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The map label for this gene is fabR [H]

Identifier: 169628679

GI number: 169628679

Start: 1618015

End: 1618668

Strand: Direct

Name: fabR [H]

Synonym: MAB_1589

Alternate gene names: 169628679

Gene position: 1618015-1618668 (Clockwise)

Preceding gene: 169628675

Following gene: 169628681

Centisome position: 31.93

GC content: 66.06

Gene sequence:

>654_bases
ATGACCAGTCACCGCGAGCGGGGAGCGCGTGCGGGTGCGTCCTCGCGCCGGGATTCGGTCCGGGGTGAGCAGAAACTGCG
CACCCGCACCGCTCTGATGGAGGCCGCCCTCGAGCTCTCACGTACACAGGCGTTCTCGGGACTGAGCCTGCGTGATGTCG
CCCGCGGTGCGGGCATTTCACCGACGGCGTTCTATCGACACTTCTCCTCCCTGGACGACCTGGGCGTGGCGCTGGCCGAG
GAGGGCATGCGCATTGCCCGCGGAATCGCACGAGAGATACGCCGTCGTGAACCGGCGACGTTGGCGGAGTCGATGCGCAT
CCTGGCCGAGCAGGTTCAGGAAAACCCGGATCAGCTGCGGTTTGTTGTCACCGAGCGGTACACCGCCCCCACGGAGGTGC
GGCGAGCAGTGAACATCGAGATGCGGCTGCTGGCAGGCGAGCTGGCGATTGACCTGGCCCGACGCGATCAGATGCGGTTA
TGGGATTCCGCCGACCTGACGACGGCGGCGAACCTCATCCTGTCGATCGCCGCCAACGCGGTGGCCGAGTTGGTTCAGCC
CGACACCGACACCACCGAGGTGGTCGACAGCGCTTCCAACGCGTTGACGATGGCGTTCGTCGGTCTACAGAACTGGAAAC
CGGCACAGCGCTAG

Upstream 100 bases:

>100_bases
GTTAGGTTAACGAATGTACACTGAAATTGTGAACCAATATGCCCCCACTCAGTCAAGCCGTAATCACCGTGTCGGTCATC
ACAGCGATACAGTGATCGTC

Downstream 100 bases:

>100_bases
CCGCGAGGCTCCGATTCGCCCAGTCGTTGATGTAGCCGATCGCGGATCTCTTCGACGGTGTACGCCTCACGTTTGCGTTG
ATCGCGGGCGACCAGCACGC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTSHRERGARAGASSRRDSVRGEQKLRTRTALMEAALELSRTQAFSGLSLRDVARGAGISPTAFYRHFSSLDDLGVALAE
EGMRIARGIAREIRRREPATLAESMRILAEQVQENPDQLRFVVTERYTAPTEVRRAVNIEMRLLAGELAIDLARRDQMRL
WDSADLTTAANLILSIAANAVAELVQPDTDTTEVVDSASNALTMAFVGLQNWKPAQR

Sequences:

>Translated_217_residues
MTSHRERGARAGASSRRDSVRGEQKLRTRTALMEAALELSRTQAFSGLSLRDVARGAGISPTAFYRHFSSLDDLGVALAE
EGMRIARGIAREIRRREPATLAESMRILAEQVQENPDQLRFVVTERYTAPTEVRRAVNIEMRLLAGELAIDLARRDQMRL
WDSADLTTAANLILSIAANAVAELVQPDTDTTEVVDSASNALTMAFVGLQNWKPAQR
>Mature_216_residues
TSHRERGARAGASSRRDSVRGEQKLRTRTALMEAALELSRTQAFSGLSLRDVARGAGISPTAFYRHFSSLDDLGVALAEE
GMRIARGIAREIRRREPATLAESMRILAEQVQENPDQLRFVVTERYTAPTEVRRAVNIEMRLLAGELAIDLARRDQMRLW
DSADLTTAANLILSIAANAVAELVQPDTDTTEVVDSASNALTMAFVGLQNWKPAQR

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=167, Percent_Identity=35.3293413173653, Blast_Score=90, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23978; Mature: 23846

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHRERGARAGASSRRDSVRGEQKLRTRTALMEAALELSRTQAFSGLSLRDVARGAGIS
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
PTAFYRHFSSLDDLGVALAEEGMRIARGIAREIRRREPATLAESMRILAEQVQENPDQLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHEE
FVVTERYTAPTEVRRAVNIEMRLLAGELAIDLARRDQMRLWDSADLTTAANLILSIAANA
EHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VAELVQPDTDTTEVVDSASNALTMAFVGLQNWKPAQR
HHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TSHRERGARAGASSRRDSVRGEQKLRTRTALMEAALELSRTQAFSGLSLRDVARGAGIS
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
PTAFYRHFSSLDDLGVALAEEGMRIARGIAREIRRREPATLAESMRILAEQVQENPDQLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHEE
FVVTERYTAPTEVRRAVNIEMRLLAGELAIDLARRDQMRLWDSADLTTAANLILSIAANA
EHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VAELVQPDTDTTEVVDSASNALTMAFVGLQNWKPAQR
HHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA