Click here to switch to the map view.

The map label for this gene is cmr [C]

Identifier: 169628392

GI number: 169628392

Start: 1301484

End: 1302692

Strand: Reverse

Name: cmr [C]

Synonym: MAB_1299c

Alternate gene names: 169628392

Gene position: 1302692-1301484 (Counterclockwise)

Preceding gene: 169628393

Following gene: 169628391

Centisome position: 25.71

GC content: 66.83

Gene sequence:

>1209_bases
GTGATTGCCCGTCTGCGCCGCTCGGCCGCCTTCGTCCTGCTCGCGTTCAGTTTCTCCGCGGTCATGATCGGCACGACGAT
GCCGACACCCATGTACGCGTTGTACTCGCAGCAGATGCACTTCTCGGTGCTCACCACCACTGTCGTCTACGCCACCTACG
CCGCCGGCGTGCTGTTCGCGCTGCTGATGTTCGGCGGCTGGTCCGATGTTCTCGGCCGCCGTCCGCTGTTGCTGACCGGC
GCCGGCTTCGCGATCCTCAGCTCGGTCATCTTCTTGTTCGTGGACTCAGTTCCGCTGCTATTGGTCGCGCGCATCGTCTC
AGGACTGTCAGCGGGCTTTTTCACCGGCGCCGCCACCGTCGCGGTCATCGAGTCGGCGCCTGAAACATGGCGGGGACGTG
CGGCCGCCGTGGCCACCGTCGCCAACACCGGCGGCCTGGGCCTGGGGCCCTTGCTCGCCGGTGTGCTGGTGCAGTATGCG
CCCTGGCCCACCCATCTGGCGTTCGTCGTTCACATCGGCCTGGTGTCGATAGCCGTGGCGGCGCTGCTCTTCGTGCCGGA
GACCGCACCGAAACACGGAAAGCTTGGTAGGCAACGTCTTTCGCTACCTCCTCAGGTGCGCGCTACCTTCGCCGCCGCCG
CGACGGCGGGCTTCGCCGGATTCGCCGCACTGGGATCCTTCACCGCGGTTGCTCCCGGATTCCTGTCCGGGGTGCTCGGC
ATCGATAACCATGCGGTCGCCGGGGCAAGCGTGTTTCTCACTTTCGGATCTTCTTGTGTGGCACAGATTCTCACCCGCCG
GGTGGCTGCCGCCAAGGCCTTGCTCATCGGCTGCACGATTCTGCTGACCGGCATGTTGCTGGTGGTGTTGGCGCTGCACA
CTTCATCGTTGCCGTGGTACCTGGCAAGTGCGGTGGTGGTCGGCATCGGGCAGGGCATCAGCTTCAGTCGTGGGCTGGCC
GCGATCGCCGACCGGACCCCCGAGGACAACCGTGCCGAGGTGACCTCCAGCTACTTCGTAGTCGCCTACATCGGCATCGC
CCTGCCGGTGATCGGCGAGGGACTCGCGGCGCAGGCGTGGGGCTTGCGCACCGCGGGGGTCACCTTCGCACTGGCGGTGG
CAGCCCTGGCGGCGCTGTGTCTCATCGCTGTCATCTGGCAGGAGCGCCCCAGCCGGACCGAGGCGCTGGCGCCGGTGTCC
ACCGGCTAA

Upstream 100 bases:

>100_bases
GGAAGCGTGAGGTTTCGGGCCCAGCAGTTCGCCGCGATTGCTGTCGCATCTGTCATCTCTCAGGGAACAACAGGGCACCG
CGGGTGACTTAGATTGGGTT

Downstream 100 bases:

>100_bases
TCAAATTCTGTAGCCGCCACGCCCTATGAGCACACTGTGGTGCCGAAAAGATAGGTAACACAGCACAGTTCGTAGACTCA
GCGTAGACGGTTAGGTCAGA

Product: multidrug ABC transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Facilitator Superfamily Protein; Facilitator Superfamily Multidrug Resistance Protein; Multi-Drug Efflux Transporter; Multidrug Efflux Protein; Mfs Transporter; Facilitator Superfamily; Arabinose Efflux Permease Family Protein; Multidrug Resistance Protein; Facilitator Superfamily Transporter Permease; Facilitator Superfamily Multidrug Efflux Transporter; Permease Of Facilitator Superfamily; General Substrate Transporter; Facilitator Superfamily Transporter; Mutlidrug Resistance Protein; ABC Transporter Membrane Protein; Drug Efflux Protein; Transmembrane Efflux Protein; Facilitator Family Transporter; Multidrug ABC Transporter; Drug Resistance Efflux Protein; Facilitator Family Protein; Multidrug-Efflux MFS Permease; Facilitator Superfamily Permease

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MIARLRRSAAFVLLAFSFSAVMIGTTMPTPMYALYSQQMHFSVLTTTVVYATYAAGVLFALLMFGGWSDVLGRRPLLLTG
AGFAILSSVIFLFVDSVPLLLVARIVSGLSAGFFTGAATVAVIESAPETWRGRAAAVATVANTGGLGLGPLLAGVLVQYA
PWPTHLAFVVHIGLVSIAVAALLFVPETAPKHGKLGRQRLSLPPQVRATFAAAATAGFAGFAALGSFTAVAPGFLSGVLG
IDNHAVAGASVFLTFGSSCVAQILTRRVAAAKALLIGCTILLTGMLLVVLALHTSSLPWYLASAVVVGIGQGISFSRGLA
AIADRTPEDNRAEVTSSYFVVAYIGIALPVIGEGLAAQAWGLRTAGVTFALAVAALAALCLIAVIWQERPSRTEALAPVS
TG

Sequences:

>Translated_402_residues
MIARLRRSAAFVLLAFSFSAVMIGTTMPTPMYALYSQQMHFSVLTTTVVYATYAAGVLFALLMFGGWSDVLGRRPLLLTG
AGFAILSSVIFLFVDSVPLLLVARIVSGLSAGFFTGAATVAVIESAPETWRGRAAAVATVANTGGLGLGPLLAGVLVQYA
PWPTHLAFVVHIGLVSIAVAALLFVPETAPKHGKLGRQRLSLPPQVRATFAAAATAGFAGFAALGSFTAVAPGFLSGVLG
IDNHAVAGASVFLTFGSSCVAQILTRRVAAAKALLIGCTILLTGMLLVVLALHTSSLPWYLASAVVVGIGQGISFSRGLA
AIADRTPEDNRAEVTSSYFVVAYIGIALPVIGEGLAAQAWGLRTAGVTFALAVAALAALCLIAVIWQERPSRTEALAPVS
TG
>Mature_402_residues
MIARLRRSAAFVLLAFSFSAVMIGTTMPTPMYALYSQQMHFSVLTTTVVYATYAAGVLFALLMFGGWSDVLGRRPLLLTG
AGFAILSSVIFLFVDSVPLLLVARIVSGLSAGFFTGAATVAVIESAPETWRGRAAAVATVANTGGLGLGPLLAGVLVQYA
PWPTHLAFVVHIGLVSIAVAALLFVPETAPKHGKLGRQRLSLPPQVRATFAAAATAGFAGFAALGSFTAVAPGFLSGVLG
IDNHAVAGASVFLTFGSSCVAQILTRRVAAAKALLIGCTILLTGMLLVVLALHTSSLPWYLASAVVVGIGQGISFSRGLA
AIADRTPEDNRAEVTSSYFVVAYIGIALPVIGEGLAAQAWGLRTAGVTFALAVAALAALCLIAVIWQERPSRTEALAPVS
TG

Specific function: Efflux Pump Driven By The Proton Motive Force. Confers Resistance To Basic, Aromatic And Lipophilic Drugs As Well As Neutral, Non-Aromatic, Zwitterionic Or Nonaromatic Hydrophilic Antibiotics. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 41359; Mature: 41359

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARLRRSAAFVLLAFSFSAVMIGTTMPTPMYALYSQQMHFSVLTTTVVYATYAAGVLFA
CCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMFGGWSDVLGRRPLLLTGAGFAILSSVIFLFVDSVPLLLVARIVSGLSAGFFTGAATV
HHHHCCCHHHHCCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AVIESAPETWRGRAAAVATVANTGGLGLGPLLAGVLVQYAPWPTHLAFVVHIGLVSIAVA
HHHHCCCHHHCCCHHHEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ALLFVPETAPKHGKLGRQRLSLPPQVRATFAAAATAGFAGFAALGSFTAVAPGFLSGVLG
HHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDNHAVAGASVFLTFGSSCVAQILTRRVAAAKALLIGCTILLTGMLLVVLALHTSSLPWY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LASAVVVGIGQGISFSRGLAAIADRTPEDNRAEVTSSYFVVAYIGIALPVIGEGLAAQAW
HHHHHHHHCCCCCCHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
GLRTAGVTFALAVAALAALCLIAVIWQERPSRTEALAPVSTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCC
>Mature Secondary Structure
MIARLRRSAAFVLLAFSFSAVMIGTTMPTPMYALYSQQMHFSVLTTTVVYATYAAGVLFA
CCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMFGGWSDVLGRRPLLLTGAGFAILSSVIFLFVDSVPLLLVARIVSGLSAGFFTGAATV
HHHHCCCHHHHCCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AVIESAPETWRGRAAAVATVANTGGLGLGPLLAGVLVQYAPWPTHLAFVVHIGLVSIAVA
HHHHCCCHHHCCCHHHEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ALLFVPETAPKHGKLGRQRLSLPPQVRATFAAAATAGFAGFAALGSFTAVAPGFLSGVLG
HHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDNHAVAGASVFLTFGSSCVAQILTRRVAAAKALLIGCTILLTGMLLVVLALHTSSLPWY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LASAVVVGIGQGISFSRGLAAIADRTPEDNRAEVTSSYFVVAYIGIALPVIGEGLAAQAW
HHHHHHHHCCCCCCHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
GLRTAGVTFALAVAALAALCLIAVIWQERPSRTEALAPVSTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA