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The map label for this gene is fadA [H]

Identifier: 169628285

GI number: 169628285

Start: 1206144

End: 1207361

Strand: Reverse

Name: fadA [H]

Synonym: MAB_1192c

Alternate gene names: 169628285

Gene position: 1207361-1206144 (Counterclockwise)

Preceding gene: 169628286

Following gene: 169628284

Centisome position: 23.83

GC content: 67.9

Gene sequence:

>1218_bases
ATGCCCGAAGCCGTGATCGTTTCCACTGCCCGCTCCCCGATCGGGCGAGCCGGCAAGGGCTCGCTGGTGAGCATGCGGCC
GGATGACCTGGCCGCGCAGATGGTGCGCGCCGCCCTCGACAAGGTGCCCGCACTGGACCCCAAGGATGTCGACGACCTGA
TGCTGGGCTGCGGTCAGCCAGGCGGCGAGGCCGGTTTCAACATCGGTCGCGCGGTGGCGGTACAGCTGGGCTACGACTTC
CTGCCCGGCACCACCGTCAACCGTTACTGCTCGTCGTCGCTGCAGACCACCCGCATGGCGTTCCACGCCATCAAGGCCGG
CGAGGGTCACGCATTCATTTCCGCTGGTGTGGAGACGGTTTCGCGCTTTCCGAAGGGCACTTCGGACGGATGGCCGGACA
GCCACAACCCGCTGTACGCCGACGCCGAGGCCCGCACCGCGACCGCGGCACAGGGTGCCACCGAATGGCACGACCCGCGC
AACGACGGCCTGACCCCCGACGTGTACATCGCGATGGGCCAGACCGCCGAGAACGTGGCACTGCACACCGGCATCAGCCG
TGAGGACCAGGACCACTGGGGCGTGCGCAGCCAGAACCGGGCCGAAAAGGCCATTGCCGATGGCTTTTTCGAGCGCGAGA
TCACCCCGGTGACGCTGGCCGACGGTACCGTCGTGGCCAAGGACGACGGCCCCCGCGCCGGCACCACCTACGAGGCCATC
AGCCAGCTGAAGCCGGTGTTCCGCCCCAACGGCACCATCACTGCCGGTAACGCCTGCCCGCTGAACGACGGTGCGGCCGC
GCTGGTCGTGATGAGCGATGTGCGCGCCAAGGAGCTGGGCCTGACCCCGCTGGCGCGCATCGTCTCTACCGGTGTGTCCG
GCCTGTCGCCGGAAATCATGGGCCTGGGCCCGATCGAGGCCGTCAAGCGCGCACTGGCCAACGCGGGCAAGTCGATTGGC
GACATCGATCTGTTCGAGATCAACGAGGCGTTCGCCGTCCAGGTGCTGGGCTCGGCGCGCGCGCTCGGCATCGATGAGGA
CAAGCTGAACGTCTCCGGCGGTGCGATCGCGCTGGGTCACCCCTTCGGCATGACCGGTGCCCGCATCACCGCCACCCTGC
TGAACAACCTGACCACCTACGACAAGACCTTCGGTGTCGAGACCATGTGTGTGGGTGGCGGCCAGGGTATGGCGATGGTC
ATCGAGCGGCTCGCCTAG

Upstream 100 bases:

>100_bases
CCGAGCCCGCAGACCGGCCCGACAATCTGCCCGTCGCATCGCTGCATTAGATTCCTGGGGAGTAGAACCAGTACTAAATC
CCCTATATTCAGGAGTTTTC

Downstream 100 bases:

>100_bases
TTCTCCCCTTTTTCGTCGACACGCCGTGTTGCGGCGGGTTCGTATCGCACGTTCCCGCCACGACACGGCGTGTCGGCGTT
TGGGGCGCCTGCCGGCCGGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPALDPKDVDDLMLGCGQPGGEAGFNIGRAVAVQLGYDF
LPGTTVNRYCSSSLQTTRMAFHAIKAGEGHAFISAGVETVSRFPKGTSDGWPDSHNPLYADAEARTATAAQGATEWHDPR
NDGLTPDVYIAMGQTAENVALHTGISREDQDHWGVRSQNRAEKAIADGFFEREITPVTLADGTVVAKDDGPRAGTTYEAI
SQLKPVFRPNGTITAGNACPLNDGAAALVVMSDVRAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKRALANAGKSIG
DIDLFEINEAFAVQVLGSARALGIDEDKLNVSGGAIALGHPFGMTGARITATLLNNLTTYDKTFGVETMCVGGGQGMAMV
IERLA

Sequences:

>Translated_405_residues
MPEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPALDPKDVDDLMLGCGQPGGEAGFNIGRAVAVQLGYDF
LPGTTVNRYCSSSLQTTRMAFHAIKAGEGHAFISAGVETVSRFPKGTSDGWPDSHNPLYADAEARTATAAQGATEWHDPR
NDGLTPDVYIAMGQTAENVALHTGISREDQDHWGVRSQNRAEKAIADGFFEREITPVTLADGTVVAKDDGPRAGTTYEAI
SQLKPVFRPNGTITAGNACPLNDGAAALVVMSDVRAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKRALANAGKSIG
DIDLFEINEAFAVQVLGSARALGIDEDKLNVSGGAIALGHPFGMTGARITATLLNNLTTYDKTFGVETMCVGGGQGMAMV
IERLA
>Mature_404_residues
PEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPALDPKDVDDLMLGCGQPGGEAGFNIGRAVAVQLGYDFL
PGTTVNRYCSSSLQTTRMAFHAIKAGEGHAFISAGVETVSRFPKGTSDGWPDSHNPLYADAEARTATAAQGATEWHDPRN
DGLTPDVYIAMGQTAENVALHTGISREDQDHWGVRSQNRAEKAIADGFFEREITPVTLADGTVVAKDDGPRAGTTYEAIS
QLKPVFRPNGTITAGNACPLNDGAAALVVMSDVRAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKRALANAGKSIGD
IDLFEINEAFAVQVLGSARALGIDEDKLNVSGGAIALGHPFGMTGARITATLLNNLTTYDKTFGVETMCVGGGQGMAMVI
ERLA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=412, Percent_Identity=39.0776699029126, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI167614485, Length=405, Percent_Identity=36.2962962962963, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4501853, Length=413, Percent_Identity=38.498789346247, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4557237, Length=414, Percent_Identity=35.024154589372, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=29.3427230046948, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI194353979, Length=405, Percent_Identity=30.1234567901235, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1787663, Length=415, Percent_Identity=43.3734939759036, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI48994986, Length=413, Percent_Identity=42.1307506053269, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=42.7872860635697, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI87082165, Length=411, Percent_Identity=37.956204379562, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1788683, Length=428, Percent_Identity=33.411214953271, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=404, Percent_Identity=37.1287128712871, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI25147385, Length=407, Percent_Identity=32.4324324324324, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=33.9066339066339, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=431, Percent_Identity=29.4663573085847, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=413, Percent_Identity=27.6029055690073, Blast_Score=118, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6322031, Length=408, Percent_Identity=35.5392156862745, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6325229, Length=415, Percent_Identity=37.3493975903614, Blast_Score=213, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24655093, Length=409, Percent_Identity=37.1638141809291, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17648125, Length=326, Percent_Identity=40.1840490797546, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24640423, Length=415, Percent_Identity=33.4939759036145, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=30.607476635514, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42246; Mature: 42115

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPALDPKDVDDLMLGCGQP
CCCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
GGEAGFNIGRAVAVQLGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGHAFISAGVETV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
SRFPKGTSDGWPDSHNPLYADAEARTATAAQGATEWHDPRNDGLTPDVYIAMGQTAENVA
HHCCCCCCCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEE
LHTGISREDQDHWGVRSQNRAEKAIADGFFEREITPVTLADGTVVAKDDGPRAGTTYEAI
EECCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCHHHHH
SQLKPVFRPNGTITAGNACPLNDGAAALVVMSDVRAKELGLTPLARIVSTGVSGLSPEIM
HHHCHHHCCCCCEECCCCCCCCCCCEEEEEEECCHHHHCCCHHHHHHHHHCCCCCCCCCC
GLGPIEAVKRALANAGKSIGDIDLFEINEAFAVQVLGSARALGIDEDKLNVSGGAIALGH
CCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCEECCCCEEEECC
PFGMTGARITATLLNNLTTYDKTFGVETMCVGGGQGMAMVIERLA
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHC
>Mature Secondary Structure 
PEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPALDPKDVDDLMLGCGQP
CCCEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
GGEAGFNIGRAVAVQLGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGHAFISAGVETV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
SRFPKGTSDGWPDSHNPLYADAEARTATAAQGATEWHDPRNDGLTPDVYIAMGQTAENVA
HHCCCCCCCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEE
LHTGISREDQDHWGVRSQNRAEKAIADGFFEREITPVTLADGTVVAKDDGPRAGTTYEAI
EECCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCHHHHH
SQLKPVFRPNGTITAGNACPLNDGAAALVVMSDVRAKELGLTPLARIVSTGVSGLSPEIM
HHHCHHHCCCCCEECCCCCCCCCCCEEEEEEECCHHHHCCCHHHHHHHHHCCCCCCCCCC
GLGPIEAVKRALANAGKSIGDIDLFEINEAFAVQVLGSARALGIDEDKLNVSGGAIALGH
CCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCEECCCCEEEECC
PFGMTGARITATLLNNLTTYDKTFGVETMCVGGGQGMAMVIERLA
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]