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The map label for this gene is atpB [H]

Identifier: 169628538

GI number: 169628538

Start: 1451775

End: 1452548

Strand: Direct

Name: atpB [H]

Synonym: MAB_1447

Alternate gene names: 169628538

Gene position: 1451775-1452548 (Clockwise)

Preceding gene: 169628537

Following gene: 169628539

Centisome position: 28.65

GC content: 59.56

Gene sequence:

>774_bases
ATGATTACGACATTCCAGGCGGAAGCCGCCATCGAGGTCGGTCACCACAAGCACTGGACCTGGCACGGTGATTTCTGGCC
GTACGAGCTGACATTCAACGTGGACACCATTGTCGCAACCGCCCTGGCAGGGGTGGTTGTGATTGCGCTGGCGCTGTTCC
TGCGTGCCAAGGTCACCTCGACCGGTGTTCCCAACGGTGTGCAGCTGTTCTTCGAAGCGGTCACCGTTCAGTTCCGTAAC
CAGGTCGAGTCGGCCATCGGCATGAAGATCGCGCCGTTCGTCTTGCCGCTGGCGGTGACGATCTTCGTCTTCATCCTGGT
GTCGAACTGGATTTCGGTGTTGCCCGTGCAGTACACCGATGACACGGGTAAGACCGCCGAACTCTTGGCACCGCCGGCCT
CGGATATCAACTACGTGCTGGCACTGGCCCTGTTCGTCTTCGTCTGCTACCACATCGCGGGCTTCGCGCGCCGTGGTCTC
ATCGGCCACCCGATCAAGCTGCTCAAGGGTCACACCTGGGTCACCGCCTTCATCAACCCGATCGAGGAGCTGGCCAAGCC
TATTTCGCTCTCGCTGCGGCTCTTCGGCAACATGTTCGCCGGTGGCATCATGGTCGCCTTGATCGCGATGTTCCCCGCAT
GGATCATGTGGGCGCCCAATGCCATCTGGAAGTCGTTCGACCTGTTCGTCGGTCTTATCCAGGCCTTCATCTTCGCGTTG
CTGACGGTTCTGTACTTCAGCCAGTCGATGGAGCTGGACGAGGACCATCACTAA

Upstream 100 bases:

>100_bases
GTTCCAGGTGCTGCTGGTGTTGACCACCGCCGTGCCGGTGTGGAAAGGGATCCGTTCAGTGAATCAGCCGCAGGCTCAGG
TTGAGGGGGCATAGCCCAGC

Downstream 100 bases:

>100_bases
CCACATAGACCAACCTGTATAGACCCTGGTAGCACAGCTACCACTTAATAAGGAGGAAGAAAATGGCGGACCCCACAATT
GTTGCTGGTGCCCTCATCGG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MITTFQAEAAIEVGHHKHWTWHGDFWPYELTFNVDTIVATALAGVVVIALALFLRAKVTSTGVPNGVQLFFEAVTVQFRN
QVESAIGMKIAPFVLPLAVTIFVFILVSNWISVLPVQYTDDTGKTAELLAPPASDINYVLALALFVFVCYHIAGFARRGL
IGHPIKLLKGHTWVTAFINPIEELAKPISLSLRLFGNMFAGGIMVALIAMFPAWIMWAPNAIWKSFDLFVGLIQAFIFAL
LTVLYFSQSMELDEDHH

Sequences:

>Translated_257_residues
MITTFQAEAAIEVGHHKHWTWHGDFWPYELTFNVDTIVATALAGVVVIALALFLRAKVTSTGVPNGVQLFFEAVTVQFRN
QVESAIGMKIAPFVLPLAVTIFVFILVSNWISVLPVQYTDDTGKTAELLAPPASDINYVLALALFVFVCYHIAGFARRGL
IGHPIKLLKGHTWVTAFINPIEELAKPISLSLRLFGNMFAGGIMVALIAMFPAWIMWAPNAIWKSFDLFVGLIQAFIFAL
LTVLYFSQSMELDEDHH
>Mature_257_residues
MITTFQAEAAIEVGHHKHWTWHGDFWPYELTFNVDTIVATALAGVVVIALALFLRAKVTSTGVPNGVQLFFEAVTVQFRN
QVESAIGMKIAPFVLPLAVTIFVFILVSNWISVLPVQYTDDTGKTAELLAPPASDINYVLALALFVFVCYHIAGFARRGL
IGHPIKLLKGHTWVTAFINPIEELAKPISLSLRLFGNMFAGGIMVALIAMFPAWIMWAPNAIWKSFDLFVGLIQAFIFAL
LTVLYFSQSMELDEDHH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Escherichia coli, GI1790176, Length=207, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 28537; Mature: 28537

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTFQAEAAIEVGHHKHWTWHGDFWPYELTFNVDTIVATALAGVVVIALALFLRAKVTS
CCCCCCHHHHHHHCCCCCEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGVPNGVQLFFEAVTVQFRNQVESAIGMKIAPFVLPLAVTIFVFILVSNWISVLPVQYTD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
DTGKTAELLAPPASDINYVLALALFVFVCYHIAGFARRGLIGHPIKLLKGHTWVTAFINP
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHH
IEELAKPISLSLRLFGNMFAGGIMVALIAMFPAWIMWAPNAIWKSFDLFVGLIQAFIFAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LTVLYFSQSMELDEDHH
HHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MITTFQAEAAIEVGHHKHWTWHGDFWPYELTFNVDTIVATALAGVVVIALALFLRAKVTS
CCCCCCHHHHHHHCCCCCEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGVPNGVQLFFEAVTVQFRNQVESAIGMKIAPFVLPLAVTIFVFILVSNWISVLPVQYTD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
DTGKTAELLAPPASDINYVLALALFVFVCYHIAGFARRGLIGHPIKLLKGHTWVTAFINP
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHH
IEELAKPISLSLRLFGNMFAGGIMVALIAMFPAWIMWAPNAIWKSFDLFVGLIQAFIFAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LTVLYFSQSMELDEDHH
HHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]