| Definition | Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010397 |
| Length | 5,067,172 |
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The map label for this gene is hdhA [C]
Identifier: 169628312
GI number: 169628312
Start: 1231688
End: 1232440
Strand: Direct
Name: hdhA [C]
Synonym: MAB_1219
Alternate gene names: 169628312
Gene position: 1231688-1232440 (Clockwise)
Preceding gene: 169628311
Following gene: 169628313
Centisome position: 24.31
GC content: 62.82
Gene sequence:
>753_bases ATGGGTGAGTTTGATAACAAGGTCGCCATTGTCACCGGCGCCGCACAGGGCATCGGCGAGGCATACGCGCACGCGCTGGC CCGCGAGGGCGCCGCGGTGGTGGTCGCCGATATCAATGCCGAGATGGGTGAGGGCGTCGCCAAGCAGATCGTCGCCGACG GCGGTAGGGCCATCTTCGCAGGTGTGGACGTCTCCGATCCCGATTCGGCGATCGCCATGGCAGACAAGGCTGTCAGCGAG TTCGGCGGCATCGACTATCTGGTGAACAACGCCGCCATCTACGGCGGTATGAAGCTCGACCTGCTGCTCTCGGTGCCCTG GGATTACTACAAGAAATTCATGAGCGTGAACCAGGACGGGGCGCTGGTGTGCACCCGCGCGGTGTACAAGCACATCGCTC AGCGCGGCGGCGGCGCCATTGTCAATCAGTCGTCCACCGCCGCGTGGCTGTACTCCGGCTTCTACGGATTGGCCAAGGTT GGCATCAACGGCCTGACGCAGCAGTTGTCCCGAGAGCTGGGCGGGCAGAAGATTCGCATCAACGCCATCGCGCCGGGGCC GACCGACACCGAGGCCACCCGCGGCACCGTGCCCGAGCAATTCCGCAGCGAGTTGGTCAAGAACATTCCGCTGAGCCGCA TGGGAACTGTTGACGACATGGTGGGCATGTGTCTTTTCCTGTTGTCGGATAAGGCGTCGTGGATCACCGGCCAGGTATTC AACGTCGATGGCGGACAGATCATCCGGTCATGA
Upstream 100 bases:
>100_bases TCGGGCAACGGCAGGGAGATGGGTGTGGCCGGTTTCGAGGAATATCTGGAAACCAAAGTCATTGCGACGGCAGTGAAATA GGAGACTTGAGGAGAGAATT
Downstream 100 bases:
>100_bases CGCAGCAAGCCATGAAACTGGGATACATCGGCCTGGGCAATATGGGGGCGCCCATGGCCCGGCGGCTTGTCGATTGGCCA GGCGGCCTCACGGTCTTCGA
Product: short chain dehydrogenase
Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+
Alternate protein names: NA
Number of amino acids: Translated: 250; Mature: 249
Protein sequence:
>250_residues MGEFDNKVAIVTGAAQGIGEAYAHALAREGAAVVVADINAEMGEGVAKQIVADGGRAIFAGVDVSDPDSAIAMADKAVSE FGGIDYLVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDGALVCTRAVYKHIAQRGGGAIVNQSSTAAWLYSGFYGLAKV GINGLTQQLSRELGGQKIRINAIAPGPTDTEATRGTVPEQFRSELVKNIPLSRMGTVDDMVGMCLFLLSDKASWITGQVF NVDGGQIIRS
Sequences:
>Translated_250_residues MGEFDNKVAIVTGAAQGIGEAYAHALAREGAAVVVADINAEMGEGVAKQIVADGGRAIFAGVDVSDPDSAIAMADKAVSE FGGIDYLVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDGALVCTRAVYKHIAQRGGGAIVNQSSTAAWLYSGFYGLAKV GINGLTQQLSRELGGQKIRINAIAPGPTDTEATRGTVPEQFRSELVKNIPLSRMGTVDDMVGMCLFLLSDKASWITGQVF NVDGGQIIRS >Mature_249_residues GEFDNKVAIVTGAAQGIGEAYAHALAREGAAVVVADINAEMGEGVAKQIVADGGRAIFAGVDVSDPDSAIAMADKAVSEF GGIDYLVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDGALVCTRAVYKHIAQRGGGAIVNQSSTAAWLYSGFYGLAKVG INGLTQQLSRELGGQKIRINAIAPGPTDTEATRGTVPEQFRSELVKNIPLSRMGTVDDMVGMCLFLLSDKASWITGQVFN VDGGQIIRS
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=34.8, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=32.9317269076305, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=30.1960784313725, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=30.7692307692308, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=30.1960784313725, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=31.1023622047244, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=31.3008130081301, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=29.6875, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=29.6, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI126723750, Length=257, Percent_Identity=29.5719844357977, Blast_Score=85, Evalue=6e-17, Organism=Homo sapiens, GI4504505, Length=212, Percent_Identity=32.0754716981132, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI7706318, Length=249, Percent_Identity=27.3092369477912, Blast_Score=81, Evalue=8e-16, Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=30.0395256916996, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI126723191, Length=189, Percent_Identity=34.9206349206349, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI40254986, Length=188, Percent_Identity=31.3829787234043, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=29.9492385786802, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI109715829, Length=202, Percent_Identity=30.1980198019802, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI31542939, Length=194, Percent_Identity=31.9587628865979, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4557649, Length=190, Percent_Identity=27.3684210526316, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI166795268, Length=215, Percent_Identity=29.7674418604651, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=28.0632411067194, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=32.9268292682927, Blast_Score=129, Evalue=2e-31, Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=34.7490347490347, Blast_Score=124, Evalue=8e-30, Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=30.6122448979592, Blast_Score=122, Evalue=3e-29, Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=30.4878048780488, Blast_Score=119, Evalue=3e-28, Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=33.4661354581673, Blast_Score=113, Evalue=1e-26, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=31.8367346938775, Blast_Score=112, Evalue=3e-26, Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=34.6774193548387, Blast_Score=107, Evalue=9e-25, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=31.0756972111554, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1789057, Length=260, Percent_Identity=30, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=25.9842519685039, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=29.4573643410853, Blast_Score=78, Evalue=5e-16, Organism=Escherichia coli, GI2367365, Length=249, Percent_Identity=26.1044176706827, Blast_Score=71, Evalue=8e-14, Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=25, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=27.7992277992278, Blast_Score=64, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=33.596837944664, Blast_Score=115, Evalue=3e-26, Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=32.3770491803279, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=30.4832713754647, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=28.4, Blast_Score=100, Evalue=5e-22, Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=30.4, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=31.0077519379845, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=30.9236947791165, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=31.5589353612167, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17562906, Length=273, Percent_Identity=27.4725274725275, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=30.4182509505703, Blast_Score=89, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17536651, Length=256, Percent_Identity=29.296875, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17559104, Length=269, Percent_Identity=30.4832713754647, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=32.0158102766798, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=31.2741312741313, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17562904, Length=270, Percent_Identity=30.3703703703704, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17531453, Length=262, Percent_Identity=28.2442748091603, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562908, Length=269, Percent_Identity=28.2527881040892, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=29.6992481203008, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=28.4644194756554, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=27.5471698113208, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=29.5880149812734, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17561272, Length=258, Percent_Identity=29.8449612403101, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=26.7657992565056, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17568967, Length=214, Percent_Identity=29.9065420560748, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17551412, Length=261, Percent_Identity=27.9693486590038, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=28.8973384030418, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI71982365, Length=196, Percent_Identity=29.0816326530612, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI193204405, Length=269, Percent_Identity=27.5092936802974, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17562990, Length=266, Percent_Identity=27.4436090225564, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17567345, Length=187, Percent_Identity=28.8770053475936, Blast_Score=70, Evalue=9e-13, Organism=Caenorhabditis elegans, GI17564282, Length=199, Percent_Identity=28.643216080402, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17565030, Length=267, Percent_Identity=28.8389513108614, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI193203115, Length=186, Percent_Identity=30.1075268817204, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI193203117, Length=186, Percent_Identity=30.1075268817204, Blast_Score=65, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=31.2, Blast_Score=100, Evalue=2e-22, Organism=Saccharomyces cerevisiae, GI6322861, Length=261, Percent_Identity=29.1187739463602, Blast_Score=80, Evalue=3e-16, Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=35.5731225296443, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=32.2709163346614, Blast_Score=107, Evalue=5e-24, Organism=Drosophila melanogaster, GI21355319, Length=262, Percent_Identity=29.3893129770992, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=29.5275590551181, Blast_Score=95, Evalue=4e-20, Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=29.4117647058824, Blast_Score=88, Evalue=4e-18, Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=29.2307692307692, Blast_Score=81, Evalue=6e-16, Organism=Drosophila melanogaster, GI116007234, Length=205, Percent_Identity=32.1951219512195, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI18859837, Length=214, Percent_Identity=31.3084112149533, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI116007236, Length=205, Percent_Identity=27.8048780487805, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=28.3950617283951, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI21357673, Length=196, Percent_Identity=27.0408163265306, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24644337, Length=253, Percent_Identity=30.0395256916996, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI281364494, Length=206, Percent_Identity=30.5825242718447, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI116007232, Length=192, Percent_Identity=30.7291666666667, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI24663911, Length=234, Percent_Identity=26.0683760683761, Blast_Score=67, Evalue=8e-12, Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=25.3807106598985, Blast_Score=65, Evalue=3e-11, Organism=Drosophila melanogaster, GI116007238, Length=192, Percent_Identity=26.5625, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI21355631, Length=172, Percent_Identity=29.0697674418605, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100
Molecular weight: Translated: 26341; Mature: 26210
Theoretical pI: Translated: 4.87; Mature: 4.87
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGEFDNKVAIVTGAAQGIGEAYAHALAREGAAVVVADINAEMGEGVAKQIVADGGRAIFA CCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHCCHHHHHHHHCCCCEEEE GVDVSDPDSAIAMADKAVSEFGGIDYLVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDG ECCCCCCCHHHHHHHHHHHHHCCCCEEECCEEEECCEEEEEEEECCHHHHHHHHCCCCCC ALVCTRAVYKHIAQRGGGAIVNQSSTAAWLYSGFYGLAKVGINGLTQQLSRELGGQKIRI CEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE NAIAPGPTDTEATRGTVPEQFRSELVKNIPLSRMGTVDDMVGMCLFLLSDKASWITGQVF EEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEE NVDGGQIIRS ECCCCCEECC >Mature Secondary Structure GEFDNKVAIVTGAAQGIGEAYAHALAREGAAVVVADINAEMGEGVAKQIVADGGRAIFA CCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHCCHHHHHHHHCCCCEEEE GVDVSDPDSAIAMADKAVSEFGGIDYLVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDG ECCCCCCCHHHHHHHHHHHHHCCCCEEECCEEEECCEEEEEEEECCHHHHHHHHCCCCCC ALVCTRAVYKHIAQRGGGAIVNQSSTAAWLYSGFYGLAKVGINGLTQQLSRELGGQKIRI CEEHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE NAIAPGPTDTEATRGTVPEQFRSELVKNIPLSRMGTVDDMVGMCLFLLSDKASWITGQVF EEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEE NVDGGQIIRS ECCCCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+
Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9655913; 12597275 [H]