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The map label for this gene is tcmA [H]

Identifier: 169629023

GI number: 169629023

Start: 1934393

End: 1935787

Strand: Direct

Name: tcmA [H]

Synonym: MAB_1935

Alternate gene names: 169629023

Gene position: 1934393-1935787 (Clockwise)

Preceding gene: 169629022

Following gene: 169629024

Centisome position: 38.18

GC content: 68.75

Gene sequence:

>1395_bases
ATGATCCTGCTCGCCGTCTGCCTGGCGGTGTTCATGTTGCTGCTCGACATGACGATCGTGTCGAGCGCGCTCGCCGACCT
GCAGGCATCGTTGGGGGCCGACCTCTCGGACCTGCAATGGGTTATCGACGCCTACGCCCTGCCGATGGCCGGGCTGCTGC
TCACTGCCGCCACCCTCGGCGACCGGCTGGGCCGTCGTCGCCTCTACCTGTTGGGCATGGCCCTCTTCACGACGGCGTCG
CTGGTCTGTGCGCTATCGGGCAGTGCGGCCATGCTGATCGGGGTGCGCGCGGTGCAGGGGACAGGGGGTGCCATCCTGCT
CGCGGTATCGCTGCCGATCATCGCCGCCGCGTATCCGCAGGAGCGCCGCGGTGGCCCCATCGCGATCTACGGCGCTGTCA
TGGGCGCGGGCAGCGCCGCGGGTCCGCTATTGGGCGGATTCCTTGTCACCCACTTCGGGTGGCAGTCGATCTTCCTGGTG
AACCTGCCGGTGGGTGTGATCGCGTTGATCATCGCGGCCCGCCACCTGCCCGAGACACGTGCCGAGCAGACGCGCCCGGT
GGACTGGGTGGGCACGATGCTGCTCACCTGCGGACTGTTGACCGGTGTATTCGCGGTGATCTCCCTGCACGGCGGGGGAA
TCGGCGCCCGTGCCTGCGCGGCCCTCGCACTCTGCGCCGTGGTGGCCCTGGCGTTGTTCCTCTGGTGGGAAGGGCGCACG
CCGGCTCCCATGTTGAGCCTGCGGCTGGTCACCTCACCGGGATTCGCCGGAGTGTGGGTGGCCGCCGCGGCGGCCTCGGG
CACGCTCATCGGTGCCACCAACTATCTGGCGTTGTATTTCATGAACACCCTGGGTTACAACGCCTTTGAGACCGGGCTAC
GTGCCGGGCCGCTGACACTGGCCACCATCGCGGGGGCGCCGTTGGGGATTCTCGTGGGCAAGCGGCTCCCCAGCGTGGTG
ACCATTCCCGGGGGTGTGGCGCTGGTCGCCGTCGGGTTGTGGGCCGCGACCGGGGCCCATGCGGGTACGGTCTGGACCCA
CTTCATTTTTGGTTCCGCGCTGGCCGGGCTGGGGTTGGGCGCGCTCTCGGCGGTGACATCCGATGCCGCCCTGCAGTTCG
TGCCGCTCGACGACGCCGGAATGGCCACGGGATCGGTAAGTACCGGCCGTCAGATCGGCATTCTGCTGGGCGTCGCGGGC
ATGGGTGTGGCATTCGGTCTGGCCGCCGCGGGCCAGTCCGGACCCCGTGCCGCCGGTGCCGCCGCCATCAACAGCGTGTT
GGCATGGGGAGCCCTCGCCGCGGCCTGCGCGGCGTTCGTTTCGCTGATTCTGCTCAGTGTGGCTACGATAAGTCGCTCGC
ACGATCCGGCCACCGGAGAGTCGCTAGCTATCTAG

Upstream 100 bases:

>100_bases
ATCACCGACATTGATGGCCGCGGTCTCCATGACCGGGTGACCCGCACTGTCGTGATTCGTGTGCGATGAGCGCTTGCGCG
AAGAGCGTGGGCAGCGCTAG

Downstream 100 bases:

>100_bases
CCATCGGTGAAGAGCGCCTGCCAGTACGGATGCCCACAGGGATTTGTGCATTGCGGTCGTGCTCCGTAGACAGAGGGAGT
AGCTTTCGATCATGGAGAGC

Product: putative drug resistance transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MILLAVCLAVFMLLLDMTIVSSALADLQASLGADLSDLQWVIDAYALPMAGLLLTAATLGDRLGRRRLYLLGMALFTTAS
LVCALSGSAAMLIGVRAVQGTGGAILLAVSLPIIAAAYPQERRGGPIAIYGAVMGAGSAAGPLLGGFLVTHFGWQSIFLV
NLPVGVIALIIAARHLPETRAEQTRPVDWVGTMLLTCGLLTGVFAVISLHGGGIGARACAALALCAVVALALFLWWEGRT
PAPMLSLRLVTSPGFAGVWVAAAAASGTLIGATNYLALYFMNTLGYNAFETGLRAGPLTLATIAGAPLGILVGKRLPSVV
TIPGGVALVAVGLWAATGAHAGTVWTHFIFGSALAGLGLGALSAVTSDAALQFVPLDDAGMATGSVSTGRQIGILLGVAG
MGVAFGLAAAGQSGPRAAGAAAINSVLAWGALAAACAAFVSLILLSVATISRSHDPATGESLAI

Sequences:

>Translated_464_residues
MILLAVCLAVFMLLLDMTIVSSALADLQASLGADLSDLQWVIDAYALPMAGLLLTAATLGDRLGRRRLYLLGMALFTTAS
LVCALSGSAAMLIGVRAVQGTGGAILLAVSLPIIAAAYPQERRGGPIAIYGAVMGAGSAAGPLLGGFLVTHFGWQSIFLV
NLPVGVIALIIAARHLPETRAEQTRPVDWVGTMLLTCGLLTGVFAVISLHGGGIGARACAALALCAVVALALFLWWEGRT
PAPMLSLRLVTSPGFAGVWVAAAAASGTLIGATNYLALYFMNTLGYNAFETGLRAGPLTLATIAGAPLGILVGKRLPSVV
TIPGGVALVAVGLWAATGAHAGTVWTHFIFGSALAGLGLGALSAVTSDAALQFVPLDDAGMATGSVSTGRQIGILLGVAG
MGVAFGLAAAGQSGPRAAGAAAINSVLAWGALAAACAAFVSLILLSVATISRSHDPATGESLAI
>Mature_464_residues
MILLAVCLAVFMLLLDMTIVSSALADLQASLGADLSDLQWVIDAYALPMAGLLLTAATLGDRLGRRRLYLLGMALFTTAS
LVCALSGSAAMLIGVRAVQGTGGAILLAVSLPIIAAAYPQERRGGPIAIYGAVMGAGSAAGPLLGGFLVTHFGWQSIFLV
NLPVGVIALIIAARHLPETRAEQTRPVDWVGTMLLTCGLLTGVFAVISLHGGGIGARACAALALCAVVALALFLWWEGRT
PAPMLSLRLVTSPGFAGVWVAAAAASGTLIGATNYLALYFMNTLGYNAFETGLRAGPLTLATIAGAPLGILVGKRLPSVV
TIPGGVALVAVGLWAATGAHAGTVWTHFIFGSALAGLGLGALSAVTSDAALQFVPLDDAGMATGSVSTGRQIGILLGVAG
MGVAFGLAAAGQSGPRAAGAAAINSVLAWGALAAACAAFVSLILLSVATISRSHDPATGESLAI

Specific function: Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=394, Percent_Identity=30.2030456852792, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1790195, Length=402, Percent_Identity=32.089552238806, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788710, Length=312, Percent_Identity=30.1282051282051, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789042, Length=362, Percent_Identity=27.0718232044199, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788392, Length=320, Percent_Identity=31.5625, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790146, Length=166, Percent_Identity=28.3132530120482, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=32, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322958, Length=194, Percent_Identity=28.8659793814433, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=140, Percent_Identity=30.7142857142857, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319770, Length=294, Percent_Identity=24.4897959183673, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46457; Mature: 46457

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLAVCLAVFMLLLDMTIVSSALADLQASLGADLSDLQWVIDAYALPMAGLLLTAATLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DRLGRRRLYLLGMALFTTASLVCALSGSAAMLIGVRAVQGTGGAILLAVSLPIIAAAYPQ
HHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEEHHHHHHHCCCH
ERRGGPIAIYGAVMGAGSAAGPLLGGFLVTHFGWQSIFLVNLPVGVIALIIAARHLPETR
HHCCCCEEEEEEHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCHHH
AEQTRPVDWVGTMLLTCGLLTGVFAVISLHGGGIGARACAALALCAVVALALFLWWEGRT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PAPMLSLRLVTSPGFAGVWVAAAAASGTLIGATNYLALYFMNTLGYNAFETGLRAGPLTL
CCCEEEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCHHHHCCCCCCCCE
ATIAGAPLGILVGKRLPSVVTIPGGVALVAVGLWAATGAHAGTVWTHFIFGSALAGLGLG
EHHCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ALSAVTSDAALQFVPLDDAGMATGSVSTGRQIGILLGVAGMGVAFGLAAAGQSGPRAAGA
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AAINSVLAWGALAAACAAFVSLILLSVATISRSHDPATGESLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MILLAVCLAVFMLLLDMTIVSSALADLQASLGADLSDLQWVIDAYALPMAGLLLTAATLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DRLGRRRLYLLGMALFTTASLVCALSGSAAMLIGVRAVQGTGGAILLAVSLPIIAAAYPQ
HHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEEHHHHHHHCCCH
ERRGGPIAIYGAVMGAGSAAGPLLGGFLVTHFGWQSIFLVNLPVGVIALIIAARHLPETR
HHCCCCEEEEEEHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCHHH
AEQTRPVDWVGTMLLTCGLLTGVFAVISLHGGGIGARACAALALCAVVALALFLWWEGRT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PAPMLSLRLVTSPGFAGVWVAAAAASGTLIGATNYLALYFMNTLGYNAFETGLRAGPLTL
CCCEEEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCHHHHCCCCCCCCE
ATIAGAPLGILVGKRLPSVVTIPGGVALVAVGLWAATGAHAGTVWTHFIFGSALAGLGLG
EHHCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ALSAVTSDAALQFVPLDDAGMATGSVSTGRQIGILLGVAGMGVAFGLAAAGQSGPRAAGA
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AAINSVLAWGALAAACAAFVSLILLSVATISRSHDPATGESLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1592819 [H]