Definition Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence.
Accession NC_010397
Length 5,067,172

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The map label for this gene is pyrD

Identifier: 169629190

GI number: 169629190

Start: 2105078

End: 2106139

Strand: Reverse

Name: pyrD

Synonym: MAB_2104c

Alternate gene names: 169629190

Gene position: 2106139-2105078 (Counterclockwise)

Preceding gene: 169629191

Following gene: 169629183

Centisome position: 41.56

GC content: 68.17

Gene sequence:

>1062_bases
GTGCTGTACCAGATCCTGCTGCGACTGTTCTTCCTGGTGTCGCCCGAGCGCGTACACACCCTGGTGTTCGCGGCCCTGCG
CGCCATCGCCGCCTTCACACCCACACGATGGTTGCTGAATCGCCTCTGCGCCCCCACCGATCCGATCCTCGGCACCGAGG
TGTTCGGGGTGCACTTCCCCGCCCCGCTGGGGCTGGCCGCCGGATTCGACAAGGACGGCGAGGGCCTGAAGGTGTGGGGA
CCCCTGGGCTTCGGCTATGCCGAGGTGGGCACGGTGACGGCAATCGCCCAGCCCGGCAATCCGAAGCCGCGTCTGTTCCG
GCTCCCGGCCGACCGTGGCCTGCTCAACCGCATGGGCTTCAACAACCACGGCGCGGCAGCCCTCGCCCCCCGGTTGGCCA
CCCGCACGTCGACAGTGCCGATCGGCGCCAACATCGGCAAATCGAAGATCGTGGAGCCCGCCTTCGCGTCCTCGGACTAT
CGGGTGAGCGCCCGGCAGGTAGGGCCCGCGGCCGATTTCTTGGTGGTGAACGTGAGCTCCCCCAACACCCCCGGGCTGCG
CGATCTGCAAGCAATCGGCGAACTGCGCAAGATCCTCTCCGCCGTGCTGGAGGAGACCACCGCGCCGGTGCTGGTGAAGA
TAGCCCCGGATCTGTCCGACGCCGACATCGACGAGATCGCGGACCTGGCAGTGGAATTGGGCCTTGCGGGAATCGTGGCC
ACCAACACCACCATCAGCCGCGCCGCGCTGAAGACGACCGGCGTCGAGGACCTCGGTGCCGGAGGCGTTTCCGGACCGCC
GGTGGCGGCACGCTCACTGGAGGTGCTGCGGCGGTTGTACCGACGGGTAGGAGATCGTCTGGTGCTCATCAGCGTCGGCG
GAATAGAGGATGCCGACGATGCGTGGGCACGGATCATCGCCGGGGCATCGCTGCTGCAGGGCTACACGGGCTTCATCTAC
CGGGGTGGTTTCTACGCCAAACGCATCCACGACGGCATCGCCCAGCGCCTGCGGGCGGGCGGCTTCGCCAGCCTTCAGGA
CGCCGTCGGGTCGGCCACCTGA

Upstream 100 bases:

>100_bases
GTGTACGGCTCTACACCGATGGAAGCCGACGAGTTCTCCTGCGCCGCAAGAAGTTACGTGGCAGCCTGGGCGCCGGCCCG
TTGACGGCACCGGTGATGTA

Downstream 100 bases:

>100_bases
CCTACGAGCAGCTAGTGCTGCTCGTAGGTGCCGTGGATGACGGCGCGGGCGATCGCATGCCCGAACAGGTTGAAGCCCAG
GTAGGCCGGCGTCGCGTTCT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MLYQILLRLFFLVSPERVHTLVFAALRAIAAFTPTRWLLNRLCAPTDPILGTEVFGVHFPAPLGLAAGFDKDGEGLKVWG
PLGFGYAEVGTVTAIAQPGNPKPRLFRLPADRGLLNRMGFNNHGAAALAPRLATRTSTVPIGANIGKSKIVEPAFASSDY
RVSARQVGPAADFLVVNVSSPNTPGLRDLQAIGELRKILSAVLEETTAPVLVKIAPDLSDADIDEIADLAVELGLAGIVA
TNTTISRAALKTTGVEDLGAGGVSGPPVAARSLEVLRRLYRRVGDRLVLISVGGIEDADDAWARIIAGASLLQGYTGFIY
RGGFYAKRIHDGIAQRLRAGGFASLQDAVGSAT

Sequences:

>Translated_353_residues
MLYQILLRLFFLVSPERVHTLVFAALRAIAAFTPTRWLLNRLCAPTDPILGTEVFGVHFPAPLGLAAGFDKDGEGLKVWG
PLGFGYAEVGTVTAIAQPGNPKPRLFRLPADRGLLNRMGFNNHGAAALAPRLATRTSTVPIGANIGKSKIVEPAFASSDY
RVSARQVGPAADFLVVNVSSPNTPGLRDLQAIGELRKILSAVLEETTAPVLVKIAPDLSDADIDEIADLAVELGLAGIVA
TNTTISRAALKTTGVEDLGAGGVSGPPVAARSLEVLRRLYRRVGDRLVLISVGGIEDADDAWARIIAGASLLQGYTGFIY
RGGFYAKRIHDGIAQRLRAGGFASLQDAVGSAT
>Mature_353_residues
MLYQILLRLFFLVSPERVHTLVFAALRAIAAFTPTRWLLNRLCAPTDPILGTEVFGVHFPAPLGLAAGFDKDGEGLKVWG
PLGFGYAEVGTVTAIAQPGNPKPRLFRLPADRGLLNRMGFNNHGAAALAPRLATRTSTVPIGANIGKSKIVEPAFASSDY
RVSARQVGPAADFLVVNVSSPNTPGLRDLQAIGELRKILSAVLEETTAPVLVKIAPDLSDADIDEIADLAVELGLAGIVA
TNTTISRAALKTTGVEDLGAGGVSGPPVAARSLEVLRRLYRRVGDRLVLISVGGIEDADDAWARIIAGASLLQGYTGFIY
RGGFYAKRIHDGIAQRLRAGGFASLQDAVGSAT

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=355, Percent_Identity=40.8450704225352, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI1787177, Length=338, Percent_Identity=40.8284023668639, Blast_Score=234, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17509475, Length=321, Percent_Identity=39.5638629283489, Blast_Score=221, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6322633, Length=271, Percent_Identity=26.1992619926199, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281361352, Length=333, Percent_Identity=37.5375375375375, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI17137316, Length=333, Percent_Identity=37.5375375375375, Blast_Score=215, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_MYCA9 (B1MPD4)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001702839.1
- ProteinModelPortal:   B1MPD4
- SMR:   B1MPD4
- EnsemblBacteria:   EBMYCT00000005005
- GeneID:   5964617
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2104c
- GeneTree:   EBGT00050000017343
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- BioCyc:   MABS561007:MAB_2104C-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37211; Mature: 37211

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLYQILLRLFFLVSPERVHTLVFAALRAIAAFTPTRWLLNRLCAPTDPILGTEVFGVHFP
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEEECC
APLGLAAGFDKDGEGLKVWGPLGFGYAEVGTVTAIAQPGNPKPRLFRLPADRGLLNRMGF
CCCCHHCCCCCCCCCEEEEECCCCCHHHHCCEEEEECCCCCCCEEEECCCCCCHHHHCCC
NNHGAAALAPRLATRTSTVPIGANIGKSKIVEPAFASSDYRVSARQVGPAADFLVVNVSS
CCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCEEEHHHCCCCCCEEEEEECC
PNTPGLRDLQAIGELRKILSAVLEETTAPVLVKIAPDLSDADIDEIADLAVELGLAGIVA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHEEE
TNTTISRAALKTTGVEDLGAGGVSGPPVAARSLEVLRRLYRRVGDRLVLISVGGIEDADD
CCCHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHH
AWARIIAGASLLQGYTGFIYRGGFYAKRIHDGIAQRLRAGGFASLQDAVGSAT
HHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure
MLYQILLRLFFLVSPERVHTLVFAALRAIAAFTPTRWLLNRLCAPTDPILGTEVFGVHFP
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEEECC
APLGLAAGFDKDGEGLKVWGPLGFGYAEVGTVTAIAQPGNPKPRLFRLPADRGLLNRMGF
CCCCHHCCCCCCCCCEEEEECCCCCHHHHCCEEEEECCCCCCCEEEECCCCCCHHHHCCC
NNHGAAALAPRLATRTSTVPIGANIGKSKIVEPAFASSDYRVSARQVGPAADFLVVNVSS
CCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCEEEHHHCCCCCCEEEEEECC
PNTPGLRDLQAIGELRKILSAVLEETTAPVLVKIAPDLSDADIDEIADLAVELGLAGIVA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHEEE
TNTTISRAALKTTGVEDLGAGGVSGPPVAARSLEVLRRLYRRVGDRLVLISVGGIEDADD
CCCHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHH
AWARIIAGASLLQGYTGFIYRGGFYAKRIHDGIAQRLRAGGFASLQDAVGSAT
HHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA