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The map label for this gene is acdA [H]

Identifier: 169629582

GI number: 169629582

Start: 2551008

End: 2552156

Strand: Direct

Name: acdA [H]

Synonym: MAB_2496

Alternate gene names: 169629582

Gene position: 2551008-2552156 (Clockwise)

Preceding gene: 169629581

Following gene: 169629586

Centisome position: 50.34

GC content: 63.19

Gene sequence:

>1149_bases
ATGGATTTCAGCCTCACCGACGAACAACAACTCCTGAAGCACTCGATATCGGATTTTCTGTCTAATCGGTACGCCTTGAA
CACCAGCCGGCGCGCGGCGCGCTCGGATATCAGGTGGCAGCCGCAGGTGTGGAAGTCCTTCGCCGAGGAGCTCGGCATCC
TCGCCGCGCCGCTGCCCGAGGACCGCGGTGGCCTCGGTGGTGGCGCCGAGGAAGTACTTGTCATTTGCGAGGTGCTCGGA
CGCCATCTCGTCGTCGAGCCGTTCATCGGCACGGTGGTGCTCGGCGGCGGGCTGCTGCGGCGGTCGAACGCCGAAGTGGC
CGGCGACCTTATCGGAGGCATTGCCTCCGGTGACGTCGTGACGGGATTCGCGGCCCTTGAACCCACTTCCGGCCAGTCGT
TCCACTCGGTGCAGACCACCGCCCGCCGCGATGGGCCGGATTGGGTGCTCGACGGTGAGAAAATCGTGGTGAGCGACGCG
CCTCTGGCCACCCATGTGATTGTCAGCGCACGAACCTCCGGCGAGGTTGCCGATACCTCCGGCCTCACGCTGTTCGTCGT
GCCGTTCGATCCGGCCGCCCCAGCTCAGGGAATCGAGGCGCATCATTACCGGACGATTGATGACCACCATGCCAGCGACT
TGGTGATATCTGGACTGCGGGTGCCGGATTCGGCACGGATTTCGGAAGTGGATCAAGCATGGCCACTCATTGAGGCCGCG
CTCGATGAAGCCACGGCTGCGACTGTGGCCGAGGCAGTTGGCATGTTGCGCAAGGTGCTGGCCGATACGGTCGAATACAC
CAAGCAGCGCCAGCAATTCGGCGTAGCGATCTCCAATTTCCAAGCGTTGCAACATCGTATGGTGGACATGCATATCGAGG
TTGAGCAGTCGGTCGCGGCTTCCTATCTGGCCTCGCTCAATCTCGATGGACCTCGCCGCGCCCGTGCTGTGTCGGCGGCC
AAGGCAACGATCGCGCGTGCCGCACGTCTGGTGGGGCAGGAGGCCGTACAGTTGCACGGCGGCATGGGCATGACCGAGGA
ACTGGCCATCGGCCATTATTTCAAGCGTCTCACCGTCATTGAGTCAGAGTTCGGCAACCGCGACTTTCACACCGCACGGT
ACGGGATCGCGCGCAGCACCCAGGGCTAG

Upstream 100 bases:

>100_bases
CGATCGCGCCGGGTCGATCTATGCCGGTTCCAACGAGATTCAACGCAACATCCTCGCCAAGGCCCAGCTGGGTCTCTGAC
AGACAAGAGCGAATATCACC

Downstream 100 bases:

>100_bases
CCGACCAGGTTGATCACCAGGTTGATCGTGCACGCGATGATCACCGTGCCGTAGATATAACTGAAAAGGCAGTGCTTCAA
CACCACGTCGCGCAGGTGTG

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDFSLTDEQQLLKHSISDFLSNRYALNTSRRAARSDIRWQPQVWKSFAEELGILAAPLPEDRGGLGGGAEEVLVICEVLG
RHLVVEPFIGTVVLGGGLLRRSNAEVAGDLIGGIASGDVVTGFAALEPTSGQSFHSVQTTARRDGPDWVLDGEKIVVSDA
PLATHVIVSARTSGEVADTSGLTLFVVPFDPAAPAQGIEAHHYRTIDDHHASDLVISGLRVPDSARISEVDQAWPLIEAA
LDEATAATVAEAVGMLRKVLADTVEYTKQRQQFGVAISNFQALQHRMVDMHIEVEQSVAASYLASLNLDGPRRARAVSAA
KATIARAARLVGQEAVQLHGGMGMTEELAIGHYFKRLTVIESEFGNRDFHTARYGIARSTQG

Sequences:

>Translated_382_residues
MDFSLTDEQQLLKHSISDFLSNRYALNTSRRAARSDIRWQPQVWKSFAEELGILAAPLPEDRGGLGGGAEEVLVICEVLG
RHLVVEPFIGTVVLGGGLLRRSNAEVAGDLIGGIASGDVVTGFAALEPTSGQSFHSVQTTARRDGPDWVLDGEKIVVSDA
PLATHVIVSARTSGEVADTSGLTLFVVPFDPAAPAQGIEAHHYRTIDDHHASDLVISGLRVPDSARISEVDQAWPLIEAA
LDEATAATVAEAVGMLRKVLADTVEYTKQRQQFGVAISNFQALQHRMVDMHIEVEQSVAASYLASLNLDGPRRARAVSAA
KATIARAARLVGQEAVQLHGGMGMTEELAIGHYFKRLTVIESEFGNRDFHTARYGIARSTQG
>Mature_382_residues
MDFSLTDEQQLLKHSISDFLSNRYALNTSRRAARSDIRWQPQVWKSFAEELGILAAPLPEDRGGLGGGAEEVLVICEVLG
RHLVVEPFIGTVVLGGGLLRRSNAEVAGDLIGGIASGDVVTGFAALEPTSGQSFHSVQTTARRDGPDWVLDGEKIVVSDA
PLATHVIVSARTSGEVADTSGLTLFVVPFDPAAPAQGIEAHHYRTIDDHHASDLVISGLRVPDSARISEVDQAWPLIEAA
LDEATAATVAEAVGMLRKVLADTVEYTKQRQQFGVAISNFQALQHRMVDMHIEVEQSVAASYLASLNLDGPRRARAVSAA
KATIARAARLVGQEAVQLHGGMGMTEELAIGHYFKRLTVIESEFGNRDFHTARYGIARSTQG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=327, Percent_Identity=24.4648318042813, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4501857, Length=353, Percent_Identity=24.0793201133144, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI226958412, Length=392, Percent_Identity=22.9591836734694, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI76496475, Length=346, Percent_Identity=26.3005780346821, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4557235, Length=346, Percent_Identity=26.3005780346821, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226958414, Length=355, Percent_Identity=23.3802816901408, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4557231, Length=314, Percent_Identity=23.2484076433121, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI187960098, Length=314, Percent_Identity=23.2484076433121, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501859, Length=355, Percent_Identity=22.8169014084507, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI21361497, Length=316, Percent_Identity=24.3670886075949, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786223, Length=363, Percent_Identity=22.8650137741047, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081958, Length=361, Percent_Identity=23.8227146814404, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17534899, Length=361, Percent_Identity=23.5457063711911, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17569725, Length=368, Percent_Identity=22.2826086956522, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=353, Percent_Identity=23.2294617563739, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17508101, Length=343, Percent_Identity=22.4489795918367, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=329, Percent_Identity=24.9240121580547, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17551932, Length=321, Percent_Identity=24.2990654205607, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17505929, Length=246, Percent_Identity=27.2357723577236, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=324, Percent_Identity=24.0740740740741, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=372, Percent_Identity=21.505376344086, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71990804, Length=181, Percent_Identity=27.6243093922652, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17533517, Length=322, Percent_Identity=21.7391304347826, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71985192, Length=291, Percent_Identity=24.0549828178694, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982178, Length=286, Percent_Identity=23.7762237762238, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24660351, Length=361, Percent_Identity=25.7617728531856, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356377, Length=362, Percent_Identity=24.8618784530387, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24666513, Length=363, Percent_Identity=22.5895316804408, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21355753, Length=372, Percent_Identity=25, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI281363737, Length=363, Percent_Identity=24.7933884297521, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24646207, Length=362, Percent_Identity=24.0331491712707, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41034; Mature: 41034

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSLTDEQQLLKHSISDFLSNRYALNTSRRAARSDIRWQPQVWKSFAEELGILAAPLPE
CCCCCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHCCCCCHHHHHHHHHHCCCEECCCCC
DRGGLGGGAEEVLVICEVLGRHLVVEPFIGTVVLGGGLLRRSNAEVAGDLIGGIASGDVV
CCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHCCCHHCCCCCHHHHHHHCCCCCCCHH
TGFAALEPTSGQSFHSVQTTARRDGPDWVLDGEKIVVSDAPLATHVIVSARTSGEVADTS
EEEEEECCCCCCCHHHHHHHHHCCCCCEEECCCEEEEECCCCCEEEEEEECCCCCCCCCC
GLTLFVVPFDPAAPAQGIEAHHYRTIDDHHASDLVISGLRVPDSARISEVDQAWPLIEAA
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHH
LDEATAATVAEAVGMLRKVLADTVEYTKQRQQFGVAISNFQALQHRMVDMHIEVEQSVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHH
SYLASLNLDGPRRARAVSAAKATIARAARLVGQEAVQLHGGMGMTEELAIGHYFKRLTVI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ESEFGNRDFHTARYGIARSTQG
HHHCCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MDFSLTDEQQLLKHSISDFLSNRYALNTSRRAARSDIRWQPQVWKSFAEELGILAAPLPE
CCCCCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHCCCCCHHHHHHHHHHCCCEECCCCC
DRGGLGGGAEEVLVICEVLGRHLVVEPFIGTVVLGGGLLRRSNAEVAGDLIGGIASGDVV
CCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHCCCHHCCCCCHHHHHHHCCCCCCCHH
TGFAALEPTSGQSFHSVQTTARRDGPDWVLDGEKIVVSDAPLATHVIVSARTSGEVADTS
EEEEEECCCCCCCHHHHHHHHHCCCCCEEECCCEEEEECCCCCEEEEEEECCCCCCCCCC
GLTLFVVPFDPAAPAQGIEAHHYRTIDDHHASDLVISGLRVPDSARISEVDQAWPLIEAA
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHHHHH
LDEATAATVAEAVGMLRKVLADTVEYTKQRQQFGVAISNFQALQHRMVDMHIEVEQSVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHH
SYLASLNLDGPRRARAVSAAKATIARAARLVGQEAVQLHGGMGMTEELAIGHYFKRLTVI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ESEFGNRDFHTARYGIARSTQG
HHHCCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]