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The map label for this gene is fadI [H]

Identifier: 169628097

GI number: 169628097

Start: 1007729

End: 1009009

Strand: Direct

Name: fadI [H]

Synonym: MAB_1002

Alternate gene names: 169628097

Gene position: 1007729-1009009 (Clockwise)

Preceding gene: 169628096

Following gene: 169628108

Centisome position: 19.89

GC content: 67.29

Gene sequence:

>1281_bases
ATGACCGGATCTGCCAAGCGCCGCGCTGTCATTGTCGCGGGCGCACGCACCCCATTTGTTCGTGCCTTCGGTGAGTTCAC
CCGCATGGACACCATTGCGCTGGCCGACGAGGCGGTGCGCGGCTTGCTGGACAACACCAAGGTCTCTTCCAGTGAGATCG
AGGCGATCGTCTGGGGCGGGGTGATCCTGCCCGCGGGCGCGCCGAACGTCGCCCGCGAGATCGCACTCGATCTCAAGCTT
GGGCACGGCGTCGAAGGCCACACCGTCACGCGCGCGTGCGCTTCCGGTCTGCAAGCCATCACCACCGCGGCCGCCGCGAT
CGAGCGCGGCGAATACGACGTGATGATCGCCGGTGGCTCCGACTCCACCTCGAACGCGGGAGTCAACCTGCCGCAGAAGC
TGATTCACGCGGCCGCCCCGTTGGCCCTGGGTAAGCCCAAGCCGAAGGATTACCTCGACGCCGCATGGAGCCTGGCCCCG
TTCACCGGACTGCTGCCACGCCGGCCCAAGATCGAGGAGCGCACCACCGGTGAGGTGATGGGGGAGTCGGCCGACAAAAT
GGCCAAGATTCACGGCATCACCCGCCAGGCCCAGGACGAGTTCGCGGTCCGCTCGCACCGCCGTGCGGCCGCGGCCATCG
CGTCGGGACGATTCGACCGGGAGGTCGTTCCCGTCGCGGGCGTGACCCGCGACGGCCTGGTCCGTGAGAACACCAGCGTG
GAAAAGCTGGCCACGCTCAAGCCCGTCTTCAATCGCGACGGCACCGTGACCGCGGGTAACGCCAGTCCGCTCACCGATGG
TGCCGCGGCGGTCCTGCTCATGAGTGAGGAGAAAGCCCGGGCGCTCGGCCTGCGGCCGTTGGCGGCCTTCCGCTCCTGGA
GCTACGTCAGCGTGGATCCGGCGGACGAGGTGCTCATCGGACCGGCGATCTCGATGCCCCGTGCGCTCGAGAAGGCGGGA
CTCGATCTCGATGACGTCGACTACATCGACATTCACGAAGCTTTTGCCGCACAGACCCTTTCGGTGCTGGAGGCACTGGG
CTCCAAGAAGTGGGCCACCGACCGGTTGGGGCGCTCGGAGGCGGTCGGCACTCCCGATATCGACAAGGTCAACGTGCACG
GCGGTTCGGTGTCGATCGGACATCCGTTCGGCGCCACCGGCGCCCGCATGGTCACCACAATGGCCAACGAGCTGGCGCTC
AGCGGGAAAGGCACGGCACTGCTGGGTATTTGCGCAGCAGGCGGTCACGGTGCCAGTGCGGTACTGGAACGGGTGGACTA
G

Upstream 100 bases:

>100_bases
ACAGGGTTTTTCGCGGCGGTTGAACTGGCAGCGGGTGCTGCGCTTTACGAACCAGACACCCGCGTAAACGGGCAACTGAC
TCGCGAGTAAGCTCGCCGCC

Downstream 100 bases:

>100_bases
CCGGCGCTCCGGTCGCCGAAACGAAAAATGCCTGCCTACAAGCGTTGTCGCTCGTAGGCAGGCATTTTCAGCAGTACTTC
TAGCCGCCGTATCCGGGACG

Product: putative acetyl-CoA C-acyltransferase (thiolase)

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTGSAKRRAVIVAGARTPFVRAFGEFTRMDTIALADEAVRGLLDNTKVSSSEIEAIVWGGVILPAGAPNVAREIALDLKL
GHGVEGHTVTRACASGLQAITTAAAAIERGEYDVMIAGGSDSTSNAGVNLPQKLIHAAAPLALGKPKPKDYLDAAWSLAP
FTGLLPRRPKIEERTTGEVMGESADKMAKIHGITRQAQDEFAVRSHRRAAAAIASGRFDREVVPVAGVTRDGLVRENTSV
EKLATLKPVFNRDGTVTAGNASPLTDGAAAVLLMSEEKARALGLRPLAAFRSWSYVSVDPADEVLIGPAISMPRALEKAG
LDLDDVDYIDIHEAFAAQTLSVLEALGSKKWATDRLGRSEAVGTPDIDKVNVHGGSVSIGHPFGATGARMVTTMANELAL
SGKGTALLGICAAGGHGASAVLERVD

Sequences:

>Translated_426_residues
MTGSAKRRAVIVAGARTPFVRAFGEFTRMDTIALADEAVRGLLDNTKVSSSEIEAIVWGGVILPAGAPNVAREIALDLKL
GHGVEGHTVTRACASGLQAITTAAAAIERGEYDVMIAGGSDSTSNAGVNLPQKLIHAAAPLALGKPKPKDYLDAAWSLAP
FTGLLPRRPKIEERTTGEVMGESADKMAKIHGITRQAQDEFAVRSHRRAAAAIASGRFDREVVPVAGVTRDGLVRENTSV
EKLATLKPVFNRDGTVTAGNASPLTDGAAAVLLMSEEKARALGLRPLAAFRSWSYVSVDPADEVLIGPAISMPRALEKAG
LDLDDVDYIDIHEAFAAQTLSVLEALGSKKWATDRLGRSEAVGTPDIDKVNVHGGSVSIGHPFGATGARMVTTMANELAL
SGKGTALLGICAAGGHGASAVLERVD
>Mature_425_residues
TGSAKRRAVIVAGARTPFVRAFGEFTRMDTIALADEAVRGLLDNTKVSSSEIEAIVWGGVILPAGAPNVAREIALDLKLG
HGVEGHTVTRACASGLQAITTAAAAIERGEYDVMIAGGSDSTSNAGVNLPQKLIHAAAPLALGKPKPKDYLDAAWSLAPF
TGLLPRRPKIEERTTGEVMGESADKMAKIHGITRQAQDEFAVRSHRRAAAAIASGRFDREVVPVAGVTRDGLVRENTSVE
KLATLKPVFNRDGTVTAGNASPLTDGAAAVLLMSEEKARALGLRPLAAFRSWSYVSVDPADEVLIGPAISMPRALEKAGL
DLDDVDYIDIHEAFAAQTLSVLEALGSKKWATDRLGRSEAVGTPDIDKVNVHGGSVSIGHPFGATGARMVTTMANELALS
GKGTALLGICAAGGHGASAVLERVD

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=422, Percent_Identity=40.7582938388626, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI4501853, Length=434, Percent_Identity=35.7142857142857, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI148539872, Length=425, Percent_Identity=30.3529411764706, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI167614485, Length=431, Percent_Identity=31.7865429234339, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI4557237, Length=425, Percent_Identity=31.7647058823529, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI194353979, Length=249, Percent_Identity=28.9156626506024, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=42.3167848699764, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1788554, Length=428, Percent_Identity=35.981308411215, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI87082165, Length=425, Percent_Identity=35.5294117647059, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI48994986, Length=433, Percent_Identity=34.4110854503464, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1787663, Length=431, Percent_Identity=34.8027842227378, Blast_Score=195, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=40.4705882352941, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI133906874, Length=431, Percent_Identity=32.0185614849188, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=432, Percent_Identity=31.25, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535921, Length=433, Percent_Identity=30.715935334873, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=433, Percent_Identity=26.3279445727483, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325229, Length=437, Percent_Identity=33.1807780320366, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322031, Length=428, Percent_Identity=30.607476635514, Blast_Score=162, Evalue=8e-41,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=40.9411764705882, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24655093, Length=424, Percent_Identity=30.6603773584906, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24640423, Length=427, Percent_Identity=32.7868852459016, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17648125, Length=435, Percent_Identity=29.1954022988506, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 44390; Mature: 44259

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSAKRRAVIVAGARTPFVRAFGEFTRMDTIALADEAVRGLLDNTKVSSSEIEAIVWGG
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECC
VILPAGAPNVAREIALDLKLGHGVEGHTVTRACASGLQAITTAAAAIERGEYDVMIAGGS
EEECCCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
DSTSNAGVNLPQKLIHAAAPLALGKPKPKDYLDAAWSLAPFTGLLPRRPKIEERTTGEVM
CCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHH
GESADKMAKIHGITRQAQDEFAVRSHRRAAAAIASGRFDREVVPVAGVTRDGLVRENTSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCH
EKLATLKPVFNRDGTVTAGNASPLTDGAAAVLLMSEEKARALGLRPLAAFRSWSYVSVDP
HHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHCCCHHHHHCCCCEEEECC
ADEVLIGPAISMPRALEKAGLDLDDVDYIDIHEAFAAQTLSVLEALGSKKWATDRLGRSE
CCCEEECCCCCCCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
AVGTPDIDKVNVHGGSVSIGHPFGATGARMVTTMANELALSGKGTALLGICAAGGHGASA
CCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHEECCCCCEEEEEEECCCCCHHH
VLERVD
HHHHCC
>Mature Secondary Structure 
TGSAKRRAVIVAGARTPFVRAFGEFTRMDTIALADEAVRGLLDNTKVSSSEIEAIVWGG
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECC
VILPAGAPNVAREIALDLKLGHGVEGHTVTRACASGLQAITTAAAAIERGEYDVMIAGGS
EEECCCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
DSTSNAGVNLPQKLIHAAAPLALGKPKPKDYLDAAWSLAPFTGLLPRRPKIEERTTGEVM
CCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHH
GESADKMAKIHGITRQAQDEFAVRSHRRAAAAIASGRFDREVVPVAGVTRDGLVRENTSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCH
EKLATLKPVFNRDGTVTAGNASPLTDGAAAVLLMSEEKARALGLRPLAAFRSWSYVSVDP
HHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHCCCHHHHHCCCCEEEECC
ADEVLIGPAISMPRALEKAGLDLDDVDYIDIHEAFAAQTLSVLEALGSKKWATDRLGRSE
CCCEEECCCCCCCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
AVGTPDIDKVNVHGGSVSIGHPFGATGARMVTTMANELALSGKGTALLGICAAGGHGASA
CCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHEECCCCCEEEEEEECCCCCHHH
VLERVD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA