629844

Following gene: 169629846

Centisome position: 55.44

GC content: 64.15

Gene sequence:

>1551_bases
ATGACCGAGGTTCTTCCCCCCGATAGCTCGTTGACGGCAAATCCGTTGCGGGACAAACGTGACAAGCGCTTGCCCCGCAT
CGCGGGCCCTTGCTCGCTGGTGATCTTCGGCGTCACCGGCGATCTGGCGCGCAAGAAGTTGATGCCGGCGATTTACGACC
TGGCCAATCGGGGGCTGCTGCCGCCGTCGTTCGCGTTGGTCGGGTTCGCCCGCCGGGATTGGGCCAACGAGGATTTCGGG
CAGATCGTGCTCGATGCTGTCAAGGCACACTCACGCACGCCGTTTCGTCAGCATGTGTGGGATCGCCTTGCCGAGGGAAT
CCGGTTCGTGCAGGGCAGTTTCGATGACGACGCGGCCTTCGAGCAGCTCAAGAAGACGCTGCAGACCCTCGATGAGGAAC
GTGGCACCGGCGGCAATCACGGTTTCTATCTGTCGATTCCGCCGAATGCCTTCCCCACCGTCTGCGAGCAGCTGTCCAAA
TCGGGCCTGGCGCAGCCCGTGGACGGCGCGTGGCGGCGCGTGGTGATCGAGAAGCCCTTCGGCCACGATCTGGCCAGCGC
CCGCGAGCTCAATGCGGTGGTCAACGAGGTTTTCCCCGAGGAGTCGGTCTTCCGCATCGACCACTACCTCGGCAAGGAGA
CGGTGCAGAACATCCTGGCGTTGCGGTTCGCCAACCAACTGTTTGACCCCATCTGGAACGCGCACTTCGTCGACCATGTG
CAGATCACCATGGCCGAGGACATCGGTTTGGGAGGCCGCGCAGGATATTACGACGGCATCGGGGCGGCGCGCGATGTCAT
CCAGAACCATCTGCTGCAGCTGCTGGCCTTCACCGCGATGGAGGAGCCCATCAACTTCTCCCCCGCCGAGTTGCAGGCCG
AGAAGATCAAGGTGCTCTCGGCAACCCGCCTGGCCGAGCCGTTGGCCGAAACCACGGCCCGTGGCCAGTATGGTCCCGGC
TGGCAGGGCAGCCAGCAGGTGCCCGGCCTGCTGGAGGAGGAAGGTTTCTCCAAAACCTCGACCACCGAGACATTCGCGGC
CATCACCCTGGAGGTGGACAGCCGGCGCTGGGCCGGGGTCCCGTTCTACCTGCGTACCGGAAAACGCTTGGGCCGCAGGG
TTACCGAGATCGCACTGGTGTTCAAGAGAGCACCGCACCTGCCCTTCGACTCCACCATGACCGAGGAACTCGGAGCCAAC
GCACTGGTGATCCGGGTGCAGCCCGACGAGGGCGTCACACTGCGGTTCGGATCCAAGGTGCCCGGAAGCGCCATGGAAGT
ACGCGATGTCAACATGGACTTCTCCTACGAGCAGGCCTTCACCGAGGAATCACCGGAGGCCTACGAACGGCTGATCCTCG
ACGTGTTGCTGGGCGAGCCGTCACTGTTCCCGGTGAACGCCGAGGTCGAATTGTCTTGGCGGATCCTCGATCCCGCCCTG
GACTTCTGGGCCTCCCAAGGCCGGCCGGACACCTACGAGTCGGGAACCTGGGGACCGCAATCGGCGGTGGAAATGCTGGC
CCGCAGCGGCCGGGAATGGAGGCGGCCATGA

Upstream 100 bases:

>100_bases
TTGCCTGGAACGAGCTCATCGACGCCACCCAAGCCCAACTCGACGCGGTATCCACCCAGGACTGAGCGTGGATGACGGTC
TTCACACGAAAGGCTCATCC

Downstream 100 bases:

>100_bases
TCATCGATCTGCCCAACACCACCACCAACGACGTCAACAAAAAGCTCGTCGAACTACGCGAGACCGGCGGAGCGGTCACC
ATGGCCCGCGTGCTGACCCT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGDLARKKLMPAIYDLANRGLLPPSFALVGFARRDWANEDFG
QIVLDAVKAHSRTPFRQHVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGGNHGFYLSIPPNAFPTVCEQLSK
SGLAQPVDGAWRRVVIEKPFGHDLASARELNAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHV
QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAELQAEKIKVLSATRLAEPLAETTARGQYGPG
WQGSQQVPGLLEEEGFSKTSTTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFDSTMTEELGAN
ALVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYEQAFTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPAL
DFWASQGRPDTYESGTWGPQSAVEMLARSGREWRRP

Sequences:

>Translated_516_residues
MTEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGDLARKKLMPAIYDLANRGLLPPSFALVGFARRDWANEDFG
QIVLDAVKAHSRTPFRQHVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGGNHGFYLSIPPNAFPTVCEQLSK
SGLAQPVDGAWRRVVIEKPFGHDLASARELNAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHV
QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAELQAEKIKVLSATRLAEPLAETTARGQYGPG
WQGSQQVPGLLEEEGFSKTSTTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFDSTMTEELGAN
ALVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYEQAFTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPAL
DFWASQGRPDTYESGTWGPQSAVEMLARSGREWRRP
>Mature_515_residues
TEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGDLARKKLMPAIYDLANRGLLPPSFALVGFARRDWANEDFGQ
IVLDAVKAHSRTPFRQHVWDRLAEGIRFVQGSFDDDAAFEQLKKTLQTLDEERGTGGNHGFYLSIPPNAFPTVCEQLSKS
GLAQPVDGAWRRVVIEKPFGHDLASARELNAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHVQ
ITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAELQAEKIKVLSATRLAEPLAETTARGQYGPGW
QGSQQVPGLLEEEGFSKTSTTETFAAITLEVDSRRWAGVPFYLRTGKRLGRRVTEIALVFKRAPHLPFDSTMTEELGANA
LVIRVQPDEGVTLRFGSKVPGSAMEVRDVNMDFSYEQAFTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPALD
FWASQGRPDTYESGTWGPQSAVEMLARSGREWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=37.319587628866, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=37.319587628866, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI52145310, Length=367, Percent_Identity=35.149863760218, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1788158, Length=497, Percent_Identity=42.4547283702213, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17538218, Length=516, Percent_Identity=35.4651162790698, Blast_Score=328, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=38.0165289256198, Blast_Score=320, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=36.6108786610879, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=36.6108786610879, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI221513548, Length=487, Percent_Identity=28.7474332648871, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57495; Mature: 57363

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGDLARKKLMPAIYDLANRGLL
CCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCC
PPSFALVGFARRDWANEDFGQIVLDAVKAHSRTPFRQHVWDRLAEGIRFVQGSFDDDAAF
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
EQLKKTLQTLDEERGTGGNHGFYLSIPPNAFPTVCEQLSKSGLAQPVDGAWRRVVIEKPF
HHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCHHEEEEEECCC
GHDLASARELNAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHE
QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAELQAEKIKVLS
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
ATRLAEPLAETTARGQYGPGWQGSQQVPGLLEEEGFSKTSTTETFAAITLEVDSRRWAGV
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEEEECCCCCCCC
PFYLRTGKRLGRRVTEIALVFKRAPHLPFDSTMTEELGANALVIRVQPDEGVTLRFGSKV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEEECCCCEEEEECCCC
PGSAMEVRDVNMDFSYEQAFTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPAL
CCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEEEEEHHHHH
DFWASQGRPDTYESGTWGPQSAVEMLARSGREWRRP
HHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEVLPPDSSLTANPLRDKRDKRLPRIAGPCSLVIFGVTGDLARKKLMPAIYDLANRGLL
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCC
PPSFALVGFARRDWANEDFGQIVLDAVKAHSRTPFRQHVWDRLAEGIRFVQGSFDDDAAF
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
EQLKKTLQTLDEERGTGGNHGFYLSIPPNAFPTVCEQLSKSGLAQPVDGAWRRVVIEKPF
HHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCHHEEEEEECCC
GHDLASARELNAVVNEVFPEESVFRIDHYLGKETVQNILALRFANQLFDPIWNAHFVDHV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHE
QITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLAFTAMEEPINFSPAELQAEKIKVLS
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
ATRLAEPLAETTARGQYGPGWQGSQQVPGLLEEEGFSKTSTTETFAAITLEVDSRRWAGV
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEEEECCCCCCCC
PFYLRTGKRLGRRVTEIALVFKRAPHLPFDSTMTEELGANALVIRVQPDEGVTLRFGSKV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEEECCCCEEEEECCCC
PGSAMEVRDVNMDFSYEQAFTEESPEAYERLILDVLLGEPSLFPVNAEVELSWRILDPAL
CCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEEEEEHHHHH
DFWASQGRPDTYESGTWGPQSAVEMLARSGREWRRP
HHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]