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The map label for this gene is tcmP [H]

Identifier: 169628388

GI number: 169628388

Start: 1298324

End: 1299172

Strand: Reverse

Name: tcmP [H]

Synonym: MAB_1295c

Alternate gene names: 169628388

Gene position: 1299172-1298324 (Counterclockwise)

Preceding gene: 169628390

Following gene: 169628387

Centisome position: 25.64

GC content: 62.54

Gene sequence:

>849_bases
ATGACCGAGTCCGATGCTCTTCGCCCGAGCGGCTCATCGCGGATCAGCGGGGACAGTCTGGAGGGCGTCTCGGCTACCAC
TTTGTGGACGCTGCACAATCGCGGTACCGAAGCCAAGCGTCCCGACAGTGTCATCCGGGACCCGCTGGCCGCGGAGCTGT
TCGATGCCATCGAGTACGACTACCGCAAGTTCGGCCGCCCGTCGCAGACTCATGCGTTGCGCGCCCTCGCCTTTGACACG
CAGGCACGCGTGTATCTCGCGACGCACCCCAGGGCCGCGATCGTCGCCCTTGCCGAAGGCATGCAAACCAGCTTTTGGCG
GCTGGGTGGTGCCGATGCCACCGCCCAGTTCACCTGGTATTCAGTGGATTTGCCGCCCGTCATGGAGCTACGCAACCAAC
TGCTGCCCAACGATGAACGAATCGTCAAGCTGGCGCAGTCCGCGCTCGATCTCAGTTGGATGGATCAGGTCGACGCCTCC
GGTGGTGCCTTTATCACCGCGGAGGGACTGCTGATGTACTTGCAACCGGAGGAGTCTCTCGGACTAATCGAGGCCTGCGC
CAAGCGTTTTCCCGGCGGGCAGATGATGTTCGACAGCATCCCGCATTGGTTCAGCAGGCGCACCCTGCAGGGCTTTAAGT
TGTCGGATCGCTATGTGGCTCCACCCATGCCGTTCGCATTGACACCCGACGAAGGCGAAGCGCTCATCTCCATCCCGGGA
GTGGTCACCGCCATCGACATACCGCTGCATCGTGGCCGCGGCATCTGGAAATTCGTCAACTCCAAGCGCCTTGATCGCGG
CTTTCTGCGCCGGACCCGCCCCTCGATGACGCTGCTGCAATTCGGGTAG

Upstream 100 bases:

>100_bases
CGTCCGCGGCCGAGTCGCCGCTCCCCTTCGAATCGGTCATACCGGTCAGCCTAGCCAAGGGACCGTCCCGCCGTCGCCCC
ATTTCACTAGCATCAGCGTC

Downstream 100 bases:

>100_bases
ACGTGCCTGACCACGGCCGATGGAATCACAACATCCACTACCAGCGCGAGGTGCTGCGCAGGGTACCGGCTCATGCGACC
GACGTTCTCGACGTGGGCTG

Product: O-methyltransferase OMT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTESDALRPSGSSRISGDSLEGVSATTLWTLHNRGTEAKRPDSVIRDPLAAELFDAIEYDYRKFGRPSQTHALRALAFDT
QARVYLATHPRAAIVALAEGMQTSFWRLGGADATAQFTWYSVDLPPVMELRNQLLPNDERIVKLAQSALDLSWMDQVDAS
GGAFITAEGLLMYLQPEESLGLIEACAKRFPGGQMMFDSIPHWFSRRTLQGFKLSDRYVAPPMPFALTPDEGEALISIPG
VVTAIDIPLHRGRGIWKFVNSKRLDRGFLRRTRPSMTLLQFG

Sequences:

>Translated_282_residues
MTESDALRPSGSSRISGDSLEGVSATTLWTLHNRGTEAKRPDSVIRDPLAAELFDAIEYDYRKFGRPSQTHALRALAFDT
QARVYLATHPRAAIVALAEGMQTSFWRLGGADATAQFTWYSVDLPPVMELRNQLLPNDERIVKLAQSALDLSWMDQVDAS
GGAFITAEGLLMYLQPEESLGLIEACAKRFPGGQMMFDSIPHWFSRRTLQGFKLSDRYVAPPMPFALTPDEGEALISIPG
VVTAIDIPLHRGRGIWKFVNSKRLDRGFLRRTRPSMTLLQFG
>Mature_281_residues
TESDALRPSGSSRISGDSLEGVSATTLWTLHNRGTEAKRPDSVIRDPLAAELFDAIEYDYRKFGRPSQTHALRALAFDTQ
ARVYLATHPRAAIVALAEGMQTSFWRLGGADATAQFTWYSVDLPPVMELRNQLLPNDERIVKLAQSALDLSWMDQVDASG
GAFITAEGLLMYLQPEESLGLIEACAKRFPGGQMMFDSIPHWFSRRTLQGFKLSDRYVAPPMPFALTPDEGEALISIPGV
VTAIDIPLHRGRGIWKFVNSKRLDRGFLRRTRPSMTLLQFG

Specific function: O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions:methylation of 8- O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007213
- InterPro:   IPR016874 [H]

Pfam domain/function: PF04072 LCM [H]

EC number: NA

Molecular weight: Translated: 31372; Mature: 31241

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESDALRPSGSSRISGDSLEGVSATTLWTLHNRGTEAKRPDSVIRDPLAAELFDAIEYD
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHCHHHHHHHHHHHHH
YRKFGRPSQTHALRALAFDTQARVYLATHPRAAIVALAEGMQTSFWRLGGADATAQFTWY
HHHCCCCCHHHHHHHEEECCCCEEEEEECCCHHHHHHHHCHHHHHHCCCCCCCEEEEEEE
SVDLPPVMELRNQLLPNDERIVKLAQSALDLSWMDQVDASGGAFITAEGLLMYLQPEESL
EECCCHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHCCCCCEEEEECCEEEEECCCCCC
GLIEACAKRFPGGQMMFDSIPHWFSRRTLQGFKLSDRYVAPPMPFALTPDEGEALISIPG
CHHHHHHHHCCCCCCHHHHCCHHHHHHHHCCCCCCCCEECCCCCEEECCCCCCEEEECCC
VVTAIDIPLHRGRGIWKFVNSKRLDRGFLRRTRPSMTLLQFG
EEEEEECCHHCCCCCEEHHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
TESDALRPSGSSRISGDSLEGVSATTLWTLHNRGTEAKRPDSVIRDPLAAELFDAIEYD
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHCHHHHHHHHHHHHH
YRKFGRPSQTHALRALAFDTQARVYLATHPRAAIVALAEGMQTSFWRLGGADATAQFTWY
HHHCCCCCHHHHHHHEEECCCCEEEEEECCCHHHHHHHHCHHHHHHCCCCCCCEEEEEEE
SVDLPPVMELRNQLLPNDERIVKLAQSALDLSWMDQVDASGGAFITAEGLLMYLQPEESL
EECCCHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHCCCCCEEEEECCEEEEECCCCCC
GLIEACAKRFPGGQMMFDSIPHWFSRRTLQGFKLSDRYVAPPMPFALTPDEGEALISIPG
CHHHHHHHHCCCCCCHHHHCCHHHHHHHHCCCCCCCCEECCCCCEEECCCCCCEEEECCC
VVTAIDIPLHRGRGIWKFVNSKRLDRGFLRRTRPSMTLLQFG
EEEEEECCHHCCCCCEEHHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8509339 [H]