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The map label for this gene is lysA [H]

Identifier: 169628525

GI number: 169628525

Start: 1438472

End: 1439884

Strand: Direct

Name: lysA [H]

Synonym: MAB_1434

Alternate gene names: 169628525

Gene position: 1438472-1439884 (Clockwise)

Preceding gene: 169628524

Following gene: 169628526

Centisome position: 28.39

GC content: 64.33

Gene sequence:

>1413_bases
GTGAGCGCACACCCGGCAGGCCCCCGCCACGCAGAAGGGGAACAGCACACCGCCATGAGCAGTGCACCACCGGCTAATCC
GACCGAATTGGCGTCAAATGTATGGCCCCGCAATGCCTCTCGCGGTGCCGACGGTGAAGTGACCCTTGCGGGCCTGGCCG
TCTCCGAACTCGCCGAGCAGTACGGCACCCCGCTGTTCGTGATTGACGAGGACGACTTCCGTTCGCGCTGCCGCGACATG
GCGGCGGCATTCGGTGGTGCTGCCCGCGTGCACTACGCGTCCAAGGCATTCCTGTGCACCGAGGTCGCGCGGTGGATCAA
GGACGAGGGGTTGGGCCTGGACGTTTGTTCGGCGGGCGAGTTGGCCGTTGCCTTGCGTGCCGAGTTTCCGCCTGAGCGAA
TCGCGCTGCACGGCAACAACAAATCCGAGGCGGAACTGGCACAGGCGGTACAGGCTGGTGTCGGGCATATTGTCGTCGAC
TCGATGATTGAGATCGATCGCCTGGATGCTATCGCCGGCCGGGCAGGCGTGGTGCAAGACGTGCTGGTGCGAGTCACCGT
CGGCGTCGAGGCACACACTCACGAGTTCATCTCCACCGCGCATGAGGATCAGAAGTTCGGGTTGTCGCTCGCGGGCGGGC
AGGCTTTGGAGGCCGTCCGGCGGGTCTTCGCCACCGATAACCTTCGGCTTGTTGGACTGCACAGCCATATCGGTTCGCAG
ATCTTTGATGTCGACGGCTTTGAGGTAGCCGCGCACCGGGTGATCGGGCTGTTGCGCGATGTGGTCGCCGAGTTCGGCAC
CGACAAGACGGCTCAGCTCAACATCATCGATCTCGGCGGCGGCCTCGGTATCAGCTATGTGCCGTCGGACGATCCGCCGC
CCATCGAGGATCTGGCCGCCAAGCTCGGCGTCATCGTGCGTACCGAGTCGGCGCTGGCGGGCCTGCCCGGGCCGCGGTTG
GTGATCGAGCCGGGCCGGGCCATCGCCGGTCCCGGCACTGTCACGCTCTACCGGGTGGGTACCACCAAGGACGTGATCCT
CTCGAACGGCCAGCGTCGTTACGTGAGTGTCGACGGTGGGATGAGTGACAACATCCGCACCTCGCTGTATCAGGCCGAGT
ATCACCCCCAACTGGTCTCCCGCGATAGCGACGTCGCACCGGTGCTGTCCCGGGTTGTCGGAAAGCATTGTGAAAGCGGC
GATATCGTGGTCAGGGACGCATGGCTACCCGAGGATGTGGCTCCCGGCGATCTGCTGGCTGTCGCTGCCACCGGGGCGTA
CTGCTATTCGATGTCCAGCCGGTACAACCTGCTGACCCGTCCGGCGGTCATCGCCGTCAAGGACGGAAGGGCGCGACTGA
TCCTGCGGCGTGAAACCGTCGAGGATTTGGTGAGTTTGGAGGTAAGTGAATGA

Upstream 100 bases:

>100_bases
CCGGCGACCTCCACGCGGCCCGGCTCGCACTGTGCCTGGCCACTCGCCAAGTCATCGCCAACGGCCTGGACATCCTCGGC
GTGAGCGCACCGGAGCGGAT

Downstream 100 bases:

>100_bases
GCGACGCGATAGGCGTGGCGATCCTGGGCCTGGGTAACGTCGGCAGTGAGGTCGCGCGCATCATCGAAAGCAGCGCAAGT
GATCTCGCGGCCCGCATAGG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSAHPAGPRHAEGEQHTAMSSAPPANPTELASNVWPRNASRGADGEVTLAGLAVSELAEQYGTPLFVIDEDDFRSRCRDM
AAAFGGAARVHYASKAFLCTEVARWIKDEGLGLDVCSAGELAVALRAEFPPERIALHGNNKSEAELAQAVQAGVGHIVVD
SMIEIDRLDAIAGRAGVVQDVLVRVTVGVEAHTHEFISTAHEDQKFGLSLAGGQALEAVRRVFATDNLRLVGLHSHIGSQ
IFDVDGFEVAAHRVIGLLRDVVAEFGTDKTAQLNIIDLGGGLGISYVPSDDPPPIEDLAAKLGVIVRTESALAGLPGPRL
VIEPGRAIAGPGTVTLYRVGTTKDVILSNGQRRYVSVDGGMSDNIRTSLYQAEYHPQLVSRDSDVAPVLSRVVGKHCESG
DIVVRDAWLPEDVAPGDLLAVAATGAYCYSMSSRYNLLTRPAVIAVKDGRARLILRRETVEDLVSLEVSE

Sequences:

>Translated_470_residues
MSAHPAGPRHAEGEQHTAMSSAPPANPTELASNVWPRNASRGADGEVTLAGLAVSELAEQYGTPLFVIDEDDFRSRCRDM
AAAFGGAARVHYASKAFLCTEVARWIKDEGLGLDVCSAGELAVALRAEFPPERIALHGNNKSEAELAQAVQAGVGHIVVD
SMIEIDRLDAIAGRAGVVQDVLVRVTVGVEAHTHEFISTAHEDQKFGLSLAGGQALEAVRRVFATDNLRLVGLHSHIGSQ
IFDVDGFEVAAHRVIGLLRDVVAEFGTDKTAQLNIIDLGGGLGISYVPSDDPPPIEDLAAKLGVIVRTESALAGLPGPRL
VIEPGRAIAGPGTVTLYRVGTTKDVILSNGQRRYVSVDGGMSDNIRTSLYQAEYHPQLVSRDSDVAPVLSRVVGKHCESG
DIVVRDAWLPEDVAPGDLLAVAATGAYCYSMSSRYNLLTRPAVIAVKDGRARLILRRETVEDLVSLEVSE
>Mature_469_residues
SAHPAGPRHAEGEQHTAMSSAPPANPTELASNVWPRNASRGADGEVTLAGLAVSELAEQYGTPLFVIDEDDFRSRCRDMA
AAFGGAARVHYASKAFLCTEVARWIKDEGLGLDVCSAGELAVALRAEFPPERIALHGNNKSEAELAQAVQAGVGHIVVDS
MIEIDRLDAIAGRAGVVQDVLVRVTVGVEAHTHEFISTAHEDQKFGLSLAGGQALEAVRRVFATDNLRLVGLHSHIGSQI
FDVDGFEVAAHRVIGLLRDVVAEFGTDKTAQLNIIDLGGGLGISYVPSDDPPPIEDLAAKLGVIVRTESALAGLPGPRLV
IEPGRAIAGPGTVTLYRVGTTKDVILSNGQRRYVSVDGGMSDNIRTSLYQAEYHPQLVSRDSDVAPVLSRVVGKHCESGD
IVVRDAWLPEDVAPGDLLAVAATGAYCYSMSSRYNLLTRPAVIAVKDGRARLILRRETVEDLVSLEVSE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=385, Percent_Identity=24.9350649350649, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=30.4038004750594, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49979; Mature: 49848

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHPAGPRHAEGEQHTAMSSAPPANPTELASNVWPRNASRGADGEVTLAGLAVSELAEQ
CCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHH
YGTPLFVIDEDDFRSRCRDMAAAFGGAARVHYASKAFLCTEVARWIKDEGLGLDVCSAGE
HCCEEEEECCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCC
LAVALRAEFPPERIALHGNNKSEAELAQAVQAGVGHIVVDSMIEIDRLDAIAGRAGVVQD
EEEEEECCCCHHHEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
VLVRVTVGVEAHTHEFISTAHEDQKFGLSLAGGQALEAVRRVFATDNLRLVGLHSHIGSQ
HHHHEEECCCHHHHHHHHHHCCCHHCCEEECCCHHHHHHHHHHHCCCEEEEEEHHHHCCC
IFDVDGFEVAAHRVIGLLRDVVAEFGTDKTAQLNIIDLGGGLGISYVPSDDPPPIEDLAA
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCCCHHHHHH
KLGVIVRTESALAGLPGPRLVIEPGRAIAGPGTVTLYRVGTTKDVILSNGQRRYVSVDGG
HHCEEEEECHHHCCCCCCEEEECCCCEECCCCEEEEEEECCCHHHEECCCCEEEEEECCC
MSDNIRTSLYQAEYHPQLVSRDSDVAPVLSRVVGKHCESGDIVVRDAWLPEDVAPGDLLA
CCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEE
VAATGAYCYSMSSRYNLLTRPAVIAVKDGRARLILRRETVEDLVSLEVSE
EEECCHHEEECCCCCCEEECCEEEEEECCCEEEEEEHHHHHHHHCEECCC
>Mature Secondary Structure 
SAHPAGPRHAEGEQHTAMSSAPPANPTELASNVWPRNASRGADGEVTLAGLAVSELAEQ
CCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHH
YGTPLFVIDEDDFRSRCRDMAAAFGGAARVHYASKAFLCTEVARWIKDEGLGLDVCSAGE
HCCEEEEECCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCC
LAVALRAEFPPERIALHGNNKSEAELAQAVQAGVGHIVVDSMIEIDRLDAIAGRAGVVQD
EEEEEECCCCHHHEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
VLVRVTVGVEAHTHEFISTAHEDQKFGLSLAGGQALEAVRRVFATDNLRLVGLHSHIGSQ
HHHHEEECCCHHHHHHHHHHCCCHHCCEEECCCHHHHHHHHHHHCCCEEEEEEHHHHCCC
IFDVDGFEVAAHRVIGLLRDVVAEFGTDKTAQLNIIDLGGGLGISYVPSDDPPPIEDLAA
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCCCHHHHHH
KLGVIVRTESALAGLPGPRLVIEPGRAIAGPGTVTLYRVGTTKDVILSNGQRRYVSVDGG
HHCEEEEECHHHCCCCCCEEEECCCCEECCCCEEEEEEECCCHHHEECCCCEEEEEECCC
MSDNIRTSLYQAEYHPQLVSRDSDVAPVLSRVVGKHCESGDIVVRDAWLPEDVAPGDLLA
CCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEE
VAATGAYCYSMSSRYNLLTRPAVIAVKDGRARLILRRETVEDLVSLEVSE
EEECCHHEEECCCCCCEEECCEEEEEECCCEEEEEEHHHHHHHHCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA