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The map label for this gene is hbd [H]

Identifier: 169628003

GI number: 169628003

Start: 897240

End: 898109

Strand: Direct

Name: hbd [H]

Synonym: MAB_0904

Alternate gene names: 169628003

Gene position: 897240-898109 (Clockwise)

Preceding gene: 169628002

Following gene: 169628004

Centisome position: 17.71

GC content: 66.32

Gene sequence:

>870_bases
ATGACCGCCACACCCCACAGCGTTCCCACGGTTGTCACCGTGATCGGCGGCGGGCCAATGGGTGCAGGTATAGCGCAGGT
GTTCGCGGCCGCGGGCGCGAATGTCACTATCGTCGAAACAGGCCGTGACAGAGCCGATGCCGCCCTCCAACGCGTGAGCG
CCGGGCTGGACCGCGCCGCCGCCAAGAACCGGCTTGCCGAGGCTCCCGAACACGTGCTCTCGCGGGTGGACGTCGTCTGC
TCGCTCACCGAACTGCCCACCGACTCTGAGCTCGTCGTCGAGGCGGTGCCCGAGAACATCAACCTCAAGATCGAGGTCCT
CGGTGCCGCAGAGAAACTCGTCGAACCCACGACGGTGCTGGCATCCAACACGAGCTCGCTCTCGATCACCGAACTGGCCG
CGGCATTACTGCGGCCCGAGCGCGTCGTGGGAATGCACTTCTTCAATCCGGTGCCAACGTCGCAGCTGGTGGAGATCGTC
CGAGCGCCCGAGACGTCAGACGACACCGTCGCAGCCGCACTCGCCTGGGTTCGAGCCCTCGGCAAGGCCGATGTCGTAGC
GCGTGATTCACCGGGATTCGCTTCGAGTCGGCTCGGCGTCGCACTTGGGCTGGAGGCGATCCGCATGCTCGAAGAGGGCG
TGGCCGACGCTGAATCCATCGACCGGGCCATGGAACTGGGCTACCGCCACCCCATGGGCCCGTTGCGCTCGACGGATCTC
GTCGGGCTCGACGTGCGGTTGGCTATTGCCGAGCATCTATGCGCGACCCTCGGCCCTCGGTTCACGCCGCCGAAACTGCT
GCGGGCCAAGGTTGCCGAGGGCAACCTTGGCCGCAAGACCGGGCAGGGCTTTTTTCGCTGGTCCAGCTGA

Upstream 100 bases:

>100_bases
ATTCCGCGCATCCGCTGATCGATGACCTCGCGCAAGCGGTGCTGTTCGAAAGCCCTGACAAAACCGACCGCATGACGCGA
TTCCTCGAAAGGCAGACCAG

Downstream 100 bases:

>100_bases
ACATCGTCAGAGGAGGAATCATGACTCAAACCGCACCGGCCGCCGTCGCGTACTCAGTGAACCACGCTGGCGTCGCTGCG
ATCGTGCTCGATCGGCCGGA

Product: putative 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTATPHSVPTVVTVIGGGPMGAGIAQVFAAAGANVTIVETGRDRADAALQRVSAGLDRAAAKNRLAEAPEHVLSRVDVVC
SLTELPTDSELVVEAVPENINLKIEVLGAAEKLVEPTTVLASNTSSLSITELAAALLRPERVVGMHFFNPVPTSQLVEIV
RAPETSDDTVAAALAWVRALGKADVVARDSPGFASSRLGVALGLEAIRMLEEGVADAESIDRAMELGYRHPMGPLRSTDL
VGLDVRLAIAEHLCATLGPRFTPPKLLRAKVAEGNLGRKTGQGFFRWSS

Sequences:

>Translated_289_residues
MTATPHSVPTVVTVIGGGPMGAGIAQVFAAAGANVTIVETGRDRADAALQRVSAGLDRAAAKNRLAEAPEHVLSRVDVVC
SLTELPTDSELVVEAVPENINLKIEVLGAAEKLVEPTTVLASNTSSLSITELAAALLRPERVVGMHFFNPVPTSQLVEIV
RAPETSDDTVAAALAWVRALGKADVVARDSPGFASSRLGVALGLEAIRMLEEGVADAESIDRAMELGYRHPMGPLRSTDL
VGLDVRLAIAEHLCATLGPRFTPPKLLRAKVAEGNLGRKTGQGFFRWSS
>Mature_288_residues
TATPHSVPTVVTVIGGGPMGAGIAQVFAAAGANVTIVETGRDRADAALQRVSAGLDRAAAKNRLAEAPEHVLSRVDVVCS
LTELPTDSELVVEAVPENINLKIEVLGAAEKLVEPTTVLASNTSSLSITELAAALLRPERVVGMHFFNPVPTSQLVEIVR
APETSDDTVAAALAWVRALGKADVVARDSPGFASSRLGVALGLEAIRMLEEGVADAESIDRAMELGYRHPMGPLRSTDLV
GLDVRLAIAEHLCATLGPRFTPPKLLRAKVAEGNLGRKTGQGFFRWSS

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=41.522491349481, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=39.2156862745098, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=36.6197183098592, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI261878539, Length=289, Percent_Identity=30.1038062283737, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI68989263, Length=289, Percent_Identity=30.1038062283737, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=28.3898305084746, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=37.2340425531915, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1790281, Length=206, Percent_Identity=40.7766990291262, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1788682, Length=201, Percent_Identity=38.3084577114428, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17549919, Length=284, Percent_Identity=39.4366197183099, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=284, Percent_Identity=36.2676056338028, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=36.1111111111111, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=34.2756183745583, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=34.2756183745583, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=34.2756183745583, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=285, Percent_Identity=34.3859649122807, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71985923, Length=285, Percent_Identity=32.280701754386, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71985930, Length=277, Percent_Identity=28.158844765343, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI193203623, Length=207, Percent_Identity=29.951690821256, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115533614, Length=166, Percent_Identity=31.3253012048193, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583077, Length=289, Percent_Identity=37.7162629757785, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24583079, Length=289, Percent_Identity=37.7162629757785, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19921000, Length=289, Percent_Identity=37.7162629757785, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI20129993, Length=236, Percent_Identity=29.6610169491525, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45549573, Length=237, Percent_Identity=29.1139240506329, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30321; Mature: 30190

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATPHSVPTVVTVIGGGPMGAGIAQVFAAAGANVTIVETGRDRADAALQRVSAGLDRAA
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
AKNRLAEAPEHVLSRVDVVCSLTELPTDSELVVEAVPENINLKIEVLGAAEKLVEPTTVL
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCCEEEEEECCHHHHCCCHHEE
ASNTSSLSITELAAALLRPERVVGMHFFNPVPTSQLVEIVRAPETSDDTVAAALAWVRAL
ECCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
GKADVVARDSPGFASSRLGVALGLEAIRMLEEGVADAESIDRAMELGYRHPMGPLRSTDL
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCE
VGLDVRLAIAEHLCATLGPRFTPPKLLRAKVAEGNLGRKTGQGFFRWSS
EEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEEECC
>Mature Secondary Structure 
TATPHSVPTVVTVIGGGPMGAGIAQVFAAAGANVTIVETGRDRADAALQRVSAGLDRAA
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
AKNRLAEAPEHVLSRVDVVCSLTELPTDSELVVEAVPENINLKIEVLGAAEKLVEPTTVL
HHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCCEEEEEECCHHHHCCCHHEE
ASNTSSLSITELAAALLRPERVVGMHFFNPVPTSQLVEIVRAPETSDDTVAAALAWVRAL
ECCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
GKADVVARDSPGFASSRLGVALGLEAIRMLEEGVADAESIDRAMELGYRHPMGPLRSTDL
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCE
VGLDVRLAIAEHLCATLGPRFTPPKLLRAKVAEGNLGRKTGQGFFRWSS
EEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]