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The map label for this gene is menE [H]

Identifier: 169629150

GI number: 169629150

Start: 2061120

End: 2062325

Strand: Reverse

Name: menE [H]

Synonym: MAB_2063c

Alternate gene names: 169629150

Gene position: 2062325-2061120 (Counterclockwise)

Preceding gene: 169629151

Following gene: 169629149

Centisome position: 40.7

GC content: 68.08

Gene sequence:

>1206_bases
ATGCAACTCGGCATCGGTCAGTGGGTGACCCGGCGCGCCTTCCTCAACGGCGGGCGCACCGCGTTGATCAGCAACGGCGC
GCACATCACCTACGCCGACCTCGATCGGCGCACCAACCAGGTCGCCGCCGCACTCATCGCCCTCGGCGTGCGCAAGGGCG
ATCGGGTCGCGATGCTGCTGGTCAATTCGACCGAGTTCATCCAGGTGCTGCTGGGCTGCGCCAAAATCGGCGCACTTGCA
GTTCCGCTCAACGTGCGCCTTGCCGGACCCGAGATCGGCTACATCCTGGCCGACTCAGGCGCCGATGTTCTGGTCTTCCA
CGAGCCGTTCGCCGCGCAGGCCAAGAGCGCCGTCACCGAGTCCGGAGTCCGCGTGCGCCATGTCGTACGCGCCGGTGGGG
CGCCGGCGCCGGGCGAGCTCGGCTACGAAGACGTCGTCTCGGGCGCCGCGCCCGAACCGCTCAACGGTGACGTCGACGGC
AGCGACCCCGCGTTCATCATGTACACGTCGGGGACGACGGGCCGACCCAAGGGCGCGATCCTCACCCACGACAACCTGCT
ATGGAACGCGATCAACGTCCTCGGCACCGACATCGGCCTGCGGGGCGAGGACGTCACCGTCGCGGTGGCGCCGATGTTCC
ACATCGGCGGGCTGGGAGTACACACCCTGCCGCTGCTCTACGTCGGCGGCACCAGCGTCATCATGCCGTCCTTCGAGCCG
CGAGCTACGCTGCAGGCGATGGCCGACCACCACGTCACGGTTCAGTTCATGGTGCCGGCCATGTGGACCGCTCTCACACA
GGTGTCCGACTTCGACTCCTTCAACCTGTCTGCGCTGCGTTTCGCCATGGGCGGCGGGTCGCCCGTCCCCCTCACGGTCA
GCGACTTCATGCGCGAGCGAGGCGTGCCCTTCACCGAGGGCTTCGGCATGACCGAGACCGCTCCCCTGGTGACCGTCCTC
GACGCCGAGAACATCAGCACGCGGGCCGGGTCGATCGGCCGCGTCGCGATGCATGTCGACGGCGTTGCGCGGGGGCTGGT
TCCACACGGGCGATCTCGGGCGCATGGACGCGGAGGGCTTCATCACCCTCGTCGACCGCAAGAAGGACATGATCATCTCC
GGCGGCGAGAACGTCTACCCGATCGAGGTCGAGCAGGTCCTCTTCCGCCACCCGGCGGTGTTCGACGCCGCCGTGATCGG
CGGTAA

Upstream 100 bases:

>100_bases
CCGCGCCGATCAGCCGCGAAATGATCCTCAACTTCGTGGCGCAGCACAGCCTGAAACTGCCCGCGTCCTACTGAGTCGCC
GCGGACGGAAAGGGAATCGC

Downstream 100 bases:

>100_bases
GGACGCGAAGTGGGGCGAACGCGTCGTCGCGGTCGTGGTTGCCGACCCGGCGACGCAGGCGCCGAGCGCCGAGGAGATCG
TGGCGTGGTGCCGGGAGCGG

Product: acid-CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MQLGIGQWVTRRAFLNGGRTALISNGAHITYADLDRRTNQVAAALIALGVRKGDRVAMLLVNSTEFIQVLLGCAKIGALA
VPLNVRLAGPEIGYILADSGADVLVFHEPFAAQAKSAVTESGVRVRHVVRAGGAPAPGELGYEDVVSGAAPEPLNGDVDG
SDPAFIMYTSGTTGRPKGAILTHDNLLWNAINVLGTDIGLRGEDVTVAVAPMFHIGGLGVHTLPLLYVGGTSVIMPSFEP
RATLQAMADHHVTVQFMVPAMWTALTQVSDFDSFNLSALRFAMGGGSPVPLTVSDFMRERGVPFTEGFGMTETAPLVTVL
DAENISTRAGSIGRVAMHVDGVARGLVPHGRSRAHGRGGLHHPRRPQEGHDHLRRRERLPDRGRAGPLPPPGGVRRRRDR
R

Sequences:

>Translated_401_residues
MQLGIGQWVTRRAFLNGGRTALISNGAHITYADLDRRTNQVAAALIALGVRKGDRVAMLLVNSTEFIQVLLGCAKIGALA
VPLNVRLAGPEIGYILADSGADVLVFHEPFAAQAKSAVTESGVRVRHVVRAGGAPAPGELGYEDVVSGAAPEPLNGDVDG
SDPAFIMYTSGTTGRPKGAILTHDNLLWNAINVLGTDIGLRGEDVTVAVAPMFHIGGLGVHTLPLLYVGGTSVIMPSFEP
RATLQAMADHHVTVQFMVPAMWTALTQVSDFDSFNLSALRFAMGGGSPVPLTVSDFMRERGVPFTEGFGMTETAPLVTVL
DAENISTRAGSIGRVAMHVDGVARGLVPHGRSRAHGRGGLHHPRRPQEGHDHLRRRERLPDRGRAGPLPPPGGVRRRRDR
R
>Mature_401_residues
MQLGIGQWVTRRAFLNGGRTALISNGAHITYADLDRRTNQVAAALIALGVRKGDRVAMLLVNSTEFIQVLLGCAKIGALA
VPLNVRLAGPEIGYILADSGADVLVFHEPFAAQAKSAVTESGVRVRHVVRAGGAPAPGELGYEDVVSGAAPEPLNGDVDG
SDPAFIMYTSGTTGRPKGAILTHDNLLWNAINVLGTDIGLRGEDVTVAVAPMFHIGGLGVHTLPLLYVGGTSVIMPSFEP
RATLQAMADHHVTVQFMVPAMWTALTQVSDFDSFNLSALRFAMGGGSPVPLTVSDFMRERGVPFTEGFGMTETAPLVTVL
DAENISTRAGSIGRVAMHVDGVARGLVPHGRSRAHGRGGLHHPRRPQEGHDHLRRRERLPDRGRAGPLPPPGGVRRRRDR
R

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=370, Percent_Identity=26.4864864864865, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI227499619, Length=335, Percent_Identity=26.2686567164179, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI187761345, Length=327, Percent_Identity=25.9938837920489, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI187761343, Length=327, Percent_Identity=25.9938837920489, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI13325057, Length=341, Percent_Identity=27.8592375366569, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI157311624, Length=332, Percent_Identity=23.7951807228916, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI157311622, Length=332, Percent_Identity=23.7951807228916, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI195947378, Length=304, Percent_Identity=24.6710526315789, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI58082049, Length=332, Percent_Identity=23.1927710843373, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI40807357, Length=316, Percent_Identity=26.8987341772152, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI115511026, Length=286, Percent_Identity=25.8741258741259, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38505220, Length=342, Percent_Identity=21.9298245614035, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI42544134, Length=302, Percent_Identity=21.523178807947, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI42544132, Length=309, Percent_Identity=21.3592233009709, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38524616, Length=341, Percent_Identity=27.8592375366569, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI227499621, Length=174, Percent_Identity=31.6091954022989, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI62865631, Length=391, Percent_Identity=22.7621483375959, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI13325055, Length=391, Percent_Identity=22.7621483375959, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI221142682, Length=341, Percent_Identity=30.791788856305, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1788107, Length=344, Percent_Identity=28.7790697674419, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI145693145, Length=333, Percent_Identity=28.8288288288288, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1790505, Length=330, Percent_Identity=26.3636363636364, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1789201, Length=178, Percent_Identity=26.4044943820225, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI32563687, Length=365, Percent_Identity=27.6712328767123, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17560308, Length=341, Percent_Identity=28.4457478005865, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17558820, Length=301, Percent_Identity=27.906976744186, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71994703, Length=349, Percent_Identity=25.214899713467, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=362, Percent_Identity=25.1381215469613, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994690, Length=362, Percent_Identity=25.1381215469613, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=343, Percent_Identity=27.4052478134111, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71996755, Length=327, Percent_Identity=25.9938837920489, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17557194, Length=323, Percent_Identity=25.077399380805, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=309, Percent_Identity=25.8899676375405, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147511, Length=375, Percent_Identity=22.9333333333333, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551278, Length=239, Percent_Identity=27.6150627615063, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=317, Percent_Identity=22.0820189274448, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115534440, Length=233, Percent_Identity=27.0386266094421, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=327, Percent_Identity=26.2996941896024, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355181, Length=343, Percent_Identity=27.1137026239067, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24581924, Length=385, Percent_Identity=26.4935064935065, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45550496, Length=254, Percent_Identity=27.1653543307087, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45552801, Length=254, Percent_Identity=27.1653543307087, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI18859661, Length=285, Percent_Identity=27.719298245614, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 42647; Mature: 42647

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00141 ASP_PROTEASE ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGIGQWVTRRAFLNGGRTALISNGAHITYADLDRRTNQVAAALIALGVRKGDRVAMLL
CCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VNSTEFIQVLLGCAKIGALAVPLNVRLAGPEIGYILADSGADVLVFHEPFAAQAKSAVTE
ECCHHHHHHHHHHHHHCEEEEEEEEEECCCCEEEEEECCCCCEEEEECCHHHHHHHHHHH
SGVRVRHVVRAGGAPAPGELGYEDVVSGAAPEPLNGDVDGSDPAFIMYTSGTTGRPKGAI
CCCCEEEHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEE
LTHDNLLWNAINVLGTDIGLRGEDVTVAVAPMFHIGGLGVHTLPLLYVGGTSVIMPSFEP
EECCCHHHHHHHHHHCCCCCCCCCEEEEEECHHHHCCCCHHHEEEEEECCCEEEECCCCC
RATLQAMADHHVTVQFMVPAMWTALTQVSDFDSFNLSALRFAMGGGSPVPLTVSDFMRER
HHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCHHEEEEECCCCCCCCEEHHHHHHHC
GVPFTEGFGMTETAPLVTVLDAENISTRAGSIGRVAMHVDGVARGLVPHGRSRAHGRGGL
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECHHHHCCCCCCCCCCCCCCCC
HHPRRPQEGHDHLRRRERLPDRGRAGPLPPPGGVRRRRDRR
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQLGIGQWVTRRAFLNGGRTALISNGAHITYADLDRRTNQVAAALIALGVRKGDRVAMLL
CCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VNSTEFIQVLLGCAKIGALAVPLNVRLAGPEIGYILADSGADVLVFHEPFAAQAKSAVTE
ECCHHHHHHHHHHHHHCEEEEEEEEEECCCCEEEEEECCCCCEEEEECCHHHHHHHHHHH
SGVRVRHVVRAGGAPAPGELGYEDVVSGAAPEPLNGDVDGSDPAFIMYTSGTTGRPKGAI
CCCCEEEHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEE
LTHDNLLWNAINVLGTDIGLRGEDVTVAVAPMFHIGGLGVHTLPLLYVGGTSVIMPSFEP
EECCCHHHHHHHHHHCCCCCCCCCEEEEEECHHHHCCCCHHHEEEEEECCCEEEECCCCC
RATLQAMADHHVTVQFMVPAMWTALTQVSDFDSFNLSALRFAMGGGSPVPLTVSDFMRER
HHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCHHEEEEECCCCCCCCEEHHHHHHHC
GVPFTEGFGMTETAPLVTVLDAENISTRAGSIGRVAMHVDGVARGLVPHGRSRAHGRGGL
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECHHHHCCCCCCCCCCCCCCCC
HHPRRPQEGHDHLRRRERLPDRGRAGPLPPPGGVRRRRDRR
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA