Click here to switch to the map view.

The map label for this gene is uppS [C]

Identifier: 169628302

GI number: 169628302

Start: 1222362

End: 1223144

Strand: Direct

Name: uppS [C]

Synonym: MAB_1209

Alternate gene names: 169628302

Gene position: 1222362-1223144 (Clockwise)

Preceding gene: 169628300

Following gene: 169628311

Centisome position: 24.12

GC content: 64.62

Gene sequence:

>783_bases
GTGGAGATCATCCCGCCGAGACTGAAGGAACCGCTGTACAAGCTCTACGAAATGCGGCTCCGCCAGGAGTTGGTCAAGGC
GTCGAAACCGCGGCATATCGCCGTTCTGTGCGACGGAAACCGGCGTTGGGCGCGGTCCGCGGGCTATACCGACGTCAGTC
ACGGGTACCGGATGGGGGCCCGCAAGATCAGCGAGATGCTCGGCTGGTGCCAGGATGCCGGTGTCGAGATGGCGACCGTG
TATCTGTTATCGGCCGAGAATCTGACACGCGACCCCGACCAGCTCACCGAGTTGCTGGAAATCATCACCGATGTCGTCGA
GGAGCTGTGCGCCCCGCAGAACAAATGGAGTGTGCGCAGTGTCGGTGATCTGGATCTGCTGCCCGATGAGGTGGCGGAGC
GCATGCGGCAGGCCGTCAAGTCCGCACCTTCGGATGCCGGTTTCCATGTCAACGTGGCGGTCGGTTACGGGGGGCGGCAG
GAGATCACCGATGCGGTGCGCACCCTGCTGAACAAAGAGCTGGCCAACGGCGCCTCCGCCGAGCAGCTGGTGCAGGCGGT
GACCGTCGACGCCATCTCCGAGAACCTCTACACCTCGGGGCAGCCCGACCCCGACCTGGTGATCCGGACCTCGGGGGAGC
AGCGGTTGTCAGGGTTCCTGCTCTGGCAGAGCGCCTATTCGGAGATGTGGTTCACCGACGCCTATTGGCCCGAGTTCCGG
CGGGTGGACTTCCTGCGCGCGCTGCGCGATTACGCCGCGCGAAACCGGCGGTTTGGGCAGTAG

Upstream 100 bases:

>100_bases
ATGCGTCACAGTATCGCGTTCCCAAAGTCAGGTTTGTGAAGGTTGTGTGCAGATCCATATCCGCTGCTCCGGCCCGCGTG
CGGCTCGCTAGGCTGGATCC

Downstream 100 bases:

>100_bases
TCAGCGTCTGCCCATCAGGTCGTCGATCTCCTCCATCGACCACGGTGCGTCCAGCGCGTGATCGCGGTATCCCAGCGGTA
CCGGCGTCTGGCGCTTGAAA

Product: short-chain Z-isoprenyl diphosphate synthetase

Products: NA

Alternate protein names: (2Z,6E)-farnesyl diphosphate synthase; Z-FPP synthase; Z-isoprenyl diphosphate synthase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MEIIPPRLKEPLYKLYEMRLRQELVKASKPRHIAVLCDGNRRWARSAGYTDVSHGYRMGARKISEMLGWCQDAGVEMATV
YLLSAENLTRDPDQLTELLEIITDVVEELCAPQNKWSVRSVGDLDLLPDEVAERMRQAVKSAPSDAGFHVNVAVGYGGRQ
EITDAVRTLLNKELANGASAEQLVQAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTDAYWPEFR
RVDFLRALRDYAARNRRFGQ

Sequences:

>Translated_260_residues
MEIIPPRLKEPLYKLYEMRLRQELVKASKPRHIAVLCDGNRRWARSAGYTDVSHGYRMGARKISEMLGWCQDAGVEMATV
YLLSAENLTRDPDQLTELLEIITDVVEELCAPQNKWSVRSVGDLDLLPDEVAERMRQAVKSAPSDAGFHVNVAVGYGGRQ
EITDAVRTLLNKELANGASAEQLVQAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTDAYWPEFR
RVDFLRALRDYAARNRRFGQ
>Mature_260_residues
MEIIPPRLKEPLYKLYEMRLRQELVKASKPRHIAVLCDGNRRWARSAGYTDVSHGYRMGARKISEMLGWCQDAGVEMATV
YLLSAENLTRDPDQLTELLEIITDVVEELCAPQNKWSVRSVGDLDLLPDEVAERMRQAVKSAPSDAGFHVNVAVGYGGRQ
EITDAVRTLLNKELANGASAEQLVQAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTDAYWPEFR
RVDFLRALRDYAARNRRFGQ

Specific function: Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family. Z-FPP synthase subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=251, Percent_Identity=33.8645418326693, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI45580742, Length=251, Percent_Identity=33.8645418326693, Blast_Score=137, Evalue=8e-33,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=33.0543933054393, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71993029, Length=243, Percent_Identity=30.4526748971193, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=32.7188940092166, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=241, Percent_Identity=25.3112033195021, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI18857969, Length=230, Percent_Identity=34.7826086956522, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.68 [H]

Molecular weight: Translated: 29486; Mature: 29486

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIPPRLKEPLYKLYEMRLRQELVKASKPRHIAVLCDGNRRWARSAGYTDVSHGYRMGA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCHHHHHHHHH
RKISEMLGWCQDAGVEMATVYLLSAENLTRDPDQLTELLEIITDVVEELCAPQNKWSVRS
HHHHHHHHHHHHCCCCEEHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VGDLDLLPDEVAERMRQAVKSAPSDAGFHVNVAVGYGGRQEITDAVRTLLNKELANGASA
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCH
EQLVQAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTDAYWPEFR
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RVDFLRALRDYAARNRRFGQ
HHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEIIPPRLKEPLYKLYEMRLRQELVKASKPRHIAVLCDGNRRWARSAGYTDVSHGYRMGA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCHHHHHHHHH
RKISEMLGWCQDAGVEMATVYLLSAENLTRDPDQLTELLEIITDVVEELCAPQNKWSVRS
HHHHHHHHHHHHCCCCEEHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VGDLDLLPDEVAERMRQAVKSAPSDAGFHVNVAVGYGGRQEITDAVRTLLNKELANGASA
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCH
EQLVQAVTVDAISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTDAYWPEFR
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RVDFLRALRDYAARNRRFGQ
HHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]