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The map label for this gene is murC

Identifier: 169629094

GI number: 169629094

Start: 2007075

End: 2008547

Strand: Direct

Name: murC

Synonym: MAB_2007

Alternate gene names: 169629094

Gene position: 2007075-2008547 (Clockwise)

Preceding gene: 169629093

Following gene: 169629095

Centisome position: 39.61

GC content: 66.33

Gene sequence:

>1473_bases
ATGAACGCAGGTCCGCTGCCGGAGCATCTGCGCCGCGTGCACATGGTCGGTATCGGTGGTGCCGGAATGTCCGGTATCGC
CCGCATTCTGCTGGATCGCGGCGCCCAGGTGTCGGGGTCCGACGCCAAGGAATCTCGTGGTGTGCTGGCATTGCGCGCCC
GTGGGGCGCTGGTCAACATCGGCCACGATGGTGACGCCCTGGATCTGCTGCCGGGTGGCCCCACGGTGGTCGTGACCACC
CACGCCGCCATTCCGAAGACGAATCCGGAGCTGGTGGAAGCGAATAGGCGTGGGATACCGGTGCTGCTCCGGCCCGTGGT
GCTGGCGGACCTGATGGCCGGATATCGCACCCTGATGGTTACCGGCACACACGGCAAGACCAGCACGACGTCCATGCTCA
TTGTGGCGCTGCAGCATTGTGGATACGACCCGTCCTTTGCGGTCGGCGGTGAACTCAATGAAGCCGGTACCAATGCCCAT
CACGGCAGCGGCGATGTATTCGTGGCCGAGGCGGACGAAAGCGACGGCTCGCTACTGCAGTACCGGCCGAACCTGATCAT
CGTGACCAATATCGAGGCGGATCACCTGGATCACTTCGGCAGCGTGGAGGCTTACTCCGCGGTGTTCGACGAATTCGCCG
AAACCCTGGGTTCCGAAGGGGTGTTGGTGGTGTGTCTGGATGACCCGGGTGCCGCGGCGCTGGCCCGCCGGGCACATGAG
CGCGGTATCCGGGTGCGCGGCTACGGCAGCGCCGACCAGGCCGAGGCGGGCGATGTCCCGGTGGCGGGGCAACTGCGGGA
TTGGCAGTTCAAGGACACCGGGGCCACCGCGCAGATCCAGCTGGCGGGGGAGAGCGCGCCGCGGACCATGCGGTTGTCGG
TACCGGGCCGGCATATGGCCCTGAACGCACTGGCCGCCGTGGTGACGGCCGCCGAGATCGGGGCGGCCGTCGACGATGTC
CTGGACGGATTGGCCGGATTCGAGGGTGTGCGCCGCCGATTCGAACTGGTCGGGTCGGTGGAGTCGGTGCGGGTTTTCGA
TGACTATGCGCACCATCCCACCGAGGTGCGTACGGTGCTGCAGGCCGTTTCCGGCATTGTGGCTCAGCAGGGTTTTGGGC
GTTCGGTGGTTGTCTTCCAGCCCCATTTGTATTCCCGCACAGCGGCTTTCGCTACAGAATTCGCCGACGCGCTAAGCATC
GCCGACCTGGTGTTCGTGCTCGATGTGTACGGCGCGCGAGAAGCGCCACTGCCGGGCGTCACCGGCGCGCTGATCGTGGA
ACAGATCGCCGGGGCGCCGGTGCACTATCTGCCCGATCTTTCGACGGTGGCCCAGCAGGTCGCCGCGGCAACCGCGCCCG
GTGACCTGGTGATCACCATGGGTGCGGGCGATGTCACCTTGCAGGGCAAGGAGATTGTGCGCGCACTGCGTGCCCGTGCC
AACGACTGGCCGCCGCCGGGAAACGGTCGATGA

Upstream 100 bases:

>100_bases
CCGCGGCACTGTCCGGACACCCGGAAGCCGCTCGACAGGTGGCGCAGGTGGCGTTGGATGTCGCGCGTGAGCGGCGTTCG
CGGGAACGGGGTGGCCGTCG

Downstream 100 bases:

>100_bases
GCGAGCCCGAGAACACCGCCGAGGACAAGGATGCGGAGGCGGCGATATCGGCGGATGCCGTCGAGTCCGAAACCACCGCG
GATGGCGGCGAAAATCCCGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MNAGPLPEHLRRVHMVGIGGAGMSGIARILLDRGAQVSGSDAKESRGVLALRARGALVNIGHDGDALDLLPGGPTVVVTT
HAAIPKTNPELVEANRRGIPVLLRPVVLADLMAGYRTLMVTGTHGKTSTTSMLIVALQHCGYDPSFAVGGELNEAGTNAH
HGSGDVFVAEADESDGSLLQYRPNLIIVTNIEADHLDHFGSVEAYSAVFDEFAETLGSEGVLVVCLDDPGAAALARRAHE
RGIRVRGYGSADQAEAGDVPVAGQLRDWQFKDTGATAQIQLAGESAPRTMRLSVPGRHMALNALAAVVTAAEIGAAVDDV
LDGLAGFEGVRRRFELVGSVESVRVFDDYAHHPTEVRTVLQAVSGIVAQQGFGRSVVVFQPHLYSRTAAFATEFADALSI
ADLVFVLDVYGAREAPLPGVTGALIVEQIAGAPVHYLPDLSTVAQQVAAATAPGDLVITMGAGDVTLQGKEIVRALRARA
NDWPPPGNGR

Sequences:

>Translated_490_residues
MNAGPLPEHLRRVHMVGIGGAGMSGIARILLDRGAQVSGSDAKESRGVLALRARGALVNIGHDGDALDLLPGGPTVVVTT
HAAIPKTNPELVEANRRGIPVLLRPVVLADLMAGYRTLMVTGTHGKTSTTSMLIVALQHCGYDPSFAVGGELNEAGTNAH
HGSGDVFVAEADESDGSLLQYRPNLIIVTNIEADHLDHFGSVEAYSAVFDEFAETLGSEGVLVVCLDDPGAAALARRAHE
RGIRVRGYGSADQAEAGDVPVAGQLRDWQFKDTGATAQIQLAGESAPRTMRLSVPGRHMALNALAAVVTAAEIGAAVDDV
LDGLAGFEGVRRRFELVGSVESVRVFDDYAHHPTEVRTVLQAVSGIVAQQGFGRSVVVFQPHLYSRTAAFATEFADALSI
ADLVFVLDVYGAREAPLPGVTGALIVEQIAGAPVHYLPDLSTVAQQVAAATAPGDLVITMGAGDVTLQGKEIVRALRARA
NDWPPPGNGR
>Mature_490_residues
MNAGPLPEHLRRVHMVGIGGAGMSGIARILLDRGAQVSGSDAKESRGVLALRARGALVNIGHDGDALDLLPGGPTVVVTT
HAAIPKTNPELVEANRRGIPVLLRPVVLADLMAGYRTLMVTGTHGKTSTTSMLIVALQHCGYDPSFAVGGELNEAGTNAH
HGSGDVFVAEADESDGSLLQYRPNLIIVTNIEADHLDHFGSVEAYSAVFDEFAETLGSEGVLVVCLDDPGAAALARRAHE
RGIRVRGYGSADQAEAGDVPVAGQLRDWQFKDTGATAQIQLAGESAPRTMRLSVPGRHMALNALAAVVTAAEIGAAVDDV
LDGLAGFEGVRRRFELVGSVESVRVFDDYAHHPTEVRTVLQAVSGIVAQQGFGRSVVVFQPHLYSRTAAFATEFADALSI
ADLVFVLDVYGAREAPLPGVTGALIVEQIAGAPVHYLPDLSTVAQQVAAATAPGDLVITMGAGDVTLQGKEIVRALRARA
NDWPPPGNGR

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=476, Percent_Identity=35.9243697478992, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=29.6774193548387, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_MYCA9 (B1MP38)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001702743.1
- ProteinModelPortal:   B1MP38
- SMR:   B1MP38
- EnsemblBacteria:   EBMYCT00000008880
- GeneID:   5964521
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2007
- GeneTree:   EBGT00050000015779
- HOGENOM:   HBG476594
- OMA:   EPNFSAV
- ProtClustDB:   PRK00421
- BioCyc:   MABS561007:MAB_2007-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51224; Mature: 51224

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAGPLPEHLRRVHMVGIGGAGMSGIARILLDRGAQVSGSDAKESRGVLALRARGALVNI
CCCCCCHHHHHHEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCEEEE
GHDGDALDLLPGGPTVVVTTHAAIPKTNPELVEANRRGIPVLLRPVVLADLMAGYRTLMV
CCCCCEEEECCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEE
TGTHGKTSTTSMLIVALQHCGYDPSFAVGGELNEAGTNAHHGSGDVFVAEADESDGSLLQ
ECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEE
YRPNLIIVTNIEADHLDHFGSVEAYSAVFDEFAETLGSEGVLVVCLDDPGAAALARRAHE
ECCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
RGIRVRGYGSADQAEAGDVPVAGQLRDWQFKDTGATAQIQLAGESAPRTMRLSVPGRHMA
CCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCCEEEEECCCHHHH
LNALAAVVTAAEIGAAVDDVLDGLAGFEGVRRRFELVGSVESVRVFDDYAHHPTEVRTVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEHHHCCCHHHHHHHH
QAVSGIVAQQGFGRSVVVFQPHLYSRTAAFATEFADALSIADLVFVLDVYGAREAPLPGV
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TGALIVEQIAGAPVHYLPDLSTVAQQVAAATAPGDLVITMGAGDVTLQGKEIVRALRARA
HHHHHHHHHCCCCCEECCCHHHHHHHHHHCCCCCCEEEEECCCCEEECHHHHHHHHHHHC
NDWPPPGNGR
CCCCCCCCCC
>Mature Secondary Structure
MNAGPLPEHLRRVHMVGIGGAGMSGIARILLDRGAQVSGSDAKESRGVLALRARGALVNI
CCCCCCHHHHHHEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCEEEE
GHDGDALDLLPGGPTVVVTTHAAIPKTNPELVEANRRGIPVLLRPVVLADLMAGYRTLMV
CCCCCEEEECCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEE
TGTHGKTSTTSMLIVALQHCGYDPSFAVGGELNEAGTNAHHGSGDVFVAEADESDGSLLQ
ECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEE
YRPNLIIVTNIEADHLDHFGSVEAYSAVFDEFAETLGSEGVLVVCLDDPGAAALARRAHE
ECCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
RGIRVRGYGSADQAEAGDVPVAGQLRDWQFKDTGATAQIQLAGESAPRTMRLSVPGRHMA
CCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCCEEEEECCCHHHH
LNALAAVVTAAEIGAAVDDVLDGLAGFEGVRRRFELVGSVESVRVFDDYAHHPTEVRTVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEHHHCCCHHHHHHHH
QAVSGIVAQQGFGRSVVVFQPHLYSRTAAFATEFADALSIADLVFVLDVYGAREAPLPGV
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TGALIVEQIAGAPVHYLPDLSTVAQQVAAATAPGDLVITMGAGDVTLQGKEIVRALRARA
HHHHHHHHHCCCCCEECCCHHHHHHHHHHCCCCCCEEEEECCCCEEECHHHHHHHHHHHC
NDWPPPGNGR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA