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The map label for this gene is hbd [H]

Identifier: 169627860

GI number: 169627860

Start: 759021

End: 759905

Strand: Reverse

Name: hbd [H]

Synonym: MAB_0759c

Alternate gene names: 169627860

Gene position: 759905-759021 (Counterclockwise)

Preceding gene: 169627861

Following gene: 169627857

Centisome position: 15.0

GC content: 61.24

Gene sequence:

>885_bases
GTGACGTACTCACCCCCGGCAGATATCGACAATCGCCCGGTCGCCGTGCTCGGCGCAGGAACACTCGGCCGCCGCATCGC
CCTGACCTTCGCCACCCGCGGCGGTGTGGTGCATCTCTACGACGTCTCGGAGGAATCACTACAGTCAGCAAAGGAGTTCC
TTGATCAGCGGATCCCGGAATTGGTCAAGGCTCGCTCCGCCCTGGGCGCTCAACCCGCGACCATCGAGTACTACACCGAC
CTGCCCAGCGCAGTGAAAGATGCTTGGTATGTAGTCGAATCGGTTCCCGAGGTGCAGGCGCTCAAGATCGATATGCTGGG
CCAGCTGGACGAAATCGCCGCACCTGATGCGATCATCGGCACCAACTCGTCGTCCTTCATGAGCAGCGAGCTCATCGGCA
AGGTCAAGCATCCGCAGCGGTTTCTCAACACCCACTACGGGCAGCCGCCCGAGGCACCGCAGGCCGAGCTGGTCACCGAC
GGACACACCAATGAACGGATTTTCGACATCCTCGGGGCCGAACTGCCCAAACACGGATTCGTGACCGCCGTCGCGCACAA
GGAAAGCGTCGGCTTCATCATCAACCGGGTATGGGCTGCCGTTAAGCGTGAAGCCTTGGCCGTTGTCGCCGAGGGAGTTT
CGACACCCGCCGAGTTCGACCGCATCTGGGTCGCATCCGGCATGAGTCCGATCGGCGTATTCCGGGCCATCGATCGCGTC
GGCCTCGACGTCGCACTGGATATCGAGGACAACTACATCAAACACTTCCCCTACATCCCCACTACGTCACGCGACCTGCT
GCAGCAATATGTCGACGAGGGCAAGCTGGGGGTGAAGTCGGGCGAGGGTTTCTACCACGACTGCCCGGAACCATCACACG
ACTAA

Upstream 100 bases:

>100_bases
CGCGAAGGTCGACGGCAACCTCACCGGAATCGTTGGAGTCTGAACCAACTCACCAATCATCGTCATAGACCGCTAGAGAC
CGCTATAGACAGGACAGAAC

Downstream 100 bases:

>100_bases
GCGCACGCTCACCTCAGTGCGTGGATCCCGTTGTACAGCACCATCACACCGATGACGATCAGTATTGCGGCCATCAACGC
GGCATTGTTCTTATCCATCC

Product: putative dehydrogenase (3-hydroxybutyryl-CoA dehydrogenase FadB)

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTYSPPADIDNRPVAVLGAGTLGRRIALTFATRGGVVHLYDVSEESLQSAKEFLDQRIPELVKARSALGAQPATIEYYTD
LPSAVKDAWYVVESVPEVQALKIDMLGQLDEIAAPDAIIGTNSSSFMSSELIGKVKHPQRFLNTHYGQPPEAPQAELVTD
GHTNERIFDILGAELPKHGFVTAVAHKESVGFIINRVWAAVKREALAVVAEGVSTPAEFDRIWVASGMSPIGVFRAIDRV
GLDVALDIEDNYIKHFPYIPTTSRDLLQQYVDEGKLGVKSGEGFYHDCPEPSHD

Sequences:

>Translated_294_residues
MTYSPPADIDNRPVAVLGAGTLGRRIALTFATRGGVVHLYDVSEESLQSAKEFLDQRIPELVKARSALGAQPATIEYYTD
LPSAVKDAWYVVESVPEVQALKIDMLGQLDEIAAPDAIIGTNSSSFMSSELIGKVKHPQRFLNTHYGQPPEAPQAELVTD
GHTNERIFDILGAELPKHGFVTAVAHKESVGFIINRVWAAVKREALAVVAEGVSTPAEFDRIWVASGMSPIGVFRAIDRV
GLDVALDIEDNYIKHFPYIPTTSRDLLQQYVDEGKLGVKSGEGFYHDCPEPSHD
>Mature_293_residues
TYSPPADIDNRPVAVLGAGTLGRRIALTFATRGGVVHLYDVSEESLQSAKEFLDQRIPELVKARSALGAQPATIEYYTDL
PSAVKDAWYVVESVPEVQALKIDMLGQLDEIAAPDAIIGTNSSSFMSSELIGKVKHPQRFLNTHYGQPPEAPQAELVTDG
HTNERIFDILGAELPKHGFVTAVAHKESVGFIINRVWAAVKREALAVVAEGVSTPAEFDRIWVASGMSPIGVFRAIDRVG
LDVALDIEDNYIKHFPYIPTTSRDLLQQYVDEGKLGVKSGEGFYHDCPEPSHD

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=215, Percent_Identity=30.6976744186047, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI296179429, Length=291, Percent_Identity=28.1786941580756, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI296179427, Length=308, Percent_Identity=26.9480519480519, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=27.9151943462898, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787661, Length=286, Percent_Identity=29.020979020979, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=23.7037037037037, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=28.9655172413793, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17549919, Length=296, Percent_Identity=29.7297297297297, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25144276, Length=279, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508951, Length=279, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508953, Length=279, Percent_Identity=29.0322580645161, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17558304, Length=285, Percent_Identity=27.3684210526316, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71985923, Length=292, Percent_Identity=23.6301369863014, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=236, Percent_Identity=27.9661016949153, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203623, Length=203, Percent_Identity=29.5566502463054, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45549573, Length=230, Percent_Identity=28.2608695652174, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=29.9107142857143, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=25.8741258741259, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=25.8741258741259, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=25.8741258741259, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32126; Mature: 31994

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSPPADIDNRPVAVLGAGTLGRRIALTFATRGGVVHLYDVSEESLQSAKEFLDQRIPE
CCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHH
LVKARSALGAQPATIEYYTDLPSAVKDAWYVVESVPEVQALKIDMLGQLDEIAAPDAIIG
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHCCCCCEEE
TNSSSFMSSELIGKVKHPQRFLNTHYGQPPEAPQAELVTDGHTNERIFDILGAELPKHGF
CCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCC
VTAVAHKESVGFIINRVWAAVKREALAVVAEGVSTPAEFDRIWVASGMSPIGVFRAIDRV
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHC
GLDVALDIEDNYIKHFPYIPTTSRDLLQQYVDEGKLGVKSGEGFYHDCPEPSHD
CCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYSPPADIDNRPVAVLGAGTLGRRIALTFATRGGVVHLYDVSEESLQSAKEFLDQRIPE
CCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHH
LVKARSALGAQPATIEYYTDLPSAVKDAWYVVESVPEVQALKIDMLGQLDEIAAPDAIIG
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHCCCCCEEE
TNSSSFMSSELIGKVKHPQRFLNTHYGQPPEAPQAELVTDGHTNERIFDILGAELPKHGF
CCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCC
VTAVAHKESVGFIINRVWAAVKREALAVVAEGVSTPAEFDRIWVASGMSPIGVFRAIDRV
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHC
GLDVALDIEDNYIKHFPYIPTTSRDLLQQYVDEGKLGVKSGEGFYHDCPEPSHD
CCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]