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The map label for this gene is purM [H]

Identifier: 169627829

GI number: 169627829

Start: 732525

End: 733613

Strand: Direct

Name: purM [H]

Synonym: MAB_0728

Alternate gene names: 169627829

Gene position: 732525-733613 (Clockwise)

Preceding gene: 169627828

Following gene: 169627832

Centisome position: 14.46

GC content: 67.13

Gene sequence:

>1089_bases
ATGCCCGATATGAGCGAGCGAGCCGACAAACCCAGTAATTCGTACGCCGCGGCCGGGGTGGACATCGAAGCCGGCGACCG
GGCCGTCGAGCTGTTCAAGAAATCCGTCGCCAAGACGCATCGTCCCGAGGTGTTGGGCGGTATCGGCGGCTTCGCCGGGC
TGTTCGCGCTCAAGGGTGGTTACCGCGAGCCGGTGCTGGCCGCCTCCACCGACGGTGTCGGTACCAAGATCGCCGTCGCA
CAGGCCATGGACAAACGCGACACCGTCGGTCTGGACCTGGTGGCCATGGTTGTCGACGACCTGGTCGTGTGCGGCGCCGA
GCCGCTGTTCCTGCAGGATTACATCGCGGTGGGCAAGGTGGTGCCCGAGCGTGTCAGCGAGCTGGTCGCCGGAATTGCCG
AGGGGTGCGCCATCGCCGGCTGCGCACTGCTCGGCGGTGAGACTGCCGAACATCCCGGGCTGATGGCTCCCGACGACTTC
GATCTGTCGGCCACCGGCGTCGGCATCGTGGAAGCCGACCGCGTGCTGGGCCCGGATCGCGTGCGTCCGGGCGATGTCGT
GATCGCCATGGGCTCGTCGGGCCTGCACTCCAACGGGTACTCCCTGGCCCGGCACGTGCTGCTGGAGATCGATCGGATGG
ATCTGTTCGGTCAGGTGGAAGAATTTGGCCGCACTCTGGGGGAGGAGCTGCTGGAACCCACCCGGATCTACGCCAAGGAC
TGCCTGGCGCTGGCTGCCGAGACCGAGGTACGGACTTTCTGCCACGTCACCGGCGGCGGGCTCGCGGGCAATCTGGCCCG
CGTCATCCCCGATGGGCTCGTTGCCGAGCTCGACCGCGGCAGTTGGACCCCCGGCCCGATCTTCGCGATGATCGCCCAGC
GCGGCCGCATCGAGCGCGCCGAGATGGAGAAGACCTTCAACATGGGCGTCGGCATGGTGGCCGTCGTCGCGCCCGAGGAT
GTCGACAGGGCACTTGCGGTCCTGACGGCACGGCACATCGATTGCTGGACCCTGGGCACCATCAAGAAGTCGGGCAAGGA
TTCAGGCAGCGAGAGCGCCCTACTCGTGGGACAGCACCCGAGGTTCTGA

Upstream 100 bases:

>100_bases
CACCTCCGCCGACCTGCCGTTGCGTGGCTTCGCGGGCCGGTTCAAATAGCCGCATCGAGGACCAGTGCGGACACCTGTGC
CAGTCGGGACGGGTACCGTA

Downstream 100 bases:

>100_bases
GAACCTCGGGTGTTTACCGCAGTGCCGTTTTAGCGGCGCCAGGCGTCCTCGTCGTCCGACCAGCGGTCGCTGGTGCGGTC
GTCGTCCGGCTGAGATACCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MPDMSERADKPSNSYAAAGVDIEAGDRAVELFKKSVAKTHRPEVLGGIGGFAGLFALKGGYREPVLAASTDGVGTKIAVA
QAMDKRDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGKVVPERVSELVAGIAEGCAIAGCALLGGETAEHPGLMAPDDF
DLSATGVGIVEADRVLGPDRVRPGDVVIAMGSSGLHSNGYSLARHVLLEIDRMDLFGQVEEFGRTLGEELLEPTRIYAKD
CLALAAETEVRTFCHVTGGGLAGNLARVIPDGLVAELDRGSWTPGPIFAMIAQRGRIERAEMEKTFNMGVGMVAVVAPED
VDRALAVLTARHIDCWTLGTIKKSGKDSGSESALLVGQHPRF

Sequences:

>Translated_362_residues
MPDMSERADKPSNSYAAAGVDIEAGDRAVELFKKSVAKTHRPEVLGGIGGFAGLFALKGGYREPVLAASTDGVGTKIAVA
QAMDKRDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGKVVPERVSELVAGIAEGCAIAGCALLGGETAEHPGLMAPDDF
DLSATGVGIVEADRVLGPDRVRPGDVVIAMGSSGLHSNGYSLARHVLLEIDRMDLFGQVEEFGRTLGEELLEPTRIYAKD
CLALAAETEVRTFCHVTGGGLAGNLARVIPDGLVAELDRGSWTPGPIFAMIAQRGRIERAEMEKTFNMGVGMVAVVAPED
VDRALAVLTARHIDCWTLGTIKKSGKDSGSESALLVGQHPRF
>Mature_361_residues
PDMSERADKPSNSYAAAGVDIEAGDRAVELFKKSVAKTHRPEVLGGIGGFAGLFALKGGYREPVLAASTDGVGTKIAVAQ
AMDKRDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGKVVPERVSELVAGIAEGCAIAGCALLGGETAEHPGLMAPDDFD
LSATGVGIVEADRVLGPDRVRPGDVVIAMGSSGLHSNGYSLARHVLLEIDRMDLFGQVEEFGRTLGEELLEPTRIYAKDC
LALAAETEVRTFCHVTGGGLAGNLARVIPDGLVAELDRGSWTPGPIFAMIAQRGRIERAEMEKTFNMGVGMVAVVAPEDV
DRALAVLTARHIDCWTLGTIKKSGKDSGSESALLVGQHPRF

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=333, Percent_Identity=42.9429429429429, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI209869995, Length=333, Percent_Identity=42.9429429429429, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI209869993, Length=333, Percent_Identity=42.9429429429429, Blast_Score=262, Evalue=3e-70,
Organism=Escherichia coli, GI1788845, Length=338, Percent_Identity=48.8165680473373, Blast_Score=309, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=36.734693877551, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321203, Length=361, Percent_Identity=41.2742382271468, Blast_Score=253, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24582400, Length=272, Percent_Identity=39.3382352941176, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38038; Mature: 37907

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDMSERADKPSNSYAAAGVDIEAGDRAVELFKKSVAKTHRPEVLGGIGGFAGLFALKGG
CCCCHHHCCCCCCCEEECCCEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
YREPVLAASTDGVGTKIAVAQAMDKRDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGKV
CCCCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VPERVSELVAGIAEGCAIAGCALLGGETAEHPGLMAPDDFDLSATGVGIVEADRVLGPDR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCC
VRPGDVVIAMGSSGLHSNGYSLARHVLLEIDRMDLFGQVEEFGRTLGEELLEPTRIYAKD
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLALAAETEVRTFCHVTGGGLAGNLARVIPDGLVAELDRGSWTPGPIFAMIAQRGRIERA
HHHHHHHHHHHHEEEECCCCHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHCCCCHHH
EMEKTFNMGVGMVAVVAPEDVDRALAVLTARHIDCWTLGTIKKSGKDSGSESALLVGQHP
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCCEEEECCCC
RF
CC
>Mature Secondary Structure 
PDMSERADKPSNSYAAAGVDIEAGDRAVELFKKSVAKTHRPEVLGGIGGFAGLFALKGG
CCCHHHCCCCCCCEEECCCEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
YREPVLAASTDGVGTKIAVAQAMDKRDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGKV
CCCCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VPERVSELVAGIAEGCAIAGCALLGGETAEHPGLMAPDDFDLSATGVGIVEADRVLGPDR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCC
VRPGDVVIAMGSSGLHSNGYSLARHVLLEIDRMDLFGQVEEFGRTLGEELLEPTRIYAKD
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLALAAETEVRTFCHVTGGGLAGNLARVIPDGLVAELDRGSWTPGPIFAMIAQRGRIERA
HHHHHHHHHHHHEEEECCCCHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHCCCCHHH
EMEKTFNMGVGMVAVVAPEDVDRALAVLTARHIDCWTLGTIKKSGKDSGSESALLVGQHP
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCCEEEECCCC
RF
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA