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The map label for this gene is copA [H]

Identifier: 169628364

GI number: 169628364

Start: 1274584

End: 1276107

Strand: Reverse

Name: copA [H]

Synonym: MAB_1271c

Alternate gene names: 169628364

Gene position: 1276107-1274584 (Counterclockwise)

Preceding gene: 169628369

Following gene: 169628361

Centisome position: 25.18

GC content: 64.83

Gene sequence:

>1524_bases
ATGAACACTGGCATGTCACCACGGCTTGACCGACGCGAGCTCCTCCGTTTGGGTATGACGGCTGCGGCTGCGGGGTTCTT
GGCCTCCTGCACCAAAAACACCTCGGGAGCTGCCACATCGCCACGCGTTAACCCGGATTCGCCACGCATCGCCGCGGTGG
AAGCGGCACGAAGAGGGCGGGGCGCTCCCGTCCGCCAATTCGCGCTGAACGCCGGCCCCACCGAGCTCGATCTCGCCGGC
ACGCGGGTATCCACCTGGGCATACGGGGGCCGGGTACCCGGGCAGGAAATCCGCCTGCGCAAGGGCGAAATTCTCCGGGT
ACAGACCGTCAACAATCTCCCGGCGCCTACGAGTGTTCATTGGCACGGCCTGGCGCTGCGCAATGACATGGACGGCGTGC
CCGGCCTCACCCAGCCGGAGATCGCACCGACCGGAGTATTCGACTACGAGTTCGCGGTACCGCACGCCGGTACGTATTGG
TTTCACCCTCATGTCGGTACGCAGATCGATCGCGGTCTCTACGCGCCGCTGATCATCGAGGATCCCGACGAGGGCGCCGA
CTATGACGAAGAACTGGTGGTGGCGCTCGATGACTGGATCGACGGTACCGGCACCGATCCCGATCGAGTACTCGAAGGAT
TACGCACCAAGGGCATGCCCCCGATGGATCATTCGATGATGGGTGGCATGGGAGCGGACCCGACGGCACCGTTGGGGATG
GATGCCGGCGATGTGACGTATCCCTACTACCTGATCAACGGGCGAGTGGCGGCCGATCCGCAGGCCGCGAACTATCGGGC
CGGACAGCGCGTCCGGCTGCGGATGGTCAATGCCGGTGGCGACACGGCGTTCCGGGTCGGCATCCCGGGTGTACCGATGA
CGGTCACTCACACCGACGGGTTCCCGGTGCAGCCCTACAAGGCCGACACCATCCTGGTCACCATGGGCGAACGAGTTGAC
GCCGTCGTCACCATCCCGGGTTCATCGGTGCCCTTGATCGCCGTTCCCGAAGGGAAAAAGGGCTTCGCGCAGTTGATCCT
GCGCTCAGGGGATACCCCGGTGCGCGGGCGCGCCGAGGACGCCGCGATGCTGATGAAGTCGCAGGTGCCTCTGGATACCG
CGATGCTGACCGCTGCCGACGCAGTTCAACTCACGCGGCGGGAACCCGGGGTGATCCACGACGTGCGGCTGGCCGGACCC
GGCGGGAAGTACACATGGACCATCAACGGCAAGACCTACGACCCGCGCGATGGCCTGCCCGTGCGCGAGGGGCAGCGTGT
GCGTTTGCGTTTCATCAACAACTCGATGATGTTCCACCCTATGCACCTGCACGGGCATACCTTCGCCGTGCGCGACGGCA
AAGGCGCGTTCCGCGCCCGCAAGGACACGGTCCTCGTCGCACCCATGAAGACCGTCGAGGTGGACTTCGACGCCGACAAC
CCCGGGCAGTGGCTTACCCACTGCCACAACATCTATCACGGTGAGACCGGGATGATGGCGGTGGTGTCGTATATGCAGGA
CTGA

Upstream 100 bases:

>100_bases
GGGTATGTGATCCGATCGCTACCTATCCGTGGTGAGCGCTCAATGTGATTGATGCTTCCAAGGTTGCCTCATATACCCCT
ACGGGGTATAGATTGGGGTC

Downstream 100 bases:

>100_bases
CGTTGCCGCCGGGCTCTCAGCGCACTCGCGAGTGCCCGGCTATGAGCGACAACGTGTCAACTGACCTGCCGCATTCTGCT
GAACATACCGACAATCCAGA

Product: oxidase (copper-binding protein)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MNTGMSPRLDRRELLRLGMTAAAAGFLASCTKNTSGAATSPRVNPDSPRIAAVEAARRGRGAPVRQFALNAGPTELDLAG
TRVSTWAYGGRVPGQEIRLRKGEILRVQTVNNLPAPTSVHWHGLALRNDMDGVPGLTQPEIAPTGVFDYEFAVPHAGTYW
FHPHVGTQIDRGLYAPLIIEDPDEGADYDEELVVALDDWIDGTGTDPDRVLEGLRTKGMPPMDHSMMGGMGADPTAPLGM
DAGDVTYPYYLINGRVAADPQAANYRAGQRVRLRMVNAGGDTAFRVGIPGVPMTVTHTDGFPVQPYKADTILVTMGERVD
AVVTIPGSSVPLIAVPEGKKGFAQLILRSGDTPVRGRAEDAAMLMKSQVPLDTAMLTAADAVQLTRREPGVIHDVRLAGP
GGKYTWTINGKTYDPRDGLPVREGQRVRLRFINNSMMFHPMHLHGHTFAVRDGKGAFRARKDTVLVAPMKTVEVDFDADN
PGQWLTHCHNIYHGETGMMAVVSYMQD

Sequences:

>Translated_507_residues
MNTGMSPRLDRRELLRLGMTAAAAGFLASCTKNTSGAATSPRVNPDSPRIAAVEAARRGRGAPVRQFALNAGPTELDLAG
TRVSTWAYGGRVPGQEIRLRKGEILRVQTVNNLPAPTSVHWHGLALRNDMDGVPGLTQPEIAPTGVFDYEFAVPHAGTYW
FHPHVGTQIDRGLYAPLIIEDPDEGADYDEELVVALDDWIDGTGTDPDRVLEGLRTKGMPPMDHSMMGGMGADPTAPLGM
DAGDVTYPYYLINGRVAADPQAANYRAGQRVRLRMVNAGGDTAFRVGIPGVPMTVTHTDGFPVQPYKADTILVTMGERVD
AVVTIPGSSVPLIAVPEGKKGFAQLILRSGDTPVRGRAEDAAMLMKSQVPLDTAMLTAADAVQLTRREPGVIHDVRLAGP
GGKYTWTINGKTYDPRDGLPVREGQRVRLRFINNSMMFHPMHLHGHTFAVRDGKGAFRARKDTVLVAPMKTVEVDFDADN
PGQWLTHCHNIYHGETGMMAVVSYMQD
>Mature_507_residues
MNTGMSPRLDRRELLRLGMTAAAAGFLASCTKNTSGAATSPRVNPDSPRIAAVEAARRGRGAPVRQFALNAGPTELDLAG
TRVSTWAYGGRVPGQEIRLRKGEILRVQTVNNLPAPTSVHWHGLALRNDMDGVPGLTQPEIAPTGVFDYEFAVPHAGTYW
FHPHVGTQIDRGLYAPLIIEDPDEGADYDEELVVALDDWIDGTGTDPDRVLEGLRTKGMPPMDHSMMGGMGADPTAPLGM
DAGDVTYPYYLINGRVAADPQAANYRAGQRVRLRMVNAGGDTAFRVGIPGVPMTVTHTDGFPVQPYKADTILVTMGERVD
AVVTIPGSSVPLIAVPEGKKGFAQLILRSGDTPVRGRAEDAAMLMKSQVPLDTAMLTAADAVQLTRREPGVIHDVRLAGP
GGKYTWTINGKTYDPRDGLPVREGQRVRLRFINNSMMFHPMHLHGHTFAVRDGKGAFRARKDTVLVAPMKTVEVDFDADN
PGQWLTHCHNIYHGETGMMAVVSYMQD

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=552, Percent_Identity=26.0869565217391, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321067, Length=494, Percent_Identity=23.2793522267206, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320714, Length=553, Percent_Identity=22.7848101265823, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6323703, Length=241, Percent_Identity=29.045643153527, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221330000, Length=247, Percent_Identity=29.1497975708502, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585842, Length=247, Percent_Identity=29.1497975708502, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281360167, Length=247, Percent_Identity=29.1497975708502, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221329998, Length=247, Percent_Identity=29.1497975708502, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI18859919, Length=246, Percent_Identity=26.0162601626016, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24650186, Length=263, Percent_Identity=25.4752851711027, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28574104, Length=123, Percent_Identity=38.2113821138211, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 54901; Mature: 54901

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTGMSPRLDRRELLRLGMTAAAAGFLASCTKNTSGAATSPRVNPDSPRIAAVEAARRGR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHCCC
GAPVRQFALNAGPTELDLAGTRVSTWAYGGRVPGQEIRLRKGEILRVQTVNNLPAPTSVH
CCCHHHEEECCCCCEEEECCCEEEEEECCCCCCCHHEEECCCCEEEEEECCCCCCCCCEE
WHGLALRNDMDGVPGLTQPEIAPTGVFDYEFAVPHAGTYWFHPHVGTQIDRGLYAPLIIE
EEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEE
DPDEGADYDEELVVALDDWIDGTGTDPDRVLEGLRTKGMPPMDHSMMGGMGADPTAPLGM
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCC
DAGDVTYPYYLINGRVAADPQAANYRAGQRVRLRMVNAGGDTAFRVGIPGVPMTVTHTDG
CCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCEEEEECCC
FPVQPYKADTILVTMGERVDAVVTIPGSSVPLIAVPEGKKGFAQLILRSGDTPVRGRAED
CCCCCCCCCEEEEEECCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCHH
AAMLMKSQVPLDTAMLTAADAVQLTRREPGVIHDVRLAGPGGKYTWTINGKTYDPRDGLP
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCEECCCCCCC
VREGQRVRLRFINNSMMFHPMHLHGHTFAVRDGKGAFRARKDTVLVAPMKTVEVDFDADN
CCCCCEEEEEEECCCEEEEEEEECCEEEEEECCCCCCEECCCEEEEECCEEEEEEECCCC
PGQWLTHCHNIYHGETGMMAVVSYMQD
CHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNTGMSPRLDRRELLRLGMTAAAAGFLASCTKNTSGAATSPRVNPDSPRIAAVEAARRGR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHCCC
GAPVRQFALNAGPTELDLAGTRVSTWAYGGRVPGQEIRLRKGEILRVQTVNNLPAPTSVH
CCCHHHEEECCCCCEEEECCCEEEEEECCCCCCCHHEEECCCCEEEEEECCCCCCCCCEE
WHGLALRNDMDGVPGLTQPEIAPTGVFDYEFAVPHAGTYWFHPHVGTQIDRGLYAPLIIE
EEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEE
DPDEGADYDEELVVALDDWIDGTGTDPDRVLEGLRTKGMPPMDHSMMGGMGADPTAPLGM
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCC
DAGDVTYPYYLINGRVAADPQAANYRAGQRVRLRMVNAGGDTAFRVGIPGVPMTVTHTDG
CCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCEEEEECCC
FPVQPYKADTILVTMGERVDAVVTIPGSSVPLIAVPEGKKGFAQLILRSGDTPVRGRAED
CCCCCCCCCEEEEEECCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCHH
AAMLMKSQVPLDTAMLTAADAVQLTRREPGVIHDVRLAGPGGKYTWTINGKTYDPRDGLP
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCEECCCCCCC
VREGQRVRLRFINNSMMFHPMHLHGHTFAVRDGKGAFRARKDTVLVAPMKTVEVDFDADN
CCCCCEEEEEEECCCEEEEEEEECCEEEEEECCCCCCEECCCEEEEECCEEEEEEECCCC
PGQWLTHCHNIYHGETGMMAVVSYMQD
CHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]