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The map label for this gene is ptpA [H]

Identifier: 169628988

GI number: 169628988

Start: 1897979

End: 1898467

Strand: Reverse

Name: ptpA [H]

Synonym: MAB_1900c

Alternate gene names: 169628988

Gene position: 1898467-1897979 (Counterclockwise)

Preceding gene: 169628989

Following gene: 169628987

Centisome position: 37.47

GC content: 66.26

Gene sequence:

>489_bases
ATGTCTGAGCTGCATGTCACCTTCGTGTGCACCGGAAACATCTGCCGCTCCCCTATCGCCGAGAAGATGCTTGCCCATCA
GCTGGCCGAACGCGGGCTGGCCGATCGAGTCCGGGTCACCAGCGCCGGTACCGGCGATTGGCATGCCGGGCAACCCGCCG
ACGAACGCGCGTCCAGCGTGCTGGCCGAGTACGGCTACCCGACGGCCCATCGCGCCGCCCAGGTCGACGAGGACCATCTG
AGCGCCGACCTCATCATCGCCTTGGCGCGCAACCACTCCCGGATGCTGTTGCACCTGGGAGCCGACCCCGAACGAGTGCG
GCTACTACGGTCCTTCGACCCACGAGCCAGCCGCGCCGCGATGGATGTCGAGGATCCGTACTACGGCAACCGCAAGGATT
TCGTGGAGGTGCTCGCGGTGATAGAGGCGGCCCTGCCTGGTGTGCACGAGTGGGTCGACAAGACCCTCGCGGAGCGTGAG
AACAGCTGA

Upstream 100 bases:

>100_bases
TGGGGCTACGGGGCAACCGATTTCGAAGGTGATCCCGGTCAGTTGGCTGAGTGGATCATCGGGCGCGTGAGCACTCCGGA
GCAGTTGCTGGAGGAACTCG

Downstream 100 bases:

>100_bases
TGCGACGGCTCGCGTTTCTCCTACGCCCGGGGTGGATCGCCCTGGCGCTGGTGGTCGTCGCATTCGCCTACCTGTGTTTC
ACGGTGCTGGCGCCGTGGCA

Product: putative low molecular weight protein tyrosine phosphatase

Products: NA

Alternate protein names: PTPase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MSELHVTFVCTGNICRSPIAEKMLAHQLAERGLADRVRVTSAGTGDWHAGQPADERASSVLAEYGYPTAHRAAQVDEDHL
SADLIIALARNHSRMLLHLGADPERVRLLRSFDPRASRAAMDVEDPYYGNRKDFVEVLAVIEAALPGVHEWVDKTLAERE
NS

Sequences:

>Translated_162_residues
MSELHVTFVCTGNICRSPIAEKMLAHQLAERGLADRVRVTSAGTGDWHAGQPADERASSVLAEYGYPTAHRAAQVDEDHL
SADLIIALARNHSRMLLHLGADPERVRLLRSFDPRASRAAMDVEDPYYGNRKDFVEVLAVIEAALPGVHEWVDKTLAERE
NS
>Mature_161_residues
SELHVTFVCTGNICRSPIAEKMLAHQLAERGLADRVRVTSAGTGDWHAGQPADERASSVLAEYGYPTAHRAAQVDEDHLS
ADLIIALARNHSRMLLHLGADPERVRLLRSFDPRASRAAMDVEDPYYGNRKDFVEVLAVIEAALPGVHEWVDKTLAEREN
S

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=137, Percent_Identity=36.4963503649635, Blast_Score=93, Evalue=8e-20,
Organism=Homo sapiens, GI6005988, Length=137, Percent_Identity=36.4963503649635, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI96304457, Length=70, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325330, Length=138, Percent_Identity=29.7101449275362, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78706764, Length=124, Percent_Identity=35.4838709677419, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706766, Length=124, Percent_Identity=35.4838709677419, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706768, Length=124, Percent_Identity=35.4838709677419, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706770, Length=124, Percent_Identity=36.2903225806452, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI78706772, Length=124, Percent_Identity=36.2903225806452, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI78711846, Length=153, Percent_Identity=30.718954248366, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17911; Mature: 17780

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELHVTFVCTGNICRSPIAEKMLAHQLAERGLADRVRVTSAGTGDWHAGQPADERASSV
CCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCHHHHHHHH
LAEYGYPTAHRAAQVDEDHLSADLIIALARNHSRMLLHLGADPERVRLLRSFDPRASRAA
HHHCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCHHCC
MDVEDPYYGNRKDFVEVLAVIEAALPGVHEWVDKTLAERENS
CCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SELHVTFVCTGNICRSPIAEKMLAHQLAERGLADRVRVTSAGTGDWHAGQPADERASSV
CCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCHHHHHHHH
LAEYGYPTAHRAAQVDEDHLSADLIIALARNHSRMLLHLGADPERVRLLRSFDPRASRAA
HHHCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCHHCC
MDVEDPYYGNRKDFVEVLAVIEAALPGVHEWVDKTLAERENS
CCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]