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The map label for this gene is hemH

Identifier: 169629805

GI number: 169629805

Start: 2769628

End: 2770650

Strand: Reverse

Name: hemH

Synonym: MAB_2721c

Alternate gene names: 169629805

Gene position: 2770650-2769628 (Counterclockwise)

Preceding gene: 169629806

Following gene: 169629803

Centisome position: 54.68

GC content: 64.52

Gene sequence:

>1023_bases
GTGTTATTTGACGCGGTGCTGCTGCTGTCCTTCGGGGGTCCCGAGGGGCCGCAGGAGGTTCGGCCGTTCCTGGAGAATGT
GACGCGTGGCCGCGGCATTCCACCCGAGCGTCTCGACGAGGTAGCCGAGCACTACTTCCATTTCGGTGGCGTGTCTCCGA
TCAACGGCATCAACCGGGCGCTTGTCGATCAGATCTCACGGCAGCTGGAGTCGGCCGGGCACCCCTTGCCGGTGTTCTTC
GGCAACCGCAATTGGCATCCCATGGTGGAGGACACGGTTGCTGAGATGCGGGACAAGGGAATTCGGCGAGCAGCTGTTTT
CACCACCTCGGCGTGGGGCGGGTATTCGGGCTGCAAGCAGTACGTGGAGGACATTGCCCGGGCCCGTGCAGCCGTCGGTG
ACGGCGCGCCGGAGCTGGTCAAACTTCGTCAGTACTTCGACCACCCGTCCTTGGTGCAGCTGTACGCCGAGGCGGTGTCC
GCCGCGATGTCGAGCCTGCGCGGTGAGGCGCGATTGGTGTTCACGGCTCATTCGATTCCCCTTGCGGCGGACCGGCGCCA
CGGCCCCGAGCTCTACAGCCGGCAAGTGCATTACCTGGCGCAATTGGTTGCCGCCGCGACTGGTCACCAGGACTACGACG
TGGTGTGGCAATCGCGTTCGGGCCCGCCTCAGGTTCCGTGGCTTGAGCCCGATATTGTCGATCACCTTGCGGCGCTGAAA
GATCGAGGGATTCGATCGGTGGCAGTGGCGCCGATCGGGTTTGTGTCCGACCACCTGGAGGTGGTCTGGGACCTGGACAA
CGAGGCTCGTGAATACGCGCAAGAGCACGATATCGAGCTCGTCCGGGCGGCCACGCCCGGTGCGGATGAACGATTCGCGC
GCCTTGCGGTCGACTTGATCACTGAGGTCGTTGAGGGACGGCCGGCGTTACGGGCCAGTGGGGTGAACCCGGTCCCGGGG
TACGGATTCAGTGTGAACGGCGCATTGTGCTCGCCCCTGTGCTGCGGTGTGCAGGAGGACTAG

Upstream 100 bases:

>100_bases
GACGGTGTGCGCGCTGCTGTCCGACTGGTTGCCCGCCACCACCGGCGACATCATTTTCGCCGACGGCGGCGCTCACACTC
AGCTGCTCTGACGGACTGCT

Downstream 100 bases:

>100_bases
CGCGCGGCCCCGATAATGGCGCTGGCCGCAGCCATCCGTGCTTCGCGCACCACTAAGATCAGCGGCCGCAAAGCGTCGGA
CACCGCACCATCATCGAGTG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLFDAVLLLSFGGPEGPQEVRPFLENVTRGRGIPPERLDEVAEHYFHFGGVSPINGINRALVDQISRQLESAGHPLPVFF
GNRNWHPMVEDTVAEMRDKGIRRAAVFTTSAWGGYSGCKQYVEDIARARAAVGDGAPELVKLRQYFDHPSLVQLYAEAVS
AAMSSLRGEARLVFTAHSIPLAADRRHGPELYSRQVHYLAQLVAAATGHQDYDVVWQSRSGPPQVPWLEPDIVDHLAALK
DRGIRSVAVAPIGFVSDHLEVVWDLDNEAREYAQEHDIELVRAATPGADERFARLAVDLITEVVEGRPALRASGVNPVPG
YGFSVNGALCSPLCCGVQED

Sequences:

>Translated_340_residues
MLFDAVLLLSFGGPEGPQEVRPFLENVTRGRGIPPERLDEVAEHYFHFGGVSPINGINRALVDQISRQLESAGHPLPVFF
GNRNWHPMVEDTVAEMRDKGIRRAAVFTTSAWGGYSGCKQYVEDIARARAAVGDGAPELVKLRQYFDHPSLVQLYAEAVS
AAMSSLRGEARLVFTAHSIPLAADRRHGPELYSRQVHYLAQLVAAATGHQDYDVVWQSRSGPPQVPWLEPDIVDHLAALK
DRGIRSVAVAPIGFVSDHLEVVWDLDNEAREYAQEHDIELVRAATPGADERFARLAVDLITEVVEGRPALRASGVNPVPG
YGFSVNGALCSPLCCGVQED
>Mature_340_residues
MLFDAVLLLSFGGPEGPQEVRPFLENVTRGRGIPPERLDEVAEHYFHFGGVSPINGINRALVDQISRQLESAGHPLPVFF
GNRNWHPMVEDTVAEMRDKGIRRAAVFTTSAWGGYSGCKQYVEDIARARAAVGDGAPELVKLRQYFDHPSLVQLYAEAVS
AAMSSLRGEARLVFTAHSIPLAADRRHGPELYSRQVHYLAQLVAAATGHQDYDVVWQSRSGPPQVPWLEPDIVDHLAALK
DRGIRSVAVAPIGFVSDHLEVVWDLDNEAREYAQEHDIELVRAATPGADERFARLAVDLITEVVEGRPALRASGVNPVPG
YGFSVNGALCSPLCCGVQED

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=354, Percent_Identity=25.9887005649718, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI60499025, Length=354, Percent_Identity=25.9887005649718, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324750, Length=287, Percent_Identity=22.2996515679443, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17864156, Length=358, Percent_Identity=26.8156424581006, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552018, Length=196, Percent_Identity=31.1224489795918, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_MYCA9 (B1MC29)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703454.1
- ProteinModelPortal:   B1MC29
- SMR:   B1MC29
- EnsemblBacteria:   EBMYCT00000006147
- GeneID:   5965229
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2721c
- GeneTree:   EBGT00050000016242
- HOGENOM:   HBG697135
- OMA:   GNRNWHP
- ProtClustDB:   PRK00035
- BioCyc:   MABS561007:MAB_2721C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 37247; Mature: 37247

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFDAVLLLSFGGPEGPQEVRPFLENVTRGRGIPPERLDEVAEHYFHFGGVSPINGINRA
CHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
LVDQISRQLESAGHPLPVFFGNRNWHPMVEDTVAEMRDKGIRRAAVFTTSAWGGYSGCKQ
HHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHEEEECCCCCHHHHHH
YVEDIARARAAVGDGAPELVKLRQYFDHPSLVQLYAEAVSAAMSSLRGEARLVFTAHSIP
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
LAADRRHGPELYSRQVHYLAQLVAAATGHQDYDVVWQSRSGPPQVPWLEPDIVDHLAALK
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCHHHHHHHHHHH
DRGIRSVAVAPIGFVSDHLEVVWDLDNEAREYAQEHDIELVRAATPGADERFARLAVDLI
HCCCCEEEECHHHHHHHHHHHEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
TEVVEGRPALRASGVNPVPGYGFSVNGALCSPLCCGVQED
HHHHCCCCCHHCCCCCCCCCCCEECCCHHHHHHHCCCCCC
>Mature Secondary Structure
MLFDAVLLLSFGGPEGPQEVRPFLENVTRGRGIPPERLDEVAEHYFHFGGVSPINGINRA
CHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
LVDQISRQLESAGHPLPVFFGNRNWHPMVEDTVAEMRDKGIRRAAVFTTSAWGGYSGCKQ
HHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHEEEECCCCCHHHHHH
YVEDIARARAAVGDGAPELVKLRQYFDHPSLVQLYAEAVSAAMSSLRGEARLVFTAHSIP
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
LAADRRHGPELYSRQVHYLAQLVAAATGHQDYDVVWQSRSGPPQVPWLEPDIVDHLAALK
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCHHHHHHHHHHH
DRGIRSVAVAPIGFVSDHLEVVWDLDNEAREYAQEHDIELVRAATPGADERFARLAVDLI
HCCCCEEEECHHHHHHHHHHHEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
TEVVEGRPALRASGVNPVPGYGFSVNGALCSPLCCGVQED
HHHHCCCCCHHCCCCCCCCCCCEECCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA