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The map label for this gene is adh [H]

Identifier: 169629128

GI number: 169629128

Start: 2042483

End: 2043583

Strand: Reverse

Name: adh [H]

Synonym: MAB_2041c

Alternate gene names: 169629128

Gene position: 2043583-2042483 (Counterclockwise)

Preceding gene: 169629129

Following gene: 169629127

Centisome position: 40.33

GC content: 65.49

Gene sequence:

>1101_bases
ATGATCGCCGAGGCGATGGTGCTGACCGGACCGCGGAGTCTGCAGCGGCGCCAGATGATCATCCCCGACGTCGGCGACCG
GGGTGCGATCCTGCGAGTTGAAGCATGCGGTCTGTGCGGAACAGATCACGAACAATTCACCGGACACCTGCCTGCCGGCT
TCTCATTCGTTCCAGGGCACGAAATCGTCGGCATCGTCGAACATGTCGGCGCTGCGGCCGGCCAACGCTGGGGTGTACAA
GCCGGCCAGCGCGTGGCCGTTGAGGTGTTCCGGTCCTGCCGAGACTGCCCCGAGTGCCGCCGCGGCGAATACCGGCGGTG
CGCGGTGAACGGCATCGCCACCATGTTCGGGTTCGTCGACGTGGAGATCGGCGCGGGCTTATGGGGCGGATACGCCACCC
ATGTGGAGCTTCCGTGGGACGCGATGCTGCTCCCGATTGCCGAAGACATGGACCCCGTTCTCGCCACGTTGTTCAACCCT
CTCGGGGCCGGTATCCAATGGGGGGCGACTCTTCCCGACACCAAGGCCGGGGACGTCGTAGCGATCCTGGGGCCCGGCAT
CCGCGGAATCTGTGCGGCGGTGGCGGCCAAAGAGGCGGGAGCCGCGTTCGTCGCGATGACCGGCGTCGGCCCACGCGACG
AACAACGACTGGCCATCGCCAGATCATTCGGTGTCGACCTGCCCATCGATGTATCGCAGGACGATGCAGCGACCGCGCTT
CAGCGTGAGACAGGCGGACGGCTTGCCGACGTGGTCGTCGACGTCACCGCCAAAGCACCCTCCGCGTTCGCCGATGCCGT
CGGCCTTGCCAGGCCCGGCGGCACAATTGTGGTGGCCGGCACCCGCGGAGGAGGCGGCGCGCCCCGGTTTGAACCAGACT
TGTTGGTCTATAAAGAATTACACGTCGTAGGCGCACTCGGCGTGGAGTATCCCGCCTACCGGGCAGCCCTCGAGATTCTC
GCCATGGGCCGCTGGCCGTTCGACCGGATCACCAGAGAATCAACCGGATTCGCTGGGCTCGCACAGCTGCTCACTTCGCT
TGCAGATGAAAGTGCCCGATCAAGTGGGGCGCTCCACAACGTCTTTTTGCCCACGCCCTAA

Upstream 100 bases:

>100_bases
GCGACGATCCGCAGATTGCCGAGGCGATGGGCGGGGAAATGTATGTAGGTAAAACGGTGTGCCTCCGAAACACAGGGTCG
TTCACCGGATTCGAGCTTCC

Downstream 100 bases:

>100_bases
CGGCGGTGCAGAGGTTCAACAGAGAGGGCCACCCGTGACCATGGCGGAACGCGTACCGATGCTCGACCGTGAGCAGGCCC
AGCTGCGAGCTGCCGAATGT

Product: zinc-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MIAEAMVLTGPRSLQRRQMIIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGHEIVGIVEHVGAAAGQRWGVQ
AGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVDVEIGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP
LGAGIQWGATLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAATAL
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKELHVVGALGVEYPAYRAALEIL
AMGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP

Sequences:

>Translated_366_residues
MIAEAMVLTGPRSLQRRQMIIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGHEIVGIVEHVGAAAGQRWGVQ
AGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVDVEIGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP
LGAGIQWGATLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAATAL
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKELHVVGALGVEYPAYRAALEIL
AMGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP
>Mature_366_residues
MIAEAMVLTGPRSLQRRQMIIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGHEIVGIVEHVGAAAGQRWGVQ
AGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVDVEIGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNP
LGAGIQWGATLPDTKAGDVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAATAL
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKELHVVGALGVEYPAYRAALEIL
AMGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI226510992, Length=345, Percent_Identity=28.1159420289855, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788073, Length=355, Percent_Identity=25.9154929577465, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790045, Length=265, Percent_Identity=26.7924528301887, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=21.3450292397661, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790718, Length=353, Percent_Identity=24.0793201133144, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787863, Length=281, Percent_Identity=25.9786476868327, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788407, Length=265, Percent_Identity=23.7735849056604, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786825, Length=274, Percent_Identity=25.5474452554745, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=26.4880952380952, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=270, Percent_Identity=26.2962962962963, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=331, Percent_Identity=26.5861027190332, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=331, Percent_Identity=26.5861027190332, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=230, Percent_Identity=26.9565217391304, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=337, Percent_Identity=25.8160237388724, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38318; Mature: 38318

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAEAMVLTGPRSLQRRQMIIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGH
CCCCEEEECCCHHHHHCCEECCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCEECCCH
EIVGIVEHVGAAAGQRWGVQAGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVD
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHEEE
VEIGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNPLGAGIQWGATLPDTKAGDVV
EEECCCCCCCEEEEEECCCCCEEECHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
AILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAATAL
EEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKEL
HHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEHHHH
HVVGALGVEYPAYRAALEILAMGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHN
HHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VFLPTP
EECCCC
>Mature Secondary Structure
MIAEAMVLTGPRSLQRRQMIIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAGFSFVPGH
CCCCEEEECCCHHHHHCCEECCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCEECCCH
EIVGIVEHVGAAAGQRWGVQAGQRVAVEVFRSCRDCPECRRGEYRRCAVNGIATMFGFVD
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHEEE
VEIGAGLWGGYATHVELPWDAMLLPIAEDMDPVLATLFNPLGAGIQWGATLPDTKAGDVV
EEECCCCCCCEEEEEECCCCCEEECHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
AILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAATAL
EEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
QRETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDLLVYKEL
HHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEHHHH
HVVGALGVEYPAYRAALEILAMGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHN
HHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VFLPTP
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]