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The map label for this gene is proY [H]

Identifier: 169629621

GI number: 169629621

Start: 2581810

End: 2583165

Strand: Direct

Name: proY [H]

Synonym: MAB_2535

Alternate gene names: 169629621

Gene position: 2581810-2583165 (Clockwise)

Preceding gene: 169629619

Following gene: 169629622

Centisome position: 50.95

GC content: 62.09

Gene sequence:

>1356_bases
GTGAACAGTGCCCCCGACACGCTCACCCGGGGCCTCTCCGCTCGCCATATCCGTTTTATCGCGCTGGGATCAGCTATCGG
GACAGGCCTGTTCTACGGTTCGGCGGAGGCGATCAGGCAAGCGGGCCCGTCGGTGCTGGTGGCCTACCTGCTGGGCGGGG
CGGTGATCTACATCGTGCTGCGATCGCTGGGGGAGATGGCGGTACGCCGCCCGGTGGCAGGATCGTTCGGTGAGTACGCC
ACGCAGTACCTAGGGCCGTTGGCAGGCTTTCTCACCGGTTGGACGTACGCGCTGGAGATGGTCGTCGTCTGCCTGGCCGA
TGTGACCGCATTCGGGGTCTACATGGGTTTCTGGTTCCCCGGAGTGCCGCGCTGGGTTTGGGTGTTCTCGATCATCTTCT
TCATCGGCGCGATAAATCTGCTCAGCGTCAAGGTTTTCGGGGAGGTCGAATTCTGGCTCAGCCTGGTGAAGGTTCTTGCC
ATTGTCGCGATGATCGCTGGTGGCATAGCAATCCTCGTGTGGGGCAGCTCAACTGGGCGCGAAGAGCAGCGCGGCATCGC
CAACTTGTGGAATGACGGGGGCTTCTTCCCTCATGGACTGGCCGGGTTCGTGGGCAGCTTCATGATCGTGATGTTCGCGT
TCGGTGGTACCGAGATCATCGGGATCACGGCGGGCGAGGCGAAGGATCCGGCGCGGACGATTCCACGGGCCGTCAACACC
GTCCCCGTGCGCATCATCTTGTTCTATGTCCTCACCCTCGCTGTGATCATGGCTCTCTACCCCTGGCGGTCGATCGATTC
GAACAGCAGCCCGTTTGTGCAGATATTTGAAGGGCTGGGATTCACATCGGCGGCGACCGTGCTGAACCTTGTTGTGGTGA
CTGCCGCGCTGTCGGCCATCAACAGCGACATCTTCGCCGCTGGCCGGATGATTTACGGCATGGCCCAGCGGGGTCAGGCT
CCGGCGGTCATGCGGCGGGTATCGCGTAATGGTGTGCCGTGGATGACGGTGGTAGTCATGACGGTCGCGCTGCTGGTAGG
CGTGGTGCTGAACTATGCGATCGAAGAGCGTGTCTTCGTCATCATCGCGTCCGTCGCCACCTTCGCGACGATCTTTGTTT
GGCTGATGATCCTTCTGGCCCACTTTAGGTTCCGCGCCCAACAGCACCACGGCGAGGCATCGGTGGCGGACTTCCCGGTG
CCGGGCTGGCCGTACCTGCAGGTGTTCGCTACGGGGTTCCTGATGTTCGTTGTGCTCTTACTCGGCTTCGGTGCGGACAC
GCGTGTCGCGCTCATCGTCGGAGCAGCGTGGCTGCTGGTGCTCGTGGGTGCTTTCGCGATGTCCAGAAGACGGTAG

Upstream 100 bases:

>100_bases
GCTTCCGGTAGTGTCCGCTACCAGTGGAGCCCTTACACTCAGCTAATTTCGCGGCGATACCGCCCACCCGCTGCGTAGTT
ATGCGATAGGAGCCCCGCCC

Downstream 100 bases:

>100_bases
ATTGCCGGCGCTCCAGCCTGCTGGGTCTTGCGCGTTTCGGGGCTGTCCGGCCCGGGTACTCGGCGTGACATTCGACAGCC
AATGGGCGATACGAGGGAGC

Product: amino acid transporter

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNSAPDTLTRGLSARHIRFIALGSAIGTGLFYGSAEAIRQAGPSVLVAYLLGGAVIYIVLRSLGEMAVRRPVAGSFGEYA
TQYLGPLAGFLTGWTYALEMVVVCLADVTAFGVYMGFWFPGVPRWVWVFSIIFFIGAINLLSVKVFGEVEFWLSLVKVLA
IVAMIAGGIAILVWGSSTGREEQRGIANLWNDGGFFPHGLAGFVGSFMIVMFAFGGTEIIGITAGEAKDPARTIPRAVNT
VPVRIILFYVLTLAVIMALYPWRSIDSNSSPFVQIFEGLGFTSAATVLNLVVVTAALSAINSDIFAAGRMIYGMAQRGQA
PAVMRRVSRNGVPWMTVVVMTVALLVGVVLNYAIEERVFVIIASVATFATIFVWLMILLAHFRFRAQQHHGEASVADFPV
PGWPYLQVFATGFLMFVVLLLGFGADTRVALIVGAAWLLVLVGAFAMSRRR

Sequences:

>Translated_451_residues
MNSAPDTLTRGLSARHIRFIALGSAIGTGLFYGSAEAIRQAGPSVLVAYLLGGAVIYIVLRSLGEMAVRRPVAGSFGEYA
TQYLGPLAGFLTGWTYALEMVVVCLADVTAFGVYMGFWFPGVPRWVWVFSIIFFIGAINLLSVKVFGEVEFWLSLVKVLA
IVAMIAGGIAILVWGSSTGREEQRGIANLWNDGGFFPHGLAGFVGSFMIVMFAFGGTEIIGITAGEAKDPARTIPRAVNT
VPVRIILFYVLTLAVIMALYPWRSIDSNSSPFVQIFEGLGFTSAATVLNLVVVTAALSAINSDIFAAGRMIYGMAQRGQA
PAVMRRVSRNGVPWMTVVVMTVALLVGVVLNYAIEERVFVIIASVATFATIFVWLMILLAHFRFRAQQHHGEASVADFPV
PGWPYLQVFATGFLMFVVLLLGFGADTRVALIVGAAWLLVLVGAFAMSRRR
>Mature_451_residues
MNSAPDTLTRGLSARHIRFIALGSAIGTGLFYGSAEAIRQAGPSVLVAYLLGGAVIYIVLRSLGEMAVRRPVAGSFGEYA
TQYLGPLAGFLTGWTYALEMVVVCLADVTAFGVYMGFWFPGVPRWVWVFSIIFFIGAINLLSVKVFGEVEFWLSLVKVLA
IVAMIAGGIAILVWGSSTGREEQRGIANLWNDGGFFPHGLAGFVGSFMIVMFAFGGTEIIGITAGEAKDPARTIPRAVNT
VPVRIILFYVLTLAVIMALYPWRSIDSNSSPFVQIFEGLGFTSAATVLNLVVVTAALSAINSDIFAAGRMIYGMAQRGQA
PAVMRRVSRNGVPWMTVVVMTVALLVGVVLNYAIEERVFVIIASVATFATIFVWLMILLAHFRFRAQQHHGEASVADFPV
PGWPYLQVFATGFLMFVVLLLGFGADTRVALIVGAAWLLVLVGAFAMSRRR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=332, Percent_Identity=25.6024096385542, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI110347453, Length=328, Percent_Identity=23.1707317073171, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI258614005, Length=351, Percent_Identity=24.5014245014245, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI258645169, Length=400, Percent_Identity=23, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI258614003, Length=351, Percent_Identity=24.5014245014245, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4507047, Length=349, Percent_Identity=24.3553008595989, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI114326544, Length=432, Percent_Identity=22.6851851851852, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI114326550, Length=432, Percent_Identity=22.6851851851852, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786602, Length=449, Percent_Identity=55.011135857461, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1786789, Length=450, Percent_Identity=43.3333333333333, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1786302, Length=439, Percent_Identity=43.9635535307517, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1790653, Length=454, Percent_Identity=41.1894273127753, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI48994972, Length=456, Percent_Identity=40.7894736842105, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=37.9901960784314, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87081708, Length=459, Percent_Identity=37.2549019607843, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1789017, Length=433, Percent_Identity=34.8729792147806, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788480, Length=431, Percent_Identity=37.3549883990719, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI87081869, Length=193, Percent_Identity=27.4611398963731, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082023, Length=278, Percent_Identity=24.1007194244604, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI2367353, Length=471, Percent_Identity=23.3545647558386, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=416, Percent_Identity=24.7596153846154, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=371, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532491, Length=359, Percent_Identity=23.1197771587744, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=441, Percent_Identity=34.6938775510204, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320772, Length=439, Percent_Identity=31.4350797266515, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=431, Percent_Identity=32.4825986078886, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=449, Percent_Identity=32.5167037861915, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=445, Percent_Identity=29.6629213483146, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=399, Percent_Identity=31.5789473684211, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=434, Percent_Identity=29.2626728110599, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=396, Percent_Identity=30.050505050505, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319824, Length=395, Percent_Identity=28.3544303797468, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=400, Percent_Identity=26, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=395, Percent_Identity=27.3417721518987, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=400, Percent_Identity=27.5, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=399, Percent_Identity=26.8170426065163, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=399, Percent_Identity=28.8220551378446, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=29.5454545454545, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321053, Length=430, Percent_Identity=25.5813953488372, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=443, Percent_Identity=24.3792325056433, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=24.7983870967742, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221512776, Length=339, Percent_Identity=24.7787610619469, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666159, Length=339, Percent_Identity=24.7787610619469, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667468, Length=350, Percent_Identity=22.8571428571429, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221331183, Length=351, Percent_Identity=23.6467236467236, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17647653, Length=351, Percent_Identity=23.6467236467236, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24664379, Length=351, Percent_Identity=23.6467236467236, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48689; Mature: 48689

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAPDTLTRGLSARHIRFIALGSAIGTGLFYGSAEAIRQAGPSVLVAYLLGGAVIYIVL
CCCCCHHHHHCCCHHHHHEEEEHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHH
RSLGEMAVRRPVAGSFGEYATQYLGPLAGFLTGWTYALEMVVVCLADVTAFGVYMGFWFP
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVPRWVWVFSIIFFIGAINLLSVKVFGEVEFWLSLVKVLAIVAMIAGGIAILVWGSSTGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCC
EEQRGIANLWNDGGFFPHGLAGFVGSFMIVMFAFGGTEIIGITAGEAKDPARTIPRAVNT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHH
VPVRIILFYVLTLAVIMALYPWRSIDSNSSPFVQIFEGLGFTSAATVLNLVVVTAALSAI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
NSDIFAAGRMIYGMAQRGQAPAVMRRVSRNGVPWMTVVVMTVALLVGVVLNYAIEERVFV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIASVATFATIFVWLMILLAHFRFRAQQHHGEASVADFPVPGWPYLQVFATGFLMFVVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LGFGADTRVALIVGAAWLLVLVGAFAMSRRR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSAPDTLTRGLSARHIRFIALGSAIGTGLFYGSAEAIRQAGPSVLVAYLLGGAVIYIVL
CCCCCHHHHHCCCHHHHHEEEEHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHH
RSLGEMAVRRPVAGSFGEYATQYLGPLAGFLTGWTYALEMVVVCLADVTAFGVYMGFWFP
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVPRWVWVFSIIFFIGAINLLSVKVFGEVEFWLSLVKVLAIVAMIAGGIAILVWGSSTGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCC
EEQRGIANLWNDGGFFPHGLAGFVGSFMIVMFAFGGTEIIGITAGEAKDPARTIPRAVNT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHH
VPVRIILFYVLTLAVIMALYPWRSIDSNSSPFVQIFEGLGFTSAATVLNLVVVTAALSAI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
NSDIFAAGRMIYGMAQRGQAPAVMRRVSRNGVPWMTVVVMTVALLVGVVLNYAIEERVFV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIASVATFATIFVWLMILLAHFRFRAQQHHGEASVADFPVPGWPYLQVFATGFLMFVVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LGFGADTRVALIVGAAWLLVLVGAFAMSRRR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]