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The map label for this gene is ureC

Identifier: 169629511

GI number: 169629511

Start: 2481754

End: 2483487

Strand: Direct

Name: ureC

Synonym: MAB_2425

Alternate gene names: 169629511

Gene position: 2481754-2483487 (Clockwise)

Preceding gene: 169629510

Following gene: 169629512

Centisome position: 48.98

GC content: 64.13

Gene sequence:

>1734_bases
GTGACCAGGCTGACGCGGGAGCATTACGCGAAGCTTTACGGCCCGACGACAGGCGATCGCATCCGCCTGGCCGATACCGA
TCTGATCATCGAGATCACCGAAGACCGTTGCGGCGGACCTGGTTTGGCCGGTGAGGAGGCGGTCTTCGGTGGAGGCAAGG
TGTTACGGGAGTCGATGGGGCAGAGCCGCCTCACCCGTGCCGGCGGCGCTCCGGATACCGTTATCACCGGTGCGATCATC
ATCGACCACTGGGGAATCATTAAGGCCGACATCGGTATCCGCGACGGTCGTATCGTCGGTATCGGCAAGGCGGGAAACCC
GGACATCATGGACGGGGTGGACCCCGCCCTGATCGTGGGGCCGTCAACCGAGATCATCGCCGGTAACAACAGGATCGTGA
CTGCCGGCGGCATCGACTGTCACGTGCACTTCATCTGTCCACAGATCCTGCCGGAGGCGCTGAGTGGCGGCATCACCACG
ATGATCGGTGGCGGTACCGGGCCCGCCGAGGGTAGTAAGGCCACTACCGTCACACCGGGAGCTTGGCATCTGGGCCGGAT
GCTACAGGCGCTCGACGGCTGGCCCATGAACATTCTGATGCTCGGCAAGGGGAATACCGTCAATCCAGATGCCATGTGGG
AGCAATTGCGTGGCGGCGCAGCGGGTTTCAAACTGCACGAAGATTGGGGAACCACCCCGGCGGTGATCGACGCCTGCCTG
CGGGTAGCGGACGAGGCCGACGTGCAAGTCGCCTTGCACTCGGACACTCTCAACGAGACCGGATTTGTGGAAGGCACACT
GGCGGCGATCGGCGGGCGGGCGATCCACGCGTACCACACCGAGGGGGCCGGTGGCGGTCACGCGCCCGACATCATCACCG
TCGCCAGCCACCCGAATGTCATGCCCAGTTCCACGAACCCGACTCGCCCGCACACGGTGAACACCCTCGACGAGCATCTC
GACATGCTCATGGTTTGCCACCACCTCAACGCCGCAGTCCCGGAGGACCTGGCATTCGCGGAGAGCCGGATCCGGCCGTC
CACCATCGCGGCCGAGGATCTGCTGCACGATATCGGGGCGATCTCGATGATCGGGAGCGACAGCCAGGCCATGGGGCGCA
TCGGCGAGGTGGTGATGCGAACATGGCAGACCGCGCATGTGATGAAGAAGCGCCGCGGCGCGCTGCCGGGAGATCCATCC
GGGCCCAACGGAAACGACAACAACCGGGTACGCCGGTACGTCGCGAAATACACGATCTGCCCGGCGATCACCCACGGCAT
CGATCACGAGATCGGCTCGGTGGAAGTGGGCAAGCTCGCCGATCTGGTGTTGTGGGAACCGGCGTTTTTCGGGGTGCGGC
CGCATGCGGTCATCAAGGGCGGAGGCATCGTCTGGGCGGCAATGGGCGATGCCAACGCGTCCATTCCCACGCCGCAGCCG
GTGTTCCCGCGCCCGATGTTCAGTGCCATGCATGCCGTCGCGGCGGGGCTGGCGGTGCATTTCGTATCGCCCACGGCCAT
CGAAGATGACCTGGCGGCCCGACTGGCGTTGCGGCGCAGACTGGTCCCAACTCGTGATGTTCGCAACCGTGGCAAGGCGG
ATCTGCCACTCAACGATGCCATGCCCGATATCCGGGTAGACCCCGATACCTTCACCGTGCGTATCGACGGCGAGGTATGG
GAAGAGCATCCCGCTGCGGAATTACCTATGGCGCAACGATATTTCCTGTTCTGA

Upstream 100 bases:

>100_bases
GTGTCGCACAACGCGTTGAGCTGGTGCCCTTGCGCGGTCGCCGCGAGGTGCACGGGCTGACCCTGGACGCACCCGGGCAG
CTCGATGGCGGTGATCCGAC

Downstream 100 bases:

>100_bases
TGGATTCGGCACATACAACCGCGCTGCTGCTGTCGCTCGCCGACTCCCGGTTACCCACCGGTTCACACATACATTCCGGT
GGGGTAGAGGAAGCCATCGC

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MTRLTREHYAKLYGPTTGDRIRLADTDLIIEITEDRCGGPGLAGEEAVFGGGKVLRESMGQSRLTRAGGAPDTVITGAII
IDHWGIIKADIGIRDGRIVGIGKAGNPDIMDGVDPALIVGPSTEIIAGNNRIVTAGGIDCHVHFICPQILPEALSGGITT
MIGGGTGPAEGSKATTVTPGAWHLGRMLQALDGWPMNILMLGKGNTVNPDAMWEQLRGGAAGFKLHEDWGTTPAVIDACL
RVADEADVQVALHSDTLNETGFVEGTLAAIGGRAIHAYHTEGAGGGHAPDIITVASHPNVMPSSTNPTRPHTVNTLDEHL
DMLMVCHHLNAAVPEDLAFAESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRIGEVVMRTWQTAHVMKKRRGALPGDPS
GPNGNDNNRVRRYVAKYTICPAITHGIDHEIGSVEVGKLADLVLWEPAFFGVRPHAVIKGGGIVWAAMGDANASIPTPQP
VFPRPMFSAMHAVAAGLAVHFVSPTAIEDDLAARLALRRRLVPTRDVRNRGKADLPLNDAMPDIRVDPDTFTVRIDGEVW
EEHPAAELPMAQRYFLF

Sequences:

>Translated_577_residues
MTRLTREHYAKLYGPTTGDRIRLADTDLIIEITEDRCGGPGLAGEEAVFGGGKVLRESMGQSRLTRAGGAPDTVITGAII
IDHWGIIKADIGIRDGRIVGIGKAGNPDIMDGVDPALIVGPSTEIIAGNNRIVTAGGIDCHVHFICPQILPEALSGGITT
MIGGGTGPAEGSKATTVTPGAWHLGRMLQALDGWPMNILMLGKGNTVNPDAMWEQLRGGAAGFKLHEDWGTTPAVIDACL
RVADEADVQVALHSDTLNETGFVEGTLAAIGGRAIHAYHTEGAGGGHAPDIITVASHPNVMPSSTNPTRPHTVNTLDEHL
DMLMVCHHLNAAVPEDLAFAESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRIGEVVMRTWQTAHVMKKRRGALPGDPS
GPNGNDNNRVRRYVAKYTICPAITHGIDHEIGSVEVGKLADLVLWEPAFFGVRPHAVIKGGGIVWAAMGDANASIPTPQP
VFPRPMFSAMHAVAAGLAVHFVSPTAIEDDLAARLALRRRLVPTRDVRNRGKADLPLNDAMPDIRVDPDTFTVRIDGEVW
EEHPAAELPMAQRYFLF
>Mature_576_residues
TRLTREHYAKLYGPTTGDRIRLADTDLIIEITEDRCGGPGLAGEEAVFGGGKVLRESMGQSRLTRAGGAPDTVITGAIII
DHWGIIKADIGIRDGRIVGIGKAGNPDIMDGVDPALIVGPSTEIIAGNNRIVTAGGIDCHVHFICPQILPEALSGGITTM
IGGGTGPAEGSKATTVTPGAWHLGRMLQALDGWPMNILMLGKGNTVNPDAMWEQLRGGAAGFKLHEDWGTTPAVIDACLR
VADEADVQVALHSDTLNETGFVEGTLAAIGGRAIHAYHTEGAGGGHAPDIITVASHPNVMPSSTNPTRPHTVNTLDEHLD
MLMVCHHLNAAVPEDLAFAESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRIGEVVMRTWQTAHVMKKRRGALPGDPSG
PNGNDNNRVRRYVAKYTICPAITHGIDHEIGSVEVGKLADLVLWEPAFFGVRPHAVIKGGGIVWAAMGDANASIPTPQPV
FPRPMFSAMHAVAAGLAVHFVSPTAIEDDLAARLALRRRLVPTRDVRNRGKADLPLNDAMPDIRVDPDTFTVRIDGEVWE
EHPAAELPMAQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_MYCA9 (B1MB85)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703160.1
- ProteinModelPortal:   B1MB85
- SMR:   B1MB85
- MEROPS:   M38.982
- EnsemblBacteria:   EBMYCT00000007147
- GeneID:   5964935
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2425
- GeneTree:   EBGT00050000017361
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13206
- BioCyc:   MABS561007:MAB_2425-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 61396; Mature: 61265

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 327-327 BINDING 226-226

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLTREHYAKLYGPTTGDRIRLADTDLIIEITEDRCGGPGLAGEEAVFGGGKVLRESMG
CCCCCHHHHHHHCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHC
QSRLTRAGGAPDTVITGAIIIDHWGIIKADIGIRDGRIVGIGKAGNPDIMDGVDPALIVG
HHHHHHCCCCCCHHEEEEEEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCEEEEC
PSTEIIAGNNRIVTAGGIDCHVHFICPQILPEALSGGITTMIGGGTGPAEGSKATTVTPG
CCCEEEECCCEEEEECCCEEEEEEECHHHHHHHHCCCCEEEECCCCCCCCCCCCEEECCC
AWHLGRMLQALDGWPMNILMLGKGNTVNPDAMWEQLRGGAAGFKLHEDWGTTPAVIDACL
HHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHH
RVADEADVQVALHSDTLNETGFVEGTLAAIGGRAIHAYHTEGAGGGHAPDIITVASHPNV
HHCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCC
MPSSTNPTRPHTVNTLDEHLDMLMVCHHLNAAVPEDLAFAESRIRPSTIAAEDLLHDIGA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCC
ISMIGSDSQAMGRIGEVVMRTWQTAHVMKKRRGALPGDPSGPNGNDNNRVRRYVAKYTIC
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
PAITHGIDHEIGSVEVGKLADLVLWEPAFFGVRPHAVIKGGGIVWAAMGDANASIPTPQP
HHHHHCCCCCCCCEEHHHHHHHEEECCHHCCCCCCEEEECCCEEEEEECCCCCCCCCCCC
VFPRPMFSAMHAVAAGLAVHFVSPTAIEDDLAARLALRRRLVPTRDVRNRGKADLPLNDA
CCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCC
MPDIRVDPDTFTVRIDGEVWEEHPAAELPMAQRYFLF
CCCCEECCCEEEEEECCHHHCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TRLTREHYAKLYGPTTGDRIRLADTDLIIEITEDRCGGPGLAGEEAVFGGGKVLRESMG
CCCCHHHHHHHCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHC
QSRLTRAGGAPDTVITGAIIIDHWGIIKADIGIRDGRIVGIGKAGNPDIMDGVDPALIVG
HHHHHHCCCCCCHHEEEEEEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCEEEEC
PSTEIIAGNNRIVTAGGIDCHVHFICPQILPEALSGGITTMIGGGTGPAEGSKATTVTPG
CCCEEEECCCEEEEECCCEEEEEEECHHHHHHHHCCCCEEEECCCCCCCCCCCCEEECCC
AWHLGRMLQALDGWPMNILMLGKGNTVNPDAMWEQLRGGAAGFKLHEDWGTTPAVIDACL
HHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHH
RVADEADVQVALHSDTLNETGFVEGTLAAIGGRAIHAYHTEGAGGGHAPDIITVASHPNV
HHCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCC
MPSSTNPTRPHTVNTLDEHLDMLMVCHHLNAAVPEDLAFAESRIRPSTIAAEDLLHDIGA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCC
ISMIGSDSQAMGRIGEVVMRTWQTAHVMKKRRGALPGDPSGPNGNDNNRVRRYVAKYTIC
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
PAITHGIDHEIGSVEVGKLADLVLWEPAFFGVRPHAVIKGGGIVWAAMGDANASIPTPQP
HHHHHCCCCCCCCEEHHHHHHHEEECCHHCCCCCCEEEECCCEEEEEECCCCCCCCCCCC
VFPRPMFSAMHAVAAGLAVHFVSPTAIEDDLAARLALRRRLVPTRDVRNRGKADLPLNDA
CCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCC
MPDIRVDPDTFTVRIDGEVWEEHPAAELPMAQRYFLF
CCCCEECCCEEEEEECCHHHCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA