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The map label for this gene is pncB1 [H]

Identifier: 169628565

GI number: 169628565

Start: 1487606

End: 1488910

Strand: Reverse

Name: pncB1 [H]

Synonym: MAB_1474c

Alternate gene names: 169628565

Gene position: 1488910-1487606 (Counterclockwise)

Preceding gene: 169628577

Following gene: 169628564

Centisome position: 29.38

GC content: 66.36

Gene sequence:

>1305_bases
ATGACGCACCCTTGCACGTCATTGCTCACCGACAAATACGAGCTCACCATGCTTGCCGCGGCACTCCGCGACGGCACCGC
GGGGCGTCGCGCCACCTTCGAGGTATTCGCCAGAAGGCTCCCCGACGGCCGCCGATACGGGGTGGTGGCCGGTACGGGCC
GGTTGCTGGAGGCACTCGCCGAATTTCGCTTCGGACCTGCTGAATTAGAATCGGTGTCTACTTTTCTGGACGAAGATTCT
CTCGAATACCTGGCCGCCTACAGATTCGGCGGCGATATCGACGGCTACCCCGAGGGCGAGCTCTACTTCCCCGGGTCCCC
CGTACTCACCCTGCGTGGCTCCTTCGCCGAATGCGTCATCCTGGAGACCCTGATCCTGTCGATCCTGAATCACGACAGCG
CCGTCGCCTCCGCCGCCGCCCGCATGGTGTCGGCGGCCGGAGACCGACCGCTCATAGAGATGGGATCGCGCCGCACTCAC
GAACTCGCGGCGGTGGCCTGCGCCCGTGCGGCTTATCTCGCGGGCTTCGAATCGACATCCAATCTGGAGGCACAACGCCG
CTACGGTGTGCCTGCCCGGGGGACCGCTGCGCACGCCTTCACGCTGCTGCACGCCAAGGACGGCATGAGCCCCGGCGAGG
CCGAACGCGAGGCGTTCCGGGCACAGGTAGAGGCGCTAGGCGTCGGCACCACCCTGCTGGTCGATACCTACGACATCACC
GCCGGAGTGGAGAACGCCATCGCCGTCGCAGGCACCGCGCTCGGCGCGGTACGCATCGATTCCGGAGATCTGGGCATGCT
GGCGAGGCAGGTCCGGGCGCAACTGGACGCGTTAGGCGCGCACCGAACCCGCATCGTGGTGTCCGGGGACCTCGACGAAT
ACTCCATCGCGGCGCTGCGCGCCGAGCCCGTCGACATCTACGGAGTGGGCACCTCGGTGGTGACCGGCTCGGGAATACCG
ACCGCGGGTATGGTCTACAAGCTCGTCGAAATCGATGGCATTCCCGTGGCTAAACGCAGCAGCCACAAGGAATCTCACGG
TGGCCATAAGTGCGCCCTGCGCATCGCCAAACCAACGGGGACCATCACCGAGGAAGTCGTGTACCGCGCCGACGCCGGTC
AACCGACAGTGCCCGAGCCACACCGGATACTGACCACCGCACTGGTGCGCGGGGGCAAGCCTGTGGCATACCACTCGCTC
ACCGAAGCCCGGAACCGCGTGCACGCCGGGCTGCTGAGCCTGCCGTGGGAAGGGCTGGGCCTTTCCCACGGGGACCCTGC
GATTGCCACCCGCCTGGTGGGATAA

Upstream 100 bases:

>100_bases
ACTGCCGAGTCTGTCAGCACGAAGTTCGGAGTTTCCCGCGACCACGCGACGCCGTCGAGCACCCGCTCACACCGCCTGAT
CTCCCGCTAACGTGGCGCAC

Downstream 100 bases:

>100_bases
TTCGGGCCGGAGGTCATATGGCAGCCAGAAGGCAATGGGCGGGAACCACTCCCGAGGAGCGTCGAGCGACGCGTCGACGG
GCATTGCTCGACGCGGGTAT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTHPCTSLLTDKYELTMLAAALRDGTAGRRATFEVFARRLPDGRRYGVVAGTGRLLEALAEFRFGPAELESVSTFLDEDS
LEYLAAYRFGGDIDGYPEGELYFPGSPVLTLRGSFAECVILETLILSILNHDSAVASAAARMVSAAGDRPLIEMGSRRTH
ELAAVACARAAYLAGFESTSNLEAQRRYGVPARGTAAHAFTLLHAKDGMSPGEAEREAFRAQVEALGVGTTLLVDTYDIT
AGVENAIAVAGTALGAVRIDSGDLGMLARQVRAQLDALGAHRTRIVVSGDLDEYSIAALRAEPVDIYGVGTSVVTGSGIP
TAGMVYKLVEIDGIPVAKRSSHKESHGGHKCALRIAKPTGTITEEVVYRADAGQPTVPEPHRILTTALVRGGKPVAYHSL
TEARNRVHAGLLSLPWEGLGLSHGDPAIATRLVG

Sequences:

>Translated_434_residues
MTHPCTSLLTDKYELTMLAAALRDGTAGRRATFEVFARRLPDGRRYGVVAGTGRLLEALAEFRFGPAELESVSTFLDEDS
LEYLAAYRFGGDIDGYPEGELYFPGSPVLTLRGSFAECVILETLILSILNHDSAVASAAARMVSAAGDRPLIEMGSRRTH
ELAAVACARAAYLAGFESTSNLEAQRRYGVPARGTAAHAFTLLHAKDGMSPGEAEREAFRAQVEALGVGTTLLVDTYDIT
AGVENAIAVAGTALGAVRIDSGDLGMLARQVRAQLDALGAHRTRIVVSGDLDEYSIAALRAEPVDIYGVGTSVVTGSGIP
TAGMVYKLVEIDGIPVAKRSSHKESHGGHKCALRIAKPTGTITEEVVYRADAGQPTVPEPHRILTTALVRGGKPVAYHSL
TEARNRVHAGLLSLPWEGLGLSHGDPAIATRLVG
>Mature_433_residues
THPCTSLLTDKYELTMLAAALRDGTAGRRATFEVFARRLPDGRRYGVVAGTGRLLEALAEFRFGPAELESVSTFLDEDSL
EYLAAYRFGGDIDGYPEGELYFPGSPVLTLRGSFAECVILETLILSILNHDSAVASAAARMVSAAGDRPLIEMGSRRTHE
LAAVACARAAYLAGFESTSNLEAQRRYGVPARGTAAHAFTLLHAKDGMSPGEAEREAFRAQVEALGVGTTLLVDTYDITA
GVENAIAVAGTALGAVRIDSGDLGMLARQVRAQLDALGAHRTRIVVSGDLDEYSIAALRAEPVDIYGVGTSVVTGSGIPT
AGMVYKLVEIDGIPVAKRSSHKESHGGHKCALRIAKPTGTITEEVVYRADAGQPTVPEPHRILTTALVRGGKPVAYHSLT
EARNRVHAGLLSLPWEGLGLSHGDPAIATRLVG

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=440, Percent_Identity=32.2727272727273, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71997952, Length=488, Percent_Identity=29.9180327868852, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71997947, Length=470, Percent_Identity=30.2127659574468, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71997955, Length=218, Percent_Identity=35.3211009174312, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24581587, Length=433, Percent_Identity=28.8683602771363, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161076680, Length=201, Percent_Identity=30.8457711442786, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24581595, Length=201, Percent_Identity=30.8457711442786, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28574709, Length=201, Percent_Identity=30.8457711442786, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24581593, Length=201, Percent_Identity=30.8457711442786, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24581591, Length=201, Percent_Identity=30.8457711442786, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 45916; Mature: 45784

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPCTSLLTDKYELTMLAAALRDGTAGRRATFEVFARRLPDGRRYGVVAGTGRLLEALA
CCCCHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
EFRFGPAELESVSTFLDEDSLEYLAAYRFGGDIDGYPEGELYFPGSPVLTLRGSFAECVI
HHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEECCCHHHHHH
LETLILSILNHDSAVASAAARMVSAAGDRPLIEMGSRRTHELAAVACARAAYLAGFESTS
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
NLEAQRRYGVPARGTAAHAFTLLHAKDGMSPGEAEREAFRAQVEALGVGTTLLVDTYDIT
CCCHHHHCCCCCCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEHH
AGVENAIAVAGTALGAVRIDSGDLGMLARQVRAQLDALGAHRTRIVVSGDLDEYSIAALR
CCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEE
AEPVDIYGVGTSVVTGSGIPTAGMVYKLVEIDGIPVAKRSSHKESHGGHKCALRIAKPTG
CCCEEEEECCCCEEECCCCCCHHHEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCC
TITEEVVYRADAGQPTVPEPHRILTTALVRGGKPVAYHSLTEARNRVHAGLLSLPWEGLG
CHHHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCC
LSHGDPAIATRLVG
CCCCCHHHHHCCCC
>Mature Secondary Structure 
THPCTSLLTDKYELTMLAAALRDGTAGRRATFEVFARRLPDGRRYGVVAGTGRLLEALA
CCCHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
EFRFGPAELESVSTFLDEDSLEYLAAYRFGGDIDGYPEGELYFPGSPVLTLRGSFAECVI
HHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEECCCHHHHHH
LETLILSILNHDSAVASAAARMVSAAGDRPLIEMGSRRTHELAAVACARAAYLAGFESTS
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
NLEAQRRYGVPARGTAAHAFTLLHAKDGMSPGEAEREAFRAQVEALGVGTTLLVDTYDIT
CCCHHHHCCCCCCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEHH
AGVENAIAVAGTALGAVRIDSGDLGMLARQVRAQLDALGAHRTRIVVSGDLDEYSIAALR
CCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEE
AEPVDIYGVGTSVVTGSGIPTAGMVYKLVEIDGIPVAKRSSHKESHGGHKCALRIAKPTG
CCCEEEEECCCCEEECCCCCCHHHEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCC
TITEEVVYRADAGQPTVPEPHRILTTALVRGGKPVAYHSLTEARNRVHAGLLSLPWEGLG
CHHHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCC
LSHGDPAIATRLVG
CCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]