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The map label for this gene is cysM [H]

Identifier: 169628571

GI number: 169628571

Start: 1491667

End: 1492641

Strand: Direct

Name: cysM [H]

Synonym: MAB_1480

Alternate gene names: 169628571

Gene position: 1491667-1492641 (Clockwise)

Preceding gene: 169628570

Following gene: 169628572

Centisome position: 29.44

GC content: 64.1

Gene sequence:

>975_bases
ATGACGCGATACGACTCGCTGCTGCAGGCGCTTGGGAACACGCCACTGGTCGGATTGCAGAGGCTGTCCCCACGGTGGGA
TTCAGGTGGTGACGGTTCTCCGCACGTGCGGTTGTGGGCCAAGCTGGAAGACCGCAATCCGACCGGATCCATCAAGGACA
GGCCCGCGTTGCGCATGATCGAGCAGGCCGAACAGGACGGATTGCTGGAGCGGGGAGCCACGATTCTGGAGCCCACCAGT
GGGAATACCGGCATTTCGATGGCGATGGCCGCGCAGCTCAAGGGTTACAAGATGATCTGCGTGATGCCCGAGAACACCTC
CATCGAACGGCGCCAGCTCCTCGAACTCTACGGGGCCCAAATCATTTTCTCCCCGGCCGAGGGCGGCTCCAACACCGCCG
TCGCGACAGCGAAAGAACTTGCCGCGCAAAATCCTTCGTGGGTGATGCTGTACCAGTACGGCAATCCGGCCAACGCCGAT
GCGCACTATCGTGGCACCGGTCCGGAGATTCTGGCCGATCTGCCGGAGATCACCCACTTCGTCGCCGGATTGGGCACCAC
CGGAACCCTGATGGGCACCGGAAGATACCTGCGCGAGAACGTGCCAGGAGTCCAGATCGTCGCCGCCGAACCGCGATACG
GCGAGGGTGTTTACGCACTGCGCAACATCGATGAGGGATTCGTACCCGAGCTGTACGACCCCGAGGTGCTCACCACGCGC
TTCTCCGTCGGGTCCTTCGACGCGGTGCGCCGCACGCGCGAACTGGTCCAGGTGGAGGGCATCTTCGCGGGCATCTCAAC
CGGCGCGATTCTGCATGCGGCGCTCGGCATGGCCGCCAAGGCGGTCAAAGCCGGGGAGCGCGCGGACATCGCGTTCGTGG
TGGCCGATGCGGGCTGGAAGTATCTGTCGACCGGTGCCTACGCCGGTACCGTGGACGACGCAGAGGATGCACTGGAAGGG
CAGCTGTGGGCGTGA

Upstream 100 bases:

>100_bases
CAACGACGAGGACGTGCGGTTCTCGGGTGGGCTGGACACCGAGATCGCCGATGGCGATTCGGTCACCATCCTGCCCGCCG
TGGCCGGTGGCTAGCAGCGC

Downstream 100 bases:

>100_bases
CGGGATATGGCGGTGGACCTGACTATCCAGGTTCTCCTTCCTCCCGTCGTGAGCGGTCGGGCCGTCCGCAATGGGTCACC
GGCGGGGTCTTGGTGGCCTC

Product: cysteine synthase

Products: NA

Alternate protein names: OPS sulfhydrylase; CysO-thiocarboxylate-dependent cysteine synthase; Cysteine synthase B; CSase B; O-phosphoserine-specific cysteine synthase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTRYDSLLQALGNTPLVGLQRLSPRWDSGGDGSPHVRLWAKLEDRNPTGSIKDRPALRMIEQAEQDGLLERGATILEPTS
GNTGISMAMAAQLKGYKMICVMPENTSIERRQLLELYGAQIIFSPAEGGSNTAVATAKELAAQNPSWVMLYQYGNPANAD
AHYRGTGPEILADLPEITHFVAGLGTTGTLMGTGRYLRENVPGVQIVAAEPRYGEGVYALRNIDEGFVPELYDPEVLTTR
FSVGSFDAVRRTRELVQVEGIFAGISTGAILHAALGMAAKAVKAGERADIAFVVADAGWKYLSTGAYAGTVDDAEDALEG
QLWA

Sequences:

>Translated_324_residues
MTRYDSLLQALGNTPLVGLQRLSPRWDSGGDGSPHVRLWAKLEDRNPTGSIKDRPALRMIEQAEQDGLLERGATILEPTS
GNTGISMAMAAQLKGYKMICVMPENTSIERRQLLELYGAQIIFSPAEGGSNTAVATAKELAAQNPSWVMLYQYGNPANAD
AHYRGTGPEILADLPEITHFVAGLGTTGTLMGTGRYLRENVPGVQIVAAEPRYGEGVYALRNIDEGFVPELYDPEVLTTR
FSVGSFDAVRRTRELVQVEGIFAGISTGAILHAALGMAAKAVKAGERADIAFVVADAGWKYLSTGAYAGTVDDAEDALEG
QLWA
>Mature_323_residues
TRYDSLLQALGNTPLVGLQRLSPRWDSGGDGSPHVRLWAKLEDRNPTGSIKDRPALRMIEQAEQDGLLERGATILEPTSG
NTGISMAMAAQLKGYKMICVMPENTSIERRQLLELYGAQIIFSPAEGGSNTAVATAKELAAQNPSWVMLYQYGNPANADA
HYRGTGPEILADLPEITHFVAGLGTTGTLMGTGRYLRENVPGVQIVAAEPRYGEGVYALRNIDEGFVPELYDPEVLTTRF
SVGSFDAVRRTRELVQVEGIFAGISTGAILHAALGMAAKAVKAGERADIAFVVADAGWKYLSTGAYAGTVDDAEDALEGQ
LWA

Specific function: Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in v

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=33.8658146964856, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=33.8658146964856, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=33.8658146964856, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI11345492, Length=202, Percent_Identity=26.7326732673267, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=40.9240924092409, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1788754, Length=322, Percent_Identity=36.6459627329193, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=317, Percent_Identity=37.5394321766561, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=37.0607028753994, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI32566674, Length=286, Percent_Identity=38.8111888111888, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=36.2745098039216, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17561720, Length=308, Percent_Identity=36.6883116883117, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=33.0188679245283, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25147552, Length=317, Percent_Identity=32.4921135646688, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI32566672, Length=221, Percent_Identity=34.841628959276, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321594, Length=321, Percent_Identity=33.3333333333333, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6321449, Length=338, Percent_Identity=31.6568047337278, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24643623, Length=315, Percent_Identity=37.7777777777778, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20129101, Length=315, Percent_Identity=37.7777777777778, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.65 [H]

Molecular weight: Translated: 34775; Mature: 34644

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYDSLLQALGNTPLVGLQRLSPRWDSGGDGSPHVRLWAKLEDRNPTGSIKDRPALRMI
CCHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHH
EQAEQDGLLERGATILEPTSGNTGISMAMAAQLKGYKMICVMPENTSIERRQLLELYGAQ
HHHHHCCHHHCCCEEEECCCCCCCEEHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCE
IIFSPAEGGSNTAVATAKELAAQNPSWVMLYQYGNPANADAHYRGTGPEILADLPEITHF
EEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHH
VAGLGTTGTLMGTGRYLRENVPGVQIVAAEPRYGEGVYALRNIDEGFVPELYDPEVLTTR
HHCCCCCCEEEECCHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCEEEEE
FSVGSFDAVRRTRELVQVEGIFAGISTGAILHAALGMAAKAVKAGERADIAFVVADAGWK
ECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCE
YLSTGAYAGTVDDAEDALEGQLWA
EEECCCCCCCCCCHHHHHCCCCCC
>Mature Secondary Structure 
TRYDSLLQALGNTPLVGLQRLSPRWDSGGDGSPHVRLWAKLEDRNPTGSIKDRPALRMI
CHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHH
EQAEQDGLLERGATILEPTSGNTGISMAMAAQLKGYKMICVMPENTSIERRQLLELYGAQ
HHHHHCCHHHCCCEEEECCCCCCCEEHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCE
IIFSPAEGGSNTAVATAKELAAQNPSWVMLYQYGNPANADAHYRGTGPEILADLPEITHF
EEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHH
VAGLGTTGTLMGTGRYLRENVPGVQIVAAEPRYGEGVYALRNIDEGFVPELYDPEVLTTR
HHCCCCCCEEEECCHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCEEEEE
FSVGSFDAVRRTRELVQVEGIFAGISTGAILHAALGMAAKAVKAGERADIAFVVADAGWK
ECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCE
YLSTGAYAGTVDDAEDALEGQLWA
EEECCCCCCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]